LOCUS       NM_053557               2474 bp    mRNA    linear   ROD 31-JUL-2016
DEFINITION  Rattus norvegicus protein arginine methyltransferase 3 (Prmt3),
            mRNA.
ACCESSION   NM_053557
VERSION     NM_053557.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2474)
  AUTHORS   Huh KH, Cho Y, Kim BS, Joo DJ, Kim MS and Kim YS.
  TITLE     PRMT3: new binding molecule to RhoGDI-alpha during mycophenolic
            acid-induced beta-cell death
  JOURNAL   Transplant. Proc. 46 (4), 1229-1232 (2014)
   PUBMED   24815167
  REMARK    GeneRIF: Suggest that interaction between PRMT3 and RhoGDI-alpha
            mediates mycophenolic acid-induced pancreatic beta-cell death.
REFERENCE   2  (bases 1 to 2474)
  AUTHORS   Di Lorenzo A and Bedford MT.
  TITLE     Histone arginine methylation
  JOURNAL   FEBS Lett. 585 (13), 2024-2031 (2011)
   PUBMED   21074527
  REMARK    Review article
REFERENCE   3  (bases 1 to 2474)
  AUTHORS   Miyata S, Mori Y and Tohyama M.
  TITLE     PRMT3 is essential for dendritic spine maturation in rat
            hippocampal neurons
  JOURNAL   Brain Res. 1352, 11-20 (2010)
   PUBMED   20647003
  REMARK    GeneRIF: PRMT3 possibly plays a pivotal role in neuronal
            translation by contributing to activity-dependent changes in the
            dendritic spines.
REFERENCE   4  (bases 1 to 2474)
  AUTHORS   Sun QZ, Jiao FF, Yang XD, Zhong B, Jiang MH, Li GL, Lu B, Han Y,
            Ning QL, Zhang FJ, Sun J and Lu SM.
  TITLE     [Expression of protein arginine N-methyltransferases in E3 rat
            models of acute asthma]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 30 (4), 716-719 (2010)
   PUBMED   20423833
REFERENCE   5  (bases 1 to 2474)
  AUTHORS   Bedford MT and Richard S.
  TITLE     Arginine methylation an emerging regulator of protein function
  JOURNAL   Mol. Cell 18 (3), 263-272 (2005)
   PUBMED   15866169
  REMARK    Review article
REFERENCE   6  (bases 1 to 2474)
  AUTHORS   Frankel A and Clarke S.
  TITLE     PRMT3 is a distinct member of the protein arginine
            N-methyltransferase family. Conferral of substrate specificity by a
            zinc-finger domain
  JOURNAL   J. Biol. Chem. 275 (42), 32974-32982 (2000)
   PUBMED   10931850
REFERENCE   7  (bases 1 to 2474)
  AUTHORS   Zhang X, Zhou L and Cheng X.
  TITLE     Crystal structure of the conserved core of protein arginine
            methyltransferase PRMT3
  JOURNAL   EMBO J. 19 (14), 3509-3519 (2000)
   PUBMED   10899106
REFERENCE   8  (bases 1 to 2474)
  AUTHORS   Tang J, Gary JD, Clarke S and Herschman HR.
  TITLE     PRMT 3, a type I protein arginine N-methyltransferase that differs
            from PRMT1 in its oligomerization, subcellular localization,
            substrate specificity, and regulation
  JOURNAL   J. Biol. Chem. 273 (27), 16935-16945 (1998)
   PUBMED   9642256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF059530.1.
            
            [WARNING] On Jul 6, 2023 this sequence was replaced by NM_053557.2.
            
            Summary: catalyzes the asymmetric NG, NG-dimethylation of arginine
            residues [RGD, Feb 2006].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF059530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00052296, SAMD00052297
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2474              AF059530.1         1-2474
FEATURES             Location/Qualifiers
     source          1..2474
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..2474
                     /gene="Prmt3"
                     /gene_synonym="Hrmt1l3"
                     /note="protein arginine methyltransferase 3"
                     /db_xref="GeneID:89820"
                     /db_xref="RGD:620413"
     CDS             82..1668
                     /gene="Prmt3"
                     /gene_synonym="Hrmt1l3"
                     /note="heterogeneous nuclear ribonucleoprotein
                     methyltransferase-like protein 3; heterogeneous nuclear
                     ribonucleoprotein methyltransferase-like 3; protein
                     arginine N-methyltransferase 3(hnRNP methyltransferase S.
                     cerevisiae)-like 3"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 3"
                     /protein_id="NP_446009.1"
                     /db_xref="GeneID:89820"
                     /db_xref="RGD:620413"
                     /translation="MCSLAAGNGQGAELGPEPLELSDSGDDAGWEDEDADAEPAQGRQ
                     HTPCLFCDRLFRSAEETFSHCKLEHQFNIDGMVHKHGLEFYGYIKLINFIRLKNPTVE
                     YMNSIYNPVPWDKDEYLKPVLEDDLLLQFDVEDLYEPVSAPFTYPNGLSENTSAVEKL
                     KLMEARALSAEAALARAREDLQKMKQFAQDFVMNVDVRTCSSTTTIADLQEDEDGVYF
                     SSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAK
                     KVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMGYFLLF
                     ESMLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMK
                     KAVIPEAVVEVVDHKTLISDPCDIKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAG
                     YFDIYFEKNCHNRVVFSTGPQSTKTHWKQTIFLLEKPFPVKAGEALKGKITVHKNKKD
                     PRSLIVTLTLNSSTQTYSLQ"
ORIGIN      
        1 gttgctttgg ggctaccgcg cgcccgcgct cgttcccagc tccggtcccg cgctgtgcgg
       61 tcgcgcgctt ggtcggcggc catgtgttcg ctggcggcgg ggaacggaca aggcgcggag
      121 ctggggccgg agcccttgga gctgtcggac agcggagacg acgcgggctg ggaggacgag
      181 gacgcggacg ctgagcccgc acagggccgg cagcacacac cctgcctgtt ctgtgacagg
      241 ctcttcaggt ctgctgaaga aacgttttca cactgtaagt tggagcatca atttaatatt
      301 gatggtatgg tccacaaaca tggactggaa ttttatggat acattaaact aataaatttt
      361 attagactta agaatcctac tgttgagtac atgaattcca tatacaaccc tgtgccttgg
      421 gataaagatg agtacctgaa gccagtgttg gaagatgatc ttttgcttca gtttgatgta
      481 gaagatcttt atgagccagt gtctgctccc ttcacatacc ccaatggact cagcgaaaac
      541 acatctgctg ttgagaaatt gaagctcatg gaggcccggg cgctgtctgc tgaggcggct
      601 ctggctcggg cgcgtgagga tctgcagaag atgaaacaat ttgctcagga ctttgtgatg
      661 aacgtagatg tcagaacctg ctcctccacg actaccattg cagacctgca ggaggacgag
      721 gatggcgtct acttcagctc ctatgggcat tatgggatac atgaagaaat gctaaaggac
      781 aaagtgcgca cagaaagcta cagagatttc atataccaaa atccacacat cttcaaagat
      841 aaggttgttc tggatgttgg ctgtggaact ggaattctct ccatgtttgc tgccaaagct
      901 ggggcaaaga aggtgattgc agttgaccag tctgaaatcc tctaccaggc tatggatatc
      961 ataaggctaa ataaacttga agataccatt gtactaatta aaggaaagat cgaagaagtg
     1021 agtcttcctg tggaaaaggt ggatgttatt atatcagagt ggatgggcta ttttcttctt
     1081 tttgagtcga tgttggattc tgtcctttat gccaagagca aatacttggc aaaaggggga
     1141 tcggtctacc ctgacatttg caccatcagc cttgtggccg tgagtgacgt gagcaaacac
     1201 gccgatagaa ttgccttctg ggatgacgtc tatggcttca acatgtcctg catgaagaaa
     1261 gcagttatac cagaagctgt tgtggaagtt gtagatcaca agactctcat ttcagaccct
     1321 tgtgatatca agcatataga ttgccacacc acatctatct cagacttgga gttttcttca
     1381 gactttaccc tgagaaccac aaagacagcc atgtgcacgg cagttgctgg gtactttgat
     1441 atatattttg agaagaactg tcacaacagg gttgtattct ctactggccc ccagagcacc
     1501 aaaacacact ggaaacagac aatatttctt ctggaaaagc cttttcccgt taaagcaggt
     1561 gaagccttaa aaggaaagat cacagttcac aagaacaaga aggatcctcg ttccctcatt
     1621 gtgaccctga ccttgaacag ttcaacccag acttacagtc tccagtgaca gtcatggtct
     1681 ccagccgcca caaagtctga agcacaccca actgtctgtt aaagcgggat aaggcaatca
     1741 gcaggagggg caggctccac ggggctgtag catggctgct cctggtcctg cagctactgg
     1801 gtagtaagcc caaataaagc agagagctca gtggaggcct gtgccctcct tcctcctact
     1861 gcttctgctc ctagagatcc tagtcacaga agcctgcttg gccagattag ctgaagagac
     1921 ttcctctcct gctagactga gagtcatttg aattggctta cttttggaac agtaatagtc
     1981 ctggttttta aattatatat atgtttctta ctataaattt tgtttttaat aatgagcaac
     2041 acaaagcagt gttttactgt agatttcctt tctagaggaa cagtttttag ttacactctt
     2101 tgctgcaata tcaggatatc ttaagactag ggagccagtg gatgggacac agcagcgtct
     2161 ctcacacatt ctgtttgcag gggctgtgct gcggtcctct ccacccacct gcagctcagc
     2221 tgtacccctc agtgttctcc agccatagcc tagcaatgtg gggaagtcta acttcagtgc
     2281 acagcctagg tgtgacagac tactcttcag gctgggatag aggtatctaa aatgctgcct
     2341 ttacagacca ggtttgtgcc aaggccatgt atccatctgc tagtactgta aaatcatgat
     2401 attcaggttg aaaaaatgaa aaatatccaa taaaatgtgt aactattgaa ataaaaaaaa
     2461 aaaaaaaaaa aaaa
//
