LOCUS       NM_001038588            1466 bp    mRNA    linear   ROD 04-DEC-2024
DEFINITION  Rattus norvegicus proline dehydrogenase 2 (Prodh2), mRNA.
ACCESSION   NM_001038588 XM_001076124 XM_001076147 XM_001076171 XM_341825
VERSION     NM_001038588.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1466)
  AUTHORS   Summitt,C.B., Johnson,L.C., Jonsson,T.J., Parsonage,D., Holmes,R.P.
            and Lowther,W.T.
  TITLE     Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase
            (HYPDH) and molecular target for treating primary hyperoxaluria
  JOURNAL   Biochem J 466 (2), 273-281 (2015)
   PUBMED   25697095
REFERENCE   2  (bases 1 to 1466)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC158806.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_341825.3, XM_001076147.1, XM_001076171.1, XM_001076124.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158806.1, AF222852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1466
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1466
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /note="proline dehydrogenase 2"
                     /db_xref="GeneID:361538"
                     /db_xref="RGD:1306761"
     exon            1..184
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1381
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /EC_number="1.5.5.2"
                     /EC_number="1.5.5.3"
                     /note="probable proline dehydrogenase 2; proline
                     oxidase-like protein; probable proline oxidase 2; proline
                     dehydrogenase (oxidase) 2"
                     /codon_start=1
                     /product="hydroxyproline dehydrogenase"
                     /protein_id="NP_001033677.1"
                     /db_xref="GeneID:361538"
                     /db_xref="RGD:1306761"
                     /translation="MVWTRLPLYGHSKPSTGGWQPLRFDGGAFHLKRTAELARALLVL
                     RLCAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRGCVQQLQA
                     IGLQPLLAVPTEEEPDSAAKTSEAWYEGNLSAMLHCVDLSRAVADAHGPARNSLMQLK
                     VTALTSPRLCKELSAWIQRPRGSSELRPERLAEAMESGRNLQLSCLSTEQNQHLQASL
                     SRLHRVAQHARAQDVRLLVDAEYTFINPALSLLVAALAMRWNSSEEEGPWVWNTYQAY
                     LKDTHERLERDAKAAHEAGLAFGVKLVRGAYLDKERSVTQLHGKEDCTQPDYEATSRS
                     YSRCLELMLRRVSNHGPRCHLMVASHNEESIRQATRRMWELGIPLDGPVCFGQLLGMC
                     DHVSLALGQAGYMVYKSIPYGCLEEVIPYLIRRAQENRSVLQGARREQALLSQELWRR
                     LLGRKA"
     exon            185..381
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            382..520
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            521..607
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            608..688
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            689..844
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1011
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1122
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1208
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1436
                     /gene="Prodh2"
                     /gene_synonym="HYPDH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcacttaca atggtctgga cgcgtctgcc gctgtacggc cactccaagc cctctacagg
       61 tggctggcag cccctgcgct ttgatggtgg ggccttccat ctcaagagaa ccgcagaact
      121 ggcacgggct ttgctggtgc ttcgcctatg cgcctggccc cctttggtca ctcatggact
      181 agcgtttcag gcctggtctc agcgactcct gggatctcgg ctctcgggcg cacttctccg
      241 agcatccatc tatggacagt ttgtggccgg ggagacagca gaggaagtga ggggctgtgt
      301 ccagcagctg caggcgatag gactccagcc cctgttggca gtgcccaccg aggaggaacc
      361 agactccgct gccaagacca gtgaagcttg gtatgagggg aaccttagcg ccatgctgca
      421 ctgtgtggac ttgtcacgag ctgtcgcaga cgcccatggc ccagccagga acagcctcat
      481 gcagctgaag gtgaccgcgc taaccagccc tcggctttgt aaggagctat cggcttggat
      541 ccaaagacca agaggctcct cggagctgag gcctgagagg ctggcagaag ccatggagtc
      601 aggtcggaac ctccagctct cctgcctcag cacggaacag aatcaacacc tgcaggcctc
      661 cctcagccgc ttgcaccgag tggcacagca cgcccgggcg caggatgtga ggctgctggt
      721 ggacgctgaa tacacgttca tcaaccctgc cctgtccctg ctggtggctg ccctggctat
      781 gcgctggaac agctcggagg aagagggccc gtgggtgtgg aacacttacc aggcctatct
      841 gaaggacact cacgaacggc tggagcggga tgctaaggcg gcacacgagg ctggcctggc
      901 atttggggtg aagttggtga gaggtgccta tctggacaag gagagatccg tgacacagct
      961 ccacgggaag gaagactgta cccagcctga ctatgaggcc actagtcgga gttacagccg
     1021 ctgtctggag ctgatgctgc gccgcgtgtc caaccacggt ccccggtgcc acctcatggt
     1081 ggcttcccac aatgaagaat ccattcgcca ggcaacgagg cgcatgtggg agctgggcat
     1141 tcctctggat gggcctgtct gcttcggaca acttctgggc atgtgtgacc acgtctccct
     1201 ggcattaggg caagctggat acatggtata taagtctatc ccctatggct gcctggaaga
     1261 ggtgataccc tacctgatcc gaagagccca ggagaacagg agtgtgctgc agggcgcccg
     1321 gagggagcag gcactactca gccaagaact gtggcggagg ctgctgggaa ggaaagccta
     1381 aggtttctcc gtcagcacca tcaggggccg tgtgctcaat aaaggtcctt agccctaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
