LOCUS       NM_138857               4285 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus prominin 2 (Prom2), mRNA.
ACCESSION   NM_138857 XM_006234947
VERSION     NM_138857.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4285)
  AUTHORS   Dowland,S.N., Madawala,R.J., Poon,C.E., Lindsay,L.A. and
            Murphy,C.R.
  TITLE     Prominin-2 Prevents the Formation of Caveolae in Normal and Ovarian
            Hyperstimulated Pregnancy
  JOURNAL   Reprod Sci 25 (8), 1231-1242 (2018)
   PUBMED   29113580
  REMARK    GeneRIF: Study shows that prominin-2 prevents the formation of
            caveolae in normal and ovarian hyperstimulated pregnancy.
REFERENCE   2  (bases 1 to 4285)
  AUTHORS   Singh,R.D., Schroeder,A.S., Scheffer,L., Holicky,E.L.,
            Wheatley,C.L., Marks,D.L. and Pagano,R.E.
  TITLE     Prominin-2 expression increases protrusions, decreases caveolae and
            inhibits Cdc42 dependent fluid phase endocytosis
  JOURNAL   Biochem Biophys Res Commun 434 (3), 466-472 (2013)
   PUBMED   23583380
REFERENCE   3  (bases 1 to 4285)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 4285)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 4285)
  AUTHORS   Florek,M., Bauer,N., Janich,P., Wilsch-Braeuninger,M.,
            Fargeas,C.A., Marzesco,A.M., Ehninger,G., Thiele,C., Huttner,W.B.
            and Corbeil,D.
  TITLE     Prominin-2 is a cholesterol-binding protein associated with apical
            and basolateral plasmalemmal protrusions in polarized epithelial
            cells and released into urine
  JOURNAL   Cell Tissue Res 328 (1), 31-47 (2007)
   PUBMED   17109118
  REMARK    GeneRIF: These data show that all the characteristics of prominin-1
            are shared by prominin-2, which is in agreement with a possible
            redundancy in their role as potential organizers of plasma membrane
            protrusions.
REFERENCE   6  (bases 1 to 4285)
  AUTHORS   Fargeas,C.A., Florek,M., Huttner,W.B. and Corbeil,D.
  TITLE     Characterization of prominin-2, a new member of the prominin family
            of pentaspan membrane glycoproteins
  JOURNAL   J Biol Chem 278 (10), 8586-8596 (2003)
   PUBMED   12514187
REFERENCE   7  (bases 1 to 4285)
  AUTHORS   Fargeas,C.A., Corbeil,D. and Huttner,W.B.
  TITLE     AC133 antigen, CD133, prominin-1, prominin-2, etc.: prominin family
            gene products in need of a rational nomenclature
  JOURNAL   Stem Cells 21 (4), 506-508 (2003)
   PUBMED   12832703
REFERENCE   8  (bases 1 to 4285)
  AUTHORS   Zhang,Q., Haleem,R., Cai,X. and Wang,Z.
  TITLE     Identification and characterization of a novel
            testosterone-regulated prominin-like gene in the rat ventral
            prostate
  JOURNAL   Endocrinology 143 (12), 4788-4796 (2002)
   PUBMED   12446606
  REMARK    GeneRIF: results argue that PROML2 is a novel proapoptotic membrane
            protein; its down-regulation may associate with aggressive
            phenotype of prostate cancer cells
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Nov 20, 2020 this sequence version replaced
            XM_006234947.3, NM_138857.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF486828.1, AF508942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-355               JAXUCZ010000003.1  135214723-135215077 c
            356-405             JAXUCZ010000003.1  135214173-135214222 c
            406-608             JAXUCZ010000003.1  135213663-135213865 c
            609-729             JAXUCZ010000003.1  135213446-135213566 c
            730-793             JAXUCZ010000003.1  135213220-135213283 c
            794-883             JAXUCZ010000003.1  135212885-135212974 c
            884-1086            JAXUCZ010000003.1  135212367-135212569 c
            1087-1161           JAXUCZ010000003.1  135211964-135212038 c
            1162-1225           JAXUCZ010000003.1  135211061-135211124 c
            1226-1385           JAXUCZ010000003.1  135210697-135210856 c
            1386-1538           JAXUCZ010000003.1  135210239-135210391 c
            1539-1662           JAXUCZ010000003.1  135209257-135209380 c
            1663-1754           JAXUCZ010000003.1  135208775-135208866 c
            1755-1839           JAXUCZ010000003.1  135208578-135208662 c
            1840-1986           JAXUCZ010000003.1  135206622-135206768 c
            1987-2058           JAXUCZ010000003.1  135205675-135205746 c
            2059-2151           JAXUCZ010000003.1  135204945-135205037 c
            2152-2205           JAXUCZ010000003.1  135204754-135204807 c
            2206-2286           JAXUCZ010000003.1  135204413-135204493 c
            2287-2355           JAXUCZ010000003.1  135204174-135204242 c
            2356-2445           JAXUCZ010000003.1  135203409-135203498 c
            2446-2552           JAXUCZ010000003.1  135203142-135203248 c
            2553-2625           JAXUCZ010000003.1  135202756-135202828 c
            2626-4285           JAXUCZ010000003.1  135200944-135202603 c
FEATURES             Location/Qualifiers
     source          1..4285
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..4285
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /note="prominin 2"
                     /db_xref="GeneID:192211"
                     /db_xref="RGD:621435"
     exon            1..355
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2616
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /note="PROM-2; rPROML2; prominin-like protein 2;
                     prominin-related protein; testosterone-regulated
                     prominin-related protein"
                     /codon_start=1
                     /product="prominin-2 precursor"
                     /protein_id="NP_620212.2"
                     /db_xref="GeneID:192211"
                     /db_xref="RGD:621435"
                     /translation="MTRTLDLMVPLLGLSLGLALSLPRAVAADCGSLGRVEHLAFAPV
                     PGTEPTAPRVRAPWPLDSLYGTVRRFLSVVQLNPFPAELIKTLLNDPSSVKTDEVVRY
                     EAGYVVCAVIAGLYLLLVPITGLCFCCCRCRRRCGGRVKTEHKAMACERGTLMTFLLL
                     TTLMLLIGMVCAFATNQFTHSQTGPSVEAVPETLLSLRGLVSDVPKKLQAVADQFSLP
                     QKQVSKDLDGVGENLGNIIHNQLKSTVYPVLASVHGLGQALQVSIDHLQSVNATSVEL
                     REGQQHLGPPVQAHRERLLALLQESWCHENCKGALSQASALQLGADFSQMPPVDDVLH
                     RLQGVPEANFSSMVQEENATFNNLPILVHMQMVSVVKDLKKALAEQPEGVRMLAQAFP
                     GSEATSRWSQALEGLEQRSRPYLQDVQRYETYRWILGCVLCSAILLVVICNLLGLSLG
                     IWGLFAREDPSHSETKGEAGARFLMAGVAFSFLFAAPLILLVFATFLVGGNVQTLVCR
                     SWESGELYEFVDTPGNLPPSMNLSYLLGLRKNISVFQAYRQCKAGTALWKVLQLNDSY
                     DLDKHLDIKQYTHKLQQELQSFKVDLKDLDLLNPAARQNLEALQSSGLEKIHYRDFLV
                     QIQKPVVKTDMGQLAKELEGLAQAHNESLRRQQLQEEARELRSLYQEKVVPQENLVAK
                     LNPSIRVLESSAPKLQVNTSDLLDIVARLKGELPAQLNHILRNATECFLTREMGYFSQ
                     YVTWVREEVTQHIATCQPFSKALDDGHMILCDMMANPWNAFWFCLGWCTFFLIPSIIF
                     AVKTSKYFRPIRKRLSSTSSEETQLFHIPRVTSLKL"
     exon            356..405
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            406..608
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            609..729
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            730..793
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            794..883
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1086
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1161
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1225
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1385
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1538
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1662
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1754
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1839
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1986
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2058
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2151
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2205
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2286
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2355
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2445
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2552
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2625
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..4285
                     /gene="Prom2"
                     /gene_synonym="Prom-rp; Promrp; Trprp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acggggactg agggaagaag gctacagaag gatgcacggc ctgccccgtg ctggtccgaa
       61 ctgtccgcac tgtctgccgt ctgagcctgt gcttcccacc ggtccgaact catgacgcgc
      121 acgctcgacc tcatggtgcc tctgctgggc ctaagcctgg gactggccct gagcctgccc
      181 cgagctgtgg cagcggactg cgggtccctc gggcgcgtgg agcacctggc attcgctccg
      241 gtgcccggga cagaaccgac agcccctcgt gtccgcgcgc cgtggcccct ggactccctc
      301 tatggcaccg tgagacgatt cctctccgtg gttcagctta accccttccc ggcagagttg
      361 ataaagaccc tcctaaatga tccatcttct gtgaagacag atgaggtggt ccggtatgag
      421 gcgggctacg tggtgtgcgc tgtgattgct ggcctctacc tcctattggt acccatcact
      481 gggctctgct tctgttgttg ccgatgccgc cggcgctgcg ggggcagggt gaagacggag
      541 cacaaggcca tggcctgtga acgtggcacc ctcatgacct tcctgctgct gaccaccctc
      601 atgcttctga tcggtatggt ctgtgctttt gctactaacc agttcacaca cagtcagacg
      661 ggccccagtg tggaagcggt ccccgagacc ctgctcagcc taagaggctt ggtctctgac
      721 gttcctaaaa agctgcaggc cgtggctgat cagttctcct tgcctcagaa gcaagtctca
      781 aaggatctgg atggtgtcgg tgagaacctt gggaatataa ttcataacca actcaagagc
      841 acagtgtacc cagtgctagc ctcagtgcac ggcctgggcc aggccctgca ggtctccata
      901 gaccaccttc aaagcgtgaa cgccacctca gtggagctgc gggaggggca gcagcacctg
      961 ggaccacctg tgcaggcaca ccgggagcgc ctgctcgccc tgcttcagga gagctggtgc
     1021 cacgagaact gcaagggggc cctgagccag gccagtgctc tgcaactggg tgctgacttt
     1081 agccagatgc cccctgtgga tgacgtcctg catcggctgc agggtgtccc agaagccaac
     1141 ttctccagca tggtccagga ggagaacgcc accttcaata acctccctat cctggttcat
     1201 atgcagatgg tcagtgtggt caaagatctg aaaaaggcac tggctgagca gcctgaaggt
     1261 gtgaggatgc tggcccaagc gttcccaggt tcagaggcaa cttcccgctg gagccaggcg
     1321 ctggaggggc tggagcagcg cagccgcccc tacttacagg atgtgcagcg atatgagaca
     1381 tacaggtgga ttttgggatg cgtgctgtgc tctgccatcc tgcttgtggt gatctgtaac
     1441 ctgctgggcc tcagcctagg catctggggg ttgtttgcca gggaggaccc cagccactct
     1501 gaaaccaagg gcgaggctgg agcccgcttc ctcatggcag gtgtggcctt cagcttcctc
     1561 tttgcagccc ccctcatcct ccttgtcttc gccactttcc tggtgggtgg caacgtgcag
     1621 acgctggtgt gccggagctg ggagagtgga gagctgtacg agtttgtgga caccccgggg
     1681 aacctgcccc catccatgaa cctgtcctac cttcttggcc tgaggaagaa catcagcgtc
     1741 ttccaggcct atcgacagtg taaggcaggg acagcactct ggaaggttct acagctcaat
     1801 gactcctatg acctggataa gcacctggat atcaaacagt atacccataa gcttcagcag
     1861 gagcttcaaa gcttcaaagt agatctgaag gatctagacc tgttgaatcc tgctgcccgc
     1921 cagaacctgg aggctttgca gagtagcggg ctggagaaaa tccactacag agacttcctt
     1981 gtacagatcc agaagcctgt ggtgaagact gacatggggc agctggcgaa ggagctggaa
     2041 ggactggccc aggcccataa tgaatcttta cggaggcagc agctacagga ggaggccaga
     2101 gaacttcgaa gcctctacca ggagaaggtt gtcccccagg agaaccttgt ggccaagctc
     2161 aaccccagca tcagggtctt ggagtcctca gccccaaaac tgcaggtgaa tacctcagac
     2221 cttcttgaca tagtcgcccg tcttaaagga gagctgcctg ctcagctcaa ccacatcctg
     2281 aggaatgcca ctgagtgttt cctgaccagg gaaatgggct acttctctca gtatgtgacc
     2341 tgggtgaggg aagaggtgac tcagcacatc gccacctgcc agcccttctc taaagccctg
     2401 gacgatggtc atatgatcct gtgtgacatg atggccaacc cctggaatgc cttctggttc
     2461 tgcctgggct ggtgcacctt cttcctcatc cccagcatca tcttcgcggt caagacctcc
     2521 aagtacttcc gtcccatccg gaaacggctc agctccacca gctccgaaga gacacagctc
     2581 ttccatatcc ccagggtcac ctccctgaag ctatagaacc caccgggcaa ggtgatacct
     2641 gggggtttcc tgtccttctt ccttgtctca gcctggacca gacgacatct gtaacctctg
     2701 ttccagagcc caggctggcc tctagtgctg ggttgtctcc agttccacat ttgtactctt
     2761 tctgctcgtg actcaaagca ctctcagtct ttactgaact acagagctaa cgggttcttg
     2821 tgggtgtcta gccttgccct cctctctgtg gtatctcaca caagagaggc ctcttcacca
     2881 cccatggcag ttctttctct gcctttagac gggacccagc cttctccatg caccctgttt
     2941 ctttctccgt ctcctaccta agctcctttc cccttgtcta agttcagtcc cctcaacctg
     3001 ccccaacatc cttcttgttc cctccccagc ccattgcttg ctctctccat ggaggtcctg
     3061 cctccccgct tgtccccttt accttgtcct tactgctacc ttgctggctc ccaggcctct
     3121 agtacggaac aaatattatg gttgaggtca tgaccgctga gccttctgca gctctcttct
     3181 ggatctcctc ctgttcccag tggggcgaga cagcctgtct gagggctgag ctgtcctgtc
     3241 tgcatcctgg gttagaaacg ccagtgttgg ccctgtcttc tccttgagca ctggctcctg
     3301 agagagagcc agggatgtgg gccatgctgg ggatctccct ttgcctcaca gacagtagtt
     3361 tgggtagtcc cactgtgttc cccaggatgt atctgatggt aagaacaggg tttctgccct
     3421 ccccctgccg tcctgcccat cacttatctc tataatgtcc ctattgctga gcactgagtc
     3481 cagaaaggac acagaaagga gagacagtat ggaccaatcc ctgctccagt agcaggttct
     3541 cacttccctc tgctttgctt ctgggtcccc aaggctgtgt ctctagggca aaggttcagt
     3601 atacagttgg tctgtaacga gcatttgtgg gaagcgttcc aaggcctctc taactgcaga
     3661 catcctggga ctgctatagc aattcagtgg gaggagcaga gcctgcctca gccgtgtgat
     3721 tcacaggctg gttctgatgc tgctagctgg ggctcctcaa acatgttcct aggtccccca
     3781 agcctcaatt tattttatta taaaacggag aggctcctcg gagcctgcgt gtaggattgt
     3841 gaaagtcaga catgatggtg ggtggaaacc caggacagac ctggtgctga gcttctgcag
     3901 tcccgaagtt gggagccagg ctgagggcag agccagggtc tggcctgaag ggggtgagcg
     3961 ccctttctgg tggtaatcct ctctctctct ctctctgggc atgttgattc ggaattacat
     4021 tatgaatgcg ccagtaccag ttttgtgcta ggactaagga tgatggtacc caatgtacaa
     4081 acatacagag actccagcca gcctattgtc aaataggaat cctgggatat gctttccccc
     4141 ccagaggttg gaaggttttg ttttgttgtt tgttttcagt tgttatttgt ttgttaacct
     4201 gggggtgagg aagtgacacc ctgtaatttt aactgattgg atttaaacaa atgaaataaa
     4261 agcaattaaa aaccatttcc ggttc
//
