LOCUS       NM_031086               3273 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus protein S (Pros1), mRNA.
ACCESSION   NM_031086 XM_343650
VERSION     NM_031086.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Ginisty,A., Oliver,L., Arnault,P., Vallette,F., Benzakour,O. and
            Coronas,V.
  TITLE     The vitamin K-dependent factor, protein S, regulates brain neural
            stem cell migration and phagocytic activities towards glioma cells
  JOURNAL   Eur J Pharmacol 855, 30-39 (2019)
   PUBMED   31028740
  REMARK    GeneRIF: vitamin K-dependent factor, protein S, regulates brain
            neural stem cell migration and phagocytic activities towards glioma
            cells
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   Zhong,F., Chen,H., Xie,Y., Azeloglu,E.U., Wei,C., Zhang,W., Li,Z.,
            Chuang,P.Y., Jim,B., Li,H., Elmastour,F., Riyad,J.M., Weber,T.,
            Chen,H., Wang,Y., Zhang,A., Jia,W., Lee,K. and He,J.C.
  TITLE     Protein S Protects against Podocyte Injury in Diabetic Nephropathy
  JOURNAL   J Am Soc Nephrol 29 (5), 1397-1410 (2018)
   PUBMED   29511111
  REMARK    GeneRIF: Our results support a protective role of PS against
            glomerular injury in DN progression.
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Alhenc-Gelas,M., Plu-Bureau,G., Horellou,M.H., Rauch,A. and
            Suchon,P.
  CONSRTM   GEHT genetic thrombophilia group
  TITLE     PROS1 genotype phenotype relationships in a large cohort of adults
            with suspicion of inherited quantitative protein S deficiency
  JOURNAL   Thromb Haemost 115 (3), 570-579 (2016)
   PUBMED   26466767
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Bouwens,E.A., Stavenuiter,F. and Mosnier,L.O.
  TITLE     Mechanisms of anticoagulant and cytoprotective actions of the
            protein C pathway
  JOURNAL   J Thromb Haemost 11 Suppl 1 (0 1), 242-253 (2013)
   PUBMED   23809128
  REMARK    Review article
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Duchemin,J., Gandrille,S., Borgel,D., Feurgard,P., Alhenc-Gelas,M.,
            Matheron,C., Dreyfus,M., Dupuy,E., Juhan-Vague,I. and Aiach,M.
  TITLE     The Ser 460 to Pro substitution of the protein S alpha (PROS1) gene
            is a frequent mutation associated with free protein S (type IIa)
            deficiency
  JOURNAL   Blood 86 (9), 3436-3443 (1995)
   PUBMED   7579448
REFERENCE   7  (bases 1 to 3273)
  AUTHORS   Jamison,C.S., McDowell,S.A., Marlar,R.A. and Degen,S.J.
  TITLE     Developmental expression of protein C and protein S in the rat
  JOURNAL   Thromb Res 78 (5), 407-419 (1995)
   PUBMED   7660357
REFERENCE   8  (bases 1 to 3273)
  AUTHORS   Yasuda,F., Hayashi,T., Tanitame,K., Nishioka,J. and Suzuki,K.
  TITLE     Molecular cloning and functional characterization of rat plasma
            protein S
  JOURNAL   J Biochem 117 (2), 374-383 (1995)
   PUBMED   7608128
REFERENCE   9  (bases 1 to 3273)
  AUTHORS   Smith,G.L. and Steele,D.S.
  TITLE     Inorganic phosphate decreases the Ca2+ content of the sarcoplasmic
            reticulum in saponin-treated rat cardiac trabeculae
  JOURNAL   J Physiol 458, 457-473 (1992)
   PUBMED   1302274
REFERENCE   10 (bases 1 to 3273)
  AUTHORS   Thur,C. and Biedermann,M.
  TITLE     [Post-traumatic impingement syndrome caused by a displaced
            tuberculum majus fragment]
  JOURNAL   Z Unfallchir Versicherungsmed 85 (4), 189-201 (1992)
   PUBMED   1299299
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB790907.1, DY571157.1, CB580854.1, CV105055.1, CK366505.1,
            DV727991.1 and BC091117.1.
            
            On Apr 19, 2007 this sequence version replaced NM_031086.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132292 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-376               CB790907.1         54-429
            377-840             DY571157.1         198-661
            841-1252            CB580854.1         198-609
            1253-1800           CV105055.1         208-755
            1801-2294           CK366505.1         226-719
            2295-2817           DV727991.1         237-759
            2818-3273           BC091117.1         777-1232
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p12"
     gene            1..3273
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /note="protein S"
                     /db_xref="GeneID:81750"
                     /db_xref="RGD:620971"
     exon            1..160
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..2112
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /note="vitamin K-dependent protein S; protein S (alpha)"
                     /codon_start=1
                     /product="vitamin K-dependent protein S precursor"
                     /protein_id="NP_112348.2"
                     /db_xref="GeneID:81750"
                     /db_xref="RGD:620971"
                     /translation="MRVLSVRFRVLLACLALVLPVSETNFLSKERASQVLVRKRRANT
                     LLEETKKGNLERECIEELCNKEEAREVFENNPETDYFYPKYLGCLGAFRVGAFSAARQ
                     SANAYPDLRSCVNAIPDQCDPMPCNEDGYLSCKDGQGAFTCICKPGWQGDKCQFDINE
                     CKDPSNINGGCSQTCDNTPGSYHCSCKIGFAMLTNKKDCKDVDECSLKPSVCGTAVCK
                     NIPGDFECECPNGYRYDPSSKSCKDVDECSENTCAQLCVNYPGGYSCYCDGKKGFKLA
                     QDQRSCEGIPVCLSLDLDKNYELLYLAEQFAGVVLYLKFRLPDITRFSAEFDFRTYDS
                     EGIILYAESLDHSNWLLIALREGKIEVQFKNEFSTQITTGGNVINNGIWNMVSVEELD
                     DSVSIKIAKEAVMNINKLGSLFKPTDGFLDTKIYFAGLPRKVESALIKPINPRLDGCI
                     RGWNLMKQGALGAKEIVEGKQNKHCFLTVEKGSYYPGSGIAQFSIDYNNVTNAEGWQI
                     NVTLNIRPSTGTGVMLALVSGDTVPFALSLVDSGSGTSQDILVFVENSVAAHLEAITL
                     CSEQPSQLKCNINRNGLELWTPVRKDVIYSKDLQRQLAILDKTMKGTVATYLGGVPDI
                     SFSATPVNAFYSGCMEVNINGVQLDLDEAISKHNDIRAHSCPSVRKIQKNF"
     exon            161..318
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            319..343
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            344..430
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            431..553
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            554..685
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            686..811
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            812..933
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1049
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1239
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1407
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1576
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1725
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1951
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..3248
                     /gene="Pros1"
                     /gene_synonym="Pros"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcccaggc tcgcagctcc tctccgccaa gctcaggcac cgtcctcccc gcgccatcac
       61 agacccccgg ccgcccgctc agcaatgagg gtcctgagcg tgcgctttcg ggtgctactg
      121 gcctgcctcg ccctggtgct ccctgtctca gagacaaact tcttgtcaaa agaacgagct
      181 tcacaagtcc tggtgaggaa gcgccgtgca aataccttgc tcgaagaaac taaaaagggc
      241 aaccttgaaa gagagtgcat tgaagaactc tgcaataagg aggaagccag ggaggtcttt
      301 gaaaataatc ccgaaacgga ttatttttat ccaaaatatt taggttgtct gggcgcattc
      361 cgagttggcg cattcagtgc tgcgaggcag tcagctaatg cttaccctga cctcaggagc
      421 tgtgtcaatg ccatcccaga ccaatgtgac cctatgccat gcaatgaaga tgggtatctg
      481 agctgcaaag acggccaagg tgcttttact tgcatctgta aaccaggctg gcaaggagac
      541 aagtgtcagt ttgatataaa tgaatgcaaa gatccctcaa atatcaatgg gggctgtagc
      601 cagacttgtg acaatactcc tggaagttac cactgctcct gtaaaattgg ctttgctatg
      661 ctcacaaata agaaagactg caaagatgtg gatgagtgct ctctaaagcc aagtgtctgt
      721 ggcacagctg tgtgcaagaa cattccagga gacttcgaat gtgaatgtcc caatggctac
      781 agatatgatc cctcatcaaa atcttgtaaa gatgtcgatg aatgctctga aaacacctgt
      841 gcccaactgt gtgtcaatta ccccggaggc tactcttgtt actgtgatgg gaagaaagga
      901 ttcaaacttg cccaagatca gaggagttgt gagggtattc cagtgtgcct ttccttggac
      961 cttgacaaaa attatgaatt attatatttg gcggaacagt tcgcaggagt tgtcttatat
     1021 ctgaaatttc gattgccaga tatcaccagg ttttcagctg aatttgattt tcggacatat
     1081 gattcagagg gcatcatact gtatgcagaa tctctcgatc actcaaattg gctcctgatt
     1141 gcacttcgtg aagggaagat tgaagttcag tttaagaatg agttttcaac ccaaatcaca
     1201 actggaggca atgttattaa caatggtata tggaatatgg tgtctgtgga agaattagac
     1261 gacagtgtta gcattaaaat agctaaggag gccgtgatga atattaataa acttgggagt
     1321 ctttttaaac ctaccgatgg atttctggac accaaaatat actttgcagg attacctcgg
     1381 aaggtggaaa gtgcactcat taagccgatt aatcctcgtc tggatggatg tatacgaggc
     1441 tggaacttga tgaaacaagg agctttgggt gcaaaggaaa tagttgaagg aaaacaaaat
     1501 aaacattgct tcctcactgt ggagaagggc tcctactacc ctggttcagg aattgctcag
     1561 ttcagcatag actacaataa tgtaactaat gcagagggtt ggcaaataaa tgtgaccttg
     1621 aatattcgcc cgtccactgg cactggagtc atgcttgctt tagtttctgg ggacacagtg
     1681 ccctttgcct tgtccttggt ggattctggc tctggaactt ctcaggacat tctggtattt
     1741 gttgaaaatt cagtagcagc tcacttagaa gccataactc tgtgctcgga acagccatcc
     1801 cagctgaaat gtaacattaa cagaaatgga ctggaactgt ggaccccagt tagaaaagac
     1861 gtcatttact ctaaagatct ccaaaggcaa ctcgccatct tggacaaaac aatgaaagga
     1921 accgtggcca cttacctggg tggcgttcca gatatttcct tcagtgccac accagtgaat
     1981 gctttttaca gcggctgcat ggaagtgaac atcaacgggg tacagttgga tctggatgaa
     2041 gccatttcca aacataatga cattagagct cactcctgtc cgtcagtgag gaaaatccag
     2101 aagaacttct aaagtctgtt tcctgggctt ctaatctctc ttttcatatt gtaattatgc
     2161 tcttgttcat gtttccatca ccaaatggca ggattacatg tgttatatgc atgtttaaat
     2221 atgatgtggt actttgtcct tcagattttt gttatataag tcgcattttt gaaaagtctt
     2281 gtactcactg ctgtctagaa attaaataac aaaacacatg aaacatttaa atttcaattt
     2341 atttcctata aatgacacgg ctttagtttt tttttttttt tattttaaag gtaagattca
     2401 tcgtcatgga actagtattt aaatgttctg tttttctcag aagacgaatc agttaaaccg
     2461 aaacaaaagc tcatgggact aaatgctaac agttggagag cgacactgta tttttgttgt
     2521 tgctttttgc ccacgacagc gacagagctg atagcatact gcatgagaat tggaaggaag
     2581 gtctcaaagc tttattctaa agtaattccg aggtgtgggg agcgcctagt ttaggcttca
     2641 tttttctttc acttgacttt acacttgagc caacaccttc accgaattag agaccagggg
     2701 cacattttca ctggagcaac acctgaatgt tgtctcaaag gcattggttt ctctccaaga
     2761 catcaggtta tgctgtaagg ggggtgtgaa cattgggcgc gcacatcact caacctaggc
     2821 tgtttagagc acataaggtc agagtcagaa aggcagctgt tcttaatggt gggaaggaga
     2881 gtgaatacat cagtaaattc atagttgtcc ttcacattgg attttaacaa ctataggtgg
     2941 tttgaatggg attgttgaag ttaaaaatgt gaccaaaagt agatttttta acaaagcgat
     3001 aatgacaaga cagatgttcg ataatgttac atgttccagc tttgtaatga aagaaacacg
     3061 aaggtaagat tgtcaaatat ttgctgatag tgcattgcaa gtgtcaggct gctttgtcgc
     3121 tcctgagttg atgatcattt caggtgtgta tcaggtacgt cattgctatc tgagaaattg
     3181 aattttattt tactgtagat attttgcatc acatgaaaca taataaaagg atacatattt
     3241 ttaaaataaa aaaaaaaaaa aaaaaaaaaa aaa
//
