LOCUS       NM_012873                620 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protamine 2 (Prm2), mRNA.
ACCESSION   NM_012873
VERSION     NM_012873.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 620)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   2  (bases 1 to 620)
  AUTHORS   Govin,J., Escoffier,E., Rousseaux,S., Kuhn,L., Ferro,M.,
            Thevenon,J., Catena,R., Davidson,I., Garin,J., Khochbin,S. and
            Caron,C.
  TITLE     Pericentric heterochromatin reprogramming by new histone variants
            during mouse spermiogenesis
  JOURNAL   J Cell Biol 176 (3), 283-294 (2007)
   PUBMED   17261847
REFERENCE   3  (bases 1 to 620)
  AUTHORS   Xing,W., Krishnamurthy,H. and Sairam,M.R.
  TITLE     Role of follitropin receptor signaling in nuclear protein
            transitions and chromatin condensation during spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 312 (3), 697-701 (2003)
   PUBMED   14680821
REFERENCE   4  (bases 1 to 620)
  AUTHORS   Cho,C., Jung-Ha,H., Willis,W.D., Goulding,E.H., Stein,P., Xu,Z.,
            Schultz,R.M., Hecht,N.B. and Eddy,E.M.
  TITLE     Protamine 2 deficiency leads to sperm DNA damage and embryo death
            in mice
  JOURNAL   Biol Reprod 69 (1), 211-217 (2003)
   PUBMED   12620939
REFERENCE   5  (bases 1 to 620)
  AUTHORS   Cho,C., Willis,W.D., Goulding,E.H., Jung-Ha,H., Choi,Y.C.,
            Hecht,N.B. and Eddy,E.M.
  TITLE     Haploinsufficiency of protamine-1 or -2 causes infertility in mice
  JOURNAL   Nat Genet 28 (1), 82-86 (2001)
   PUBMED   11326282
REFERENCE   6  (bases 1 to 620)
  AUTHORS   Schluter,G., Celik,A., Obata,R., Schlicker,M., Hofferbert,S.,
            Schlung,A., Adham,I.M. and Engel,W.
  TITLE     Sequence analysis of the conserved protamine gene cluster shows
            that it contains a fourth expressed gene
  JOURNAL   Mol Reprod Dev 43 (1), 1-6 (1996)
   PUBMED   8720108
REFERENCE   7  (bases 1 to 620)
  AUTHORS   Green,G.R., Balhorn,R., Poccia,D.L. and Hecht,N.B.
  TITLE     Synthesis and processing of mammalian protamines and transition
            proteins
  JOURNAL   Mol Reprod Dev 37 (3), 255-263 (1994)
   PUBMED   8185929
REFERENCE   8  (bases 1 to 620)
  AUTHORS   Keime,S., Heitland,K., Kumm,S., Schlosser,M., Hroch,N., Holtz,W.
            and Engel,W.
  TITLE     Characterization of four genes encoding basic proteins of the
            porcine spermatid nucleus and close linkage of three of them
  JOURNAL   Biol Chem Hoppe Seyler 373 (5), 261-270 (1992)
   PUBMED   1627265
REFERENCE   9  (bases 1 to 620)
  AUTHORS   Gatewood,J.M., Schroth,G.P., Schmid,C.W. and Bradbury,E.M.
  TITLE     Zinc-induced secondary structure transitions in human sperm
            protamines
  JOURNAL   J Biol Chem 265 (33), 20667-20672 (1990)
   PUBMED   2243113
REFERENCE   10 (bases 1 to 620)
  AUTHORS   Tanhauser,S.M. and Hecht,N.B.
  TITLE     Nucleotide sequence of the rat protamine 2 gene
  JOURNAL   Nucleic Acids Res 17 (11), 4395 (1989)
   PUBMED   2740236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 24, 2022 this sequence version replaced NM_012873.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF404984.1, BF412942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               JAXUCZ010000010.1  5383208-5383570
            364-620             JAXUCZ010000010.1  5383693-5383949
FEATURES             Location/Qualifiers
     source          1..620
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..620
                     /gene="Prm2"
                     /gene_synonym="PROTA2"
                     /note="protamine 2"
                     /db_xref="GeneID:25345"
                     /db_xref="RGD:3409"
     exon            1..363
                     /gene="Prm2"
                     /gene_synonym="PROTA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..428
                     /gene="Prm2"
                     /gene_synonym="PROTA2"
                     /note="sperm histone P2; sperm protamine P2"
                     /codon_start=1
                     /product="protamine-2"
                     /protein_id="NP_037005.1"
                     /db_xref="GeneID:25345"
                     /db_xref="RGD:3409"
                     /translation="MVRYRMRSPSEGQHQGPGQDHEREEQGQGQELSPERVEDYGRTE
                     RGHHHRHRRCKRLHRIHKRRRSCRRRRRHSCRHRRRHRRGCRRSRRRRSCRCRKCRWH
                     YY"
     exon            364..620
                     /gene="Prm2"
                     /gene_synonym="PROTA2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacacacca gaccatcatc accaccaaga gcaggtgggc aggctaccgt ccctcctctt
       61 ccaatccagg tcagctgcag cctcaaccca gaacctcctg acctcctggc actatggttc
      121 gctaccgaat gaggagcccc agtgagggtc agcaccaggg gcctgggcaa gaccatgagc
      181 gcgaggagca ggggcagggg caagagctga gcccagagcg cgtggaggac tatgggagga
      241 cagaaagggg ccaccaccac agacacaggc gctgcaagag gcttcacagg atccacaaga
      301 ggcgccggtc atgcagaagg cggaggagac actcctgccg ccacaggagg cggcatcgca
      361 gaggctgcag aagatcccga aggaggagga gctgcaggtg caggaaatgc aggtggcact
      421 attattaagc ctccccaggt cgatccattc tgcctggagc taaggaagtc acctgcctca
      481 ggaagtcacc tgcccaagca aagtcatgta aggccacaac accattccat gttgatatct
      541 gagccctgag ctgccaagga gccacgaaat ctaagtaatg agcaaagcca cctgctaaat
      601 aaagcttgtc atgagattaa
//
