LOCUS       NM_001102431            2384 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus prion like protein doppel (Prnd), transcript
            variant 2, mRNA.
ACCESSION   NM_001102431 XM_001081220 XM_006235058 XM_230542
VERSION     NM_001102431.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2384)
  AUTHORS   La Mendola,D., Magri,A., Campagna,T., Campitiello,M.A., Raiola,L.,
            Isernia,C., Hansson,O., Bonomo,R.P. and Rizzarelli,E.
  TITLE     A doppel alpha-helix peptide fragment mimics the copper(II)
            interactions with the whole protein
  JOURNAL   Chemistry 16 (21), 6212-6223 (2010)
   PUBMED   20411530
REFERENCE   2  (bases 1 to 2384)
  AUTHORS   Premzl,M. and Gamulin,V.
  TITLE     Comparative genomic analysis of prion genes
  JOURNAL   BMC Genomics 8, 1 (2007)
   PUBMED   17199895
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2384)
  AUTHORS   Serres,C., Peoc'h,K., Courtot,A.M., Lesaffre,C., Jouannet,P. and
            Laplanche,J.L.
  TITLE     Spatio-developmental distribution of the prion-like protein doppel
            in Mammalian testis: a comparative analysis focusing on its
            presence in the acrosome of spermatids
  JOURNAL   Biol Reprod 74 (5), 816-823 (2006)
   PUBMED   16421231
  REMARK    GeneRIF: Doppel is expressed early during ontogenesis, and is found
            in both germ cells and Sertoli cells. Doppel may play a
            physiological role in acrosome biogenesis.
REFERENCE   4  (bases 1 to 2384)
  AUTHORS   Paisley,D., Banks,S., Selfridge,J., McLennan,N.F., Ritchie,A.M.,
            McEwan,C., Irvine,D.S., Saunders,P.T., Manson,J.C. and Melton,D.W.
  TITLE     Male infertility and DNA damage in Doppel knockout and prion
            protein/Doppel double-knockout mice
  JOURNAL   Am J Pathol 164 (6), 2279-2288 (2004)
   PUBMED   15161660
REFERENCE   5  (bases 1 to 2384)
  AUTHORS   Qin,K., Coomaraswamy,J., Mastrangelo,P., Yang,Y., Lugowski,S.,
            Petromilli,C., Prusiner,S.B., Fraser,P.E., Goldberg,J.M.,
            Chakrabartty,A. and Westaway,D.
  TITLE     The PrP-like protein Doppel binds copper
  JOURNAL   J Biol Chem 278 (11), 8888-8896 (2003)
   PUBMED   12482851
REFERENCE   6  (bases 1 to 2384)
  AUTHORS   Peoc'h,K., Serres,C., Frobert,Y., Martin,C., Lehmann,S.,
            Chasseigneaux,S., Sazdovitch,V., Grassi,J., Jouannet,P.,
            Launay,J.M. and Laplanche,J.L.
  TITLE     The human 'prion-like' protein Doppel is expressed in both Sertoli
            cells and spermatozoa
  JOURNAL   J Biol Chem 277 (45), 43071-43078 (2002)
   PUBMED   12200435
REFERENCE   7  (bases 1 to 2384)
  AUTHORS   Behrens,A., Genoud,N., Naumann,H., Rulicke,T., Janett,F.,
            Heppner,F.L., Ledermann,B. and Aguzzi,A.
  TITLE     Absence of the prion protein homologue Doppel causes male sterility
  JOURNAL   EMBO J 21 (14), 3652-3658 (2002)
   PUBMED   12110578
REFERENCE   8  (bases 1 to 2384)
  AUTHORS   Silverman,G.L., Qin,K., Moore,R.C., Yang,Y., Mastrangelo,P.,
            Tremblay,P., Prusiner,S.B., Cohen,F.E. and Westaway,D.
  TITLE     Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored
            protein. Expression in testis and ectopic production in the brains
            of Prnp(0/0) mice predisposed to Purkinje cell loss
  JOURNAL   J Biol Chem 275 (35), 26834-26841 (2000)
   PUBMED   10842180
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Apr 24, 2024 this sequence was replaced by
            NM_001102431.3.
            
            On or before Dec 22, 2022 this sequence version replaced
            XM_006235058.4, NM_001102431.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.16092.1,
                                           SRR26643293.18988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                JAXUCZ010000003.1  139666383-139666437
            56-630              JAXUCZ010000003.1  139668452-139669026
            631-2384            JAXUCZ010000003.1  139669891-139671644
FEATURES             Location/Qualifiers
     source          1..2384
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q36"
     gene            1..2384
                     /gene="Prnd"
                     /note="prion like protein doppel"
                     /db_xref="GeneID:113910"
                     /db_xref="RGD:1306618"
     exon            1..55
                     /gene="Prnd"
                     /inference="alignment:Splign:2.1.0"
     exon            56..630
                     /gene="Prnd"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..603
                     /gene="Prnd"
                     /note="prion protein-like protein; prion protein dublet;
                     prion protein 2 (dublet)"
                     /codon_start=1
                     /product="prion-like protein doppel precursor"
                     /protein_id="NP_001095901.1"
                     /db_xref="GeneID:113910"
                     /db_xref="RGD:1306618"
                     /translation="MKNRVGTWGLAILCLLLASHLSTVKARGIKHRFKWNRKVLPSSG
                     QITEAQVAENRPGAFIKQGRKLDIDFGAEGNKYYAANYWQFPDGIYYEGCSEANVTKE
                     VLVTRCVNATQAANQAEFSREKQDSKLHQRVLWRLIKEICSTKHCDFWLERGAALRIT
                     VDQQAMVCLLGFIWFIVK"
     exon            631..2384
                     /gene="Prnd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttccagaga agtgagggct ccaagcttca gaggccagag tagcagagaa caaagattct
       61 cccaccatga agaaccgtgt gggtacatgg gggctggcca tcctctgcct gctgcttgct
      121 agccacctct ccacggttaa ggccaggggc ataaagcata ggttcaagtg gaaccggaag
      181 gtcctgccca gcagcggcca gattaccgaa gcccaggtgg ctgagaaccg cccaggagcc
      241 ttcatcaagc aaggccgaaa gctggacatc gactttggag cagagggcaa caagtactat
      301 gcggccaact actggcagtt ccctgatggg atctactacg aaggctgctc tgaagccaac
      361 gtgaccaagg aggtgctggt gacccgctgc gtcaacgcca cccaggcggc caatcaggct
      421 gagttctccc gggagaagca ggatagcaag ctccaccagc gagtcctgtg gcggctgatc
      481 aaagagatct gttccaccaa gcactgcgat ttctggctgg aaaggggagc cgcgctgcga
      541 atcaccgtgg accaacaggc gatggtctgc ctgctgggtt tcatttggtt tattgtgaag
      601 taaacagcaa tgaaactggc agccacagag aaaggaattt atgtacccag gttggcccca
      661 aactcatgat cttctggcct ctgcctcctg aatgccggga ttacagacat agcaccaagc
      721 ccgatgtgtg tttactgctg aagtcccctg gccctatgtg catgcgtgtt cttagacatc
      781 tgtgacgctt gctttgcaca ggactctctg caatcactcc gtttttaaaa cctctttggt
      841 aagagctaat ctctgtgaat catttaacac tccaaaaata taattattgg ccaaaaggct
      901 gaagagaaat gacaccttta gagagaccca ataacaaatc gatatgccac tttgtggatt
      961 taaatgtgta ttaaactatg agtgctactt gaatgtttaa aaatctttta agattcttct
     1021 gcaggctttc ctcacctttc aggaccccag aagttgctga actgaacggt tctggagata
     1081 accgctgctg gttgtagtct cttgtaaaag gaacatctgc caggggggtc gggtattgtc
     1141 aaaggagtca tctgcaacgt tccagaacac gagtgctgat aacagtacct cacgagccga
     1201 gttccctgtg ctatcagttc tcctcaagga cacctctggg aagcttcaca tggtaaaggg
     1261 acatgaagca gggcagccca aggattcaca gccttcccct ggaacctgta ccactggaca
     1321 gacagccccc gaaaaccaac ctgctacagt actccactgc cgccaagaca cgccccctcg
     1381 gcttactgtc tactaattct acagcagagg gcgtggagaa gcccagaaca cacagtttat
     1441 cccttgcatg tcattttaaa tatcaggcaa gaaagaagga atagttctta gatggtgatg
     1501 ttgtcatttc agctccaggc ttaaggctta gtttccaggg cgcacaaagc catggacagc
     1561 caacttcctt ctggcgagaa aatgcttagg ctggacagag tccatgctcc acgattgccg
     1621 tgttctctcc gactattggt cgtctctgcc cacgaactaa ctgcgacagc caataagtgt
     1681 cagtgtgatt tgactaccaa attcgcttat ttcgttttgt ttttttattt aagcagggat
     1741 gttcttgctt acttacttac ggatcaggag ggggtttctt agcccttcta agagttcctg
     1801 agctaaaacg tgtgctctgt agaactgcac gcaaactgac agccgagtaa aagggggcgg
     1861 ggctgcaatt cctgagtctg atcggtcaca aagttttcac ctctccagac tccccactcc
     1921 tttactcatt tgcaactgca aatgtagcaa tttgcaatcc taataccggg ccagaacgct
     1981 gggtacctta aagctttact tgacatcatt tagtgctttc tgtccatttt ttaatgactt
     2041 ttgttttctt gtttctttaa ccctatcccc tccttctacc ctagtatgag acccgtaccc
     2101 ctttactgtg tctaaatata aagatgaggg ttttaatttt gtttcattac aacctttaaa
     2161 atacaaagag cacttgtatg tttgtttctc tgcggcttgt attcctgact taatggaata
     2221 ccattacact ctctggatcg gtaactaggt aacatctaac tagtcctttt agatgaccat
     2281 gaaatattcc acaggacaga tgcacttcaa gtgacttagc aatttccttg ttgacagatt
     2341 ctcagattgt tcttatcctg caaacaataa acacccgtaa atag
//
