LOCUS       NM_001107201            4129 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus prospero homeobox 1 (Prox1), mRNA.
ACCESSION   NM_001107201 XM_001067440 XM_223067
VERSION     NM_001107201.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4129)
  AUTHORS   Pan,J., Luo,X., Zhao,S., Li,J. and Jiang,Z.
  TITLE     miR-340-5p mediates the therapeutic effect of mesenchymal stem
            cells on corneal neovascularization
  JOURNAL   Graefes Arch Clin Exp Ophthalmol 260 (2), 497-507 (2022)
   PUBMED   34495369
  REMARK    GeneRIF: miR-340-5p mediates the therapeutic effect of mesenchymal
            stem cells on corneal neovascularization.
REFERENCE   2  (bases 1 to 4129)
  AUTHORS   Kivela,R., Salmela,I., Nguyen,Y.H., Petrova,T.V., Koistinen,H.A.,
            Wiener,Z. and Alitalo,K.
  TITLE     The transcription factor Prox1 is essential for satellite cell
            differentiation and muscle fibre-type regulation
  JOURNAL   Nat Commun 7, 13124 (2016)
   PUBMED   27731315
  REMARK    GeneRIF: Prox1 is a critical transcription factor for the
            differentiation of myoblasts via bi-directional crosstalk with
            Notch1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4129)
  AUTHORS   Takeda,Y. and Jetten,A.M.
  TITLE     Prospero-related homeobox 1 (Prox1) functions as a novel modulator
            of retinoic acid-related orphan receptors alpha- and gamma-mediated
            transactivation
  JOURNAL   Nucleic Acids Res 41 (14), 6992-7008 (2013)
   PUBMED   23723244
REFERENCE   4  (bases 1 to 4129)
  AUTHORS   Westmoreland,J.J., Kilic,G., Sartain,C., Sirma,S., Blain,J.,
            Rehg,J., Harvey,N. and Sosa-Pineda,B.
  TITLE     Pancreas-specific deletion of Prox1 affects development and
            disrupts homeostasis of the exocrine pancreas
  JOURNAL   Gastroenterology 142 (4), 999-1009 (2012)
   PUBMED   22178591
REFERENCE   5  (bases 1 to 4129)
  AUTHORS   Tateya,T., Imayoshi,I., Tateya,I., Ito,J. and Kageyama,R.
  TITLE     Cooperative functions of Hes/Hey genes in auditory hair cell and
            supporting cell development
  JOURNAL   Dev Biol 352 (2), 329-340 (2011)
   PUBMED   21300049
REFERENCE   6  (bases 1 to 4129)
  AUTHORS   Duncan,M.K., Cui,W., Oh,D.J. and Tomarev,S.I.
  TITLE     Prox1 is differentially localized during lens development
  JOURNAL   Mech Dev 112 (1-2), 195-198 (2002)
   PUBMED   11850194
  REMARK    GeneRIF: Prox1 is differentially localized during lens development.
REFERENCE   7  (bases 1 to 4129)
  AUTHORS   Rodriguez-Niedenfuhr,M., Papoutsi,M., Christ,B., Nicolaides,K.H.,
            von Kaisenberg,C.S., Tomarev,S.I. and Wilting,J.
  TITLE     Prox1 is a marker of ectodermal placodes, endodermal compartments,
            lymphatic endothelium and lymphangioblasts
  JOURNAL   Anat Embryol (Berl) 204 (5), 399-406 (2001)
   PUBMED   11789987
REFERENCE   8  (bases 1 to 4129)
  AUTHORS   Sosa-Pineda,B., Wigle,J.T. and Oliver,G.
  TITLE     Hepatocyte migration during liver development requires Prox1
  JOURNAL   Nat Genet 25 (3), 254-255 (2000)
   PUBMED   10888866
REFERENCE   9  (bases 1 to 4129)
  AUTHORS   Wigle,J.T., Chowdhury,K., Gruss,P. and Oliver,G.
  TITLE     Prox1 function is crucial for mouse lens-fibre elongation
  JOURNAL   Nat Genet 21 (3), 318-322 (1999)
   PUBMED   10080188
REFERENCE   10 (bases 1 to 4129)
  AUTHORS   Zinovieva,R.D., Duncan,M.K., Johnson,T.R., Torres,R.,
            Polymeropoulos,M.H. and Tomarev,S.I.
  TITLE     Structure and chromosomal localization of the human homeobox gene
            Prox 1
  JOURNAL   Genomics 35 (3), 517-522 (1996)
   PUBMED   8812486
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473985.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001067440.1, XM_223067.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760400 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4129
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q26"
     gene            1..4129
                     /gene="Prox1"
                     /note="prospero homeobox 1"
                     /db_xref="GeneID:305066"
                     /db_xref="RGD:1306890"
     exon            1..410
                     /gene="Prox1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..2204
                     /gene="Prox1"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..2229
                     /gene="Prox1"
                     /note="prospero-related homeobox 1"
                     /codon_start=1
                     /product="prospero homeobox protein 1"
                     /protein_id="NP_001100671.1"
                     /db_xref="GeneID:305066"
                     /db_xref="RGD:1306890"
                     /translation="MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSA
                     MNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMN
                     KNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDVDRLCDE
                     HLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQ
                     QSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQVYDSTDSENDEDGDLSE
                     DSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGSNKER
                     DHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQAR
                     FAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGNVQMPSSTDQTEALPLVVRKNSSEQ
                     SASGPATGGHHQPLHQSPLSATAGFTTPSFRHPFPLPLMAYPFQSPLGAPSGSFSGKD
                     RASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMS
                     DISPYSGSAMKGYHPIT"
     exon            2205..2306
                     /gene="Prox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2501
                     /gene="Prox1"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..4129
                     /gene="Prox1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgagagag cgctgggaaa gcgaccgcca ctgcagccgg gggaagccgc gcggcgcaca
       61 caaacctctc cgccgcgccc gctgcgcctc gggccaccgc tctgcgcccc agccctcgcc
      121 gccttctcca ctctctctgc ccttctttcc ccgggctccc ggctctgccc tgcgcgcctc
      181 tcccctcccc tccctccttt ctcccctcgc ctctcagcac tcgcccagat cactcgctcc
      241 cgcacagact caccgacccc tgggccaatt atcaccagta agacatcacc gcgtgcgcgc
      301 gtgggtttct tctctgcccg caagagagag gaagagagtg ggggagagag agagaaaaga
      361 aagagagaga gaaagagaga gcggctgcgc cccgctgctg cccgcaccgc ggtcccggga
      421 ttcttgagct gtgcccagct gacaagcttt tgaagatggc acaataactg tccagtgatg
      481 cctgaccatg acagcacagc cctcttaagc cggcaaacca agaggagaag ggttgacatt
      541 ggagtgaaaa ggacggtagg gacagcatct gcattttttg ctaaggcaag ggcaacattt
      601 ttcagtgcca tgaatcccca aggttcagag caggatgttg aatattctgt ggtgcaacac
      661 gcagatgggg aaaagtcgaa tgtactccgc aagctgctga agagggcgaa ctcgtatgaa
      721 gatgccatga tgccttttcc aggagcaact ataatttccc agctgttgaa aaataacatg
      781 aacaaaaacg gtggcaccga gcccagtttc caagccagcg gactctctag cacgggctct
      841 gaagtacatc aggaggatat atgtagcaac tcttcaagag acagcccccc agagtgtctt
      901 tccccttttg gcaggcctac tatgagccag tttgatgtgg atcgcttatg tgatgagcac
      961 ctgagagcaa agcgcgcccg ggttgagaat atcattcggg gtatgagcca ttcccccagt
     1021 gtggcattaa ggggcaatga aaacgaaaga gagatggccc cgcagtctgt gagtccccga
     1081 gaaagttaca gagaaaacaa acgcaagcag aagctgcccc agcagcagca acagagtttc
     1141 cagcagctgg tttcagcccg aaaagaacag aagcgagagg agcgccgaca gctgaaacag
     1201 cagctggaag acatgcagaa gcagctgcgc cagctgcagg agaagttcta ccaggtctac
     1261 gacagcaccg actccgaaaa tgatgaagat ggcgacctgt ctgaagacag catgcgctca
     1321 gagatcctgg atgcacgggc ccaggactcg gtggggcgct cagacaatga gatgtgtgag
     1381 ctggacccgg ggcagttcat cgacagggcc cgagccctca tcagggagca ggagatggcc
     1441 gagaacaagc ctaaacgaga aggcagcaac aaagaaagag accacgggcc aaactccctg
     1501 cagccggaag gcaagcatct ggcagagacc ttaaaacagg agctgaacac ggccatgtca
     1561 caggtcgtgg acacagtggt caaagtcttc tcagccaaac cctctcgcca ggttcctcag
     1621 gtcttcccac ctctccagat cccccaggcc agattcgcag tcaatgggga aaaccacaat
     1681 ttccacaccg ccaaccagcg cctgcaatgc tttggtgatg tcatcattcc gaacccccta
     1741 gacacctttg gcaatgtgca gatgcctagt tccacagacc agacggaagc ccttcccctg
     1801 gtggtccgaa aaaactcatc tgagcaatcc gcctctggcc cggccactgg tggccaccac
     1861 cagcccctgc accagtcgcc cctttctgcc accgcaggct tcaccacccc cagcttccgc
     1921 catccctttc ccctgccctt aatggcttac ccatttcaga gtccattagg tgctccctcc
     1981 ggctccttct cgggaaaaga cagagcctct cctgagtcct tagacttgac tcgggacaca
     2041 acgagtctga ggaccaagat gtcatcccac cacctgagcc accacccctg ttcaccagca
     2101 cacccaccca gcaccgcaga aggactctct ttgtcactca taaagtccga gtgtggagat
     2161 cttcaagata tgtccgacat ctctccttat tcgggaagcg caatgaaggg ctatcaccca
     2221 atcacttgaa aaaggcaaag ctcatgttct tttacacccg ttaccccagc tccaacatgc
     2281 tgaagaccta cttctcggac gtaaagttca acagatgcat cacatcccag ctcatcaaat
     2341 ggtttagcaa cttccgtgag ttttactata ttcagatgga gaagtatgcg cgccaagcca
     2401 tcaatgatgg agtcaccagc acagaggaac tgtccatcac cagggactgc gagctgtaca
     2461 gagccctcaa catgcactac aacaaagcaa acgactttga ggttccagag agattcctgg
     2521 aagttgcgca gatcacgtta cgggagtttt tcaatgccat catcgcgggc aaagatgttg
     2581 atccttcctg gaagaaggcc atttacaagg tcatctgcaa gctggatagt gaagttcctg
     2641 agattttcaa atcccctaac tgcctacaag aactccttca cgagtagaga tcgcaacgcc
     2701 cttttgaatg tatggataga agaagtcccc cttggatgtc caacttctct gtgtctagat
     2761 tttggtttta tatgtttgtg tgggggaggc atggatactt tgtgatgtca gctggtggtc
     2821 cctgctcatc ctctttgggt tccttttatt ttccctcatc gtaaggggat gggtattttc
     2881 cttctacacc ctttagttta cttttgccca aggcccttaa tgtttggaga cttaaggtag
     2941 ggttggtctt caggagaagg gaatgtcagc ctgtgtaaag tgtataaaag ctatggagtg
     3001 agccggtgac tgtgacacag ctcacgtgca caccccccgt gctgtgtctc ctgtttctag
     3061 ggttaagaag ttctggaaga acctgaggaa aagcacttca cacactggaa taccttgttt
     3121 gatttgagcc tgataaataa ccttttctta cacgtttaag ccaatgccct tggctgctgg
     3181 gtagctcaca tctcaaaagt accctcaaaa agtacaaagg attgtcacca agtcctttgt
     3241 aagagaaatg gcataaaccc ccagacccaa ttttgtataa aaccggctct cctgagacta
     3301 gcaaggctgg gaatgcacgc aggccgacct gctgtctctg tgaactttag agcaggctct
     3361 gggtgagatg tgagcttggc tgtgtcgact tagaggaaac cccgttcttt gtcactagtt
     3421 gctgtttact ttgcttcaga tattaaaagg cacgcacttt tcaaacgctc agctccttat
     3481 gtgcttacca ttgctactgc tttttgaccc tctttcttct cctcaaacac taatttctgg
     3541 atacctttct acagtaagga attaagaact cccattgacc gagaaaccct tgcctactct
     3601 tggagcatgc tggcagctgc tagtggacct gacctgcact tcctgtgagg atggcaccca
     3661 gggatggctc gtttgcacat gggtacggag ggtggctgtc tgtctctccc ctctgggttg
     3721 taatatctta aagcagctga tgatgtctct tctactccag aagctgatgt ttgacccaag
     3781 tgtgtacaat aggttagttt ccagcatact gagaaagctg gctgctcttt ctcccattct
     3841 cagatggctc ttcccaaccc tccaggtttc tgatgactta ccacctccta cacctattta
     3901 aaatgctaaa taccactcgt gcttcttttc ctaactggat ttgtgtgtgt gtgtgtgtgt
     3961 gtgtgtgtgt gtgtacaggt gcagtaaaca gcactgttca ctctaacggt gtgatccagg
     4021 cccctacttc cccttagata atctgatgtg cccactgtaa aaacgacata gcaacagggc
     4081 tggtatttga aacagaaagg atgaaaatgc catttttcct taatttctt
//
