LOCUS       NM_001037541            1924 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus prokineticin 2 (Prok2), transcript variant 1,
            mRNA.
ACCESSION   NM_001037541
VERSION     NM_001037541.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Chen,L., Lv,F., Min,S., Yang,Y. and Liu,D.
  TITLE     Roles of prokineticin 2 in electroconvulsive shock-induced memory
            impairment via regulation of phenotype polarization in astrocytes
  JOURNAL   Behav Brain Res 446, 114350 (2023)
   PUBMED   36804440
  REMARK    GeneRIF: Roles of prokineticin 2 in electroconvulsive shock-induced
            memory impairment via regulation of phenotype polarization in
            astrocytes.
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Su,G., Sun,G., Liu,H., Shu,L., Zhang,W. and Liang,Z.
  TITLE     Prokineticin 2 relieves hypoxia/reoxygenation-induced injury
            through activation of Akt/mTOR pathway in H9c2 cardiomyocytes
  JOURNAL   Artif Cells Nanomed Biotechnol 48 (1), 345-352 (2020)
   PUBMED   31899964
  REMARK    GeneRIF: Prokineticin 2 relieves hypoxia/reoxygenation-induced
            injury through activation of Akt/mTOR pathway in H9c2
            cardiomyocytes.
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Ma,M., Li,H., Wu,J., Zhang,Y., Shen,H., Li,X., Wang,Z. and Chen,G.
  TITLE     Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced Early
            Brain Injury via Regulation of Phenotype Polarization in Astrocytes
  JOURNAL   Mol Neurobiol 57 (9), 3744-3758 (2020)
   PUBMED   32572760
  REMARK    GeneRIF: Roles of Prokineticin 2 in Subarachnoid Hemorrhage-Induced
            Early Brain Injury via Regulation of Phenotype Polarization in
            Astrocytes.
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Li,Y., Zhou,T., Su,Y.F., Hu,Z.Y., Wei,J.J., Wang,W., Liu,C.Y.,
            Zhao,K. and Zhang,H.P.
  TITLE     Prokineticin 2 overexpression induces spermatocyte apoptosis in
            varicocele in rats
  JOURNAL   Asian J Androl 22 (5), 500-506 (2020)
   PUBMED   31744994
  REMARK    GeneRIF: Prokineticin 2 overexpression induces spermatocyte
            apoptosis in varicocele in rats.
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Lattanzi,R., Maftei,D., Petrella,C., Pieri,M., Sancesario,G.,
            Schirinzi,T., Bernardini,S., Barbato,C., Ralli,M., Greco,A.,
            Possenti,R., Sancesario,G. and Severini,C.
  TITLE     Involvement of the Chemokine Prokineticin-2 (PROK2) in Alzheimer's
            Disease: From Animal Models to the Human Pathology
  JOURNAL   Cells 8 (11), 1430 (2019)
   PUBMED   31766244
  REMARK    GeneRIF: We demonstrated a significant upregulation of PROK2 levels
            in brain tissues of Abeta1-42 i.c.v. injected rats, transgenic AD
            mice (Tg2576), and in the hippocampus of AD patients. Additionally,
            through a pilot study, an approximate twofold increase of PROK2
            levels has been proved in the serum of AD patients, compared to the
            control subjects, identifying a potential blood-based biomarker of
            the disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   LeCouter,J., Lin,R., Tejada,M., Frantz,G., Peale,F., Hillan,K.J.
            and Ferrara,N.
  TITLE     The endocrine-gland-derived VEGF homologue Bv8 promotes
            angiogenesis in the testis: Localization of Bv8 receptors to
            endothelial cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2685-2690 (2003)
   PUBMED   12604792
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Cheng,M.Y., Bullock,C.M., Li,C., Lee,A.G., Bermak,J.C.,
            Belluzzi,J., Weaver,D.R., Leslie,F.M. and Zhou,Q.Y.
  TITLE     Prokineticin 2 transmits the behavioural circadian rhythm of the
            suprachiasmatic nucleus
  JOURNAL   Nature 417 (6887), 405-410 (2002)
   PUBMED   12024206
REFERENCE   8  (bases 1 to 1924)
  AUTHORS   Masuda,Y., Takatsu,Y., Terao,Y., Kumano,S., Ishibashi,Y.,
            Suenaga,M., Abe,M., Fukusumi,S., Watanabe,T., Shintani,Y.,
            Yamada,T., Hinuma,S., Inatomi,N., Ohtaki,T., Onda,H. and Fujino,M.
  TITLE     Isolation and identification of EG-VEGF/prokineticins as cognate
            ligands for two orphan G-protein-coupled receptors
  JOURNAL   Biochem Biophys Res Commun 293 (1), 396-402 (2002)
   PUBMED   12054613
REFERENCE   9  (bases 1 to 1924)
  AUTHORS   Li,M., Bullock,C.M., Knauer,D.J., Ehlert,F.J. and Zhou,Q.Y.
  TITLE     Identification of two prokineticin cDNAs: recombinant proteins
            potently contract gastrointestinal smooth muscle
  JOURNAL   Mol Pharmacol 59 (4), 692-698 (2001)
   PUBMED   11259612
REFERENCE   10 (bases 1 to 1924)
  AUTHORS   Wechselberger,C., Puglisi,R., Engel,E., Lepperdinger,G., Boitani,C.
            and Kreil,G.
  TITLE     The mammalian homologues of frog Bv8 are mainly expressed in
            spermatocytes
  JOURNAL   FEBS Lett 462 (1-2), 177-181 (1999)
   PUBMED   10580115
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000148.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001037541.3.
            
            On Feb 14, 2022 this sequence version replaced NM_001037541.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY348322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760434
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               JACYVU010000148.1  29691231-29691409   c
            180-305             JACYVU010000148.1  29687753-29687878   c
            306-368             JACYVU010000148.1  29680594-29680656   c
            369-1924            JACYVU010000148.1  29676683-29678238   c
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..1924
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2"
                     /note="prokineticin 2"
                     /db_xref="GeneID:192206"
                     /db_xref="RGD:620280"
     exon            1..179
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..473
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; prokineticin 2 beta; homolog of mouse Bv8
                     (Bombina variegata 8 kDa); prokineticin 2"
                     /codon_start=1
                     /product="prokineticin-2 isoform 1 precursor"
                     /protein_id="NP_001032630.1"
                     /db_xref="GeneID:192206"
                     /db_xref="RGD:620280"
                     /translation="MEDPRCAPLLLLLLLPLLLTPPAGDAAVITGACDKDSQCGGGMC
                     CAVSIWVKSIRICTPMGQVGDSCHPLTRKSHVANGRQERRRAKRRKRKKEVPFWGRRM
                     HHTCPCLPGLACLRTSFNRFICLARK"
     exon            180..305
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2"
                     /inference="alignment:Splign:2.1.0"
     exon            306..368
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2"
                     /inference="alignment:Splign:2.1.0"
     exon            369..1924
                     /gene="Prok2"
                     /gene_synonym="Bv8; PK2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcagccg ggccacgcgt ccccaacgtc ccgggtccca acgtcccgga acgcgtccct
       61 aaccgccacc gcctcctcgg gacgccatgg aggacccgcg ctgtgccccg ctactgctac
      121 ttttgctgct accgctgctg ctcacaccgc ccgccggaga tgccgcggtc atcaccgggg
      181 cttgcgacaa ggactctcag tgtggaggag gaatgtgctg cgctgtcagt atctgggtta
      241 agagcataag gatctgcaca cctatgggcc aagtgggaga cagctgccac cccctgactc
      301 ggaaaagtca tgttgcaaat ggaaggcagg aaagaagaag ggcgaagaga agaaagagga
      361 agaaggaggt tccattttgg gggcggagga tgcaccacac ttgtccctgc ctgccaggtt
      421 tggcatgttt aaggacttct ttcaaccgtt ttatttgttt ggcccggaag tgatcactct
      481 gaagcaggag ctggaaatgt gaacctctac tcactgaaca atgtctgtca agtctcgctt
      541 gtaattgtgt caaagaatat gccagaaaga aatgttctcc cttcctctcc acttttcaag
      601 aaacattcct atctttgatt ttttttaaaa gtggcctttt tctttttttt cgtttttctt
      661 tctttttttt ttaaggagag ttttcatttt tggagagatt tataaagtgc aaggctttct
      721 ggaatggctt ctcatttccc tatttatgtt ttgccttgac atttttttga agaccaacaa
      781 caaccatttc cacaaataga gtaagagtga acgtctgttg cagaaactcc cttttgccct
      841 gcctcccctc tgccagtcct gcccagtgtc cagacagaca cacccttact cttgaaacat
      901 tctgacgatc ctcacctcag gctagcgttg tggggcctct cccctccctg gctggccggt
      961 agacccactg aagaggcatt tgaaccagtc cgtccaggca gttcactggg gcagacattc
     1021 ggagtgcccc aagaactttc ctgaacccat ctggcccacc ggctttcagt tccactggtt
     1081 aactggtggg aggacaaaat taatgggata ctgaaggagt ctggtctatt tttctagatg
     1141 tgttttagta aaagacattt tctccttagt ggaatattac atgtcttttt ttttttttca
     1201 gcctgctttt ttttttgaag ttttcttgtt ggagacattt taaagaatgt cacttgagga
     1261 agcgttggtt ttcatctggc atgacaggaa tcattttaaa aaatcggtgt taagttataa
     1321 tttaaactct tatttgtaac ccaaaggttt attgcaatgg atttcctgat atcctgccat
     1381 ttgtactggt atcaatattt ctatgtaaaa aattctgtat cagaataatg acgatactgt
     1441 atatcctttg atttattttg atattatatc cttatttttg tcacggctgt caccagtttt
     1501 tattacaagc ggatttctat atagccctca tcctaaagtc ggcagatacc ccaagctggt
     1561 gaaatcaccc caacagtaca tgcattttca tctcgcatcc aggagagctg tgtttgtgtg
     1621 gatttcaagg tagtacaaaa agtaataagt aaaccatgtg tatccgttaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaac ctttagagag cgaaggcaag cgagacaccc ggaagtgact
     1741 attagcggga atggacccgt aggcttgccc tgggaaatcc gatggagcat ggagcgtatg
     1801 taatgcttgg cgtggcatga gttaggctct aactgcacag tggtgccaat atggtctgac
     1861 cttgaacaac tcacaaagtg ttgtcaaccc atattgtgtc acaaataaac atctgaaacc
     1921 tcaa
//
