LOCUS       NM_001393859            2960 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus protein arginine methyltransferase 6 (Prmt6),
            transcript variant 2, mRNA.
ACCESSION   NM_001393859 XM_017590781
VERSION     NM_001393859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Yan,W.W., Liang,Y.L., Zhang,Q.X., Wang,D., Lei,M.Z., Qu,J.,
            He,X.H., Lei,Q.Y. and Wang,Y.P.
  TITLE     Arginine methylation of SIRT7 couples glucose sensing with
            mitochondria biogenesis
  JOURNAL   EMBO Rep 19 (12) (2018)
   PUBMED   30420520
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Huang,J., Cardamone,M.D., Johnson,H.E., Neault,M., Chan,M.,
            Floyd,Z.E., Mallette,F.A. and Perissi,V.
  TITLE     Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate
            in Protecting G Protein Pathway Suppressor 2 (GPS2) from
            Proteasomal Degradation
  JOURNAL   J Biol Chem 290 (31), 19044-19054 (2015)
   PUBMED   26070566
REFERENCE   3  (bases 1 to 2960)
  AUTHORS   Casadio,F., Lu,X., Pollock,S.B., LeRoy,G., Garcia,B.A., Muir,T.W.,
            Roeder,R.G. and Allis,C.D.
  TITLE     H3R42me2a is a histone modification with positive transcriptional
            effects
  JOURNAL   Proc Natl Acad Sci U S A 110 (37), 14894-14899 (2013)
   PUBMED   23980157
REFERENCE   4  (bases 1 to 2960)
  AUTHORS   Herglotz,J., Kuvardina,O.N., Kolodziej,S., Kumar,A., Hussong,H.,
            Grez,M. and Lausen,J.
  TITLE     Histone arginine methylation keeps RUNX1 target genes in an
            intermediate state
  JOURNAL   Oncogene 32 (20), 2565-2575 (2013)
   PUBMED   22777353
REFERENCE   5  (bases 1 to 2960)
  AUTHORS   Neault,M., Mallette,F.A., Vogel,G., Michaud-Levesque,J. and
            Richard,S.
  TITLE     Ablation of PRMT6 reveals a role as a negative transcriptional
            regulator of the p53 tumor suppressor
  JOURNAL   Nucleic Acids Res 40 (19), 9513-9521 (2012)
   PUBMED   22904064
REFERENCE   6  (bases 1 to 2960)
  AUTHORS   Guccione,E., Bassi,C., Casadio,F., Martinato,F., Cesaroni,M.,
            Schuchlautz,H., Luscher,B. and Amati,B.
  TITLE     Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are
            mutually exclusive
  JOURNAL   Nature 449 (7164), 933-937 (2007)
   PUBMED   17898714
REFERENCE   7  (bases 1 to 2960)
  AUTHORS   El-Andaloussi,N., Valovka,T., Toueille,M., Steinacher,R., Focke,F.,
            Gehrig,P., Covic,M., Hassa,P.O., Schar,P., Hubscher,U. and
            Hottiger,M.O.
  TITLE     Arginine methylation regulates DNA polymerase beta
  JOURNAL   Mol Cell 22 (1), 51-62 (2006)
   PUBMED   16600869
REFERENCE   8  (bases 1 to 2960)
  AUTHORS   Miranda,T.B., Webb,K.J., Edberg,D.D., Reeves,R. and Clarke,S.
  TITLE     Protein arginine methyltransferase 6 specifically methylates the
            nonhistone chromatin protein HMGA1a
  JOURNAL   Biochem Biophys Res Commun 336 (3), 831-835 (2005)
   PUBMED   16157300
REFERENCE   9  (bases 1 to 2960)
  AUTHORS   Bedford,M.T. and Richard,S.
  TITLE     Arginine methylation an emerging regulator of protein function
  JOURNAL   Mol Cell 18 (3), 263-272 (2005)
   PUBMED   15866169
  REMARK    Review article
REFERENCE   10 (bases 1 to 2960)
  AUTHORS   Frankel,A., Yadav,N., Lee,J., Branscombe,T.L., Clarke,S. and
            Bedford,M.T.
  TITLE     The novel human protein arginine N-methyltransferase PRMT6 is a
            nuclear enzyme displaying unique substrate specificity
  JOURNAL   J Biol Chem 277 (5), 3537-3543 (2002)
   PUBMED   11724789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Mar 19, 2021 this sequence version replaced XM_017590781.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.9256.1,
                                           SRR26360190.1237519.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760433, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1182              JAXUCZ010000002.1  200619609-200620790 c
            1183-2960           JAXUCZ010000002.1  200615780-200617557 c
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q41"
     gene            1..2960
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /note="protein arginine methyltransferase 6"
                     /db_xref="GeneID:295384"
                     /db_xref="RGD:1304701"
     exon            1..1182
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1147
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /EC_number="2.1.1.125"
                     /note="HMT1 hnRNP methyltransferase-like 6"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 6"
                     /protein_id="NP_001380788.1"
                     /db_xref="GeneID:295384"
                     /db_xref="RGD:1304701"
                     /translation="MSLSKKRKLESGVGGAGGEGAEEENGGEQEAAPPRPRRTKRERD
                     QLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQ
                     AGARRVYAVEASAIWQQAQEVVRLNGLEDRVHILPGPVETVELPEQVDAIVSEWMGYG
                     LLHESMLSSVLHARTKWLKEGGLLLPDSAELFVAPISDQMLEWRLGFWSQVKQHYGVD
                     MSCMESFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELARAGLEQELEAGVGGRFR
                     CSCYGSAPLHGFAIWFQVTFPGGDSEKPLVLSTSPFHPATHWKQALLYLNEPVPVEQD
                     TDISGEITLLPSRDNPRRLRVLLRYKVGDHEEKTKDFAMED"
     exon            1183..2960
                     /gene="Prmt6"
                     /gene_synonym="Hrmt1l6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggctgcc gggaccaaga tgtcgctgag caagaaaaga aagcttgagt cgggggtcgg
       61 cggcgcagga ggggagggag ctgaggagga aaatggcggg gagcaggagg cagccccgcc
      121 acgaccccgg aggaccaagc gcgagcggga ccagctgtac tacgagtgct actccgacgt
      181 atcggtccac gaggagatga tcgccgaccg cgtccgcacc gacgcctacc gcctaggcat
      241 cctgaggaac tgggccgctc tgcgaggcaa gaccgtgctg gacgtgggcg caggcaccgg
      301 cattcttagc atcttctgcg cccaggccgg ggcccggcgc gtatacgctg tggaggccag
      361 cgccatctgg caacaggccc aggaggtggt gcggctcaac gggttggagg accgcgtgca
      421 catcctgcca ggcccggtgg agacggtgga gctgccggag caagtggacg ccatcgtaag
      481 cgagtggatg ggctacggac tactgcacga gtccatgctg agctccgtgc tccacgcgcg
      541 gaccaaatgg ctgaaggagg gcggtctcct cctgccagat tccgctgagc tcttcgtggc
      601 cccgattagc gaccagatgc tggaatggcg cttgggtttc tggagccaag tgaagcagca
      661 ctatggcgtg gatatgagct gcatggaaag cttcgccacg cgctgcctca tgggccattc
      721 ggagatcgtg gtgcagggtc tgtccggaga ggacgtgctg gcccggccac agcgctttgc
      781 ccagctcgag ctggcccgcg ctggcctgga gcaggagctg gaggccggtg tgggcgggcg
      841 cttccgctgc agctgctatg gctccgcgcc tctacatggt tttgccatct ggtttcaggt
      901 aacctttcct ggaggggact cggagaaacc tctggtgctg tccacctcac ctttccaccc
      961 ggccacgcac tggaagcagg cgctcctcta cttgaatgag ccggtgccgg tggaacaaga
     1021 tacagacatt tctggagaga tcaccctgct gccctcccgg gacaaccccc ggcgtctgcg
     1081 cgtacttctg cgctacaaag tgggggacca tgaggaaaag accaaagact ttgccatgga
     1141 ggactgagcg ttgccttttc tcccatctac cttcttagga aggcactgac agcatcgcct
     1201 tggctataca tgaagagcaa cgtatgccac ggggtaccag atgatccaaa gaagcaccac
     1261 agtctttggg atgaagacac ctgggaaaga ggaaagcctg aggtgtgtgg acacccaggc
     1321 actatctgat gtgttatgtg gattgggact ggtaactgaa acccttaggg ccacaggcct
     1381 ggattattag actctagaga gagcatcatg gtaaagtccc acctacctcc ctcacacctt
     1441 acctttattt agccctccca aatttcccaa ttttgtcgct aatttattaa accaatgagc
     1501 ataatacatt ctaaaggtca ctgtggtagg tatttgggat tacatgctac ttgaactctg
     1561 cccataagta gatgtctaca ctaaaggaag taaaggccat aattttaggt tagttaggac
     1621 ctgggtggtt ttagtgtcag aaaagatgga ttatttgttt tacacactaa gtgaaaaagg
     1681 tttcgtagat gctgacagaa agttacatac ataattcttc ctggtttgga aatgtgatca
     1741 tacattgtgc aaggctaaat tggaacccag gatatagctg aggatgactt tgaactcttt
     1801 cctccacctt ccacattctg gagttaatag ctctgtacca ctgtgcccag catagaccca
     1861 gtttttggct gacccttacc cacaattctt gacttttcaa aggtaaacaa aaatttactc
     1921 tcatattaat cccacatgct tcacttaaaa acaggagact atgtgccacc ttaatagtaa
     1981 caagggcttt attatttgat gatgacggga aagtgtttag tactagaaag gctcttagac
     2041 ctgcccaaaa gaaacatctg cagtgtgtaa cttgagtttg acatagtggg cactcatttc
     2101 aacagccctt atgtttattt ctgtaacaat agtcaaatgg gacactttct agggtctcca
     2161 gaaaactgaa tgcatgacag tagcaaagac aagtgaactc cctgtcattt gggcagggat
     2221 gtaaaagaga caagaaaatg gagttcaaga aagtgaatgt gaaaagcacc tgctgcgaac
     2281 agctgcctgc cgtcttcttt actgccagct ttgctcttat ccccacagtt tacctagtgc
     2341 tgaggaaaga tggctcctaa ggagcattta ctaacaggcc ccactcctcc acatgttcat
     2401 ctctgtatat gtctctccat taatttcatt atcaacagct acataatagc taagcactgt
     2461 aataactgag cacatctgcc cttcagagaa cagggtacag tgggagcagt aaagcagcat
     2521 cagttgttct catgcattcg taagcctgga aatccttccc agctcttagc tctgctgagt
     2581 gagtatggaa agggtgctgt caccctttaa ggctctctga ggatcaaagg tctgattcct
     2641 atcagcagga agattgtgaa cacctgagaa actcccatct gatgttctag aattagacag
     2701 tattccccaa aatactagtc tgttccataa tagaccaact atattaaata ggtaatcccc
     2761 agctactaaa acaaagactc taagccaagt ttatgggtcg tctgtgtgtc tgtgtgtata
     2821 ctgtgtgtat actgtgtgcg cgagtgtgtg catgtgcaca tttgcttgta tcttccccaa
     2881 ctttctgtgt gatttttatg cttcaatttg tttatgattt atcctctcac ttttaataaa
     2941 tattacatgt attttttgaa
//
