LOCUS       NM_001415154            3250 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Rattus norvegicus prion like protein doppel (Prnd), transcript
            variant 1, mRNA.
ACCESSION   NM_001415154
VERSION     NM_001415154.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3250)
  AUTHORS   La Mendola D, Magri A, Campagna T, Campitiello MA, Raiola L,
            Isernia C, Hansson O, Bonomo RP and Rizzarelli E.
  TITLE     A doppel alpha-helix peptide fragment mimics the copper(II)
            interactions with the whole protein
  JOURNAL   Chemistry 16 (21), 6212-6223 (2010)
   PUBMED   20411530
REFERENCE   2  (bases 1 to 3250)
  AUTHORS   Premzl M and Gamulin V.
  TITLE     Comparative genomic analysis of prion genes
  JOURNAL   BMC Genomics 8, 1 (2007)
   PUBMED   17199895
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3250)
  AUTHORS   Serres C, Peoc'h K, Courtot AM, Lesaffre C, Jouannet P and
            Laplanche JL.
  TITLE     Spatio-developmental distribution of the prion-like protein doppel
            in Mammalian testis: a comparative analysis focusing on its
            presence in the acrosome of spermatids
  JOURNAL   Biol Reprod 74 (5), 816-823 (2006)
   PUBMED   16421231
  REMARK    GeneRIF: Doppel is expressed early during ontogenesis, and is found
            in both germ cells and Sertoli cells. Doppel may play a
            physiological role in acrosome biogenesis.
REFERENCE   4  (bases 1 to 3250)
  AUTHORS   Paisley D, Banks S, Selfridge J, McLennan NF, Ritchie AM, McEwan C,
            Irvine DS, Saunders PT, Manson JC and Melton DW.
  TITLE     Male infertility and DNA damage in Doppel knockout and prion
            protein/Doppel double-knockout mice
  JOURNAL   Am J Pathol 164 (6), 2279-2288 (2004)
   PUBMED   15161660
REFERENCE   5  (bases 1 to 3250)
  AUTHORS   Qin K, Coomaraswamy J, Mastrangelo P, Yang Y, Lugowski S,
            Petromilli C, Prusiner SB, Fraser PE, Goldberg JM, Chakrabartty A
            and Westaway D.
  TITLE     The PrP-like protein Doppel binds copper
  JOURNAL   J Biol Chem 278 (11), 8888-8896 (2003)
   PUBMED   12482851
REFERENCE   6  (bases 1 to 3250)
  AUTHORS   Peoc'h K, Serres C, Frobert Y, Martin C, Lehmann S, Chasseigneaux
            S, Sazdovitch V, Grassi J, Jouannet P, Launay JM and Laplanche JL.
  TITLE     The human 'prion-like' protein Doppel is expressed in both Sertoli
            cells and spermatozoa
  JOURNAL   J Biol Chem 277 (45), 43071-43078 (2002)
   PUBMED   12200435
REFERENCE   7  (bases 1 to 3250)
  AUTHORS   Behrens A, Genoud N, Naumann H, Rulicke T, Janett F, Heppner FL,
            Ledermann B and Aguzzi A.
  TITLE     Absence of the prion protein homologue Doppel causes male sterility
  JOURNAL   EMBO J 21 (14), 3652-3658 (2002)
   PUBMED   12110578
REFERENCE   8  (bases 1 to 3250)
  AUTHORS   Silverman GL, Qin K, Moore RC, Yang Y, Mastrangelo P, Tremblay P,
            Prusiner SB, Cohen FE and Westaway D.
  TITLE     Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored
            protein. Expression in testis and ectopic production in the brains
            of Prnp(0/0) mice predisposed to Purkinje cell loss
  JOURNAL   J Biol Chem 275 (35), 26834-26841 (2000)
   PUBMED   10842180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000118.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001415154.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JACYVU010000118.1  43080541-43080595
            56-3250             JACYVU010000118.1  43082610-43085804
FEATURES             Location/Qualifiers
     source          1..3250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..3250
                     /gene="Prnd"
                     /note="prion like protein doppel"
                     /db_xref="GeneID:113910"
                     /db_xref="RGD:1306618"
     exon            1..55
                     /gene="Prnd"
                     /inference="alignment:Splign:2.1.0"
     exon            56..3250
                     /gene="Prnd"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..603
                     /gene="Prnd"
                     /note="prion protein-like protein; prion protein dublet;
                     prion protein 2 (dublet)"
                     /codon_start=1
                     /product="prion-like protein doppel precursor"
                     /protein_id="NP_001402083.1"
                     /db_xref="GeneID:113910"
                     /db_xref="RGD:1306618"
                     /translation="MKNRVGTWGLAILCLLLASHLSTVKARGIKHRFKWNRKVLPSSG
                     QITEAQVAENRPGAFIKQGRKLDIDFGAEGNKYYAANYWQFPDGIYYEGCSEANVTKE
                     VLVTRCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSTKHCDFWLERGAALRIT
                     VDQQAMVCLLGFIWFIVK"
ORIGIN      
        1 gttccagaga agtgagggct ccaagcttca gaggccagag tagcagagaa caaagattct
       61 cccaccatga agaaccgtgt gggtacatgg gggctggcca tcctctgcct gctgcttgct
      121 agccacctct ccacggttaa ggccaggggc ataaagcata ggttcaagtg gaaccggaag
      181 gtcctgccca gcagcggcca gattaccgaa gcccaggtgg ctgagaaccg cccaggagcc
      241 ttcatcaagc aaggccgaaa gctggacatc gactttggag cagagggcaa caagtactat
      301 gcggccaact actggcagtt ccctgatggg atctactacg aaggctgctc tgaagccaac
      361 gtgaccaagg aggtgctggt gacccgctgc gtcaacgcca cccaggcggc caatcaggct
      421 gagttctccc gggagaagca ggatagcaag ctccaccagc gagtcctgtg gcggctgatc
      481 aaagagatct gttccaccaa gcactgcgat ttctggctgg aaaggggagc cgcgctgcga
      541 atcaccgtgg accaacaggc gatggtctgc ctgctgggtt tcatttggtt tattgtgaag
      601 taaacagcaa tgaaactggc agccacagag gtgagctggt gggcaaaggt gaacagaggt
      661 agcccagttc tcactctcta gcccccgagt gtcctgaaag tacagtgtgt agcgattctc
      721 ggcaacttcc aaagtccctc ccgagtactc cctctgctcc ctgtgtttga taaggtgtta
      781 cagtgccccc atgccccacc cctgtgggac ctagcttgtt cctgccttta cagctacact
      841 aggtgataaa ccagtcaaag tatgaaagaa ttgtcctggg cactccacct gattttccaa
      901 ctccaggaaa ctgaggctca cattgctgga gtccccctcc aggacagtta gaaaatagca
      961 gagctggggt tcccctggtc tatcttccct caggttttct gctctgggta gcctagagct
     1021 acacaagagg ctgtgtagag ctgcctcctg gtcccttcaa gactcaggtc caagtgcagt
     1081 cctgaatgtg gagtgaaatg tggaagtcac actctgaagt aagtgggaag ccctgagcac
     1141 cttgacacga caccttgccc gacactacaa tataacagaa gtcaaactaa agtagacgtg
     1201 acactagaca aaggctcaga aatcagattg tagggaaatt catcactcac ctcccagaca
     1261 gcagcttcag ggcggatgtg tttgtggttt ctagatgctt cttcacaagg attgccggtt
     1321 gctagttggg tccctgcaat atctgcaaag ttaaaaaaaa aaaacaccct tgtaaataac
     1381 acatttgcat ctctctctct ctctctctct ctctctctct ctctctctct ctctctctgt
     1441 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt tcctttgttt ttctagaaag
     1501 gaatttatgt acccaggttg gccccaaact catgatcttc tggcctctgc ctcctgaatg
     1561 ccgggattac agacatagca ccaagcccga tgtgtgttta ctgctgaagt cccctggccc
     1621 tatgtgcatg cgtgttctta gacatctgtg acgcttgctt tgcacaggac tctctgcaat
     1681 cactccgttt ttaaaacctc tttggtaaga gctaatctct gtgaatcatt taacactcca
     1741 aaaatataat tattggccaa aaggctgaag agaaatgaca cctttagaga gacccaataa
     1801 caaatcgata tgccactttg tggatttaaa tgtgtattaa actatgagtg ctacttgaat
     1861 gtttaaaaat cttttaagat tcttctgcag gctttcctca cctttcagga ccccagaagt
     1921 tgctgaactg aacggttctg gagataaccg ctgctggttg tagtctcttg taaaaggaac
     1981 atctgccagg ggggtcgggt attgtcaaag gagtcatctg caacgttcca gaacacgagt
     2041 gctgataaca gtacctcacg agccgagttc cctgtgctat cagttctcct caaggacacc
     2101 tctgggaagc ttcacatggt aaagggacat gaagcagggc agcccaagga ttcacagcct
     2161 tcccctggaa cctgtaccac tggacagaca gcccccgaaa accaacctgc tacagtactc
     2221 cactgccgcc aagacacgcc ccctcggctt actgtctact aattctacag cagagggcgt
     2281 ggagaagccc agaacacaca gtttatccct tgcatgtcat tttaaatatc aggcaagaaa
     2341 gaaggaatag ttcttagatg gtgatgttgt catttcagct ccaggcttaa ggcttagttt
     2401 ccagggcgca caaagccatg gacagccaac ttccttctgg cgagaaaatg cttaggctgg
     2461 acagagtcca tgctccacga ttgccgtgtt ctctccgact attggtcgtc tctgcccacg
     2521 aactaactgc gacagccaat aagtgtcagt gtgatttgac taccaaattc gcttatttcg
     2581 ttttgttttt ttatttaagc agggatgttc ttgcttactt acttacggat caggaggggg
     2641 tttcttagcc cttctaagag ttcctgagct aaaacgtgtg ctctgtagaa ctgcacgcaa
     2701 actgacagcc gagtaaaagg gggcggggct gcaattcctg agtctgatcg gtcacaaagt
     2761 tttcacctct ccagactccc cactccttta ctcatttgca actgcaaatg tagcaatttg
     2821 caatcctaat accgggccag aacgctgggt accttaaagc tttacttgac atcatttagt
     2881 gctttctgtc cattttttaa tgacttttgt tttcttgttt ctttaaccct atcccctcct
     2941 tctaccctag tatgagaccc gtaccccttt actgtgtcta aatataaaga tgagggtttt
     3001 aattttgttt cattacaacc tttaaaatac aaagagcact tgtatgtttg tttctctgcg
     3061 gcttgtattc ctgacttaat ggaataccat tacactctct ggatcggtaa ctaggtaaca
     3121 tctaactagt ccttttagat gaccatgaaa tattccacag gacagatgca cttcaagtga
     3181 cttagcaatt tccttgttga cagattctca gattgttctt atcctgcaaa caataaacac
     3241 ccgtaaatag
//
