LOCUS       NM_001108867            2553 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Rattus norvegicus protein arginine methyltransferase 5 (Prmt5),
            mRNA.
ACCESSION   NM_001108867 XM_001054376 XM_344405
VERSION     NM_001108867.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2553)
  AUTHORS   Yeh,C.M., Lai,C.Y., Peng,H.Y., Lin,T.B., Chou,D., Wang,H.H.,
            Yang,P.S., Cheng,J.K., Peng,Y.C. and Hsieh,M.C.
  TITLE     Protein Arginine Methyltransferase 5 Contributes to
            Paclitaxel-Induced Neuropathic Pain by Activating Transient
            Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal
            Root Ganglion
  JOURNAL   Anesth Analg 138 (5), 1107-1119 (2024)
   PUBMED   37390022
  REMARK    GeneRIF: Protein Arginine Methyltransferase 5 Contributes to
            Paclitaxel-Induced Neuropathic Pain by Activating Transient
            Receptor Potential Vanilloid 1 Epigenetic Modification in Dorsal
            Root Ganglion.
REFERENCE   2  (bases 1 to 2553)
  AUTHORS   Cai,S., Wang,P., Xie,T., Li,Z., Li,J., Lan,R., Ding,Y., Lu,J.,
            Ye,J., Wang,J., Li,Z. and Liu,P.
  TITLE     Histone H4R3 symmetric di-methylation by Prmt5 protects against
            cardiac hypertrophy via regulation of Filip1L/beta-catenin
  JOURNAL   Pharmacol Res 161, 105104 (2020)
   PUBMED   32739429
  REMARK    GeneRIF: Histone H4R3 symmetric di-methylation by Prmt5 protects
            against cardiac hypertrophy via regulation of Filip1L/beta-catenin.
REFERENCE   3  (bases 1 to 2553)
  AUTHORS   Sun,M., Hussain,S., Hu,Y., Yan,J., Min,Z., Lan,X., Guo,Y., Zhao,Y.,
            Huang,H., Feng,M., Han,Y., Zhang,F., Zhu,W., Meng,L., Li,D., Sun,J.
            and Lu,S.
  TITLE     Maintenance of SOX9 stability and ECM homeostasis by
            selenium-sensitive PRMT5 in cartilage
  JOURNAL   Osteoarthritis Cartilage 27 (6), 932-944 (2019)
   PUBMED   30858101
  REMARK    GeneRIF: Maintenance of SOX9 stability and ECM homeostasis by
            selenium-sensitive PRMT5 in cartilage.
REFERENCE   4  (bases 1 to 2553)
  AUTHORS   Zhao,D.Y., Gish,G., Braunschweig,U., Li,Y., Ni,Z., Schmitges,F.W.,
            Zhong,G., Liu,K., Li,W., Moffat,J., Vedadi,M., Min,J., Pawson,T.J.,
            Blencowe,B.J. and Greenblatt,J.F.
  TITLE     SMN and symmetric arginine dimethylation of RNA polymerase II
            C-terminal domain control termination
  JOURNAL   Nature 529 (7584), 48-53 (2016)
   PUBMED   26700805
REFERENCE   5  (bases 1 to 2553)
  AUTHORS   Likhite,N., Jackson,C.A., Liang,M.S., Krzyzanowski,M.C., Lei,P.,
            Wood,J.F., Birkaya,B., Michaels,K.L., Andreadis,S.T., Clark,S.D.,
            Yu,M.C. and Ferkey,D.M.
  TITLE     The protein arginine methyltransferase PRMT5 promotes D2-like
            dopamine receptor signaling
  JOURNAL   Sci Signal 8 (402), ra115 (2015)
   PUBMED   26554819
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2553)
  AUTHORS   Lim,Y., Kwon,Y.H., Won,N.H., Min,B.H., Park,I.S., Paik,W.K. and
            Kim,S.
  TITLE     Multimerization of expressed protein-arginine methyltransferases
            during the growth and differentiation of rat liver
  JOURNAL   Biochim Biophys Acta 1723 (1-3), 240-247 (2005)
   PUBMED   15837430
REFERENCE   7  (bases 1 to 2553)
  AUTHORS   Bedford,M.T. and Richard,S.
  TITLE     Arginine methylation an emerging regulator of protein function
  JOURNAL   Mol Cell 18 (3), 263-272 (2005)
   PUBMED   15866169
  REMARK    Review article
REFERENCE   8  (bases 1 to 2553)
  AUTHORS   Miranda,T.B., Khusial,P., Cook,J.R., Lee,J.H., Gunderson,S.I.,
            Pestka,S., Zieve,G.W. and Clarke,S.
  TITLE     Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically
            dimethylated at arginine residues in the nucleus
  JOURNAL   Biochem Biophys Res Commun 323 (2), 382-387 (2004)
   PUBMED   15369763
REFERENCE   9  (bases 1 to 2553)
  AUTHORS   Fabbrizio,E., El Messaoudi,S., Polanowska,J., Paul,C., Cook,J.R.,
            Lee,J.H., Negre,V., Rousset,M., Pestka,S., Le Cam,A. and Sardet,C.
  TITLE     Negative regulation of transcription by the type II arginine
            methyltransferase PRMT5
  JOURNAL   EMBO Rep 3 (7), 641-645 (2002)
   PUBMED   12101096
  REMARK    GeneRIF: These data provide the first direct experimental evidence
            that PRMT5, a type II arginine methylase, is involved in the
            control of transcription and proliferation.
REFERENCE   10 (bases 1 to 2553)
  AUTHORS   Friesen,W.J., Wyce,A., Paushkin,S., Abel,L., Rappsilber,J., Mann,M.
            and Dreyfuss,G.
  TITLE     A novel WD repeat protein component of the methylosome binds Sm
            proteins
  JOURNAL   J Biol Chem 277 (10), 8243-8247 (2002)
   PUBMED   11756452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB814013.1, CO573950.1, DY553859.1, CB793692.1, CK845516.1,
            BQ210423.1, BE116721.1 and AI713913.1.
            
            On Apr 21, 2008 this sequence version replaced NM_001108867.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-344               CB814013.1         12-355
            345-1012            CO573950.1         145-812
            1013-1413           DY553859.1         267-667
            1414-1614           CB793692.1         204-404
            1615-1774           CK845516.1         488-647             c
            1775-2261           BQ210423.1         1-487               c
            2262-2521           BE116721.1         18-277              c
            2522-2553           AI713913.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..2553
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p13"
     gene            1..2553
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /note="protein arginine methyltransferase 5"
                     /db_xref="GeneID:364382"
                     /db_xref="RGD:1309053"
     exon            1..124
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1928
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /EC_number="2.1.1.125"
                     /note="SKB1 homolog; HMT1 hnRNP methyltransferase-like 5"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 5"
                     /protein_id="NP_001102337.2"
                     /db_xref="GeneID:364382"
                     /db_xref="RGD:1309053"
                     /translation="MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMP
                     VFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIHPDSKVEKIRRN
                     SEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAP
                     EDLRDDVIENAPTAHTEEYSGEEKTWLWWHNFRTLCDYSKRIAVALEIGADLPSSHVI
                     DRWLGEPIKAAILPTSIFLTNKKGFPVLSKMQQRLIFRLLKLEVQFIITGTNHHSEKE
                     FCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKY
                     SQYQQAIYKCLLDRVPEEEKETNVQVLMVLGAGRGPLVNASLRAAKQAERRIRLYAVE
                     KNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECL
                     DGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHN
                     FHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYRDITLS
                     IRPETHSPGMFSWFPIFFPIKQPITVHEGQNICVRFWRCSNSKKVWYEWAVTAPVCSS
                     IHNPTGRSYTIGL"
     exon            125..243
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            244..329
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..464
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..577
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..627
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..791
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..953
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1031
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1090
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1213
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1389
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1499
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1593
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1710
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1775
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..2536
                     /gene="Prmt5"
                     /gene_synonym="Hrmt1l5; Skb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcgaggga aaagatggcg gcgatggcag tcggaggtgc tggtggcagc cgcgtgtcca
       61 gcgggaggga cctgaattgc gtccctgaaa tagctgacac actgggtgct gtggccaagc
      121 aggggtttga tttcctctgc atgcctgtct tccacccgcg tttcaagagg gagttcattc
      181 aggaacctgc taagaatcgg cctggccccc agacacgatc agacctactg ctgtcaggaa
      241 gggactggaa tacgctaatt gtgggaaagc tttctccatg gattcatcca gactcaaaag
      301 tggagaagat ccgaaggaac tctgaggcgg ctatgttgca ggagctgaat tttggggcat
      361 atctaggtct tccagctttc ctattgcccc ttaatcagga agataacaca aatctggcca
      421 gagttctgac caaccacatc cacactggcc accattcttc catgttctgg atgagggtcc
      481 ccttggtggc cccagaggac ctgagagatg atgtaattga gaatgcacca actgcacaca
      541 cagaggagta cagtggagag gagaagacgt ggttgtggtg gcataacttc cggactctgt
      601 gtgactatag taagaggatt gcagtagctc ttgaaatcgg agctgacctc ccgtctagtc
      661 acgtcattga tcgttggctt ggagagccca tcaaagccgc cattctcccc accagcattt
      721 tcctaaccaa caagaagggg tttcctgttc tttctaagat gcagcagagg ctgatcttcc
      781 ggctcctcaa gttggaagtg caatttatca tcacgggaac caaccaccac tcagagaagg
      841 agttctgctc ctacctccag tacttggaat acttaagcca aaatcgtccc ccacccaatg
      901 cttacgaact ctttgccaaa ggctatgaag actatctgca gtccccactt cagcctctga
      961 tggacaatct ggaatctcag acgtacgaag tgttcgaaaa ggaccccatc aaatactctc
     1021 agtaccagca ggccatctat aaatgtttgc tagaccgagt accagaagaa gaaaaggaga
     1081 ccaatgtcca ggtacttatg gtgctgggtg caggccgagg tcctctagtg aatgcgtctc
     1141 tccgggcagc caagcaggct gagcggcgga ttaggctgta tgccgtggag aagaacccca
     1201 atgctgtggt gacgctagag aactggcagt ttgaagaatg ggggagtcag gtgacagttg
     1261 tctcgtcaga catgcgggaa tgggtggctc cggagaaggc agacatcatt gtcagtgaac
     1321 ttctgggctc ctttgccgac aatgagctgt cacctgagtg tctggatgga gcacagcact
     1381 tcctgaaaga tgatggtgta agcatccccg gagaatacac ctccttcctg gctcccattt
     1441 cttcctcgaa gttgtacaac gaggtccgcg cctgtcggga gaaggaccgt gaccctgagg
     1501 cacagtttga gatgccttat gtggttcggc tgcacaactt ccaccagctt tctgctcctc
     1561 agccctgttt taccttcagc catcccaacc gagatcctat gattgacaac aaccgctact
     1621 gtaccttgga gtttcctgtg gaggtgaaca cggtgcttca tggctttgca ggctactttg
     1681 aaactgtgct ttaccgggac atcactctga gtatccgccc agagacccac tctcctggca
     1741 tgttctcatg gttccccatc ttcttcccca tcaagcagcc catcacggtg catgaaggcc
     1801 agaacatctg tgtgcgtttc tggcgatgca gcaattctaa gaaggtgtgg tacgagtggg
     1861 cggtgacagc gccagtctgt tcttctattc acaaccctac tggtcgctcc tataccattg
     1921 gcctctagcc ctgcacacag cgtcagagcc ttggaagcag ctctgagttc tcttcctgta
     1981 gcacagaagg tgcagaacat ctactggttc agttcatctg tgagaccctc acctgccagc
     2041 gaggaacgat tcagtctgct tttctaccta tgtcatggtg gccagggggt aggcattcca
     2101 ggactgccaa gcatggtggt gcatactttt tatcccagca ctccagaggc agaggcaggt
     2161 gaatttcttt aagttcaagg ctagcctggt ctacccagca agtttcaggc cacctagggg
     2221 ctacatagtg agatcctgtc tccaaaaaag aaaaaaaaaa aaaaagaatt gcaggacaca
     2281 agccagcagc agttttcaga agcctctgtc gagggcacga ggactcagta gcactggagg
     2341 aagtggcatc ggcgggcgct caccctccag agcttcccag gggtcaggag aaaaggcaga
     2401 ggcttgtggg agagccccag gagtgtgcat gaacacttgc ggccttcccc tggccttact
     2461 ctgttgttgt ttggatgctt tgtgtcagaa ggaaacacaa ataaagagaa gttacggcct
     2521 ctgctgctct cccctgaaaa aaaaaaaaaa aaa
//
