LOCUS       NM_001106219            2404 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus pre-mRNA processing factor 31 (Prpf31), mRNA.
ACCESSION   NM_001106219 XM_001066420 XM_218173
VERSION     NM_001106219.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2404)
  AUTHORS   Bertram K, Agafonov DE, Dybkov O, Haselbach D, Leelaram MN, Will
            CL, Urlaub H, Kastner B, Luhrmann R and Stark H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 2404)
  AUTHORS   Agafonov DE, Kastner B, Dybkov O, Hofele RV, Liu WT, Urlaub H,
            Luhrmann R and Stark H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 2404)
  AUTHORS   Pabis M, Neufeld N, Steiner MC, Bojic T, Shav-Tal Y and Neugebauer
            KM.
  TITLE     The nuclear cap-binding complex interacts with the U4/U6.U5
            tri-snRNP and promotes spliceosome assembly in mammalian cells
  JOURNAL   RNA 19 (8), 1054-1063 (2013)
   PUBMED   23793891
REFERENCE   4  (bases 1 to 2404)
  AUTHORS   Daiger SP, Sullivan LS and Bowne SJ.
  TITLE     Genes and mutations causing retinitis pigmentosa
  JOURNAL   Clin Genet 84 (2), 132-141 (2013)
   PUBMED   23701314
  REMARK    Review article
REFERENCE   5  (bases 1 to 2404)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2404)
  AUTHORS   Liu S, Li P, Dybkov O, Nottrott S, Hartmuth K, Luhrmann R,
            Carlomagno T and Wahl MC.
  TITLE     Binding of the human Prp31 Nop domain to a composite RNA-protein
            platform in U4 snRNP
  JOURNAL   Science 316 (5821), 115-120 (2007)
   PUBMED   17412961
REFERENCE   7  (bases 1 to 2404)
  AUTHORS   Schultz A, Nottrott S, Hartmuth K and Luhrmann R.
  TITLE     RNA structural requirements for the association of the spliceosomal
            hPrp31 protein with the U4 and U4atac small nuclear
            ribonucleoproteins
  JOURNAL   J Biol Chem 281 (38), 28278-28286 (2006)
   PUBMED   16857676
REFERENCE   8  (bases 1 to 2404)
  AUTHORS   Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis
            CD, Chait BT, Hess JL and Roeder RG.
  TITLE     Physical association and coordinate function of the H3 K4
            methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
  JOURNAL   Cell 121 (6), 873-885 (2005)
   PUBMED   15960975
REFERENCE   9  (bases 1 to 2404)
  AUTHORS   Schaffert N, Hossbach M, Heintzmann R, Achsel T and Luhrmann R.
  TITLE     RNAi knockdown of hPrp31 leads to an accumulation of U4/U6
            di-snRNPs in Cajal bodies
  JOURNAL   EMBO J 23 (15), 3000-3009 (2004)
   PUBMED   15257298
REFERENCE   10 (bases 1 to 2404)
  AUTHORS   Makarova OV, Makarov EM, Liu S, Vornlocher HP and Luhrmann R.
  TITLE     Protein 61K, encoded by a gene (PRPF31) linked to autosomal
            dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP
            formation and pre-mRNA splicing
  JOURNAL   EMBO J 21 (5), 1148-1157 (2002)
   PUBMED   11867543
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474101.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066420.1, XM_218173.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2404
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2404
                     /gene="Prpf31"
                     /note="pre-mRNA processing factor 31"
                     /db_xref="GeneID:292536"
                     /db_xref="RGD:1305832"
     exon            1..75
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            76..260
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1583
                     /gene="Prpf31"
                     /note="PRP31 pre-mRNA processing factor 31 homolog"
                     /codon_start=1
                     /product="U4/U6 small nuclear ribonucleoprotein Prp31"
                     /protein_id="NP_001099689.1"
                     /db_xref="GeneID:292536"
                     /db_xref="RGD:1305832"
                     /translation="MSLADELLADLEEAAEEEEGGSYGEEEEEPAIEDVQEETQLDLS
                     GDSVKSIAKLWDSKMFAEIMMKIEEYISKQAKASEVMGPVEAAPEYRVIVDANNLTVE
                     IENELNIIHKFIRDKYSKRFPELESLVPNALDYIRTVKELGNSLDKCKNNENLQQILT
                     NATIMVVSVTASTTQGQQLSDEELERLEEACDMALELNASKHRIYEYVESRMSFIAPN
                     LSIIIGASTAAKIMGVAGGLTNLSKMPACNIMLLGAQRKTLSGFSSTSVLPHTGYIYH
                     SDIVQSLPPDLRRKAARLVAAKCTLAARVDSFHESTEGKVGYELKDEIERKFDKWQEP
                     PPVKQVKPLPAPLDGQRKKRGGRRYRKMKERLGLTEIRKQANRMSFGEIEEDAYQEDL
                     GFSLGHLGKSGSGRVRQTQVNEATKARISKTLQRTLQKQSVVYGGKSTIRDRSSGTAS
                     SVAFTPLQGLEIVNPQAAEKKVAEANQKYFSSMAEFLKVKGEKSGTMST"
     exon            261..321
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            322..405
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            406..503
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            504..610
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            611..780
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            781..938
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1028
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1156
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1229
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1358
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1457
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..2404
                     /gene="Prpf31"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaaagcgtc atcaaagagc gccgaagctc tggggaagcg gatttcttag aaacgatcgt
       61 gagaggattg aagcggtctt gggatgtcgc tggcagatga gctcttggct gaccttgagg
      121 aggcagcaga agaagaagaa ggaggaagct atggagaaga agaggaggag ccagcaattg
      181 aggatgtaca agaggagaca caactggatc tttctggaga ttcagtcaag agcattgcca
      241 agctatggga tagcaagatg tttgctgaga tcatgatgaa gattgaggag tatatcagca
      301 agcaagccaa agcttcagaa gtgatgggac cggtggaggc agcccctgag taccgagtca
      361 ttgtggatgc caacaacctg actgtggaga tagaaaacga gctgaacatt atccataagt
      421 tcatccggga taaatactca aagagattcc ctgagctaga atccttggtg cccaacgctc
      481 tggattacat ccgcacagtc aaggaactgg gcaacagcct ggataagtgt aagaacaatg
      541 agaatctcca gcagatcctg accaatgcta ccatcatggt tgttagtgtt actgcctcta
      601 ccacccaggg gcagcagctg tcagatgagg aactagagcg actagaggag gcctgtgaca
      661 tggcactgga gctgaatgcc tccaagcacc gcatctatga gtacgtggag tcccggatgt
      721 cgttcattgc acccaacttg tccatcatca ttggagcttc cacggctgcc aagatcatgg
      781 gtgtggctgg agggctgacc aacctgtcta agatgcctgc ctgcaacatc atgctgttgg
      841 gagcccagcg caagacactg tctggcttct cttctacctc agtgctgcct cacactggct
      901 acatctacca cagtgacatt gtgcagtctc tgcccccaga tcttcggcgg aaggcagccc
      961 gcctagtggc tgccaaatgt acactggcag ctcgtgtgga cagtttccat gagagcacag
     1021 aggggaaggt gggctatgaa ctaaaggacg agattgagcg caagtttgac aagtggcagg
     1081 agccaccacc tgtgaagcag gtgaagcccc tgcctgcacc ccttgatggg cagcggaaga
     1141 agcgaggggg ccgaaggtac cgcaagatga aagaacggct aggactgact gagatccgga
     1201 agcaggccaa ccgcatgagc tttggagaga ttgaggagga tgcctatcaa gaagacctgg
     1261 gctttagcct gggccacttg ggcaagtcag gcagtgggcg tgtgcggcag acacaggtga
     1321 atgaggccac caaggctagg atctccaaga cactacagcg gaccttacag aaacagagtg
     1381 tggtgtatgg tgggaagtca acaattcgtg accgctcctc ggggactgcc tctagtgtgg
     1441 ccttcactcc actccagggt ctggagattg tgaacccaca agcagccgag aagaaggtgg
     1501 cagaggccaa tcagaagtat ttctctagca tggccgagtt cctcaaggtc aagggtgaga
     1561 aaagtggcac catgtctact tgaaggggcc cacagcccag gtggccatcc actgaaagga
     1621 cataaaggac tggagcttct gaagtgacag atatccagcc aggaagtttg gtgtggtgga
     1681 ggcagccttc catgctctgt ccttggccca aggccacagc atccaagaaa aggatgaaga
     1741 accttagcct gtctccccca gcactcatgc tgctgctgtt ccaatcgggc aggaaggtct
     1801 tccacacact cagctttttt acttacaggg gaaaaaggaa gtgctttttt tttttttttt
     1861 tttttttttt ttttagactg aatacaatta aatgcatagt gtctagctct gaacagaggg
     1921 tatgatttgt ttatgaaaga accagaggac tcagagctgt ggggcttcca gagtgagtag
     1981 catggaccca gctctctttt gctcttgtcc tggaatctaa gaaaaaccct gtctatctct
     2041 taacaccaca cttaatgaga acatcagcat catggccaaa cagtatggcc accacaaaat
     2101 tccggaccca acaagagcca gaggattatt gtccctcagg ctagaaactt cacccacaca
     2161 aagtgaagca cctaaaaggt ttgggaagta tgttcagaaa gcaccaccca gtactgcatt
     2221 catggtgcag cctattttta attcatgttc gttagggggc cacacctagg tcctcagcaa
     2281 gggtgaggca agtgggtacc ctgccctatg aggtaccaat gccaggtaag caaaagaagt
     2341 gcagtgcaca ctacccagtt tgatttgcaa actggggctt catcaaggga aaagaagaac
     2401 agtg
//
