LOCUS       NM_012631               2142 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus prion protein (Prnp), transcript variant 1, mRNA.
ACCESSION   NM_012631 XM_346677
VERSION     NM_012631.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2142)
  AUTHORS   Bose,R., Jana,S.S. and Ain,R.
  TITLE     Cellular Prion protein moonlights vascular smooth muscle cell fate:
            Surveilled by trophoblast cells
  JOURNAL   J Cell Physiol 238 (12), 2794-2811 (2023)
   PUBMED   37819170
  REMARK    GeneRIF: Cellular Prion protein moonlights vascular smooth muscle
            cell fate: Surveilled by trophoblast cells.
REFERENCE   2  (bases 1 to 2142)
  AUTHORS   Mantuano,E., Azmoon,P., Banki,M.A., Lam,M.S., Sigurdson,C.J. and
            Gonias,S.L.
  TITLE     A soluble derivative of PrPC activates cell-signaling and regulates
            cell physiology through LRP1 and the NMDA receptor
  JOURNAL   J Biol Chem 295 (41), 14178-14188 (2020)
   PUBMED   32788217
  REMARK    GeneRIF: A soluble derivative of PrP(C) activates cell-signaling
            and regulates cell physiology through LRP1 and the NMDA receptor.
REFERENCE   3  (bases 1 to 2142)
  AUTHORS   Lopez,T.P., Giles,K., Dugger,B.N., Oehler,A., Condello,C.,
            Krejciova,Z., Castaneda,J.A., Carlson,G.A. and Prusiner,S.B.
  TITLE     A novel vector for transgenesis in the rat CNS
  JOURNAL   Acta Neuropathol Commun 5 (1), 84 (2017)
   PUBMED   29157304
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2142)
  AUTHORS   Mattei,V., Martellucci,S., Santilli,F., Manganelli,V., Garofalo,T.,
            Candelise,N., Caruso,A., Sorice,M., Scaccianoce,S. and Misasi,R.
  TITLE     Morphine Withdrawal Modifies Prion Protein Expression in Rat
            Hippocampus
  JOURNAL   PLoS One 12 (1), e0169571 (2017)
   PUBMED   28081197
  REMARK    GeneRIF: the mechanism by which stressful stimuli induced by opiate
            withdrawal and the subsequent long-term homeostatic changes in
            hippocampal plasticity, modulate the expression and the dynamics of
            Prion protein.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2142)
  AUTHORS   Carneiro,M.V., Americo,T.A., Guimaraes,M.Z. and Linden,R.
  TITLE     The prion protein selectively binds to and modulates the content of
            purinergic receptor P2X4R
  JOURNAL   Biochem Biophys Res Commun 472 (2), 293-298 (2016)
   PUBMED   26946358
  REMARK    GeneRIF: The results suggest a role of PrP(C) in proteostasis,
            dysfunctions of which may be involved in the pathogenesis of
            neurodegenerative diseases such as TSE and Alzheimer's Disease.
REFERENCE   6  (bases 1 to 2142)
  AUTHORS   Saeki,K., Matsumoto,Y., Matsumoto,Y. and Onodera,T.
  TITLE     Identification of a promoter region in the rat prion protein gene
  JOURNAL   Biochem Biophys Res Commun 219 (1), 47-52 (1996)
   PUBMED   8619825
REFERENCE   7  (bases 1 to 2142)
  AUTHORS   Saeki,K., Matsumoto,Y., Hirota,Y., Matsumoto,Y. and Onodera,T.
  TITLE     Three-exon structure of the gene encoding the rat prion protein and
            its expression in tissues
  JOURNAL   Virus Genes 12 (1), 15-20 (1996)
   PUBMED   8879116
REFERENCE   8  (bases 1 to 2142)
  AUTHORS   Gomi,H., Ikeda,T., Kunieda,T., Itohara,S., Prusiner,S.B. and
            Yamanouchi,K.
  TITLE     Prion protein (PrP) is not involved in the pathogenesis of
            spongiform encephalopathy in zitter rats
  JOURNAL   Neurosci Lett 166 (2), 171-174 (1994)
   PUBMED   7909925
REFERENCE   9  (bases 1 to 2142)
  AUTHORS   Goldfarb,L.G., Brown,P., Mitrova,E., Cervenakova,L., Goldin,L.,
            Korczyn,A.D., Chapman,J., Galvez,S., Cartier,L., Rubenstein,R. et
            al.
  TITLE     Creutzfeldt-Jacob disease associated with the PRNP codon 200Lys
            mutation: an analysis of 45 families
  JOURNAL   Eur J Epidemiol 7 (5), 477-486 (1991)
   PUBMED   1684755
REFERENCE   10 (bases 1 to 2142)
  AUTHORS   Liao,Y.C., Tokes,Z., Lim,E., Lackey,A., Woo,C.H., Button,J.D. and
            Clawson,G.A.
  TITLE     Cloning of rat 'prion-related protein' cDNA
  JOURNAL   Lab Invest 57 (4), 370-374 (1987)
   PUBMED   2889848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Jul 29, 2021 this sequence version replaced NM_012631.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.10352.1,
                                           SRR26643285.13372.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000003.1  139639078-139639124
            48-145              JAXUCZ010000003.1  139641359-139641456
            146-2142            JAXUCZ010000003.1  139652420-139654416
FEATURES             Location/Qualifiers
     source          1..2142
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2142
                     /gene="Prnp"
                     /gene_synonym="Prn; PrP"
                     /note="prion protein"
                     /db_xref="GeneID:24686"
                     /db_xref="RGD:3410"
     exon            1..47
                     /gene="Prnp"
                     /gene_synonym="Prn; PrP"
                     /inference="alignment:Splign:2.1.0"
     exon            48..145
                     /gene="Prnp"
                     /gene_synonym="Prn; PrP"
                     /inference="alignment:Splign:2.1.0"
     exon            146..2142
                     /gene="Prnp"
                     /gene_synonym="Prn; PrP"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..920
                     /gene="Prnp"
                     /gene_synonym="Prn; PrP"
                     /note="major prion protein; prion protein, PrP; prion
                     protein, structural"
                     /codon_start=1
                     /product="major prion protein precursor"
                     /protein_id="NP_036763.1"
                     /db_xref="GeneID:24686"
                     /db_xref="RGD:3410"
                     /translation="MANLGYWLLALFVTTCTDVGLCKKRPKPGGWNTGGSRYPGQGSP
                     GGNRYPPQSGGTWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWSQGGGTHNQWNKP
                     SKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMLHFGNDWEDRYYRENMYRYPNQ
                     VYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQY
                     QKESQAYYDGRRSSAVLFSSPPVILLISFLIFLIVG"
ORIGIN      
        1 gcgttgtcag agcagcagac ggagtctgag cgtcgcgtcg gtggcaggac tcctgaatat
       61 atttcaaaac tgaaccattt caacccaact gaagtattct gccttcttag cggtaccagt
      121 ccggtttagg agagccaagc cgactatcag ccatcatggc gaaccttggc tactggctgc
      181 tggccctctt tgtgactaca tgtactgatg ttggcctctg caaaaagcgg ccaaagcctg
      241 gagggtggaa cactggtgga agccggtacc ctgggcaggg aagccctgga ggcaaccgtt
      301 acccacctca gagtggtggt acctgggggc agccccatgg tggtggctgg ggacaacctc
      361 atggtggtgg ctggggacaa cctcatggtg gtggctgggg tcagccccat ggcgggggct
      421 ggagtcaagg agggggtacc cataatcagt ggaacaagcc cagcaagcca aaaaccaacc
      481 tcaagcatgt ggcaggggct gccgcagctg gggcagtagt ggggggcctt ggtggctaca
      541 tgttggggag tgccatgagc aggcccatgc tccattttgg caacgactgg gaggaccgct
      601 actaccgaga aaacatgtac cgttacccta accaagtgta ctacaggccg gtggatcagt
      661 acagcaacca gaacaacttc gtgcacgact gtgtcaatat caccatcaag cagcatacag
      721 tcaccaccac caccaagggg gagaacttca cggagaccga cgtgaagatg atggagcgtg
      781 tggtggagca gatgtgcgtc acccagtatc agaaggagtc ccaggcctat tacgacggga
      841 gaagatctag cgccgtgctt ttctcctccc ctcctgtgat cctcctcatc tccttcctca
      901 tcttcctgat cgtgggatga ggaggccttc ctgcttgttc cttctcattc tcgtggtcta
      961 ggctggggga ggggttaccc acctgtagct ctttcaattg aggtggtgtc tcattcttgc
     1021 ttctctttgt cccccatagg ctaataccct tggcagtgat gggtctgggg aaatgtacag
     1081 tagaccagat gctattcgct tcagcgtcct ttgattgagt ccatcatggg ccagggttaa
     1141 caccaggcca gtaagaatat aacaccaaat aactgctggc tagtcagggc tttgttttgg
     1201 tctactgagt aaatactgtg taacccctga attgtaccca gaggacatgg tgacagagac
     1261 acacataact tagtataggc aaagggttct atagccaaag aagccactgt gtgggcatgg
     1321 caccctggaa aacagcctcc cgcctgggat atctagagca tccacatgtg gaattctttc
     1381 ttttctaaca taaaccatag ctgattgaag gcaacaagaa aaagaatcaa attatcctac
     1441 tgacattgaa agcaaactgt gttcattccc taggcgctgg aatgattttt agccttggat
     1501 taaaccagga gattttgact ctgaggagaa ccagcagtac aaaagcatgg tctcctgtga
     1561 tgggagagat ggtgaaggga caaaggcaag acccctgcgt ttcttcattt ctgtctcata
     1621 attatcaaga gctagaatta ggtcgtgccc taagtttctg tactcgtatt tgaactggac
     1681 aacaaagaga caatctacaa attctcttgg gctgcagagg agagaaatag gctccattcc
     1741 aaagtggaaa gagaaattct gctagcattg tctaagtaag gctaactttt ccttaaatcg
     1801 ctttgtattt cccccagcag acatcacaac cctgtgatcg gttcagcctg caccgcgggt
     1861 gttctgtgta gaatatataa atataacttc aagcttaggc cttctatttt aaagcatctg
     1921 aagtgtggaa cgcactggcc gttctgtgca gtactaagtg tgacccttgg gctttcaatg
     1981 tgcactcggt tccgtatgat tccaaagtag agccctagct ggtcttcgaa tctgcatgta
     2041 cttcacgttt tctatatttg taacttcgca tgtatttgtt ttgtcatata aaaagtttat
     2101 aaatgtttgc tatctgactg acattaaata gaagctatga tg
//
