LOCUS       NM_139333               2156 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus pre-mRNA processing factor 19 (Prpf19), mRNA.
ACCESSION   NM_139333
VERSION     NM_139333.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2156)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   2  (bases 1 to 2156)
  AUTHORS   Marechal,A., Li,J.M., Ji,X.Y., Wu,C.S., Yazinski,S.A., Nguyen,H.D.,
            Liu,S., Jimenez,A.E., Jin,J. and Zou,L.
  TITLE     PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and
            drives ATR activation via a ubiquitin-mediated circuitry
  JOURNAL   Mol Cell 53 (2), 235-246 (2014)
   PUBMED   24332808
REFERENCE   3  (bases 1 to 2156)
  AUTHORS   Chanarat,S. and Strasser,K.
  TITLE     Splicing and beyond: the many faces of the Prp19 complex
  JOURNAL   Biochim Biophys Acta 1833 (10), 2126-2134 (2013)
   PUBMED   23742842
  REMARK    Review article
REFERENCE   4  (bases 1 to 2156)
  AUTHORS   Yamada,T., Urano-Tashiro,Y., Hashi,Y., Sakumoto,M., Akiyama,H. and
            Tashiro,F.
  TITLE     The U-box-type ubiquitin ligase PRP19beta regulates astrocyte
            differentiation via ubiquitination of PTP1B
  JOURNAL   Brain Res 1524, 12-25 (2013)
   PUBMED   23769735
  REMARK    GeneRIF: these results indicate that PRP19beta activates the
            gp130/Janus kinase (JAK)/STAT signaling pathway during astrocyte
            differentiation via PTP1B ubiquitination
REFERENCE   5  (bases 1 to 2156)
  AUTHORS   Song,E.J., Werner,S.L., Neubauer,J., Stegmeier,F., Aspden,J.,
            Rio,D., Harper,J.W., Elledge,S.J., Kirschner,M.W. and Rape,M.
  TITLE     The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control
            reversible ubiquitination at the spliceosome
  JOURNAL   Genes Dev 24 (13), 1434-1447 (2010)
   PUBMED   20595234
REFERENCE   6  (bases 1 to 2156)
  AUTHORS   Cho,S.Y., Shin,E.S., Park,P.J., Shin,D.W., Chang,H.K., Kim,D.,
            Lee,H.H., Lee,J.H., Kim,S.H., Song,M.J., Chang,I.S., Lee,O.S. and
            Lee,T.R.
  TITLE     Identification of mouse Prp19p as a lipid droplet-associated
            protein and its possible involvement in the biogenesis of lipid
            droplets
  JOURNAL   J Biol Chem 282 (4), 2456-2465 (2007)
   PUBMED   17118936
REFERENCE   7  (bases 1 to 2156)
  AUTHORS   Urano,Y., Iiduka,M., Sugiyama,A., Akiyama,H., Uzawa,K.,
            Matsumoto,G., Kawasaki,Y. and Tashiro,F.
  TITLE     Involvement of the mouse Prp19 gene in neuronal/astroglial cell
            fate decisions
  JOURNAL   J Biol Chem 281 (11), 7498-7514 (2006)
   PUBMED   16352598
REFERENCE   8  (bases 1 to 2156)
  AUTHORS   Grillari,J., Ajuh,P., Stadler,G., Loscher,M., Voglauer,R.,
            Ernst,W., Chusainow,J., Eisenhaber,F., Pokar,M., Fortschegger,K.,
            Grey,M., Lamond,A.I. and Katinger,H.
  TITLE     SNEV is an evolutionarily conserved splicing factor whose
            oligomerization is necessary for spliceosome assembly
  JOURNAL   Nucleic Acids Res 33 (21), 6868-6883 (2005)
   PUBMED   16332694
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2156)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   10 (bases 1 to 2156)
  AUTHORS   Hatakeyama,S., Yada,M., Matsumoto,M., Ishida,N. and Nakayama,K.I.
  TITLE     U box proteins as a new family of ubiquitin-protein ligases
  JOURNAL   J Biol Chem 276 (35), 33111-33120 (2001)
   PUBMED   11435423
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC107669.1.
            
            On Oct 31, 2005 this sequence version replaced NM_139333.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC107669.1, AB020022.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2156
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2156
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /note="pre-mRNA processing factor 19"
                     /db_xref="GeneID:246216"
                     /db_xref="RGD:708496"
     exon            1..206
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..1702
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /EC_number="2.3.2.27"
                     /note="PRP19/PSO4 homolog; neuronal
                     differentiation-related gene protein; PRP19/PSO4 pre-mRNA
                     processing factor 19 homolog; RING-type E3 ubiquitin
                     transferase PRP19"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 19"
                     /protein_id="NP_647549.2"
                     /db_xref="GeneID:246216"
                     /db_xref="RGD:708496"
                     /translation="MSLICSISNEVPEHPCVSPVSNHVYERRLIEKYIAENGTDPINN
                     QPLSEEQLIDIKVAHPIRPKPPSATSIPAILKALQDEWDAVMLHSFTLRQQLQTTRQE
                     LSHALYQHDAACRVIARLTKEVTAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPM
                     DLGELVGMTPEIIQKLQDKATVLTTERKKRGKTVPEELVKPEELSKYRQVASHVGLHS
                     ASIPGILALDLCPSDTNKILTGGADKNVVVFDKSTEQILATLKGHTKKVTSVVFHPSQ
                     ELVFSASPDATIRIWSVPNTSCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSD
                     IQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHS
                     GPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYL
                     ALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTGMDRSLKFYSL"
     exon            207..356
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            357..433
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            434..575
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            576..649
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            650..712
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            713..754
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            755..829
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            830..905
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1015
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1171
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1241
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1327
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1498
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1604
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..2117
                     /gene="Prpf19"
                     /gene_synonym="Prp19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctgaggcg cgccaccggc cacctcccca cgtgaagcag ttgtgcgagc atcgccacgc
       61 cgggcagctg tctacccgcg tccgagcgct ccggaagcgg cgggggaccg gaagtggccc
      121 gcggaggctg cagagctagt ccgggaaccc gctgtgaggc gactggcagc agcgctacga
      181 cggcgccatg tccctgatct gctcgatctc caacgaagtg ccagagcacc catgcgtgtc
      241 ccctgtctct aatcatgtgt atgagcggcg actcattgag aagtacattg cagagaatgg
      301 cacagatcct atcaacaacc agcctctctc agaggagcag ctcatcgaca tcaaagttgc
      361 tcatccaatc cggcccaagc ctccctctgc caccagcatc ccagccattc tgaaagcctt
      421 gcaggatgag tgggatgcag tcatgctgca cagcttcact cttcgccagc agctgcagac
      481 aacccgccag gaactgtccc acgctctgta ccagcacgat gctgcctgcc gagtcattgc
      541 ccggctcacc aaggaggtca ctgctgctcg agaagctctg gctactctga aaccacaggc
      601 tggtcttatt gtacctcagg ctgtgccaag ctcacagccc agtgttgtgg gtgcaggaga
      661 gcccatggat ttgggtgagc ttgtgggaat gacccctgag attatccaga agcttcaaga
      721 caaggccact gtactaacca cggagcgtaa gaagagagga aaaactgtcc ctgaggagct
      781 ggtgaagcct gaagagctca gcaagtaccg gcaggtggca tcccatgtgg ggctacacag
      841 tgctagcatt cctgggattc ttgctctgga cctgtgtccc tcagacacca acaagattct
      901 tactggtggg gcagataaaa acgttgttgt ctttgataag agtactgagc aaatcctggc
      961 cactctcaaa ggccatacca agaaggtcac cagtgtggtg tttcatcctt ctcaggaatt
     1021 ggtgttttct gcgtcccctg atgctactat caggatttgg tccgtcccga acacttcttg
     1081 tgtacaggtt gttcgggccc atgagagtgc ggtgacagga ctcagcctcc atgccactgg
     1141 agactatcta ctgagctcct ctgatgatca gtactgggcg ttctctgaca ttcagacagg
     1201 gcgtgtgctc accaaggtga cagatgagac ttccggctgc tctcttacct gtgcacagtt
     1261 ccaccctgat ggcctcatct ttggaacagg aaccatggac tcccagatca agatctggga
     1321 cttgaaggaa cgcaccaatg tggcgaactt ccctggccac tccggcccca ttaccagcat
     1381 tgccttctct gagaatgggt actacctggc cacggcagct gatgactcct cagtcaagct
     1441 ctgggactta cgcaagttga agaacttcaa gacattgcag ctggacaaca actttgaggt
     1501 gaagtcacta atctttgacc agagtggcac ctacctggcg cttgggggta cagatgtcca
     1561 gatctacatc tgcaaacagt ggacagagat tcttcacttt acagagcata gtggcctgac
     1621 cactggagtg gcctttgggc accacgccaa gttcatcgct tcaaccggca tggacaggag
     1681 cctcaaattc tacagtctgt aggccctatg ccttgtcaca gttctgggcc tcatctcagt
     1741 agtgggttag agttagaggg tgggggtggg gggtgggact ttaggaggag agggaggtct
     1801 ggttaggggg ggacattcac atcatttcat tctggtctgg atgatggtct gagccagggc
     1861 acatggaaca ctgctatcca tgcagccttt gggccccagg gaacggacat ggaggaactg
     1921 tcaccctgta aaatgctcag agtcggagtt cagcacctcc cccagtggtg gcagctgttc
     1981 catgcctgct ctgtttcagc tcttctgaga cagggaggtg agccaaggga actgtgaagg
     2041 ggaggggcag gagggctctt gcaggttttt gtaagcagtg atctagtttc attaaaaaaa
     2101 aaaagccaca cagtaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
