LOCUS       NM_001135778            2182 bp    mRNA    linear   ROD 19-JUL-2024
DEFINITION  Rattus norvegicus proline dehydrogenase (Prodh), transcript variant
            4, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001135778 XM_001058939
VERSION     NM_001135778.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Yasuda,T., Kaji,Y., Agatsuma,T., Niki,T., Arisawa,M., Shuto,S.,
            Ariga,H. and Iguchi-Ariga,S.M.
  TITLE     DJ-1 cooperates with PYCR1 in cell protection against oxidative
            stress
  JOURNAL   Biochem Biophys Res Commun 436 (2), 289-294 (2013)
   PUBMED   23743200
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Maynard,T.M., Meechan,D.W., Dudevoir,M.L., Gopalakrishna,D.,
            Peters,A.Z., Heindel,C.C., Sugimoto,T.J., Wu,Y., Lieberman,J.A. and
            Lamantia,A.S.
  TITLE     Mitochondrial localization and function of a subset of 22q11
            deletion syndrome candidate genes
  JOURNAL   Mol Cell Neurosci 39 (3), 439-451 (2008)
   PUBMED   18775783
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Bender,H.U., Almashanu,S., Steel,G., Hu,C.A., Lin,W.W., Willis,A.,
            Pulver,A. and Valle,D.
  TITLE     Functional consequences of PRODH missense mutations
  JOURNAL   Am J Hum Genet 76 (3), 409-420 (2005)
   PUBMED   15662599
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Jacquet,H., Berthelot,J., Bonnemains,C., Simard,G.,
            Saugier-Veber,P., Raux,G., Campion,D., Bonneau,D. and Frebourg,T.
  TITLE     The severe form of type I hyperprolinaemia results from homozygous
            inactivation of the PRODH gene
  JOURNAL   J Med Genet 40 (1), e7 (2003)
   PUBMED   12525555
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Jacquet,H., Raux,G., Thibaut,F., Hecketsweiler,B., Houy,E.,
            Demilly,C., Haouzir,S., Allio,G., Fouldrin,G., Drouin,V., Bou,J.,
            Petit,M., Campion,D. and Frebourg,T.
  TITLE     PRODH mutations and hyperprolinemia in a subset of schizophrenic
            patients
  JOURNAL   Hum Mol Genet 11 (19), 2243-2249 (2002)
   PUBMED   12217952
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Tritsch,D., Mawlawi,H. and Biellmann,J.F.
  TITLE     Mechanism-based inhibition of proline dehydrogenase by proline
            analogues
  JOURNAL   Biochim Biophys Acta 1202 (1), 77-81 (1993)
   PUBMED   8373828
REFERENCE   8  (bases 1 to 2182)
  AUTHORS   Dabrowska,A.
  TITLE     [Necrotizing scleritis--successful treatment with solcoseryl]
  JOURNAL   Klin Oczna 94 (7-8), 211-212 (1992)
   PUBMED   1300406
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Feb 4, 2021 this sequence version replaced NM_001135778.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-294               JAXUCZ010000011.1  96414438-96414731
            295-503             JAXUCZ010000011.1  96418957-96419165
            504-538             JAXUCZ010000011.1  96422433-96422467
            539-688             JAXUCZ010000011.1  96422823-96422972
            689-753             JAXUCZ010000011.1  96423390-96423454
            754-870             JAXUCZ010000011.1  96423635-96423751
            871-950             JAXUCZ010000011.1  96423917-96423996
            951-1032            JAXUCZ010000011.1  96424679-96424760
            1033-1127           JAXUCZ010000011.1  96426059-96426153
            1128-1272           JAXUCZ010000011.1  96426448-96426592
            1273-1448           JAXUCZ010000011.1  96427539-96427714
            1449-1547           JAXUCZ010000011.1  96430007-96430105
            1548-1636           JAXUCZ010000011.1  96430882-96430970
            1637-2182           JAXUCZ010000011.1  96431059-96431604
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2182
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /note="proline dehydrogenase"
                     /db_xref="GeneID:680409"
                     /db_xref="RGD:1590932"
     exon            1..294
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1824
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /EC_number="1.5.5.2"
                     /note="isoform 4 is encoded by transcript variant 4;
                     proline dehydrogenase, mitochondrial; proline
                     dehydrogenase (oxidase) 1; proline dehydrogenase 1,
                     mitochondrial; proline dehydrogenase (proline oxidase)"
                     /codon_start=1
                     /product="proline dehydrogenase 1, mitochondrial isoform
                     4"
                     /protein_id="NP_001129250.3"
                     /db_xref="GeneID:680409"
                     /db_xref="RGD:1590932"
                     /translation="MALKRVFLLRSVAPRVAALSTKPRAQEQPPANPEALRGCGAAEA
                     VRPPVPAVDFTNTQEAYRSRRSWELARNLLVLRLCASPVLLAHHEQLFQVARKLLGQR
                     MFERLMKMTFYGHFVAGEDQESIRPLIRHNKAFGVGFILDYGVEEDLSPEEAERKEME
                     SCTSEAERDGSGANKREKQYQVHPAFGDRRDGVISARTYFYASEAKCDNYMENLLQCI
                     EASGGASDGGFSAIKLTALGRPQFLLQFSDVLTRWRQFFHQMAAEQGQAGRPAVDTKL
                     EVAVLQESIAKMGISSRAEIERWFTPETLGVSGTVDLLDWNSLIDSRTQLSRHLVVPN
                     VQTGQLEPLLSRFTEEEEQQMKRMLQRMDVLAKVAREAGVRLMIDAEQSYFQPAISRL
                     TLEMQRRFNVDKPFIFNTFQCYLKDAYDNVTIDMELSRREGWCFGAKLVRGAYMAQER
                     ARAVEIGYEDPINPTYEATNAMYHRCLNYVLEELKHSTKAEVMVASHNEDTVSFTLCR
                     MKELGLHPADGQVCFGQLLGMCDQISFPLGQAGFPVYKYVPYGPVMEVLPYLSRRALE
                     NSSIMKGAQRERQLLWQELCRRLRTGSLFHHPA"
     exon            295..503
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            504..538
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..688
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..753
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..870
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            871..950
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1032
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1127
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1272
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1448
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1547
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1636
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..2182
                     /gene="Prodh"
                     /gene_synonym="Prodh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgagcgcgc ttaccggctc cgccatggct ctgaagcggg tctttttgct gcgctcggtg
       61 gcaccacgcg ttgctgccct ctcaaccaaa ccgcgagccc aggagcagcc tcccgcgaac
      121 cctgaggctt tgcggggatg tggagcggct gaggctgtgc ggccgcctgt gccagccgtg
      181 gacttcacca acacacagga ggcgtaccgc agccgtcgaa gctgggaact ggcgcgcaac
      241 ctgctagtgc tgcggctgtg tgcgtcgccg gtgctgctag cgcaccatga gcagttgttc
      301 caagttgcca ggaagcttct ggggcagagg atgttcgaga gactgatgaa gatgaccttc
      361 tacggccatt tcgtggctgg cgaggaccag gagtctatca ggcctctgat tcggcacaac
      421 aaagcctttg gtgttggctt tatcctggac tatggtgtgg aggaagatct gagccccgag
      481 gaggcggagc gcaaagaaat ggagtcatgc acctctgaag ctgaaagaga tggcagtgga
      541 gcaaataaga gggagaagca gtatcaggtc caccccgcct tcggagaccg cagagatggc
      601 gtcatcagtg cccgcactta cttctatgcc agcgaagcca aatgtgacaa ctacatggag
      661 aacttactgc agtgcatcga ggcctcaggc ggagccagtg acggtggttt ttcagccatt
      721 aagctcacgg cactggggag accacagttt ctgctgcagt tctcagacgt gctgaccagg
      781 tggagacagt tttttcatca aatggctgca gagcagggac aggctgggcg tcctgctgtg
      841 gacacgaagc tggaggtggc ggtgctccag gagagcatcg ccaagatggg catctcgtcc
      901 agggctgaga tcgagaggtg gttcacacca gagacgctgg gagtgtctgg cactgtggac
      961 ctactggact ggaacagcct cattgacagc aggacccagc tctccaggca cctggtggtc
     1021 cccaatgtac agactggcca gctggagccc ctgctgtcac ggttcactga ggaggaagag
     1081 cagcagatga agaggatgct gcagaggatg gatgtgctgg ccaaggtagc gagagaggca
     1141 ggcgtgcggc tgatgattga cgccgagcag agctacttcc agccggccat cagccgcctg
     1201 accctggaga tgcagcgcag gttcaatgtg gataagccgt tcatcttcaa cacgttccag
     1261 tgctacctca aggatgccta tgacaatgtg accatagata tggaactgtc tcgccgtgag
     1321 ggctggtgtt ttggggccaa gctggtacgt ggtgcataca tggcccagga gcgagccagg
     1381 gctgtggaga tcggctacga ggaccccatc aaccctacat atgaagccac caatgccatg
     1441 taccacaggt gccttaacta tgttctggag gagctgaagc acagcacaaa ggccgaggtg
     1501 atggtggctt cccacaatga ggacaccgtg agctttacgt tgtgcaggat gaaggagtta
     1561 ggcctgcatc ctgctgatgg tcaggtgtgc ttcggacagc tgctggggat gtgtgaccaa
     1621 attagcttcc cactaggcca ggcaggcttc cctgtgtaca agtatgtacc ctacgggcct
     1681 gtgatggagg tgctcccgta cctgtcccgc cgtgccctgg agaacagcag catcatgaag
     1741 ggtgctcagc gagagaggca gctgctatgg caggagctct gcaggcggct gcgcacaggc
     1801 agcctcttcc accatccggc ctagtcactg caggggccat gcctacctat tccactcaac
     1861 ttgttacctc tgcggctcca ggcagggctt agtccaacct gcccagacac ggttcacctt
     1921 tttatgccca agctttcggg gtgctgaggt aggggctgcc ttcctgcacc cccaaggagc
     1981 agacactcaa gaatggagtc agctagaacc cctgggagct gcctcactaa tcctctgagt
     2041 aagcactgag cacctctgca agctgcagag ccctcatcta gaactaacct tctgccaggg
     2101 tctaacctat cttccctgca ctgggcagag gacaggctgg gaagcctgtt tagtcaataa
     2161 atcatcttgt agtcaagagt ca
//
