LOCUS       NM_001271385            2012 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus protein arginine methyltransferase 8 (Prmt8),
            mRNA.
ACCESSION   NM_001271385 XM_001071456 XM_002726433
VERSION     NM_001271385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2012)
  AUTHORS   Zou,Z., Liu,R., Wang,Y., Tan,H., An,G., Zhang,B., Wang,Y. and
            Dong,D.
  TITLE     Protein arginine methyltransferase 8 regulates ferroptosis and
            macrophage polarization in spinal cord injury via glial
            cell-derived neurotrophic factor
  JOURNAL   CNS Neurosci Ther 29 (8), 2145-2161 (2023)
   PUBMED   36914965
  REMARK    GeneRIF: Protein arginine methyltransferase 8 regulates ferroptosis
            and macrophage polarization in spinal cord injury via glial
            cell-derived neurotrophic factor.
REFERENCE   2  (bases 1 to 2012)
  AUTHORS   Lo,L.H., Dong,R., Lyu,Q. and Lai,K.O.
  TITLE     The Protein Arginine Methyltransferase PRMT8 and Substrate G3BP1
            Control Rac1-PAK1 Signaling and Actin Cytoskeleton for Dendritic
            Spine Maturation
  JOURNAL   Cell Rep 31 (10), 107744 (2020)
   PUBMED   32521269
REFERENCE   3  (bases 1 to 2012)
  AUTHORS   Toma-Fukai,S., Kim,J.D., Park,K.E., Kuwabara,N., Shimizu,N.,
            Krayukhina,E., Uchiyama,S., Fukamizu,A. and Shimizu,T.
  TITLE     Novel helical assembly in arginine methyltransferase 8
  JOURNAL   J Mol Biol 428 (6), 1197-1208 (2016)
   PUBMED   26876602
REFERENCE   4  (bases 1 to 2012)
  AUTHORS   Weimann,M., Grossmann,A., Woodsmith,J., Ozkan,Z., Birth,P.,
            Meierhofer,D., Benlasfer,N., Valovka,T., Timmermann,B.,
            Wanker,E.E., Sauer,S. and Stelzl,U.
  TITLE     A Y2H-seq approach defines the human protein methyltransferase
            interactome
  JOURNAL   Nat Methods 10 (4), 339-342 (2013)
   PUBMED   23455924
REFERENCE   5  (bases 1 to 2012)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   6  (bases 1 to 2012)
  AUTHORS   Pahlich,S., Zakaryan,R.P. and Gehring,H.
  TITLE     Identification of proteins interacting with protein arginine
            methyltransferase 8: the Ewing sarcoma (EWS) protein binds
            independent of its methylation state
  JOURNAL   Proteins 72 (4), 1125-1137 (2008)
   PUBMED   18320585
REFERENCE   7  (bases 1 to 2012)
  AUTHORS   Sayegh,J., Webb,K., Cheng,D., Bedford,M.T. and Clarke,S.G.
  TITLE     Regulation of protein arginine methyltransferase 8 (PRMT8) activity
            by its N-terminal domain
  JOURNAL   J Biol Chem 282 (50), 36444-36453 (2007)
   PUBMED   17925405
REFERENCE   8  (bases 1 to 2012)
  AUTHORS   Lee,J., Sayegh,J., Daniel,J., Clarke,S. and Bedford,M.T.
  TITLE     PRMT8, a new membrane-bound tissue-specific member of the protein
            arginine methyltransferase family
  JOURNAL   J Biol Chem 280 (38), 32890-32896 (2005)
   PUBMED   16051612
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On or before Sep 21, 2012 this sequence version replaced
            XM_001071456.3, XM_002726433.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.2249953.1,
                                           SRR22399492.871561.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                JAXUCZ010000004.1  162303271-162303345 c
            76-261              JAXUCZ010000004.1  162266345-162266530 c
            262-417             JAXUCZ010000004.1  162262458-162262613 c
            418-481             JAXUCZ010000004.1  162259193-162259256 c
            482-624             JAXUCZ010000004.1  162244788-162244930 c
            625-712             JAXUCZ010000004.1  162244150-162244237 c
            713-828             JAXUCZ010000004.1  162236696-162236811 c
            829-979             JAXUCZ010000004.1  162230695-162230845 c
            980-1101            JAXUCZ010000004.1  162223569-162223690 c
            1102-2012           JAXUCZ010000004.1  162221986-162222896 c
FEATURES             Location/Qualifiers
     source          1..2012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2012
                     /gene="Prmt8"
                     /note="protein arginine methyltransferase 8"
                     /db_xref="GeneID:688502"
                     /db_xref="RGD:1587677"
     CDS             1..1185
                     /gene="Prmt8"
                     /EC_number="2.1.1.319"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 8"
                     /protein_id="NP_001258314.1"
                     /db_xref="GeneID:688502"
                     /db_xref="RGD:1587677"
                     /translation="MGMKHSSRCLLLRRKMAENAVESTEVSSAPPQPPQPVIPAKPVQ
                     CVHHVSTQPSCPGRGKMSKLLNPEEMTSRDYYFDSYAHFGIHEEMLKDEVRTLTYRNS
                     MYHNKHVFKDKVVLDVGSGTGILSMFAAKAGAKKVFGIECSSISDYSEKIIKANHLDN
                     VITIFKGKVEEVELPVEKVDIIISEWMGYCLFYESMLNTVIFARDKWLKPGGLMFPDR
                     AALYVVAIEDRQYKDFKIHWWENVYGFDMTCIRDVAMKEPLVDIVDPKQVVTNACLIK
                     EVDIYTVKTEELSFTSAFCLQIQRNDYVHALVTYFNIEFTKCHKKMGFSTAPDAPYTH
                     WKQTVFYLEDYLTVRRGEEIYGTISMKPNAKNVRDLDFTVDLDFKGQLCETSVSNDYK
                     MR"
     exon            1..75
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            76..261
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            262..417
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            418..481
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            482..624
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            625..712
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            713..828
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            829..979
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1101
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..2012
                     /gene="Prmt8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgggcatga aacactcctc ccgctgcctg ctcctccgga ggaaaatggc ggagaacgca
       61 gtcgaaagca cggaggtgag cagtgccccc cctcagcccc ctcagcctgt cattccagcg
      121 aagcctgtgc aatgcgtcca ccatgtgtcc acacagccca gctgcccagg acggggcaag
      181 atgtccaagc tgctgaatcc cgaggagatg acatcgagag attactattt tgactcatat
      241 gctcactttg ggatccacga ggaaatgctg aaggatgagg tgaggacact cacgtaccgg
      301 aactccatgt accataataa gcacgtgttc aaggacaaag tggttctgga tgttgggagt
      361 ggtacaggga tcctttccat gtttgctgcc aaagcagggg ccaagaaggt gtttgggatt
      421 gaatgttcca gtatttctga ctactcagag aagatcatta aggccaacca cctggacaat
      481 gtcattacca tatttaaggg caaagtggag gaggtggagc tgccagtgga gaaggtggac
      541 atcatcatca gcgagtggat gggctactgt ctgttctacg agtccatgct caacaccgtg
      601 atctttgcca gggacaagtg gttgaaacct ggagggctca tgtttccaga ccgggcagct
      661 ttgtacgtgg tagcaattga agacagacag tacaaggact tcaaaatcca ctggtgggag
      721 aacgtctatg gctttgacat gacttgcatc cgggatgttg ctatgaagga gcccctggtg
      781 gatatcgtgg acccaaagca agtggtgacc aatgcctgtt taataaagga agtggacatt
      841 tacactgtga agacggaaga gctgtctttt acatctgcct tctgcctgca gatacagcgc
      901 aacgactatg tccatgccct cgtcacctac tttaatattg aatttaccaa gtgccacaag
      961 aaaatgggtt tttctacagc ccctgatgcc ccctacactc actggaagca gactgtcttc
     1021 tacttagaag actacctcac tgttcgaaga ggggaggaaa tctacgggac catatccatg
     1081 aagccaaatg ccaaaaatgt gcgagacctc gatttcacag tagacttgga ttttaaggga
     1141 cagctgtgtg aaacatctgt atctaatgac tacaaaatgc gttagcacat gtgggaagct
     1201 gcggagagca atcgagaaga ggcactcact tcagtctgcc acgctgcccc aaggaatact
     1261 gttaagagga ccacactcga caaccagagc tttccactct gccttgaaga ttggcgaact
     1321 cgcccagggc tctcctgggc cccgctatca cagggagcct ccagctcctc ggttctgccc
     1381 ctggagccct tcacaaaggc tgtgttgttg ccttccgtgc tgtggctggg gctctgagga
     1441 gggaagcata cccatgtgcc cccattgtcc taaactgact ctctggatct tccaagtttt
     1501 gcatgctgca gacatctagg acaggttact tctgctagaa cctggagaca tacgtctttg
     1561 atagcataag ccagattttc tgtctgtgtg gtggtggtgt gtgtgagcgt gtgtgcgtgc
     1621 gtgcgtgcgc gcgcatgagt atacagcata tatattattt tacttgccca caaacatctg
     1681 tatatgcatg catatacaac taagtgggca tacttgggtg ttcattctga ggtgtgtgtg
     1741 tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgtgtgtgtg gtgggtgtgt gcgcctagaa
     1801 tctatattac tctcagagga ggttctgttg cttttggata ggaatttgtt tcgtgattag
     1861 ttttccccat cccgatccct taacagatgt tacacagcta tgaaacattc tgtgtactag
     1921 ctctggtctc gttttgacta gactgtggct ctgaatcctg agcacagtac catgggctct
     1981 gcgggcactc aataaacaca catgagaaag aa
//
