LOCUS       NM_138523               5427 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus pre-mRNA processing factor 18 (Prpf18), mRNA.
ACCESSION   NM_138523
VERSION     NM_138523.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5427)
  AUTHORS   Matera,A.G. and Wang,Z.
  TITLE     A day in the life of the spliceosome
  JOURNAL   Nat Rev Mol Cell Biol 15 (2), 108-121 (2014)
   PUBMED   24452469
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2014 Apr;15(4):294]
REFERENCE   2  (bases 1 to 5427)
  AUTHORS   Farkas,R.H., Qian,J., Goldberg,J.L., Quigley,H.A. and Zack,D.J.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   3  (bases 1 to 5427)
  AUTHORS   Keren-Raifman,T., Ivanina,T., Bismuth,Y. and Dascal,N.
  TITLE     Expression cloning of KCRF, a potassium channel regulatory factor
  JOURNAL   Biochem Biophys Res Commun 274 (3), 852-858 (2000)
   PUBMED   10924366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138523.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.52987.1,
                                           SRR26643288.58199.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000017.1  78539890-78540059
            171-248             JAXUCZ010000017.1  78542995-78543072
            249-353             JAXUCZ010000017.1  78545596-78545700
            354-467             JAXUCZ010000017.1  78547088-78547201
            468-614             JAXUCZ010000017.1  78551413-78551559
            615-683             JAXUCZ010000017.1  78553361-78553429
            684-824             JAXUCZ010000017.1  78554687-78554827
            825-896             JAXUCZ010000017.1  78554970-78555041
            897-1052            JAXUCZ010000017.1  78556688-78556843
            1053-5427           JAXUCZ010000017.1  78566109-78570483
FEATURES             Location/Qualifiers
     source          1..5427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..5427
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /note="pre-mRNA processing factor 18"
                     /db_xref="GeneID:171552"
                     /db_xref="RGD:708550"
     exon            1..170
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1133
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /note="PRP18 homolog; potassium channel regulatory factor;
                     PRP18 pre-mRNA processing factor 18 homolog"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor 18"
                     /protein_id="NP_612532.1"
                     /db_xref="GeneID:171552"
                     /db_xref="RGD:708550"
                     /translation="MDILKSEILRKRQLVEDRNLLVENKKYFKRSELAKKEEEAYFER
                     CGYKVQPKEDDQKPLTSSNPVLELELAEEKLPMTLSRQEVIRRLRERGEPMRLFGETD
                     YDAFQRLRKIEILTPEVNKGLRNDLKAALDKIDQQYLNEIVGGQEPGEEDTQNDLKVH
                     EENTTIEELEALGESLGKGDDHKDMDIITKFLKFLLGVWAKELNSREDYVKRSVQGKL
                     NSATQKQTESYLRPLFRKLRKRNLPADIKESITDIIKFMLQREYVKANDAYLQMAIGN
                     APWPIGVTMVGIHARTGREKIFSKHVAHVLNDETQRKYIQGLKRLMTICQKHFPTDPS
                     KCVEYNAL"
     exon            171..248
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     exon            249..353
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     exon            354..467
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     exon            468..614
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     exon            615..683
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     exon            684..824
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     exon            825..896
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1052
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..5427
                     /gene="Prpf18"
                     /gene_synonym="KCRF; Pprf18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctctggt tttgtggtag ttcgtcctct accccctccc ctagcgggtg aggttacagc
       61 gacgggctgg agaggcaaag tggagttaag acactgggag cgagatggac atcctgaagt
      121 cagagattct gcggaagcgg cagctggtgg aggacaggaa cctgctggtg gaaaataaaa
      181 agtacttcaa gcggagtgaa cttgcaaaaa aggaagagga agcttatttt gaaagatgtg
      241 gctacaaggt acagccaaaa gaggatgacc agaaaccact aacgtcatca aatccagtgc
      301 tggaacttga actagcagag gaaaagcttc ctatgactct ttctaggcaa gaggtcatca
      361 gaagactgag agagagagga gagccaatga ggctgtttgg ggaaactgac tatgatgctt
      421 tccagcgttt aagaaaaata gagattctca caccagaagt taacaagggc ttaaggaatg
      481 acctaaaagc ggctctggac aagattgacc agcagtactt gaatgaaatc gtgggtggtc
      541 aggaacctgg agaggaggac acacagaatg atctgaaggt tcacgaggaa aacaccacca
      601 ttgaggagtt agaggcactg ggggagtcct tagggaaagg tgacgatcac aaggacatgg
      661 acatcatcac caagttcctg aagtttcttc ttggtgtttg ggctaaagaa ttgaattcca
      721 gagaggatta cgtgaaacgc agcgtgcagg gcaaactgaa cagtgctacc cagaagcaga
      781 ccgagtccta cctcagacca cttttcagaa agctccggaa aaggaatctt cctgctgata
      841 ttaaagaatc aataacagat attattaagt tcatgctaca gagagagtac gtgaaggcga
      901 atgacgctta ccttcagatg gccattggca atgctccctg gcctattggt gtcactatgg
      961 tcggcatcca cgccagaact ggcagggaaa agattttttc caagcatgtt gcccatgtct
     1021 taaatgatga aacccaacga aaatacattc agggactgaa gaggttaatg acaatctgcc
     1081 agaagcactt tcctacagac ccgtccaagt gtgtggagta caatgcactg taaggtgctg
     1141 taaagtctga gcacggtgtg taacaggcgc ctctccgcgg cccgcagccc acagccctta
     1201 gccctctgac ttccagcctt accatggcga cgagggagga gctgcagggt gccgctccac
     1261 cgggtgcact tcctgttaac ttcaaaaact ggggtgcctt tcacatggta ttggactgca
     1321 aactaatttt cgtgtcttga tttaatttta atcagttgaa aattaagttc taaaaatgtt
     1381 atctgggttt tttttttttc ctttggaaca atttcaaact ttattgtcaa gatagcagaa
     1441 gcttagttca caagaatcag cagtagttgg tgatctactt gcaaacacct tttttttttt
     1501 ttttttggtg catttctctc tacaccatca tgagagagga agaccagcaa agagtagcaa
     1561 agtgaactga caccacacag ggctgcccac cgtctactgg gctatattta taccctttcc
     1621 aaatatcgtg ctttctctca aatgtctgct ctagcaaagt atcatatgac ttctttccag
     1681 gcagcttaca ggaaaacacc atgtgtctgt tcttagcaaa atataccccc acctctttgc
     1741 ttcagcaaaa atatactctt ataagacagc ttccagaaaa acatctcaag tcacaaccaa
     1801 gtctccaaaa atccaaaatt tctactttag aagcttttat gtggcattta agaaatgttg
     1861 attttcaaat acctttcact gagcttcaag gagtcaatat gtctctattt tagaatacag
     1921 aatttacatt catacaatgg tattttcaca aatatatcct ttaggaattt ttctgtctct
     1981 ttgtctttgt ccatgtcttt gtctctaccc tccatatttc tctgtttctc tgtatctgtc
     2041 tgtttttcag tttgcctttg tcttaactgt ctctctcttc tgtgcgtgtg tgcatgtgtg
     2101 tgtgtgtgtt cctcattttg tcacgaaatc ttttttgttc atgttcaccc tgaccattag
     2161 agtagaattt gttgccactg cacatgatca gaaagactac atgtagatca ctgaagctaa
     2221 gagaaacaat catgatttag tgaaccacac ctctgagtat agttgacagc ctgacattgg
     2281 gatatggaca acaatctagg cacgctcaat tgaaacaatt ctacaacata agcccactta
     2341 ctgacacttt ttttttgtgc tttttttttt caaaaacata cttcatattt cctcttttat
     2401 tatataaata tcggtttaac tttttactgt aagaatataa atgttttaag aggatctttg
     2461 ttatcattta tacaaattca caaacagtac aattaattga taaaggcctc tgggtttctc
     2521 catggtctct catgttgctg tgaaggactc ttgaggcagg gcagctgcgt gatgcgcacc
     2581 aggccacgat tggtgatcct agtgcagccg tacaggtcta tgcctgtgag ctggctcagg
     2641 tgctcagcga tcagctccag tcccttgtct gtgatgcgca cacactgtcc aatgttgagc
     2701 gtgcgcagcc cgtgcatctg ccgcaccatg cggttgatgc catcgtcact gatatggcaa
     2761 gagcaaagag agagggactt gaggccgtcc agtccctggg ctatgtaagc caggctctga
     2821 tctcccacct tgtcacagaa tgacacatcc agaccggaga ggtgcaggct gcccatggcc
     2881 aaatgcatga tgccggtgtc gctgatgttg tcgcaggagc gcaggttaag gctgcgcagg
     2941 ctgcccatgt gcgacaggtg cagaaggccc gcgtccgaga tccggccaca gaagctgagg
     3001 ttgaggagcc tgaggcccgt cagccctcgc gagatgtgct tcagagaaag atccgtgagt
     3061 ttctggcagt cctgtagagc gagctgttcc aggcccaggc agccctcggc agcgctgcgc
     3121 gtcatgccgg ccaggtgccc gatgcccacg tccgagagat ggcggcagct gcggaggtta
     3181 aggctcttga ggcgctgcag cccccaggcg atgaacagaa gaccggtgtt ggtgatgttg
     3241 ctgcagcgcc cccagctcca gcacctccag gcccttgagg tactgggcta tgcggcccag
     3301 gctgctgtct gtgatctgct tgcagaggct caaattgaga gcgtgcagcg agccgatctg
     3361 cacgaacgcg tggcccaggc cgttatcggt gaagttgtag cagcggctga ggttgaggct
     3421 ctcgatgttc gctatgccct ggatcacgta gctgaggctg cggcggaagc tgaggatctg
     3481 cacgcggcgg atgccccggc ctgaaggctg gggaacacca acgggttcga cgggcccaag
     3541 tgcagcttgg cctccacgcc cggccacact gacttgtggt aggcggcgtc ccgccaggcc
     3601 gtgcacacct gccccgcgcg accctagtct cggacgtcca agtagccgaa gatcatggcc
     3661 agcagctccg ggaacaggca cgagatgtgg gtctccatct tcctccccgc cccgggaggc
     3721 gcggagagcg ggccatcgcg ggccaacctt atctgggttt taaatgtgga gacaacaata
     3781 ccacaggaaa ggggatttgg gatgaccatt ctcaagatcc aaaatgtgtc attggatacc
     3841 tagaagcatt tgagggtgtc ttcgaactgt ttgtaaattg tgatttgcac atttttctat
     3901 gtggtattta tagaaaatat tttttgtatt tcaacaaaag tgtgggacca ctgactgctc
     3961 cttcacagtt cttatgttcg tggactcttc gctgtctttc agtaggtgta atggtaccga
     4021 taagtgttat ttttcttggg tttcagactt gcttttcttt ctacagagca cgtctgtcac
     4081 cttgctggac agacagaatt aaggagatag aaggttgaaa gtgtcccagc gtaagttcag
     4141 aacaccagtg catcgaggcc agggggaaga agtgggccgt gggccagcaa gagcagcagc
     4201 ctggtgcctg gatccggaga gtttctggct gcactgtgcc tcactcagtc ctcacttgcc
     4261 ttacaaaatg aggacttgct ctgggtctta cagagtggag ctttgagcac catgaccact
     4321 ccgtcccgcg gtgctgagag atctggacta acacagtgat ctgtgcagat gggctgttac
     4381 cccaccagtt ggatgcgtca gagaaggaag agcgggtggg ccacatcagg actgacggct
     4441 ccccagctcc gtgctctaac tcagtcaccg gcaagttcca tcttgctgag ccttggctcc
     4501 cttatctgac agtgatgaga gtccgctctc acatgggtat tgtgtggtga tggatgctga
     4561 ccactgccta gcgggtgaca agagggcact attaccgctc gttacagtgt agaccacggc
     4621 ctttctgggg ccctgcggct acaagtgcag agagcagggc ctggaggctg ctgtggaccg
     4681 tccagagtca gagttgttta tgttggcccc tcgtgagaaa gagtagaagc cactttagct
     4741 acttggggtc cagtgtgggc atggatagca tagcctctcc agttatttgc caatggcggc
     4801 tgtcttgggt tgaatcagtg ttccctgcac tacagctgaa gccttttctt aggattaagt
     4861 catgtagaac ttaggggtta tttggcagag gaaactttcg taagatgttc agcaagtccc
     4921 tcctgtggca tgaagttttg tcatgagggt cttctttata aatcctattg aaatggccaa
     4981 ctcactcact cttcatccac tcctgggcca cacagcatgg gaagtcactt tatgctgtct
     5041 cccttctctt gataatatcc atgtgaagaa gaaactgtat cctgatatct gcattcccta
     5101 acactgatct gtgtgcgctg ggcttttgtt ctgttctttt ccctggttgg tttgtgtttg
     5161 agcttatttt gtgtgcagag ggagtgtatg ttctatagga ctgaccttag tcattctcag
     5221 gtcgggtgga gaagcatggt actatgtggc tctctcggtc aagtttttca taaccgaaat
     5281 taaaaagctg tgtacaaatt aaagaagctg tatggaaact gctaggacat gttgaaaatg
     5341 atctttcctt caagccatgg acatttactt ctgcatagac tatatatttt aaaacaataa
     5401 agacataact ttccttttaa acagtca
//
