LOCUS       NM_001025733            1400 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus protein C receptor (Procr), mRNA.
ACCESSION   NM_001025733 XM_342554
VERSION     NM_001025733.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1400)
  AUTHORS   Gera,O., Shavit-Stein,E., Bushi,D., Harnof,S., Shimon,M.B.,
            Weiss,R., Golderman,V., Dori,A., Maggio,N., Finegold,K. and
            Chapman,J.
  TITLE     Thrombin and protein C pathway in peripheral nerve Schwann cells
  JOURNAL   Neuroscience 339, 587-598 (2016)
   PUBMED   27771530
REFERENCE   2  (bases 1 to 1400)
  AUTHORS   Adukpo,S., Gyan,B.A., Ofori,M.F., Dodoo,D., Velavan,T.P. and
            Meyer,C.G.
  TITLE     Triggering receptor expressed on myeloid cells 1 (TREM-1) and
            cytokine gene variants in complicated and uncomplicated malaria
  JOURNAL   Trop Med Int Health 21 (12), 1592-1601 (2016)
   PUBMED   27671831
REFERENCE   3  (bases 1 to 1400)
  AUTHORS   Guillou,S., Tamareille,S., Giraud,S., Poitevin,G.,
            Prunier-Mirebeau,D., Nguyen,P., Prunier,F. and Macchi,L.
  TITLE     Fondaparinux upregulates thrombomodulin and the endothelial protein
            C receptor during early-stage reperfusion in a rat model of
            myocardial infarction
  JOURNAL   Thromb Res 141, 98-103 (2016)
   PUBMED   26994471
REFERENCE   4  (bases 1 to 1400)
  AUTHORS   Ge,N., Xia,Q., Yang,Z.H., Ding,Q.F. and Zeng,Z.
  TITLE     Vascular endothelial injury and apoptosis in rats with severe acute
            pancreatitis
  JOURNAL   Gastroenterol Res Pract 2015, 235017 (2015)
   PUBMED   25688263
REFERENCE   5  (bases 1 to 1400)
  AUTHORS   Ge,N., Zeng,Z., Lin,Z.Q., Yang,Z.H. and Xia,Q.
  TITLE     [Endothelial protection of tanshinone in rats of severe acute
            pancreatitis]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 45 (2), 230-234 (2014)
   PUBMED   24749346
REFERENCE   6  (bases 1 to 1400)
  AUTHORS   Ping,C., Yongping,Z., Minmin,Q., Weiyan,Y. and Yaozong,Y.
  TITLE     Activated protein C improves the severity of severe acute
            pancreatitis via up-regulating the expressions of endothelial cell
            protein C receptor and thrombomodulin
  JOURNAL   Dig Dis Sci 55 (6), 1599-1609 (2010)
   PUBMED   19680809
  REMARK    GeneRIF: Activated protein C could augment the anti-coagulation and
            anti-inflammatory activity by up-regulating endothelial cell
            protein C receptor and thrombomodulin expression, thus attenuating
            the severity of severe acute pancreatis.
REFERENCE   7  (bases 1 to 1400)
  AUTHORS   Teckchandani,A., Toida,N., Goodchild,J., Henderson,C., Watts,J.,
            Wollscheid,B. and Cooper,J.A.
  TITLE     Quantitative proteomics identifies a Dab2/integrin module
            regulating cell migration
  JOURNAL   J Cell Biol 186 (1), 99-111 (2009)
   PUBMED   19581412
REFERENCE   8  (bases 1 to 1400)
  AUTHORS   Dahlback,B. and Villoutreix,B.O.
  TITLE     The anticoagulant protein C pathway
  JOURNAL   FEBS Lett 579 (15), 3310-3316 (2005)
   PUBMED   15943976
  REMARK    Review article
REFERENCE   9  (bases 1 to 1400)
  AUTHORS   Esmon,C.T.
  TITLE     The protein C pathway
  JOURNAL   Chest 124 (3 Suppl), 26S-32S (2003)
   PUBMED   12970121
  REMARK    Review article
REFERENCE   10 (bases 1 to 1400)
  AUTHORS   Rothbarth,K., Petzelt,C., Lu,X., Todorov,I.T., Joswig,G.,
            Pepperkok,R., Ansorge,W. and Werner,D.
  TITLE     cDNA-derived molecular characteristics and antibodies to a new
            centrosome-associated and G2/M phase-prevalent protein
  JOURNAL   J Cell Sci 104 (Pt 1), 19-30 (1993)
   PUBMED   8449997
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099115.1.
            
            On Jul 26, 2005 this sequence version replaced NM_001025733.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099115.1, FQ222113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132285, SAMD00132287
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1400
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1400
                     /gene="Procr"
                     /gene_synonym="EPCR"
                     /note="protein C receptor"
                     /db_xref="GeneID:362248"
                     /db_xref="RGD:1305991"
     exon            1..197
                     /gene="Procr"
                     /gene_synonym="EPCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..853
                     /gene="Procr"
                     /gene_synonym="EPCR"
                     /note="endothelial protein C receptor; APC receptor;
                     activated protein C receptor; endothelial cell protein C
                     receptor; protein C receptor, endothelial"
                     /codon_start=1
                     /product="endothelial protein C receptor precursor"
                     /protein_id="NP_001020904.1"
                     /db_xref="GeneID:362248"
                     /db_xref="RGD:1305991"
                     /translation="MLTKFLSLLLLLLLLGCAFCNSDGSQSLHMLQISYFPDPYHGRH
                     QGNASLGKLLTHTLEGPSNNVTILQLQDWQDPDSWARTESGLKIYLSQFNSLVQLIYR
                     ERKNDVVFPLTVSCSVGCELPPEEGSEPHVFFDVAVNGSAFVSFQPKTAIWVTGSQEP
                     SEAINFTLKQLNTYNRTRYELQEFLQDTCVQYLENHITTQNTKGSQTGRSYTSLVLGI
                     LMGCFIIAGVAVGIFLCTGGRRC"
     exon            198..455
                     /gene="Procr"
                     /gene_synonym="EPCR"
                     /inference="alignment:Splign:2.1.0"
     exon            456..737
                     /gene="Procr"
                     /gene_synonym="EPCR"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1380
                     /gene="Procr"
                     /gene_synonym="EPCR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtctctttc cacccttccc tctccctccc gcccttcccg gacagccgcc cttctctttc
       61 ctaatcagca acctcaggag cccgagcctg cccggaccca ggtgggaccc agaacttcag
      121 ctccaggatg ttgacgaagt ttctgtcgct gctgctgctg ctgctgctgc ttggctgcgc
      181 cttttgtaac tccgatggct cccaaagcct gcacatgctc cagatctcct acttcccaga
      241 cccctatcac gggaggcatc agggcaacgc ctctctggga aaactcctga cacacacgct
      301 ggaaggcccg agcaacaacg tcaccattct ccagctccag gactggcagg atccggatag
      361 ctgggcgcgc acagagagtg gcctgaagat ctacctgtcc cagttcaaca gcctggtgca
      421 gttgatctat cgcgagcgca agaacgacgt ggtctttcct ctgactgtta gctgctccgt
      481 gggctgtgag ctgccgccag aggagggctc tgaaccccat gtcttctttg atgtggctgt
      541 gaatggaagt gccttcgtaa gtttccagcc aaagactgcc atatgggtga caggctccca
      601 ggagccctcc gaagccatca acttcaccct gaagcaactc aatacctaca atcggactcg
      661 gtatgaactg caggaatttc tgcaggacac ctgtgtgcag tacctggaga accacatcac
      721 cacgcaaaac accaaaggga gccaaacagg ccgctcttat acttcactgg tcctgggtat
      781 cctgatgggc tgtttcataa tcgctggtgt ggccgtgggc atcttcctgt gcacgggtgg
      841 acggcgttgc taatttttct ccaggttcct cagagaaagg gctggactgg tgggagctgg
      901 tatgggaagg tcaaatgaag ccaaacagac tcccccagcg ggccaccata tctcaggagg
      961 ttagagcaac agctccagca tctgcctacg aagaatgtga ggaagggata tgaggaggtt
     1021 atgtagacaa aataaccggt ttgcaaagga ctcgagaaca tgcatgcttt gggtagctgg
     1081 tctgagaagt gggtgtttat ctgtgaaaat gagatcatag acttgggggg aggccaggag
     1141 gtctgcgacc tcccggaatg ggcagattta ctgtaggcat tcaaaacatc taactaaaat
     1201 aaaaggaatt gtctgtcacc aaaataaaac atttaatgta tccaggtgtg tccaacttgg
     1261 gaagggacac tggtatgata gggaagaaag aaccatagaa atgtcacagt tgtaagatta
     1321 attaatattg gaagcagtta attaataatt aaatattaaa atttcttatt tatgtaaaaa
     1381 aaaaaaaaaa aaaaaaaaaa
//
