LOCUS       NM_001034111            2132 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus prolactin receptor (Prlr), transcript variant 1,
            mRNA.
ACCESSION   NM_001034111
VERSION     NM_001034111.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2132)
  AUTHORS   Ortiz-Perez,A., Limon-Morales,O., Rojas-Castaneda,J.C., Cerbon,M.
            and Picazo,O.
  TITLE     Prolactin prevents the kainic acid-induced neuronal loss in the rat
            hippocampus by inducing prolactin receptor and putatively
            increasing the VGLUT1 overexpression
  JOURNAL   Neurosci Lett 694, 116-123 (2019)
   PUBMED   30500398
  REMARK    GeneRIF: Study indicates that chronic prolactin administration
            before kainic acid induced damage induces hippocampal
            neuroprotection associated with prolactin receptor and VGLUT1
            overexpression.
REFERENCE   2  (bases 1 to 2132)
  AUTHORS   Vergara-Castaneda,E., Grattan,D.R., Pasantes-Morales,H.,
            Perez-Dominguez,M., Cabrera-Reyes,E.A., Morales,T. and Cerbon,M.
  TITLE     Prolactin mediates neuroprotection against excitotoxicity in
            primary cell cultures of hippocampal neurons via its receptor
  JOURNAL   Brain Res 1636, 193-199 (2016)
   PUBMED   26874070
  REMARK    GeneRIF: This study demonstrated that the Cultured neurons
            expressed mRNA for both PRL and its receptor (PRLR), and both PRL
            and PRLR expression levels changed after the excitotoxic insult.
REFERENCE   3  (bases 1 to 2132)
  AUTHORS   Rojas-Duran,F., Pascual-Mathey,L.I., Serrano,K., Aranda-Abreu,G.E.,
            Manzo,J., Soto-Cid,A.H. and Hernandez,M.E.
  TITLE     Correlation of prolactin levels and PRL-receptor expression with
            Stat and Mapk cell signaling in the prostate of long-term sexually
            active rats
  JOURNAL   Physiol Behav 138, 188-192 (2015)
   PUBMED   25446202
  REMARK    GeneRIF: Results showed that an active sexual life, with constant
            execution of sexual behavior, produces a sustained increase in
            serum PRL, prostate PRL receptors, and the pStat3 signaling pathway
REFERENCE   4  (bases 1 to 2132)
  AUTHORS   Arumugam,R., Fleenor,D. and Freemark,M.
  TITLE     Knockdown of prolactin receptors in a pancreatic beta cell line:
            effects on DNA synthesis, apoptosis, and gene expression
  JOURNAL   Endocrine 46 (3), 568-576 (2014)
   PUBMED   24114406
  REMARK    GeneRIF: PRLR signaling is required for DNA synthesis and survival
            of rat insulinoma cells
REFERENCE   5  (bases 1 to 2132)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   6  (bases 1 to 2132)
  AUTHORS   Ali,S., Pellegrini,I. and Kelly,P.A.
  TITLE     A prolactin-dependent immune cell line (Nb2) expresses a mutant
            form of prolactin receptor
  JOURNAL   J Biol Chem 266 (30), 20110-20117 (1991)
   PUBMED   1718958
REFERENCE   7  (bases 1 to 2132)
  AUTHORS   Shirota,M., Banville,D., Ali,S., Jolicoeur,C., Boutin,J.M.,
            Edery,M., Djiane,J. and Kelly,P.A.
  TITLE     Expression of two forms of prolactin receptor in rat ovary and
            liver
  JOURNAL   Mol Endocrinol 4 (8), 1136-1143 (1990)
   PUBMED   2293022
REFERENCE   8  (bases 1 to 2132)
  AUTHORS   Zhang,R., Buczko,E., Tsai-Morris,C.H., Hu,Z.Z. and Dufau,M.L.
  TITLE     Isolation and characterization of two novel rat ovarian lactogen
            receptor cDNA species
  JOURNAL   Biochem Biophys Res Commun 168 (2), 415-422 (1990)
   PUBMED   2159291
REFERENCE   9  (bases 1 to 2132)
  AUTHORS   Boutin,J.M., Jolicoeur,C., Okamura,H., Gagnon,J., Edery,M.,
            Shirota,M., Banville,D., Dusanter-Fourt,I., Djiane,J. and
            Kelly,P.A.
  TITLE     Cloning and expression of the rat prolactin receptor, a member of
            the growth hormone/prolactin receptor gene family
  JOURNAL   Cell 53 (1), 69-77 (1988)
   PUBMED   2832068
REFERENCE   10 (bases 1 to 2132)
  AUTHORS   Herington,A.C., Harrison,D. and Graystone,J.
  TITLE     Hepatic binding of human and bovine growth hormones and ovine
            prolactin in the dwarf 'little' mouse
  JOURNAL   Endocrinology 112 (6), 2032-2038 (1983)
   PUBMED   6303755
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M57668.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M57668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2132
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..2132
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="prolactin receptor"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
     exon            1..118
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            119..141
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            142..251
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..2029
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; PRL-R; lactogen receptor"
                     /codon_start=1
                     /product="prolactin receptor isoform a precursor"
                     /protein_id="NP_001029283.1"
                     /db_xref="GeneID:24684"
                     /db_xref="RGD:3407"
                     /translation="MPSALAFVLLVLNISLLKGQSPPGKPEIHKCRSPDKETFTCWWN
                     PGTDGGLPTNYSLTYSKEGEKTTYECPDYKTSGPNSCFFSKQYTSIWKIYIITVNATN
                     QMGSSSSDPLYVDVTYIVEPEPPRNLTLEVKQLKDKKTYLWVKWSPPTITDVKTGWFT
                     MEYEIRLKPEEAEEWEIHFTGHQTQFKVFDLYPGQKYLVQTRCKPDHGYWSRWSQESS
                     VEMPNDFTLKDTTVWIIVAILSAVICLIMVWAVALKGYSMMTCIFPPVPGPKIKGFDT
                     HLLEKGKSEELLSALGCQDFPPTSDCEDLLVEFLEVDDNEDERLMPSHSKEYPGQGVK
                     PTHLDPDSDSGHGSYDSHSLLSEKCEEPQAYPPTLHIPEITEKPENPEANIPPTVDPQ
                     STNPNFHVDAPKSSTWPLLPGQHMPRSPYHSVADVCKLAGSPVNTLDSFLDKAEENVL
                     KLSKALETGEEEVAKQKGAKSFPSDKQNTPWPLLQEKSPTVYVKPPDYVEIHKVNKDG
                     VLSLFPKQRENNQTEKPGVPETSKEYAKVSGIMDNNILVLVPDSRAQNTALLEESAKK
                     APPSFEADQSEKDLASFTATSSNRRLQLGRLDYLDPTCFMHSFH"
     exon            252..384
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            385..554
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            555..724
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            725..866
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            867..966
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1036
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..2132
                     /gene="Prlr"
                     /gene_synonym="RATPRLR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcgttctg gattttacac ggggctcagg aaacagcttt acctgtcaga gacagagctc
       61 acgtcctttg caggaagtgc acagcctctg gtatggcaga cttttctctc cagcagaact
      121 aaaggacact tctctgtgaa gggagcctct gatacattgc ctatagcaag aagaaggggc
      181 caacctgaag aaaaacatgc catctgcact tgctttcgtc ctacttgttc tcaacatcag
      241 cctcctgaag ggacagtcac caccagggaa acctgagatc cacaaatgtc gctctcctga
      301 caaggaaaca ttcacctgct ggtggaatcc tgggacagat ggaggacttc ctaccaatta
      361 ttcactgact tacagcaaag aaggagagaa aaccacctac gaatgtccag actacaaaac
      421 cagtggcccc aactcctgct tctttagcaa gcagtacact tccatctgga aaatatatat
      481 catcacagta aatgccacga accaaatggg aagcagttcc tcggatccac tttatgtgga
      541 tgtgacttac atcgttgagc cagagcctcc tcggaacctg acattagaag taaaacagct
      601 aaaagacaaa aaaacatatc tgtgggtaaa atggtcccca cccaccataa ctgatgtgaa
      661 aactggttgg tttacaatgg aatatgaaat tcgattaaag cctgaagaag cagaagagtg
      721 ggagatccat tttacaggtc atcaaacaca gtttaaagtt tttgacctat atccagggca
      781 aaagtatctt gtccagactc gctgcaagcc agaccatgga tactggagta gatggagcca
      841 ggagagttcc gttgaaatgc caaatgactt caccttgaag gacacaaccg tgtggatcat
      901 tgtggccatt ctctctgctg tcatctgttt gattatggtc tgggcagtgg ctttgaaggg
      961 ctatagcatg atgacctgca tctttccacc agttcctggg ccaaaaataa aaggatttga
     1021 tacccatctg ctggagaagg gcaagtctga agagctgctg agtgccttgg ggtgccaaga
     1081 ctttccccct acttctgact gtgaggactt gctggtggag ttcttagaag ttgatgacaa
     1141 tgaggacgag cggctaatgc catcccattc caaagagtat ccaggtcaag gtgttaagcc
     1201 cacacaccta gatcccgaca gtgactctgg tcacggaagc tatgacagcc attctctttt
     1261 atctgaaaag tgtgaggaac cccaggccta cccccctact ttgcacatcc ctgagatcac
     1321 tgagaagcca gagaatcctg aagcaaatat tcctcccacc gtggaccccc aaagcaccaa
     1381 ccccaatttt catgtagatg cacccaaatc ttcaacatgg ccattactgc ctggccaaca
     1441 catgcccaga tctccttacc acagtgttgc tgatgtgtgc aagctagccg gaagtcctgt
     1501 gaatacactg gactctttct tggacaaagc agaggaaaat gttctaaagt tgtctaaagc
     1561 ccttgagact ggagaggaag aagtggctaa gcaaaaaggg gcaaaaagct tcccttctga
     1621 caaacaaaac acaccttggc cgctgctcca ggagaaaagc cccactgtct atgttaaacc
     1681 cccagattat gtggagattc acaaagtcaa caaagatgga gtgctatcat tattccccaa
     1741 gcagagagaa aacaaccaga cagagaagcc tggggttcct gaaaccagta aggagtatgc
     1801 caaggtgtct ggcattatgg ataacaatat cctcgtatta gtgccagact cacgagccca
     1861 gaacacagcg ttgctcgagg aatcagccaa gaaggctcca ccatcgtttg aagctgacca
     1921 atctgagaaa gatctggcca gcttcactgc aacctcaagc aaccgcagac tccaactggg
     1981 taggctggat tacctggatc ctacgtgctt catgcactcc tttcactgat agctagactt
     2041 atggaacgat tggctaaact gtgatttctc ttcaggtaac actacagagt catgaagtaa
     2101 tgtggtctgc tagcaaatgt tacaggatgt gg
//
