LOCUS       NM_001108559            2331 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Rattus norvegicus pre-mRNA processing factor 3 (Prpf3), mRNA.
ACCESSION   NM_001108559 XM_001057756 XM_342295
VERSION     NM_001108559.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2331)
  AUTHORS   Bertram,K., Agafonov,D.E., Dybkov,O., Haselbach,D., Leelaram,M.N.,
            Will,C.L., Urlaub,H., Kastner,B., Luhrmann,R. and Stark,H.
  TITLE     Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for
            Activation
  JOURNAL   Cell 170 (4), 701-713 (2017)
   PUBMED   28781166
REFERENCE   2  (bases 1 to 2331)
  AUTHORS   Agafonov,D.E., Kastner,B., Dybkov,O., Hofele,R.V., Liu,W.T.,
            Urlaub,H., Luhrmann,R. and Stark,H.
  TITLE     Molecular architecture of the human U4/U6.U5 tri-snRNP
  JOURNAL   Science 351 (6280), 1416-1420 (2016)
   PUBMED   26912367
REFERENCE   3  (bases 1 to 2331)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 2331)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   5  (bases 1 to 2331)
  AUTHORS   Long,S.W., Ooi,J.Y., Yau,P.M. and Jones,P.L.
  TITLE     A brain-derived MeCP2 complex supports a role for MeCP2 in RNA
            processing
  JOURNAL   Biosci Rep 31 (5), 333-343 (2011)
   PUBMED   21070191
REFERENCE   6  (bases 1 to 2331)
  AUTHORS   Song,E.J., Werner,S.L., Neubauer,J., Stegmeier,F., Aspden,J.,
            Rio,D., Harper,J.W., Elledge,S.J., Kirschner,M.W. and Rape,M.
  TITLE     The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control
            reversible ubiquitination at the spliceosome
  JOURNAL   Genes Dev 24 (13), 1434-1447 (2010)
   PUBMED   20595234
REFERENCE   7  (bases 1 to 2331)
  AUTHORS   Wahl,M.C., Will,C.L. and Luhrmann,R.
  TITLE     The spliceosome: design principles of a dynamic RNP machine
  JOURNAL   Cell 136 (4), 701-718 (2009)
   PUBMED   19239890
  REMARK    Review article
REFERENCE   8  (bases 1 to 2331)
  AUTHORS   Schaffert,N., Hossbach,M., Heintzmann,R., Achsel,T. and Luhrmann,R.
  TITLE     RNAi knockdown of hPrp31 leads to an accumulation of U4/U6
            di-snRNPs in Cajal bodies
  JOURNAL   EMBO J 23 (15), 3000-3009 (2004)
   PUBMED   15257298
REFERENCE   9  (bases 1 to 2331)
  AUTHORS   Chakarova,C.F., Hims,M.M., Bolz,H., Abu-Safieh,L., Patel,R.J.,
            Papaioannou,M.G., Inglehearn,C.F., Keen,T.J., Willis,C.,
            Moore,A.T., Rosenberg,T., Webster,A.R., Bird,A.C., Gal,A., Hunt,D.,
            Vithana,E.N. and Bhattacharya,S.S.
  TITLE     Mutations in HPRP3, a third member of pre-mRNA splicing factor
            genes, implicated in autosomal dominant retinitis pigmentosa
  JOURNAL   Hum Mol Genet 11 (1), 87-92 (2002)
   PUBMED   11773002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001057756.1, XM_342295.3.
FEATURES             Location/Qualifiers
     source          1..2331
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2331
                     /gene="Prpf3"
                     /note="pre-mRNA processing factor 3"
                     /db_xref="GeneID:361995"
                     /db_xref="RGD:1310555"
     exon            1..110
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            111..303
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2072
                     /gene="Prpf3"
                     /note="PRP3 pre-mRNA processing factor 3 homolog"
                     /codon_start=1
                     /product="U4/U6 small nuclear ribonucleoprotein Prp3"
                     /protein_id="NP_001102029.1"
                     /db_xref="GeneID:361995"
                     /db_xref="RGD:1310555"
                     /translation="MALSKRELDELKPWIEKTVKRVLGFSEPTVVTAALNCVGKGMDK
                     KKAADHLKPFLDDSTLRFVDKLFEAVEEGRSSRHSKSSSDRSRKRELKEVFGDDSEIS
                     KESSGVKKRRIPRFEEVEEEPEVIPGPPSESPGMLTKLQIKQMMEAATRQIEERKKQL
                     SFISPPAPQPKTPSSSQPERLPIGNTIQPSQAATFMNDAIEKARKAAELQARIQAQLA
                     LKPGLIGNANMVGLANLHAMGIAPPKVELKDQTKPTPLILDEQGRTVDATGKEVELTH
                     RMPTLKANIRAVKREQFKQQLKEKPSEDMESNTFFDPRVSIAPSQRQRRTFKFHDKGK
                     FEKIAQRLRTKAQLEKLQAEISQAARKTGIHTSTRLALIAPKKELKEGDIPEIEWWDS
                     YIIPNGFDLTEENPKREDYFGITNLVEHPAQLNPPVDNDTPVTLGVYLTKKEQKKLRR
                     QTRREAQKELQEKVRLGLTPPPEPKVRISNLMRVLGTEAVQDPTKVEAHVRAQMAKRQ
                     KAHEEANAARKLTAEQRKVKKVKKLKEDISQGVHISVYRVRNLSNPAKKFKIEANAGQ
                     LYLTGVVVLHKDVNVVVVEGGPKAQKKFKRLMLHRIKWDEQTSNTKGDGHSQRPELWR
                     DEVQTVPYREHGA"
     exon            304..434
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            435..581
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..665
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            666..886
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1193
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1360
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1440
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1584
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1684
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1798
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1917
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2001
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2331
                     /gene="Prpf3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcgtggc ggtggctctg gcggtagcga cggcgggcca tagggcaacc ggaaggtttc
       61 cggttccggt gtaacgttcg ggctccgtct caggggctga agtttgtgag gtgtagtact
      121 ttgtccgatt tgagctctta gtctctgttt cctccaaaat ggcactgtct aagcgggaac
      181 tggatgagct gaaaccatgg atagagaaga cagtgaagag agtgctgggt ttctcagagc
      241 ccacggtggt cacagcggca ttgaactgtg tggggaaggg catggacaaa aagaaggcgg
      301 ctgatcacct gaaacctttt cttgatgact ccactctccg atttgtggat aagttgtttg
      361 aagctgtgga ggaaggccgg agctcaagac actccaagtc tagcagtgac agaagcagga
      421 aacgagagtt aaaggaggtg tttggtgatg actctgagat ctcaaaggaa tcatcagggg
      481 taaagaagcg gcgaataccc cgttttgagg aggtagaaga ggaaccagag gtgatccctg
      541 gacctccgtc agaaagccct ggcatgctaa cgaagctcca gatcaaacag atgatggagg
      601 cagcaacgag acaaatcgag gaaaggaaaa agcagctgag cttcatcagc ccccctgcac
      661 ctcagccaaa gacaccttct tcttcccaac cagagcgact tccaattggc aacactattc
      721 agccctccca ggccgctacc tttatgaatg atgccattga gaaggcaagg aaagccgctg
      781 aactacaagc ccgaatccag gcccagctgg ctttgaagcc agggcttatt ggcaatgcca
      841 acatggtggg cctagctaat ctccatgcca tgggcatagc tccaccgaaa gtcgagttaa
      901 aagatcagac gaagcccacc ccactgatcc tggatgagca aggccgcact gtggatgcca
      961 caggcaagga ggtggagctc acacaccgca tgcccaccct gaaggcaaac attcgagctg
     1021 tgaagaggga acagttcaaa cagcaactaa aagaaaagcc atcagaagac atggaatcta
     1081 ataccttttt tgaccccaga gtctcaattg ccccttccca gcgtcaaaga cgcactttta
     1141 aattccatga caagggcaaa tttgagaaga ttgctcaacg attacggaca aaggctcagt
     1201 tggaaaagct gcaagcagag atttcacagg ctgctagaaa aacaggcatt catacgtcga
     1261 ctagacttgc cctcattgct cctaaaaaag agctgaagga aggcgacatc cctgaaattg
     1321 agtggtggga ctcctacatc attcccaatg gctttgacct tacagaggaa aatcccaaga
     1381 gagaagatta ttttggaatc acaaatcttg ttgaacatcc agcccagctt aaccctccag
     1441 ttgacaatga cacaccagtt accctgggtg tgtatcttac aaagaaggag cagaagaaac
     1501 ttcggaggca aacaaggagg gaggcacaga aggagctaca ggagaaagtc aggctaggcc
     1561 tgacacctcc tccagagccc aaagtgagga tctccaattt aatgcgagta ttaggaacag
     1621 aagcagttca agaccctaca aaggtagaag cccacgtcag agctcagatg gcaaagagac
     1681 agaaagcgca cgaagaggcc aacgctgccc gaaaacttac agcagaacag agaaaggtca
     1741 agaaagttaa aaagcttaaa gaagacattt cacagggggt gcacatatct gtgtatagag
     1801 ttcgaaattt gagcaaccca gccaagaagt tcaagatcga ggccaatgct gggcagctgt
     1861 acctgacggg ggtggtagtg ctgcacaagg atgtcaacgt ggtggtcgtg gaagggggcc
     1921 ccaaagccca gaagaaattt aagcgtctca tgctacatcg gataaagtgg gatgagcaga
     1981 cgtctaacac gaagggagat gggcacagcc aaagaccgga gctttggaga gatgaagttc
     2041 aaacagtgcc ctacagagaa catggcgcgt gagcatttca agaagcacgg ggctgagcac
     2101 tactgggacc ttgccctgag tgaatctgtg ctggagtcca ccgactgaga cgactgctag
     2161 ccttgtgtct tcttctcact ctgcttccca accttaccca actgtgcgtg tgatctcaga
     2221 accgtgccag gctgatactg gggcaaagag actaccaagt tcacccagtc agcctggtgc
     2281 tacccttcct cctgtatgtg catatgatta aagagttatt tttaaaatta g
//
