LOCUS       NM_138851               3863 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus prokineticin 1 (Prok1), mRNA.
ACCESSION   NM_138851
VERSION     NM_138851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3863)
  AUTHORS   Meng,L., Yang,H., Jin,C. and Quan,S.
  TITLE     miR-28-5p suppresses cell proliferation and weakens the progression
            of polycystic ovary syndrome by targeting prokineticin-1
  JOURNAL   Mol Med Rep 20 (3), 2468-2475 (2019)
   PUBMED   31322191
  REMARK    GeneRIF: Polycystic ovary syndrome development promoted by PROK1
            overexpression is inhibited by miR-28-5p via the PI3K/AKT/mTOR
            signaling pathway.
REFERENCE   2  (bases 1 to 3863)
  AUTHORS   LeCouter,J., Lin,R., Frantz,G., Zhang,Z., Hillan,K. and Ferrara,N.
  TITLE     Mouse endocrine gland-derived vascular endothelial growth factor: a
            distinct expression pattern from its human ortholog suggests
            different roles as a regulator of organ-specific angiogenesis
  JOURNAL   Endocrinology 144 (6), 2606-2616 (2003)
   PUBMED   12746324
REFERENCE   3  (bases 1 to 3863)
  AUTHORS   Masuda,Y., Takatsu,Y., Terao,Y., Kumano,S., Ishibashi,Y.,
            Suenaga,M., Abe,M., Fukusumi,S., Watanabe,T., Shintani,Y.,
            Yamada,T., Hinuma,S., Inatomi,N., Ohtaki,T., Onda,H. and Fujino,M.
  TITLE     Isolation and identification of EG-VEGF/prokineticins as cognate
            ligands for two orphan G-protein-coupled receptors
  JOURNAL   Biochem Biophys Res Commun 293 (1), 396-402 (2002)
   PUBMED   12054613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Oct 4, 2022 this sequence version replaced NM_138851.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY089983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               JAXUCZ010000002.1  197547386-197547550 c
            166-291             JAXUCZ010000002.1  197544963-197545088 c
            292-3863            JAXUCZ010000002.1  197538747-197542318 c
FEATURES             Location/Qualifiers
     source          1..3863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3863
                     /gene="Prok1"
                     /note="prokineticin 1"
                     /db_xref="GeneID:192205"
                     /db_xref="RGD:620898"
     exon            1..165
                     /gene="Prok1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..411
                     /gene="Prok1"
                     /note="EG-VEGF; endocrine-gland-derived vascular
                     endothelial growth factor"
                     /codon_start=1
                     /product="prokineticin-1 precursor"
                     /protein_id="NP_620206.1"
                     /db_xref="GeneID:192205"
                     /db_xref="RGD:620898"
                     /translation="MRGAVQVFIMLLLATVSDCAVITGACERDVQCGAGTCCAISLWL
                     RGLRLCTPLGREGEECHPGSHKIPFFRKRQHHTCPCSPSLLCSRFPDGRYRCSQDLKN
                     VNF"
     exon            166..291
                     /gene="Prok1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..3863
                     /gene="Prok1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttggcct tcttagcttg tctagtgcaa ggcagtgcag aaggaagtga gggattccag
       61 agtggacagt gtttgccttc accccaagtg atcatgagag gtgctgtgca agtcttcatc
      121 atgctccttc tagcaactgt ctctgactgt gcggtgatca caggggcctg tgaacgagat
      181 gtccagtgtg gggctggcac ctgctgtgct atcagcctgt ggctgcgggg cctgaggctg
      241 tgtacccctc tggggcggga aggagaggag tgccaccctg gaagccacaa gatccctttc
      301 tttaggaaac gccaacacca tacctgtccc tgttcaccca gcctgctgtg ctccaggttc
      361 ccagatggca ggtaccgctg ctcccaggac ttgaagaatg tcaactttta gtttatctgg
      421 actctgtctg ggtccctact gggtgacctc ttgtgttaca tctgtgtgac ttagttccgt
      481 gcaacttctc cactccccac cctgtccgtg tgtgtgcaga caagcatatc ttccactacg
      541 gaacagtcca gcagcgtgca gagaggagtt tgcagccttg agaagtgggc cagcctggcc
      601 ttcctggcca gaccgcctga agttgtgaca ctgggacctc ctcaattgtc tgcccttcct
      661 gcatgtgccc ttctccctaa accacacctc ccaggccctg gcctgtgggt gcgtcactaa
      721 gtcacggggt ccatgggggg aagatcaaca ttctcctcat tttctttcat tggctagctc
      781 cttgttttag gagtaagtcc gaagtcagca cttcttaggg caccattcta aagcaagagg
      841 atttcaggga ctctttgagt ttggggtgag aggcatctca gaggctctgg gtatgagtgt
      901 gaggtgggct gggaagggat gggagggtga ggaaaccatg gagcagactt agcatgggcc
      961 tactgcaact cttggagctg aagtccagtc cctttgggtt tatgtgaaat atttgaccca
     1021 caggccatgt gtgcctagtg acagtaattt gtgtcaggaa cggagctggc aaggcccaga
     1081 gcctgaagca ggcctgggag ctttctctac atgcaggtcg ctggtacctc tgacttccca
     1141 acctaattct tattctacac acagggtgtc caacaacact gtgacaaaat gttgccatct
     1201 acaaagttca gagaggagca attgagttag gacaacacaa tccctttttc agaaagctta
     1261 cacttttgtc ttgggccaca ctgacagctc tccaaagcaa gcaatggagc aagcaagcaa
     1321 acaaacgaat gaacaaacac ttaaagaaca taaaatatga aaagacaggg tgctacactc
     1381 ccccgccccc catcctgccc tctacccgtc tctgctcagt ccttaatcca gggcccacta
     1441 gcctgggcac tggccagcac agggtccttt ccgagctttt gttcatttag acagacactg
     1501 tcacctgttc tgctgacctg tgcagctctt ccctgaatgc accacgatct ctttccttcc
     1561 aggttccagc cctggttcct aggtgtgaag ttcccttcca agtctgtggg cccatgctgc
     1621 tccttgtctc acaggtctct aggtttcact actgtcctcg ggtcctgatt gtgtcccttg
     1681 cagcacacag agcaactctg agtgcagtgg tctacagcca gtgcctcagt gctccataga
     1741 taagacgttg gggtggccta tggcaccccc agcacactgt cattttgcct gtccatccta
     1801 gccacagaac tatagggtga aacaacaatt taatgcgact ttattcgttt tttttttttt
     1861 ctttttcttt ttttcggagc tggggaccga acccagggcc ttgtgcttgc taggcaagtg
     1921 ctctaccgct gagctaaatc cccaacccca actttattcg ttttcgttat taatctccta
     1981 attttgagga ctgtgtaatg agtctcccgt cttctctgct gtggcaaaaa ataggacagt
     2041 ggagaggtta ggaagcttag aaaatatatt tatattcggg aatatgctct tcagaaatag
     2101 ggatattaaa aaaactacct acagagctag tatgcaccta agaagaatat attttagaag
     2161 aatgagaggc gaagttgaca ttctctcaag attatcaatt taagcgactg tgcttcagct
     2221 caatctttcc ttttcgacta ttggtttctg gcgccatctc gtggacaaaa tggaaatagc
     2281 aaggaacgcg aagaggactg tgtgcttcca gaattagaag tgggagtttt tcatgatttg
     2341 gattccatcg gagatccgga acagtgcttg ccaagaagcc tgccgtacga aggaccccaa
     2401 aaacaacgct ttattaacac gctgccctgc cccaccttac aaacggtcac ggaagcctca
     2461 gtttccttcc tgctgagttt agaccaggtg ctacgatttt cctgctcaca ggttctctag
     2521 aatgagagag cagatgtgga taagcccctc accccaacct cccgctgtga gtcaccagga
     2581 agtagcgact ccgcagagcc gcttttaaaa cttaatcact tgaactcctc ctcatctctg
     2641 gctcatttga gtgactgcct ccattgtctc cacaagtctt taggtagcca gggcctagag
     2701 attcccccat atctccagac aaaagggcca gacacataag gccagagcag agactgtgtg
     2761 gggatgtgtg ctcccagatc tgctgccaga gtctcctctt tctgttgttc atccttaaac
     2821 tcccccattg tggctcttag cgctctgagt aaggtcctgg taaactagcc gggtactgat
     2881 ctgtccagtt actacctggt gataaagggc ttcctgaaag ccataaccaa gggcgagcct
     2941 ggaccaagga ggagcaagag gctcctaaag ttgaagagaa aaattagaga gggaagaaag
     3001 gctgcagggt tggacactga cccacagatg agcctgcaga gtggacccaa atcgttgacc
     3061 caaggtcagc tcaacctttg acccaaagag ccaacctcga ggctttgtgt ggaatttatt
     3121 taaaaaaaaa aatcgtaccc tgccatgtag gtagagaaga agcacatgct ggcctggggc
     3181 acactaagtg ttggcattct gtctaagctc cacccccacc gttacatggc aacaggcagg
     3241 tatgctctgc cccacagtta caacaggtaa cagccagctg tgcctggcac tataaaaggg
     3301 gctgcttggg ggctggggat ttagctcagt ggtagagcgc ttacctagga agcgcaaggc
     3361 cctgggttcg atccccagct ccgaaaaaaa gaaccaaaaa aaaaaaaaag gggctgcttg
     3421 ccccctcctc attctcttgt tcttttgctc tcacttgctc ttcccccctt ctcctttctc
     3481 ccttctctcc ccattcctct ccccccttcc tccacatgct catggctggc ctttacttct
     3541 ctcctcttct cttctttcat tagacctttc cacgtggaac catgttggct tgtgctttgt
     3601 ccggatgcga gccaagattt ctaccccaac agaatgtgtg cactgtgcag tgcaaagtgg
     3661 cttgacttcc ctgaaaacag gagcatgttt tttaatggtt atttagcact cattttgtgg
     3721 cgaagagggt tgatatctca ttaactaaag ctacatatag tttcatacaa accaaactac
     3781 agcttgtcag ccctctgaac cctggggctt cttcacggga attccaccaa ctggggatca
     3841 acatattaaa aagtacatgt gca
//
