LOCUS       NM_138977               3273 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus prokineticin receptor 1 (Prokr1), mRNA.
ACCESSION   NM_138977 XM_006236821
VERSION     NM_138977.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Li,Y., Zhou,T., Su,Y.F., Hu,Z.Y., Wei,J.J., Wang,W., Liu,C.Y.,
            Zhao,K. and Zhang,H.P.
  TITLE     Prokineticin 2 overexpression induces spermatocyte apoptosis in
            varicocele in rats
  JOURNAL   Asian J Androl 22 (5), 500-506 (2020)
   PUBMED   31744994
  REMARK    GeneRIF: Prokineticin 2 overexpression induces spermatocyte
            apoptosis in varicocele in rats.
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   Chen,B., Yu,L., Wang,J., Li,C., Zhao,K. and Zhang,H.
  TITLE     Involvement of Prokineticin 2 and Prokineticin Receptor 1 in
            Lipopolysaccharide-Induced Testitis in Rats
  JOURNAL   Inflammation 39 (2), 534-542 (2016)
   PUBMED   26490969
  REMARK    GeneRIF: Given one of the cognate receptors of prokineticin 2,
            prokineticin receptor 1 (PKR1) was significantly upregulated in
            orchitis as discussed in the current study, it is very likely that
            PK2/PKR1 signaling contribute to the development of
            inflammation-related testicular diseases.
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Iwasa,T., Matsuzaki,T., Tungalagsuvd,A., Munkhzaya,M., Kawami,T.,
            Yamasaki,M., Murakami,M., Kato,T., Kuwahara,A., Yasui,T. and
            Irahara,M.
  TITLE     Changes in the responsiveness of hypothalamic PK2 and PKR1 gene
            expression to fasting in developing male rats
  JOURNAL   Int J Dev Neurosci 38, 87-90 (2014)
   PUBMED   25153663
  REMARK    GeneRIF: These results indicate that Prokr1 is sensitive to
            nutritional status in male rats and that this sensitivity has
            already been established by the early neonatal period.
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   Urayama,K., Guilini,C., Messaddeq,N., Hu,K., Steenman,M.,
            Kurose,H., Ert,G. and Nebigil,C.G.
  TITLE     The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival
            and angiogenesis
  JOURNAL   FASEB J 21 (11), 2980-2993 (2007)
   PUBMED   17442730
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Tsuji,A.B., Sugyo,A., Ogiu,T., Sagara,M., Kimura,T., Ishikawa,A.,
            Sudo,H., Ohtsuki,M., Aburatani,H., Imai,T. and Harada,Y.N.
  TITLE     Fine mapping of radiation susceptibility and gene expression
            analysis of LEC congenic rat lines
  JOURNAL   Genomics 86 (3), 271-279 (2005)
   PUBMED   15978772
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Masuda,Y., Takatsu,Y., Terao,Y., Kumano,S., Ishibashi,Y.,
            Suenaga,M., Abe,M., Fukusumi,S., Watanabe,T., Shintani,Y.,
            Yamada,T., Hinuma,S., Inatomi,N., Ohtaki,T., Onda,H. and Fujino,M.
  TITLE     Isolation and identification of EG-VEGF/prokineticins as cognate
            ligands for two orphan G-protein-coupled receptors
  JOURNAL   Biochem Biophys Res Commun 293 (1), 396-402 (2002)
   PUBMED   12054613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_006236821.4, NM_138977.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2424071.1,
                                           SRR26360172.53024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680413, SAMN06680421
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               JAXUCZ010000004.1  121590576-121590695 c
            121-750             JAXUCZ010000004.1  121588437-121589066 c
            751-3273            JAXUCZ010000004.1  121579630-121582152 c
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..3273
                     /gene="Prokr1"
                     /gene_synonym="Gpr73"
                     /note="prokineticin receptor 1"
                     /db_xref="GeneID:192648"
                     /db_xref="RGD:708443"
     exon            1..120
                     /gene="Prokr1"
                     /gene_synonym="Gpr73"
                     /inference="alignment:Splign:2.1.0"
     exon            121..750
                     /gene="Prokr1"
                     /gene_synonym="Gpr73"
                     /inference="alignment:Splign:2.1.0"
     CDS             266..1447
                     /gene="Prokr1"
                     /gene_synonym="Gpr73"
                     /note="G protein-coupled receptor 73; G protein-coupled
                     receptor ZAQ; PK-R1"
                     /codon_start=1
                     /product="prokineticin receptor 1"
                     /protein_id="NP_620433.1"
                     /db_xref="GeneID:192648"
                     /db_xref="RGD:708443"
                     /translation="METTVGTLGENTTNTFTDFFSARDGSGAETSPLPFTFSYGDYDM
                     PSDEEEDVTNSRTFFAAKIVIGMALVGIMLVCGIGNFIFITALARYKKLRNLTNLLIA
                     NLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAI
                     DRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCG
                     QIWPVDQQFYYRSYFLLVFGLEFVGPVIAMTLCYARVSRELWFKAVPGFQTEQIRRRL
                     RCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSN
                     SMINTLCFVTVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGIPATEEVDCIRL
                     K"
     exon            751..3273
                     /gene="Prokr1"
                     /gene_synonym="Gpr73"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggtagca ggaacccagc tgacaaccaa gcacggaaag accctcagaa gacagagggg
       61 ttcctggtcc ttgctgcaga gctccgggga agcgtctggg atcctcaccc tggtctgcag
      121 gtttaaaatg ggactcagat actgggcccc tcagatgctg gctgggaaga tctgactcac
      181 tgaggaagag ccaagtgcct gcagagagga gtcatcaacc ttgcagacgc cagtgggaca
      241 gcttcagggg tgtgcacctg cctagatgga gaccactgtg gggaccctgg gcgagaatac
      301 cacaaacact ttcaccgact tcttttctgc acgtgatggc agtggagccg aaacctcccc
      361 cttgccattc actttcagct atggtgacta tgacatgccc tcggatgaag aggaggatgt
      421 gaccaactct cggactttct ttgctgccaa gattgtcatt ggcatggctt tggtgggcat
      481 catgctggtg tgtggcatcg gcaacttcat cttcatcact gcgctggccc gctacaaaaa
      541 gcttcgcaac ctcaccaacc tgcttatcgc caacctggcc atttcggact tcctggtagc
      601 catcgtgtgc tgcccctttg agatggacta ctatgtggta cgccagctct cctgggagca
      661 cggccatgtc ctgtgcgcct ccgtcaacta cttgcgcacc gtctccctct acgtgtccac
      721 taacgcccta ctggccattg ccattgacag gtatctggcc attgtgcacc cgctgagacc
      781 gcggatgaag tgtcaaacgg ctgcaggcct gatcttcctg gtgtggtctg tgtccatcct
      841 catcgccatc ccagccgcct acttcaccac tgagacggtg ttggtcatcg tggaaagcca
      901 ggagaagatc ttctgcggcc agatctggcc ggtggatcag cagttctact acaggtccta
      961 tttccttttg gtcttcggcc tcgagttcgt gggtcctgta atcgccatga ccctgtgcta
     1021 tgccagggtg tcccgagagc tctggttcaa ggcggtgccc ggcttccaga cagagcagat
     1081 ccgccggagg ctgcgctgtc gccgacggac ggtactgggg ctcgtgtgcg tcctttccgc
     1141 ctatgtgctg tgctgggctc ccttctatgg cttcaccatc gtgcgtgact tcttcccctc
     1201 cgtgtttgtg aaagagaagc actacctcac cgccttttat gtggtggagt gcatcgccat
     1261 gagcaacagt atgatcaata cgctgtgctt tgtgactgtc aggaataaca ccagtaagta
     1321 cctcaagagg atcctgcggc tccagtggag ggcctctcct agcgggagca aggccagcgc
     1381 tgacctcgac ctcaggacca cggggattcc tgccacggag gaggtggact gcatccgact
     1441 gaaataagca aaatggtacc acagcgcccg ggtgcacaca gcaacgatga actcggcttt
     1501 ctgtggaagg cagaggaaag agacaaccac ttagacacac tatttaagga gcactgaagt
     1561 gtggaatttc tgaaatggag atctgagata ctgtcactag tggtcagggt tcactggatg
     1621 tctaaatttt gcaagagtag acaccattga aagtcctttg acaaaatgaa gtggggatta
     1681 tagccaggaa atatggtttg gagggtctgg aaaagggtgt ttccagagag aaggcagagc
     1741 aggctgtgta ggtaggactc tcctgtctgt gcttagggtg agtacatggg ctctatgtgg
     1801 gcctagctca cctctggcag cactcctggg cttttgttca ggtctagcat tagcaagctt
     1861 agagcaagag cacaggagag tttcccagct ctgctgcagt cctctgctca cctcagaatc
     1921 cccactgaga ggggaatcaa aggcatgagg acccatggct aagttctaac cacccacccc
     1981 caactcttag gcctagggct ctgcacacag acagtggggg tgggggttct tctggagcat
     2041 ggacttgggg gaggagccat ggactctggg tgccatttac atagggaatt ttgggttctg
     2101 agtcataagt agagtgaagt ttgagctcgg gtgaaatgat ttcctcactt catggtctac
     2161 tcactgcagg ggagaaggag atgaagaatg ggagggtatg gtgggacctc tgaaagcatg
     2221 tgtacaggtt aaaggatgct gttgctccat ctctcagctt ctgtgccctg gaccactcat
     2281 gtttcttgga tcttcatgct tctgtgttta tggagcatag aactcttgaa ggtataaaca
     2341 tagcacctca ctctcccatc cccactagcc ctcaaacaag atgtgttcat ctcaactagt
     2401 ctatttgatg aggtcccctc atccactggt atgatgggga gaaagatttc ttagccactg
     2461 gcacctgact cttggcctgg tcacgatcct aggaattaag actggatgct ctttcagaat
     2521 gaaggtgacc ttggagaaat caccacagtt ctgctcttca gtacaaatga agacttgtat
     2581 gtcaggggtg cagcctggac actcaggaaa aagagattga ccaacagcaa gctctaggga
     2641 ccccacagac atttgaaagt ctcatcccac ttggtaactc gccttcttag tctggcattt
     2701 agaattctgg cctgagaaaa tctgaggccc agctttgact aagtcatcta cacagacctg
     2761 agatgagact ttctgaggac aaaggtaata acctaagaaa ccttgttaga attgttgtga
     2821 gatcaatcaa ataatgtatg gaagatatgc tgttaaccat ctgaatagta aagtatcacc
     2881 accatcacca ccaccaccac caccatcacc accatcacca tcaccaccat ctctaccacc
     2941 accaccatca tcaccatctc cattaccatc atcaccatct tctccaccac caccatcacc
     3001 accaacacca ccatctctac ctccaccatc accaccaaca ccaccatctc taccaccacc
     3061 atcatcacca tctccatcac caccaccact accttctctg ccaccaccac caccaccatc
     3121 tctaccatca tcatcaccat ctccaccacc acctccatca ccatctcctc caccaccagc
     3181 agcaacagca acgatggtga actagcaact gtgggatgac tggacaaaga caaacttgta
     3241 catacatctc atgtatctgt caatctaacc agc
//
