LOCUS       NM_021751               3714 bp    mRNA    linear   ROD 05-MAR-2024
DEFINITION  Rattus norvegicus prominin 1 (Prom1), transcript variant 1, mRNA.
ACCESSION   NM_021751
VERSION     NM_021751.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3714)
  AUTHORS   Zhang,Y., Xu,L., Guo,C., Li,X., Tian,Y., Liao,L. and Dong,J.
  TITLE     High CD133 expression in proximal tubular cells in diabetic kidney
            disease: good or bad?
  JOURNAL   J Transl Med 22 (1), 159 (2024)
   PUBMED   38365731
  REMARK    GeneRIF: High CD133 expression in proximal tubular cells in
            diabetic kidney disease: good or bad?
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3714)
  AUTHORS   Zou,X., Hou,Y., Xu,J., Zhong,L., Zhou,J., Zhang,G. and Sun,J.
  TITLE     Mitochondria transfer via tunneling nanotubes is an important
            mechanism by which CD133+ scattered tubular cells eliminate hypoxic
            tubular cell injury
  JOURNAL   Biochem Biophys Res Commun 522 (1), 205-212 (2020)
   PUBMED   31759629
  REMARK    GeneRIF: Mitochondria transfer via tunneling nanotubes is an
            important mechanism by which CD133+ scattered tubular cells
            eliminate hypoxic tubular cell injury.
REFERENCE   3  (bases 1 to 3714)
  AUTHORS   Almasry,S.M., Habib,E.K., Elmansy,R.A. and Hassan,Z.A.
  TITLE     Hyperglycemia Alters the Protein Levels of Prominin-1 and VEGFA in
            the Retina of Albino Rats
  JOURNAL   J Histochem Cytochem 66 (1), 33-45 (2018)
   PUBMED   29076766
  REMARK    GeneRIF: The here presented data revealed the upregulation of
            retinal tissue levels and immunoreactivity of VEGFA and prom1
            during hyperglycemia that could contribute to the development of
            diabetic vasculopathy and neuropathy.
REFERENCE   4  (bases 1 to 3714)
  AUTHORS   Dowland,S.N., Madawala,R.J., Poon,C.E., Lindsay,L.A. and
            Murphy,C.R.
  TITLE     Prominin-1 glycosylation changes throughout early pregnancy in
            uterine epithelial cells under the influence of maternal ovarian
            hormones
  JOURNAL   Reprod Fertil Dev 29 (6), 1194-1208 (2017)
   PUBMED   27166505
  REMARK    GeneRIF: Data suggest that, at fertilization, Prom1 (97-kDa core
            protein and 147-/120-kDa glycoforms) is located diffusely in apical
            domain of UECs (uterine epithelial cells); at implantation, Prom1
            is concentrated toward APM (apical plasma membrane) with
            down-regulation of 120-kDa glycoform and up-regulation of 97-kDa
            core protein.
REFERENCE   5  (bases 1 to 3714)
  AUTHORS   Fang,J.Z., Li,C., Liu,X.Y., Hu,T.T., Fan,Z.S. and Han,Z.G.
  TITLE     Hepatocyte-Specific Arid1a Deficiency Initiates Mouse
            Steatohepatitis and Hepatocellular Carcinoma
  JOURNAL   PLoS One 10 (11), e0143042 (2015)
   PUBMED   26569409
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3714)
  AUTHORS   Yu,Y., Flint,A., Dvorin,E.L. and Bischoff,J.
  TITLE     AC133-2, a novel isoform of human AC133 stem cell antigen
  JOURNAL   J Biol Chem 277 (23), 20711-20716 (2002)
   PUBMED   12042327
REFERENCE   7  (bases 1 to 3714)
  AUTHORS   Corbeil,D., Fargeas,C.A. and Huttner,W.B.
  TITLE     Rat prominin, like its mouse and human orthologues, is a pentaspan
            membrane glycoprotein
  JOURNAL   Biochem Biophys Res Commun 285 (4), 939-944 (2001)
   PUBMED   11467842
REFERENCE   8  (bases 1 to 3714)
  AUTHORS   Zhu,G., Chang,Y., Zuo,J., Dong,X., Zhang,M., Hu,G. and Fang,F.
  TITLE     Fudenine, a C-terminal truncated rat homologue of mouse prominin,
            is blood glucose-regulated and can up-regulate the expression of
            GAPDH
  JOURNAL   Biochem Biophys Res Commun 281 (4), 951-956 (2001)
   PUBMED   11237753
REFERENCE   9  (bases 1 to 3714)
  AUTHORS   Maw,M.A., Corbeil,D., Koch,J., Hellwig,A., Wilson-Wheeler,J.C.,
            Bridges,R.J., Kumaramanickavel,G., John,S., Nancarrow,D., Roper,K.,
            Weigmann,A., Huttner,W.B. and Denton,M.J.
  TITLE     A frameshift mutation in prominin (mouse)-like 1 causes human
            retinal degeneration
  JOURNAL   Hum Mol Genet 9 (1), 27-34 (2000)
   PUBMED   10587575
REFERENCE   10 (bases 1 to 3714)
  AUTHORS   Weigmann,A., Corbeil,D., Hellwig,A. and Huttner,W.B.
  TITLE     Prominin, a novel microvilli-specific polytopic membrane protein of
            the apical surface of epithelial cells, is targeted to plasmalemmal
            protrusions of non-epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 94 (23), 12425-12430 (1997)
   PUBMED   9356465
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB780214.1, AF386758.1 and BI286840.1.
            
            On Oct 25, 2007 this sequence version replaced NM_021751.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF386758.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA5760384, SAMEA5760393 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               CB780214.1         1-121
            122-3570            AF386758.1         1-3449
            3571-3714           BI286840.1         1-144               c
FEATURES             Location/Qualifiers
     source          1..3714
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3714
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /note="prominin 1"
                     /db_xref="GeneID:60357"
                     /db_xref="RGD:69367"
     exon            1..67
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            68..438
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..2792
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fudenine"
                     /codon_start=1
                     /product="prominin-1 isoform 1 precursor"
                     /protein_id="NP_068519.2"
                     /db_xref="GeneID:60357"
                     /db_xref="RGD:69367"
                     /translation="MALVFSVLLLLGLCGKMASGGQPAFDNTPGALNYELPTTEYETQ
                     DTFNAGIIDPLYQMVHIFLNVVQPNDFPQDLVKKLIQKRFDISVDTKEVAIYEIGVLI
                     CVILGLLFIFLMPLVGFFFCMCRCCNKCGGEMHQRQKQNESCRRKCLAISLLLICLLM
                     SLGIAFGFVANQQTRTRIQRTQKLAESNYRDLRALLTEAPKQIDYILGQYNTTKNKAF
                     SDLDSIDSVLGGRIKGQLKPKVTPVLEEIKAMATAIRQTKDALQNMSSSLKSLRDAST
                     QLSTNLTSVRNSIENSLNSNDCASDPASKICDSLRPQLSNLGSNHNGSQLPSVDRELN
                     TVNDVDRTDLESLVKRGYMSIDEIPNMIQNQTGDVIKDVKKTLDSVSSKVKNMSQSIP
                     VEEVLLQFSHYLNDSNRYIHESLPRVEEYDSYWWLGGLIVCFLLTLIVTFFYLGLLCG
                     VFGYDKRATPTRRGCVSNTGGIFLMAGVGFSFLFCWILMILVVLTFVVGANVEKLLCE
                     PYENKKLLQVLDTPYLLNDQWQFYLSGILLKNPDINMTFEQVYRDCKRGRGVYATFQL
                     ENVFNITENFNIERLSEDIVKELEKLNVNIDSIELLDKTGRKSLEDFAQSGIDRINYS
                     MYLQEAEKPPTKVDLLTFASFLETEANQLPDGNLKQAFLMDAQNIRAIHQQHVPPVQQ
                     SLNSLKQSVWALKQTSSKLPEEVKKVLASLDSAQHFLTSNLSSIVIGETKKFGRTIIG
                     YFEHYLQWVLYAITEKMTSCKPMITAMDSAVNGILCSYVADPLNLFWFGIGKATMLLL
                     PAVIIAIKLAKYYRRMDSEDVYDDVETVPMKNLENGSNGYHKDHLYGVHNPVMTSPSR
                     Y"
     exon            439..494
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            495..700
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            701..821
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            822..885
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            886..975
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1193
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1268
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1332
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1492
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1645
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1769
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1873
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1958
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2105
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2177
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..2270
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2324
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2405
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2474
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2475..2567
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2683
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2707
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..2776
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2816
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..3702
                     /gene="Prom1"
                     /gene_synonym="CD133; Prom"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggagccca gcctggaggc gaggggctgg cgggttccaa gacccaggcg ggagctggac
       61 gggagcgaga tgttactttg agtgaatgac ctccttggag accattcttc tgctcccctt
      121 cttaccagcc aggaggcaga agattccaca ggtccaggaa agacataatt cccttgagct
      181 tccagaaagt accttatgcc tgggggatca ggccaactat ggctctcgta ttcagtgtcc
      241 tgctgctact ggggctgtgt ggaaagatgg cttcaggagg tcagcctgca ttcgataaca
      301 ctcccggggc tttgaattat gaattgccta ccacagaata tgagacccaa gacaccttca
      361 atgctgggat tattgaccct ctctaccaaa tggtgcacat cttcctcaac gtggtccagc
      421 cgaatgactt ccctcaagat ttggtcaaaa aactcataca gaagaggttt gacatctcgg
      481 ttgataccaa ggaggtcgcc atctatgaaa ttggagttct tatctgcgtc atcctgggcc
      541 tgctgttcat tttcctcatg cccctggtgg gcttcttctt ttgtatgtgc cgttgctgta
      601 acaaatgcgg cggagaaatg caccagcggc agaagcagaa cgagtcgtgc cggaggaagt
      661 gcttagccat ctccctcttg ctgatttgtc tgctcatgag tcttggcatc gcgtttggct
      721 ttgtggccaa ccagcagaca aggactcgga tccaaaggac ccagaagctg gcagagagca
      781 attacagaga cttgcgggct ctcctgactg aagccccaaa gcaaatcgac tatattctgg
      841 ggcaatacaa cacaaccaag aacaaggcat tctcagacct ggacagtatc gattccgtgc
      901 tgggaggcag aataaagggc caactaaaac ccaaagttac tcctgttctc gaagagatta
      961 aggccatggc aacagccatt agacagacca aggatgccct gcagaacatg agcagcagtc
     1021 tgaaaagtct acgtgacgca agcacccagc tcagtaccaa cctgacgtct gtgagaaaca
     1081 gcatcgagaa ttcactcaac agcaacgact gtgcttcaga cccagccagc aagatctgtg
     1141 atagcctcag accacagctg agcaatctgg ggagcaacca caacggaagt cagctcccat
     1201 cagtggacag ggaactcaac accgttaatg atgtcgacag aaccgatctg gagagcctcg
     1261 tcaaaagggg gtatatgtcg attgatgaaa tacccaatat gatacaaaac caaactgggg
     1321 atgtcatcaa agatgtcaaa aagaccttgg attctgttag ctccaaggtt aagaacatga
     1381 gccaaagtat tcctgtcgag gaggtgctgc ttcagttctc ccactacctt aatgacagca
     1441 acaggtacat ccacgagtcg ctgcccagag tggaagaata tgactcatac tggtggctgg
     1501 gtggcttaat agtctgcttc ctgctgaccc tcattgtgac tttcttttac ctgggcttgc
     1561 tgtgtggtgt gtttggctat gacaagcgtg ccaccccaac cagaagaggc tgcgtgtcca
     1621 acactggagg catcttcctc atggctgggg ttggattcag cttccttttt tgctggatat
     1681 tgatgatcct tgtggttctt acttttgttg ttggtgcaaa tgtggaaaag ttgctctgtg
     1741 aaccttatga aaacaagaaa ttactacagg ttttggatac tccctacctg ctcaacgatc
     1801 aatggcaatt ctatctctct ggcatactac tcaaaaaccc agacattaac atgacctttg
     1861 agcaagtcta cagggattgc aaaagaggtc gaggagtgta tgccactttt cagcttgaga
     1921 atgtcttcaa catcactgag aatttcaaca ttgagaggct ttctgaagac atagtgaagg
     1981 agttggaaaa gctgaatgtg aacattgaca gcatcgaact gttggacaaa acaggaagga
     2041 agagcctcga ggactttgca caatctggga tagatagaat caattattcc atgtacttac
     2101 aggaggctga gaaaccccct accaaagtgg acctgctgac atttgcctct tttctggaaa
     2161 cagaagcaaa ccagttgcct gacggaaatc tgaaacaggc cttcttaatg gatgcacaga
     2221 acattcgagc catccaccag cagcacgtcc ctcctgtgca gcagtcactg aattcattaa
     2281 aacaaagtgt ctgggccctt aagcaaacaa gcagcaagtt gccggaggaa gtgaagaagg
     2341 tccttgcctc tttggattct gctcagcatt tcctcaccag taacctctcc tccatcgtta
     2401 ttggagaaac aaagaagttt gggagaacaa taataggcta ctttgaacat tatctgcaat
     2461 gggtcttgta cgccatcaca gagaagatga catcctgcaa acccatgatt acagcaatgg
     2521 actctgctgt taatggcatt ctgtgtagct atgttgctga ccctctgaat ctgttctggt
     2581 tcggcatagg gaaagccacc atgctcttac ttccggctgt aatcatcgct atcaagttgg
     2641 ccaagtacta tcgcaggatg gattcagagg atgtatatga tgatgttgag actgtaccca
     2701 tgaaaaattt ggaaaacggt agtaatggtt atcataaaga tcatttatat ggtgttcaca
     2761 atcctgttat gacaagcccg tctcgatact gacaactgaa gtggaaattg cttgaacatc
     2821 aagatagcta actcggaaag aatcccagac tttggatagt ttctgagtct tctagaattt
     2881 tccaagaaga aaccatggtg gcaaatgcgg agactcgggc gggcactggg aacacagcac
     2941 agtggtctta gggaggtgct ttgtcaggaa tgaacagtca tggttataat ccacgtttcc
     3001 attgctactc acgaatgatt ctcttctgtt ttgtttttaa aattttttta cactgaattt
     3061 ctatttagac actaaaacat ataggggtgc ttgtcacccg gatacattta tctgtgagcc
     3121 agctattcgg atgtcatggc tgggtaccta acttacttcc atatgtgaag tgtgctaaac
     3181 tcaaaccagt ttacagaaac gatgtatttt gtgtatagta aattgtatat tcaccctttt
     3241 accacggccg gttttttaaa caaatgaata ctctagattt ttcttccaaa tgaggttact
     3301 gttggggtgg ggttgactta gtgatgctgt agaagggaat ccgcatgcac taaaaagtgt
     3361 gtctgcctaa aagtgtgtac agcaggcaca accttccttg tggatttccg tctgctcact
     3421 gcagatctgc ctgtggttta gaaatagaat tcaagagcca tcaaggagtg accagcttga
     3481 caccactgcc aaattcagaa tgaggaacct tgagagaagg aactgtcgct cagccagaag
     3541 cagatgaagc cactggtcct ggttcacagt ttagtgtcat gctctggttt ataaggatgg
     3601 gcattacgtt cggtgttatc tggttatctg cgagattcta aaccgaggtg caagagctcc
     3661 tatcctgatt ctgagatttg aaataaagca tgaatgaaca aaaaaaaaaa aaaa
//
