LOCUS       NM_001002850             405 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protamine 1 (Prm1), mRNA.
ACCESSION   NM_001002850
VERSION     NM_001002850.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 405)
  AUTHORS   Xing,W., Krishnamurthy,H. and Sairam,M.R.
  TITLE     Role of follitropin receptor signaling in nuclear protein
            transitions and chromatin condensation during spermatogenesis
  JOURNAL   Biochem Biophys Res Commun 312 (3), 697-701 (2003)
   PUBMED   14680821
REFERENCE   2  (bases 1 to 405)
  AUTHORS   Cho,C., Willis,W.D., Goulding,E.H., Jung-Ha,H., Choi,Y.C.,
            Hecht,N.B. and Eddy,E.M.
  TITLE     Haploinsufficiency of protamine-1 or -2 causes infertility in mice
  JOURNAL   Nat Genet 28 (1), 82-86 (2001)
   PUBMED   11326282
REFERENCE   3  (bases 1 to 405)
  AUTHORS   Zhong,J., Peters,A.H., Lee,K. and Braun,R.E.
  TITLE     A double-stranded RNA binding protein required for activation of
            repressed messages in mammalian germ cells
  JOURNAL   Nat Genet 22 (2), 171-174 (1999)
   PUBMED   10369260
REFERENCE   4  (bases 1 to 405)
  AUTHORS   Schluter,G., Celik,A., Obata,R., Schlicker,M., Hofferbert,S.,
            Schlung,A., Adham,I.M. and Engel,W.
  TITLE     Sequence analysis of the conserved protamine gene cluster shows
            that it contains a fourth expressed gene
  JOURNAL   Mol Reprod Dev 43 (1), 1-6 (1996)
   PUBMED   8720108
REFERENCE   5  (bases 1 to 405)
  AUTHORS   Lee,K., Haugen,H.S., Clegg,C.H. and Braun,R.E.
  TITLE     Premature translation of protamine 1 mRNA causes precocious nuclear
            condensation and arrests spermatid differentiation in mice
  JOURNAL   Proc Natl Acad Sci U S A 92 (26), 12451-12455 (1995)
   PUBMED   8618919
REFERENCE   6  (bases 1 to 405)
  AUTHORS   Green,G.R., Balhorn,R., Poccia,D.L. and Hecht,N.B.
  TITLE     Synthesis and processing of mammalian protamines and transition
            proteins
  JOURNAL   Mol Reprod Dev 37 (3), 255-263 (1994)
   PUBMED   8185929
REFERENCE   7  (bases 1 to 405)
  AUTHORS   Keime,S., Heitland,K., Kumm,S., Schlosser,M., Hroch,N., Holtz,W.
            and Engel,W.
  TITLE     Characterization of four genes encoding basic proteins of the
            porcine spermatid nucleus and close linkage of three of them
  JOURNAL   Biol Chem Hoppe Seyler 373 (5), 261-270 (1992)
   PUBMED   1627265
REFERENCE   8  (bases 1 to 405)
  AUTHORS   Klemm,U., Lee,C.H., Burfeind,P., Hake,S. and Engel,W.
  TITLE     Nucleotide sequence of a cDNA encoding rat protamine and the
            haploid expression of the gene during rat spermatogenesis
  JOURNAL   Biol Chem Hoppe Seyler 370 (4), 293-301 (1989)
   PUBMED   2757789
REFERENCE   9  (bases 1 to 405)
  AUTHORS   Ammer,H. and Henschen,A.
  TITLE     Rat sperm protamine. Isolation and sequence analysis
  JOURNAL   Biol Chem Hoppe Seyler 369 (12), 1301-1306 (1988)
   PUBMED   3072011
REFERENCE   10 (bases 1 to 405)
  AUTHORS   Kistler,W.S., Keim,P.S. and Heinrikson,R.L.
  TITLE     Partial structural analysis of the basic chromosomal protein of rat
            spermatozoa
  JOURNAL   Biochim Biophys Acta 427 (2), 752-757 (1976)
   PUBMED   1268226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 24, 2022 this sequence version replaced NM_001002850.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126070.1, CB744388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               JAXUCZ010000010.1  5378740-5378937
            199-405             JAXUCZ010000010.1  5379029-5379235
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..405
                     /gene="Prm1"
                     /note="protamine 1"
                     /db_xref="GeneID:24685"
                     /db_xref="RGD:1583873"
     exon            1..198
                     /gene="Prm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..248
                     /gene="Prm1"
                     /note="cysteine-rich protamine; protamine P1"
                     /codon_start=1
                     /product="sperm protamine P1"
                     /protein_id="NP_001002850.1"
                     /db_xref="GeneID:24685"
                     /db_xref="RGD:1583873"
                     /translation="MARYRCCRSKSRSRCRRRRRRCRRRRRRCCRRRRRRCCRRRRSY
                     TFRCKRY"
     exon            199..405
                     /gene="Prm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcccaca aaattccacc tgctcacagg ttggctggct cgacccaggt ggtgccccct
       61 gctctgagcc agctcccggc caagctagca ccatggccag ataccgatgc tgccgcagca
      121 aaagcaggag cagatgccgc cgccgcaggc gaagatgtcg cagacggagg aggcggtgct
      181 gcaggcggag gcggcgaagg tgctgccgcc gccgccgctc atacaccttt aggtgtaaaa
      241 gatactagat gcacagatag caagtccacc aaaactcctg cctgagaatt ttaccagact
      301 tcaagagcat ctcgccacat cttgaaaaat gccaccgtcc gatggaaaac aggagcctgc
      361 taaggaacaa tgccacctgt caataaatgt tgaaaactca tccca
//
