LOCUS       NM_138978               4551 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus prokineticin receptor 2 (Prokr2), mRNA.
ACCESSION   NM_138978 XM_006235059
VERSION     NM_138978.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4551)
  AUTHORS   Lattanzi,R., Maftei,D., Fullone,M.R. and Miele,R.
  TITLE     Identification and characterization of Prokineticin receptor 2
            splicing variant and its modulation in an animal model of
            Alzheimer's disease
  JOURNAL   Neuropeptides 73, 49-56 (2019)
   PUBMED   30553543
  REMARK    GeneRIF: Study identified a prokineticin receptor 2 (PKR2) splice
            variant, which lacking the second exon gives rise to a protein
            comprising only four transmembrane elements, denominated TM 4-7.
REFERENCE   2  (bases 1 to 4551)
  AUTHORS   Qiu,C.Y., Liu,Y.Q., Qiu,F., Wu,J., Zhou,Q.Y. and Hu,W.P.
  TITLE     Prokineticin 2 potentiates acid-sensing ion channel activity in rat
            dorsal root ganglion neurons
  JOURNAL   J Neuroinflammation 9, 108 (2012)
   PUBMED   22642848
  REMARK    GeneRIF: PK2 increases the activity of acid-sensing ion channels
            via the PK2 receptor and protein kinase C-dependent signal pathways
            in rat primary sensory neurons.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4551)
  AUTHORS   Monnier,C., Dode,C., Fabre,L., Teixeira,L., Labesse,G., Pin,J.P.,
            Hardelin,J.P. and Rondard,P.
  TITLE     PROKR2 missense mutations associated with Kallmann syndrome impair
            receptor signalling activity
  JOURNAL   Hum Mol Genet 18 (1), 75-81 (2009)
   PUBMED   18826963
REFERENCE   4  (bases 1 to 4551)
  AUTHORS   Masumoto,K.H., Nagano,M., Takashima,N., Hayasaka,N., Hiyama,H.,
            Matsumoto,S., Inouye,S.T. and Shigeyoshi,Y.
  TITLE     Distinct localization of prokineticin 2 and prokineticin receptor 2
            mRNAs in the rat suprachiasmatic nucleus
  JOURNAL   Eur J Neurosci 23 (11), 2959-2970 (2006)
   PUBMED   16819985
  REMARK    GeneRIF: The results of this study suggested an intrinsic PK2
            neurotransmission and functionally distinct roles for
            PKR2-expressing neurons in the SCN.
REFERENCE   5  (bases 1 to 4551)
  AUTHORS   Cheng,M.Y., Bullock,C.M., Li,C., Lee,A.G., Bermak,J.C.,
            Belluzzi,J., Weaver,D.R., Leslie,F.M. and Zhou,Q.Y.
  TITLE     Prokineticin 2 transmits the behavioural circadian rhythm of the
            suprachiasmatic nucleus
  JOURNAL   Nature 417 (6887), 405-410 (2002)
   PUBMED   12024206
REFERENCE   6  (bases 1 to 4551)
  AUTHORS   Masuda,Y., Takatsu,Y., Terao,Y., Kumano,S., Ishibashi,Y.,
            Suenaga,M., Abe,M., Fukusumi,S., Watanabe,T., Shintani,Y.,
            Yamada,T., Hinuma,S., Inatomi,N., Ohtaki,T., Onda,H. and Fujino,M.
  TITLE     Isolation and identification of EG-VEGF/prokineticins as cognate
            ligands for two orphan G-protein-coupled receptors
  JOURNAL   Biochem Biophys Res Commun 293 (1), 396-402 (2002)
   PUBMED   12054613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Dec 5, 2020 this sequence version replaced
            XM_006235059.3, NM_138978.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.13076.1,
                                           SRR26360176.2128243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000003.1  140091861-140092093 c
            234-413             JAXUCZ010000003.1  140088797-140088976 c
            414-992             JAXUCZ010000003.1  140088038-140088616 c
            993-4551            JAXUCZ010000003.1  140077630-140081188 c
FEATURES             Location/Qualifiers
     source          1..4551
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..4551
                     /gene="Prokr2"
                     /gene_synonym="Gpr73l1"
                     /note="prokineticin receptor 2"
                     /db_xref="GeneID:192649"
                     /db_xref="RGD:708445"
     exon            1..233
                     /gene="Prokr2"
                     /gene_synonym="Gpr73l1"
                     /inference="alignment:Splign:2.1.0"
     exon            234..413
                     /gene="Prokr2"
                     /gene_synonym="Gpr73l1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..992
                     /gene="Prokr2"
                     /gene_synonym="Gpr73l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..1689
                     /gene="Prokr2"
                     /gene_synonym="Gpr73l1"
                     /note="G protein-coupled receptor 73-like 1; G
                     protein-coupled receptor I5E; PK-R2"
                     /codon_start=1
                     /product="prokineticin receptor 2"
                     /protein_id="NP_620434.2"
                     /db_xref="GeneID:192649"
                     /db_xref="RGD:708445"
                     /translation="MVSVLSNRDLHTLAPAEVLNSTWAYLPDTYQPTCHIINMGDQNG
                     NTSFAPDLNPPQDHVSLLPLNYSYGDYDIPLDDDEDVTKTQTFFAAKIVIGVALAGIM
                     LVCGVGNFVFIAALARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWE
                     HGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMV
                     SILIAIPSAYFTTETILVIVKNQEKLFCGQIWPVDQQLYYKSYFLFVFGLEFVGPVVT
                     MTLCYARISQELWFKAVPGFQTEQIRKRLRCRRKTVLLLMGILTAYVLCWAPFYGFTI
                     VRDFFPTLVVKEKHYLTAFYVVECIAMSNSMINTICFVTVKNNTMKYFKKMLLLHWRP
                     SHYGSKSSADLDLKTSGVPATEEVDCIRLK"
     exon            993..4551
                     /gene="Prokr2"
                     /gene_synonym="Gpr73l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggacacc tgggctgggt cccaggctgt aggatgagct gcagagcgaa gcagcaactc
       61 cagaaagact gatgcgcctt agaagagccc gaaggagagc aggagagagt gacacccgcc
      121 ggtcaagcgc gcaagcctcc gccagcgcta gctagtgtcc ccagagctcg ggcggcgccc
      181 acctacgacg gagccgcggg ccagggggtg cgcccctgga ggcaccaaga caattatgca
      241 aaccccatag agcaagagac tggcttctag cgttccttgg caaagaacag aagagtagca
      301 ggaaaaccac tcccagccac caatacattc ctgtccagcc cctgccttgt gccattgtct
      361 gagacgccgt tgagagtaac aacagtccaa ccagcactgt ggctggaaga aggatcctgg
      421 atggtatcag ttctgtccaa cagggacctc cacacactgg ccccagctga agtgctgaac
      481 tccacgtggg cctatctccc tgacacatac cagcctacct gccacatcat caacatggga
      541 gaccagaacg gaaacacaag ctttgcacca gacttgaacc caccccaaga ccacgtctcc
      601 ttgctcccct taaactacag ttatggagat tatgacatcc ccctggatga cgatgaggat
      661 gtgaccaaga cacagacctt ctttgcagcc aaaatcgtca ttggcgtagc cctggcaggc
      721 atcatgctag tctgcggcgt tggcaacttt gtcttcattg ctgccctcgc ccgctacaag
      781 aagctgcgca accttaccaa cctcctcatc gctaacctgg ccatctctga cttcctggtg
      841 gcgatcgtct gctgcccctt tgagatggac tactacgtag tacgtcagct ttcctgggag
      901 catggtcacg tgctttgtgc ctccgtcaac taccttcgta cagtctccct gtacgtctcc
      961 accaatgctc tgctggccat cgctattgac agatatctcg ctattgtcca ccccttaaaa
     1021 ccacggatga attaccagac cgcctccttc ctgatcgctt tggtctggat ggtctccatc
     1081 ctcatcgcca tcccatctgc ctacttcacc acagaaacca tccttgttat cgtcaagaat
     1141 caggaaaagc tcttctgtgg tcagatctgg cccgtggacc agcagctcta ctacaaatcc
     1201 tacttcctct tcgtcttcgg gcttgagttc gtgggtcccg tggtcactat gaccctgtgc
     1261 tatgccagga tctcccagga gctctggttc aaggctgtac ctggtttcca gacggagcag
     1321 atccgcaagc gactgcgctg ccgccgaaag acagtgctat tgctcatggg tatcctcaca
     1381 gcctacgtgc tgtgctgggc gcctttctat ggctttacca tagtgcgaga cttcttcccc
     1441 acgctggttg tgaaggagaa gcactacctc accgccttct atgtcgtcga gtgcattgcc
     1501 atgagcaaca gcatgatcaa tactatatgc ttcgtgacgg tcaagaacaa caccatgaaa
     1561 tacttcaaga agatgctgct gctgcactgg cggccctctc actacgggag taagtccagc
     1621 gcggacctcg acctcaaaac cagtggggtt cctgccaccg aagaggtgga ctgtatcagg
     1681 ctaaagtagc ctgcaggtgt tgcccaagga aaaacttaac attcgatatt cagtatatcg
     1741 cactccatca actactcaca agctgcatag aaagatacag ctgtattcat gctttcctgc
     1801 tctaaggtac ctggatgctt ctatgtcatg acatacagca caactgttgt ctgcacaaac
     1861 accttaagag actacacaca aatagtaacg agtggcgtgg actgaatgct tctgtctgca
     1921 aaccacacca acagattatt caaggatgag agctgacatt tgagggttac ctgctatgtg
     1981 cagaaacagt taccaaaaaa aatggtagaa gctatttgga gttaggctct atctatctat
     2041 ccatccatcc atccatccat ccatctatca tccatccatc caggtcacta gaaagagatt
     2101 gcaaatctca cgctccatat tctttcattc tgtgtctttt ctgcacagac atgtcaaagg
     2161 caatagaata aagcacttag acatactaga aatatatgga taacttcaca atatcaaatc
     2221 tcatcagcct ataaggtggc gatgggagtc cctgagacaa gaaatgtata cagttctgga
     2281 tatttaatgc taagaatttc agagttctgg ggtcatggag gaagaggaca cagaaagagc
     2341 agagatttcc agtggcaacg agtataatct aaacatttgc tatgatttgg acaattttct
     2401 agcgcatact ctgacttaca aaaggagctc tgtttgagat ccaaagatct gggtaaaagt
     2461 tctaactcca ggactcgcct ctgtgtgtct ccactttaat gaaatgggaa taatgaaaac
     2521 ggatcattag gaacatcagc ctgctgaagt catggcgtgg atgtgatttt cacctcttcc
     2581 cttgttaaga ctgtgatact gagcagctca ttagagggtg ttcagaattg agaaactgcg
     2641 ccacaatgtc catccttctt ctttggatca gagaccactg aactcatttt gaaggagcat
     2701 atctgtagtg gggcataaag gcctccccat cacagtatgc aattaagaag atacagtcaa
     2761 tgcccgtaat ctcagcatcc ctgtggtctt agtgtaccat gggtatttcc ttcctccttc
     2821 acagctcctt atgtatccct ccctttaacg cacactcagt taccaaggaa gaccttctta
     2881 aacaaggagg atcatcattc cgtccaggac accagtgtca tgtttccctg atacacctcc
     2941 aataacctct ccagtagaca ctgtaccctt cgtgtgtcaa cagaatttgc ctccttcttg
     3001 tatttgaaca tatcatcctc ctttcattta gatttaacta gaaagcattc ctgtaaatat
     3061 caagtctctg tgctatccca gtggaaaaaa gtgtatgctg ttaccagatg ggataattaa
     3121 catacagaat tgtaaccaca gagcccagag ggttccctac aatgtcttat gctatgttta
     3181 tgtgtttgat gtaaatgaag ttgtgtagct gtctaagcag ctcaactctg gaataaggga
     3241 atttccaaag gtgtttgttc ttagagcagg gccatctcat gctagcaact ggcctcatgt
     3301 ctgtgctctc tcgggagtgt gttcttgaat gtgaattagc aggaaaccat tatcctattg
     3361 ccctcttgtt tataaatgat ttttaaaata caggcttctt ttcacttaga gaatacttat
     3421 gagtctggtt agaactaagg ttataagtta attacatttg tgttcagtct tcccaagact
     3481 aattaaaggc aagcttaaga cactttttaa catgtcaaga taagtacaca cttatgccta
     3541 ctacttcatg tagtaagcta atctcattta gcaaagccag atctgttttc ttggctacag
     3601 tacgagaaaa gacggttata caatgaagct gttacagatt tttgttaagc atccaacatt
     3661 taaaataagt tacttctaaa tttggagaaa tcaaaaaatg cttcaggccc tcaggcatga
     3721 caaacaactc cagacttcac aaggaacaat gtgacatgtg ggaggtaatt agacatctca
     3781 acacgagttc tgtttctact taaaaatggt ggctccaaaa cccatctttg cataggacca
     3841 tatactccct tggtcataag aacacacaca cacacacaca cacacacaca cacacacaca
     3901 cacacacaca caccacatca ctgggacacc agaccaagaa atgccttgag aacataacat
     3961 tcagctcctt tctttgctag gtctgaattc taaagaagga atgacctatg aagggtacag
     4021 agttaattct tattagagca aaagtcttgc cctaagattt tatctccagg acaatgagca
     4081 gctttcagtg actgcctaca cttgagtcca aaggacctgg cacactttgg cgtgccgcag
     4141 aatatgtaga atcttaagtc tctaggttgc tttgcttgtt cattgaaaag aagttaaatc
     4201 cccattctgg atgccttgtg gtataagcta agatcaagag gcaaagtgtg ggttgtacat
     4261 agagattcct catagacagc tgttggaagt tcatggtacc aactctatcc agaagatgtt
     4321 caaaaaataa catccagttt tggaaaatga acatttctct aaaaggtttt ccacagtgca
     4381 ttttaattaa tattaatgtt aatatatact ccattttcta catacagttg aaaatattaa
     4441 gaatgtgtat cctcatgggt tgtcacgata tatgtgtata tgcatagtct cattgtagga
     4501 ttgcatgttt ataaatttgt ttacaaacta aaatgtattt gtaatcccca a
//
