LOCUS       NM_139193               1462 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus prolactin releasing hormone receptor (Prlhr),
            mRNA.
ACCESSION   NM_139193
VERSION     NM_139193.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1462)
  AUTHORS   Keele,G.R., Prokop,J.W., He,H., Holl,K., Littrell,J., Deal,A.,
            Francic,S., Cui,L., Gatti,D.M., Broman,K.W., Tschannen,M.,
            Tsaih,S.W., Zagloul,M., Kim,Y., Baur,B., Fox,J., Robinson,M.,
            Levy,S., Flister,M.J., Mott,R., Valdar,W. and Solberg Woods,L.C.
  TITLE     Genetic Fine-Mapping and Identification of Candidate Genes and
            Variants for Adiposity Traits in Outbred Rats
  JOURNAL   Obesity (Silver Spring) 26 (1), 213-222 (2018)
   PUBMED   29193816
REFERENCE   2  (bases 1 to 1462)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   3  (bases 1 to 1462)
  AUTHORS   Sun,B., Mochiduki,A., Nakamura,K., Yokoyama,K., Adachi,S.,
            Fujiwara,K., Matsumoto,H. and Inoue,K.
  TITLE     Blockade of PrRP attenuates MPTP-induced toxicity in mice
  JOURNAL   Peptides 30 (7), 1267-1275 (2009)
   PUBMED   19540425
  REMARK    GeneRIF: Data report that PrRP and its receptor, GPR10, were found
            in the mouse substantia nigra pars compacta (SNpc), the main
            location of dopaminergic (DA) neurons of the nigrostriatal system.
REFERENCE   4  (bases 1 to 1462)
  AUTHORS   Watanabe,T.K., Suzuki,M., Yamasaki,Y., Okuno,S., Hishigaki,H.,
            Ono,T., Oga,K., Mizoguchi-Miyakita,A., Tsuji,A., Kanemoto,N.,
            Wakitani,S., Takagi,T., Nakamura,Y. and Tanigami,A.
  TITLE     Mutated G-protein-coupled receptor GPR10 is responsible for the
            hyperphagia/dyslipidaemia/obesity locus of Dmo1 in the OLETF rat
  JOURNAL   Clin Exp Pharmacol Physiol 32 (5-6), 355-366 (2005)
   PUBMED   15854142
  REMARK    GeneRIF: the mutated GPR10 receptor is responsible for the
            hyperphagia leading to obesity and dyslipidemia in the obese
            diabetic OLETF strain rat.
REFERENCE   5  (bases 1 to 1462)
  AUTHORS   Ellacott,K.L., Donald,E.L., Clarkson,P., Morten,J., Masters,D.,
            Brennand,J. and Luckman,S.M.
  TITLE     Characterization of a naturally-occurring polymorphism in the UHR-1
            gene encoding the putative rat prolactin-releasing peptide receptor
  JOURNAL   Peptides 26 (4), 675-681 (2005)
   PUBMED   15752583
  REMARK    GeneRIF: naturally occurring polymorphism in the UHR-1 gene that
            results in an ATG to ATA change at the putative translational
            initiation site.
REFERENCE   6  (bases 1 to 1462)
  AUTHORS   Franks,P.W., Bhattacharyya,S., Luan,J., Montague,C., Brennand,J.,
            Challis,B., Brage,S., Ekelund,U., Middelberg,R.P., O'Rahilly,S. and
            Wareham,N.J.
  TITLE     Association between physical activity and blood pressure is
            modified by variants in the G-protein coupled receptor 10
  JOURNAL   Hypertension 43 (2), 224-228 (2004)
   PUBMED   14691196
REFERENCE   7  (bases 1 to 1462)
  AUTHORS   Gu,W., Geddes,B.J., Zhang,C., Foley,K.P. and Stricker-Krongrad,A.
  TITLE     The prolactin-releasing peptide receptor (GPR10) regulates body
            weight homeostasis in mice
  JOURNAL   J Mol Neurosci 22 (1-2), 93-103 (2004)
   PUBMED   14742914
REFERENCE   8  (bases 1 to 1462)
  AUTHORS   Nieminen,M.L., Nystedt,J. and Panula,P.
  TITLE     Expression of neuropeptide FF, prolactin-releasing peptide, and the
            receptor UHR1/GPR10 genes during embryogenesis in the rat
  JOURNAL   Dev Dyn 226 (3), 561-569 (2003)
   PUBMED   12619141
  REMARK    GeneRIF: The receptor UHR1/GPR10 gene was expressed consistently in
            the medullary reticular formation and the adrenal gland but also
            transiently in several locations.
REFERENCE   9  (bases 1 to 1462)
  AUTHORS   Fujii,R., Fukusumi,S., Hosoya,M., Kawamata,Y., Habata,Y.,
            Hinuma,S., Sekiguchi,M., Kitada,C., Kurokawa,T., Nishimura,O.,
            Onda,H., Sumino,Y. and Fujino,M.
  TITLE     Tissue distribution of prolactin-releasing peptide (PrRP) and its
            receptor
  JOURNAL   Regul Pept 83 (1), 1-10 (1999)
   PUBMED   10498338
REFERENCE   10 (bases 1 to 1462)
  AUTHORS   Welch,S.K., O'Hara,B.F., Kilduff,T.S. and Heller,H.C.
  TITLE     Sequence and tissue distribution of a candidate G-coupled receptor
            cloned from rat hypothalamus
  JOURNAL   Biochem Biophys Res Commun 209 (2), 606-613 (1995)
   PUBMED   7733930
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139193.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.8756.1,
                                           SRR26360194.2172223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                JAXUCZ010000001.1  269594409-269594422 c
            15-1462             JAXUCZ010000001.1  269592735-269594182 c
FEATURES             Location/Qualifiers
     source          1..1462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q55"
     gene            1..1462
                     /gene="Prlhr"
                     /gene_synonym="Gpr10; Uhr-1"
                     /note="prolactin releasing hormone receptor"
                     /db_xref="GeneID:246075"
                     /db_xref="RGD:71037"
     exon            1..14
                     /gene="Prlhr"
                     /gene_synonym="Gpr10; Uhr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            15..1462
                     /gene="Prlhr"
                     /gene_synonym="Gpr10; Uhr-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1133
                     /gene="Prlhr"
                     /gene_synonym="Gpr10; Uhr-1"
                     /note="prRPR; prRP receptor; G-protein coupled receptor
                     10"
                     /codon_start=1
                     /product="prolactin-releasing peptide receptor"
                     /protein_id="NP_631932.4"
                     /db_xref="GeneID:246075"
                     /db_xref="RGD:71037"
                     /translation="MTSLPPGTTGDPDLFSGPSPAGSTPANQSAEASESNVSATVPRA
                     AAVTPFQSLQLVHQLKGLIVMLYSIVVVVGLVGNCLLVLVIARVRRLHNVTNFLIGNL
                     ALSDVLMCAACVPLTLAYAFEPRGWVFGGGLCHLVFFLQPVTVYVSVFTLTTIAVDRY
                     VVLVHPLRRRISLKLSAYAVLGIWALSAVLALPAAVHTYHVELKPHDVRLCEEFWGSQ
                     ERQRQIYAWGLLLGTYLLPLLAILLSYVRVSVKLRNRVVPGSVTQSQADWDRARRRRT
                     FCLLVVVVVVFAVCWLPLHIFNLLRDLDPRAIDPYAFGLVQLLCHWLAMSSACYNPFI
                     YAWLHDSFREELRKMLLSWPRKIVPHGQNMTVSVVI"
ORIGIN      
        1 aagcttgttc acaggtggcc atgacctcac tgccccctgg aaccactggg gaccccgatt
       61 tgttttctgg gccgtcgcca gccggctcca ctccagccaa ccagagtgca gaggcttcag
      121 agagcaatgt gtctgcgacg gttcccagag ctgcagcagt cacgccgttc cagagcctgc
      181 aactagtgca ccagctgaag ggactgatcg tgatgctgta cagcatcgtg gtggtcgtgg
      241 gtctggtggg caactgcctt cttgtgctgg tgatcgcgcg cgtgcgccgg ctgcacaacg
      301 tgaccaactt cctcatcggc aacctggcct tgtccgatgt gctcatgtgt gccgcctgtg
      361 tgcctctcac gctggcctac gcctttgaac ctcgtggctg ggtgttcggt ggaggcctgt
      421 gccaccttgt tttcttcctg cagccggtca ccgtctacgt atcggtgttc acactcacca
      481 caatcgctgt ggaccgctat gtggttctgg tgcacccgct acgtcggcgc atttcactga
      541 agctcagcgc ctacgctgtg ctgggcatct gggctctatc tgcagtgctg gcgctgccgg
      601 ccgcggtgca cacctaccat gtagagctca agccccacga cgtgcgcctc tgcgaggagt
      661 tctggggttc gcaggagcgc cagcgacaga tctatgcctg ggggctgctg ctgggcacct
      721 atttgctccc cctgctggcc attctcctgt cttacgtccg ggtgtcggtg aagttgcgga
      781 accgcgtggt gcctggcagc gtgacccaga gccaggctga ctgggaccga gcgcgtcgcc
      841 gtcgcacttt ctgcctgctg gtggtggtgg tggtcgtgtt cgcggtctgc tggctgcctc
      901 tgcacatttt caacctgctg cgggacctgg acccgcgtgc catcgacccc tacgccttcg
      961 ggctggtgca gctcctctgc cactggcttg ccatgagctc cgcctgctac aaccccttca
     1021 tctatgcgtg gctgcacgac agcttccgag aggagctacg caagatgctt ctgtcttggc
     1081 cccgcaagat cgtgcctcat ggccagaata tgaccgtcag tgtggtcatc tgatgacact
     1141 ctgccaggtc tgagctgggg agcttcagag tcattagccc cggaagtcat catgagatct
     1201 tattcccatt accagagtta agccaacaca agtgaaattc ctacccagcc ctctagacta
     1261 gctatatgtc tgtttttgtg cttgtgtgaa atgttagata ggctttggag tagaagagcc
     1321 tgaggagaga gaagcagatt tatcaggtct acccctgaaa gcaaaagaga tatttttctg
     1381 ggttcagaaa aaataaatca gaagcagtct ttctttcctt ctctctctct ctctctctct
     1441 ctctctctct ctctctctct ct
//
