LOCUS       NM_001025144            2014 bp    mRNA    linear   ROD 11-JUN-2024
DEFINITION  Rattus norvegicus protein arginine methyltransferase 2 (Prmt2),
            mRNA.
ACCESSION   NM_001025144 XM_574738
VERSION     NM_001025144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2014)
  AUTHORS   Liu,S., Zhang,B., Guo,H., Ding,Z., Hou,W., Hu,X., Wang,Y., Tan,W.
            and Zhou,S.
  TITLE     The antidepressant effects of protein arginine methyltransferase 2
            involve neuroinflammation
  JOURNAL   Neurochem Int 176, 105728 (2024)
   PUBMED   38561150
  REMARK    GeneRIF: The antidepressant effects of protein arginine
            methyltransferase 2 involve neuroinflammation.
REFERENCE   2  (bases 1 to 2014)
  AUTHORS   Gayatri,S. and Bedford,M.T.
  TITLE     Readers of histone methylarginine marks
  JOURNAL   Biochim Biophys Acta 1839 (8), 702-710 (2014)
   PUBMED   24583552
  REMARK    Review article
REFERENCE   3  (bases 1 to 2014)
  AUTHORS   Di Lorenzo,A. and Bedford,M.T.
  TITLE     Histone arginine methylation
  JOURNAL   FEBS Lett 585 (13), 2024-2031 (2011)
   PUBMED   21074527
  REMARK    Review article
REFERENCE   4  (bases 1 to 2014)
  AUTHORS   Iwasaki,H., Kovacic,J.C., Olive,M., Beers,J.K., Yoshimoto,T.,
            Crook,M.F., Tonelli,L.H. and Nabel,E.G.
  TITLE     Disruption of protein arginine N-methyltransferase 2 regulates
            leptin signaling and produces leanness in vivo through loss of
            STAT3 methylation
  JOURNAL   Circ Res 107 (8), 992-1001 (2010)
   PUBMED   20798359
REFERENCE   5  (bases 1 to 2014)
  AUTHORS   Blythe,S.A., Cha,S.W., Tadjuidje,E., Heasman,J. and Klein,P.S.
  TITLE     beta-Catenin primes organizer gene expression by recruiting a
            histone H3 arginine 8 methyltransferase, Prmt2
  JOURNAL   Dev Cell 19 (2), 220-231 (2010)
   PUBMED   20708585
REFERENCE   6  (bases 1 to 2014)
  AUTHORS   Yildirim,A.O., Bulau,P., Zakrzewicz,D., Kitowska,K.E.,
            Weissmann,N., Grimminger,F., Morty,R.E. and Eickelberg,O.
  TITLE     Increased protein arginine methylation in chronic hypoxia: role of
            protein arginine methyltransferases
  JOURNAL   Am J Respir Cell Mol Biol 35 (4), 436-443 (2006)
   PUBMED   16690984
REFERENCE   7  (bases 1 to 2014)
  AUTHORS   Yoshimoto,T., Boehm,M., Olive,M., Crook,M.F., San,H.,
            Langenickel,T. and Nabel,E.G.
  TITLE     The arginine methyltransferase PRMT2 binds RB and regulates E2F
            function
  JOURNAL   Exp Cell Res 312 (11), 2040-2053 (2006)
   PUBMED   16616919
REFERENCE   8  (bases 1 to 2014)
  AUTHORS   Ganesh,L., Yoshimoto,T., Moorthy,N.C., Akahata,W., Boehm,M.,
            Nabel,E.G. and Nabel,G.J.
  TITLE     Protein methyltransferase 2 inhibits NF-kappaB function and
            promotes apoptosis
  JOURNAL   Mol Cell Biol 26 (10), 3864-3874 (2006)
   PUBMED   16648481
REFERENCE   9  (bases 1 to 2014)
  AUTHORS   Qi,C., Chang,J., Zhu,Y., Yeldandi,A.V., Rao,S.M. and Zhu,Y.J.
  TITLE     Identification of protein arginine methyltransferase 2 as a
            coactivator for estrogen receptor alpha
  JOURNAL   J Biol Chem 277 (32), 28624-28630 (2002)
   PUBMED   12039952
REFERENCE   10 (bases 1 to 2014)
  AUTHORS   Kzhyshkowska,J., Schutt,H., Liss,M., Kremmer,E., Stauber,R.,
            Wolf,H. and Dobner,T.
  TITLE     Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in
            its Arg-Gly-Gly (RGG) box and interacts with human arginine
            methyltransferase HRMT1L1
  JOURNAL   Biochem J 358 (Pt 2), 305-314 (2001)
   PUBMED   11513728
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079112.1.
            
            On Jul 1, 2005 this sequence version replaced XM_574738.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079112.1, SRR8487231.110690.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2014
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2014
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /note="protein arginine methyltransferase 2"
                     /db_xref="GeneID:499420"
                     /db_xref="RGD:1565519"
     exon            1..49
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..158
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1442
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /EC_number="2.1.1.125"
                     /note="HMT1 hnRNP methyltransferase-like 1"
                     /codon_start=1
                     /product="protein arginine N-methyltransferase 2"
                     /protein_id="NP_001020315.1"
                     /db_xref="GeneID:499420"
                     /db_xref="RGD:1565519"
                     /translation="MEAPAEDPSHESQVTPAPEEDPVDYGCEMQLLQDGAQLQLQLQP
                     EEFVAIADYTATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHLGKQVEE
                     YDPEDTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVILQNKESLKDKVILDVGCGT
                     GIISLFCAHHARPKAVYAVEASDMAQHTGQLVLQNGFADTITVFQQKVEDVVLPEKVD
                     VLVSEWMGTCLLFEFMIESILYARDAWLKEDGIIWPTTAALHLVPCSAEKDYHSKVLF
                     WDNAYEFNLSALKSLAIKEFFSRPKSNHILKPEDCLSEPCTILQLDMRTVQVSDLETM
                     RGELRFDIQKAGTLHGFTAWFSVHFQSLEEGQPQQVLSTGPLHPTTHWKQTLFMMDDP
                     VPVHTGDVVTGSVVLQRNPVWRRHMSVCLSWVVTSAVDPTSQRAGEKVFPIWR"
     exon            159..284
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..467
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            468..629
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..794
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..970
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1100
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1237
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1409
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1981
                     /gene="Prmt2"
                     /gene_synonym="Hrmt1l1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgttccttt ctgggctagc ctagaattca gcggagaaac gcggctgaga cgtgatgaga
       61 agatgaagtg aggcaccagt tatgagacat gagcttactg aactatggag gcaccagctg
      121 aagatcccag ccatgagtca caggtcaccc cagctccgga ggaagaccct gtggactatg
      181 gctgtgagat gcagctcctt caggacgggg cacagttgca gctgcagctg cagcccgagg
      241 agttcgtagc cattgcagat tacaccgcca ccgacgagac acagctcagc tttctgagag
      301 gagaaaaaat tctgatcctg aggcaaacca cggcggactg gtggtggggc gaacgtgcgg
      361 gctgctgcgg gtacatcccc gcaaaccacc ttgggaagca ggtggaggag tacgacccgg
      421 aggacacctg gcaagatgag gagtacttcg acagctatgg gactctgaaa cttcacctgg
      481 aaatgttggc tgaccagcct cggacaacca agtaccacag tgtcatcctg cagaacaagg
      541 agtctctgaa ggacaaggtc atactggatg tgggctgcgg caccggcatc atcagccttt
      601 tctgcgctca tcatgcccgg cccaaggcag tgtacgcggt agaagccagt gacatggccc
      661 agcacacggg ccagctggtc ctgcagaatg gctttgctga cacaatcact gtgtttcagc
      721 agaaggtgga ggacgtggtg ttgcccgaga aggtggacgt gctggtgtcg gagtggatgg
      781 ggacctgtct cttgtttgag ttcatgatcg agtccatcct gtacgcccgg gatgcctggt
      841 taaaggaaga tggcatcatt tggccaacca cggcggcact gcacttggta ccctgcagcg
      901 ctgagaaaga ctaccacagc aaggtgctct tctgggacaa cgcgtacgag ttcaacctca
      961 gtgcactcaa gtcgttagca atcaaggagt tcttttcaag gccaaagtct aatcatatct
     1021 tgaagccaga agactgcctc tctgagccat gcacaatatt gcagttggac atgagaactg
     1081 tgcaggtctc tgacctggag accatgcgtg gcgagctgcg atttgacatc caaaaggctg
     1141 ggaccctgca tggcttcaca gcttggttca gtgtacattt ccagagcctg gaggagggcc
     1201 agcctcagca ggttctcagc acaggaccgc tgcaccccac cacacactgg aagcagacct
     1261 tgtttatgat ggacgaccca gtcccagtcc acacaggaga cgtggtcacg ggttcggtgg
     1321 tgttacagag aaatccggtg tggagaaggc acatgtccgt ctgtctgagc tgggtcgtca
     1381 cttccgcagt tgatcccacg tctcaaaggg ctggagagaa agtctttccg atctggaggt
     1441 gacggttaag caccgcgtgg gagtcacggc cgtggtgtgc atcttggtgg aagaagatgc
     1501 gtctggccac cttctgtgac gtacacactc acccgtccca tgctgacccc ttcccaccca
     1561 gcaggtgaca tcgggcccct cacagctcac cccccaaccc ccagtgtcat ttctcccgta
     1621 ggctgtgtat atatataggt gttcatcctg tggtgcccgt cgctgccagc cgtgttccca
     1681 gccgggagta gttgtagatc cctcagacac acatttcagc ctgtgtacct gtgactgtga
     1741 tgtccacacc ttgtgtcagt ggtgtccttg atgccctcga ccagctgctg cacctgtgga
     1801 ctgtggcttg ccgagccgtg ctccggtatg agagatggcc gagcacccgt gtctcggggc
     1861 aaggactgga ggtggcagcg tgcgcagtgg gctctgcatg ggtagccgcg tgtaacgtct
     1921 tatgggtaaa ttatatgtgg ggcatagtac atgctcaata aatatttttt aatgaacaaa
     1981 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
