LOCUS       NP_001100129             521 aa            linear   ROD 14-JAN-2025
DEFINITION  U4/U6 small nuclear ribonucleoprotein Prp4 [Rattus norvegicus].
ACCESSION   NP_001100129 XP_001057634 XP_233022
VERSION     NP_001100129.1
DBSOURCE    REFSEQ: accession NM_001106659.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 521)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (residues 1 to 521)
  AUTHORS   Linder,B., Hirmer,A., Gal,A., Ruther,K., Bolz,H.J., Winkler,C.,
            Laggerbauer,B. and Fischer,U.
  TITLE     Identification of a PRPF4 loss-of-function variant that abrogates
            U4/U6.U5 tri-snRNP integration and is associated with retinitis
            pigmentosa
  JOURNAL   PLoS One 9 (11), e111754 (2014)
   PUBMED   25383878
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 521)
  AUTHORS   Pabis,M., Neufeld,N., Steiner,M.C., Bojic,T., Shav-Tal,Y. and
            Neugebauer,K.M.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   4  (residues 1 to 521)
  AUTHORS   Wahl,M.C., Will,C.L. and Luhrmann,R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   5  (residues 1 to 521)
  AUTHORS   Schaffert,N., Hossbach,M., Heintzmann,R., Achsel,T. and Luhrmann,R.
  TITLE     RNAi knockdown of hPrp31 leads to an accumulation of U4/U6
            di-snRNPs in Cajal bodies
  JOURNAL   EMBO J 23 (15), 3000-3009 (2004)
   PUBMED   15257298
REFERENCE   6  (residues 1 to 521)
  AUTHORS   Teigelkamp,S., Achsel,T., Mundt,C., Gothel,S.F., Cronshagen,U.,
            Lane,W.S., Marahiel,M. and Luhrmann,R.
  TITLE     The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel
            cyclophilin that forms a complex with the U4/U6-specific 60kD and
            90kD proteins
  JOURNAL   RNA 4 (2), 127-141 (1998)
   PUBMED   9570313
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473978.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_233022.3, XP_001057634.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..521
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     Protein         1..521
                     /product="U4/U6 small nuclear ribonucleoprotein Prp4"
                     /note="PRP4 pre-mRNA processing factor 4 homolog; pre-mRNA
                     splicing tri-snRNP complex factor 4"
                     /calculated_mol_wt=58212
     Region          102..140
                     /region_name="SFM"
                     /note="Splicing Factor Motif, present in Prp18 and Pr04;
                     smart00500"
                     /db_xref="CDD:128776"
     Region          <228..518
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          233..270
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          284..320
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          325..361
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          368..403
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          409..443
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          451..488
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          494..518
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..521
                     /gene="Prpf4"
                     /coded_by="NM_001106659.1:76..1641"
                     /db_xref="GeneID:298095"
                     /db_xref="RGD:1311303"
ORIGIN      
        1 massrasstt tktkapddlv apvvkkphiy ygsleekere rlakgesgil gkeglkagie
       61 agninitsge vfeieehise rqaevlaefe rrkrarqinv stddsevkac lralgepitl
      121 fgegpaerre rlrnilsvvg tdalkktkkd dekskkskee yqqtwyhegp nslkvarlwi
      181 anyslpramk rleearlhke ipettrtsqm qelhkslrsl nnfcsqigdd rpisychfsp
      241 nskmlatacw sglcklwsvp dcsllhtlrg hntnvgaivf hpkstvsldq kdvnlascaa
      301 dgsvklwsld sdepvadieg htvrvarvmw hpsgrflgtt cydrswrlwd leaqeeilhq
      361 eghsmgvydi afhqdgslag tggldafgrv wdlrtgrcim fleghlkeiy gisfspngyh
      421 iatgsgdntc kvwdlrqrrc vytipahqnl vtgvkfepih gdflltgayd ntakiwthpg
      481 wsplktlagh egkvmgldis sdgqliatcs ydrtfklwma e
//
