LOCUS       NM_022222                485 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus prolactin releasing hormone (Prlh), mRNA.
ACCESSION   NM_022222
VERSION     NM_022222.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Navarro I Batista,K., Schraner,M. and Riediger,T.
  TITLE     Brainstem prolactin-releasing peptide contributes to cancer
            anorexia-cachexia syndrome in rats
  JOURNAL   Neuropharmacology 180, 108289 (2020)
   PUBMED   32890590
  REMARK    GeneRIF: Brainstem prolactin-releasing peptide contributes to
            cancer anorexia-cachexia syndrome in rats.
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Matuska,R., Zelena,D., Konczol,K., Papp,R.S., Durst,M., Guba,D.,
            Torok,B., Varnai,P. and Toth,Z.E.
  TITLE     Colocalized neurotransmitters in the hindbrain cooperate in
            adaptation to chronic hypernatremia
  JOURNAL   Brain Struct Funct 225 (3), 969-984 (2020)
   PUBMED   32200401
  REMARK    GeneRIF: Colocalized neurotransmitters in the hindbrain cooperate
            in adaptation to chronic hypernatremia.
REFERENCE   3  (bases 1 to 485)
  AUTHORS   Papanikolaou,N.A., Tillinger,A., Liu,X., Papavassiliou,A.G. and
            Sabban,E.L.
  TITLE     A systems approach identifies co-signaling molecules of early
            growth response 1 transcription factor in immobilization stress
  JOURNAL   BMC Syst Biol 8, 100 (2014)
   PUBMED   25217033
  REMARK    GeneRIF: Possible involvement of Stat3 and Prlh1/Chgb up-regulation
            in the transition from short to repeated stress activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 485)
  AUTHORS   Yoshida,M., Takayanagi,Y. and Onaka,T.
  TITLE     The medial amygdala-medullary PrRP-synthesizing neuron pathway
            mediates neuroendocrine responses to contextual conditioned fear in
            male rodents
  JOURNAL   Endocrinology 155 (8), 2996-3004 (2014)
   PUBMED   24877622
  REMARK    GeneRIF: The medial amygdala-medullary PrRP-synthesizing neuron
            pathway plays an important role in neuroendocrine responses to
            contextual conditioned fear
REFERENCE   5  (bases 1 to 485)
  AUTHORS   Xia,Y.F. and Arai,A.C.
  TITLE     Prolactin-releasing peptide enhances synaptic transmission in rat
            thalamus
  JOURNAL   Neuroscience 172, 1-11 (2011)
   PUBMED   21056089
  REMARK    GeneRIF: PrRP increases the amplitude of the GABAA
            receptor-mediated inhibitory postsynaptic current in both
            ventrobasal nucleus and reticular thalamic nucleus neurons.
REFERENCE   6  (bases 1 to 485)
  AUTHORS   Nieminen,M.L., Nystedt,J. and Panula,P.
  TITLE     Expression of neuropeptide FF, prolactin-releasing peptide, and the
            receptor UHR1/GPR10 genes during embryogenesis in the rat
  JOURNAL   Dev Dyn 226 (3), 561-569 (2003)
   PUBMED   12619141
  REMARK    GeneRIF: PrRP gene expression was seen in the embryonic caudal
            solitary tract nucleus, medullary reticular formation, pontine
            isthmus and liver, kidney, and testis.
REFERENCE   7  (bases 1 to 485)
  AUTHORS   Samson,W.K., Keown,C., Samson,C.K., Samson,H.W., Lane,B.,
            Baker,J.R. and Taylor,M.M.
  TITLE     Prolactin-releasing peptide and its homolog RFRP-1 act in
            hypothalamus but not in anterior pituitary gland to stimulate
            stress hormone secretion
  JOURNAL   Endocrine 20 (1-2), 59-66 (2003)
   PUBMED   12668869
  REMARK    GeneRIF: not true neuroendocrine regulators of stress hormone
            secretion in the rat but, instead, act centrally to alter the
            release of neuroendocrine factors that do act in the pituitary
            gland to control prolactin and ACTH release.
REFERENCE   8  (bases 1 to 485)
  AUTHORS   Yamada,M., Ozawa,A., Ishii,S., Shibusawa,N., Hashida,T.,
            Ishizuka,T., Hosoya,T., Monden,T., Satoh,T. and Mori,M.
  TITLE     Isolation and characterization of the rat prolactin-releasing
            peptide gene: multiple TATA boxes in the promoter region
  JOURNAL   Biochem Biophys Res Commun 281 (1), 53-56 (2001)
   PUBMED   11178959
REFERENCE   9  (bases 1 to 485)
  AUTHORS   Fujii,R., Fukusumi,S., Hosoya,M., Kawamata,Y., Habata,Y.,
            Hinuma,S., Sekiguchi,M., Kitada,C., Kurokawa,T., Nishimura,O.,
            Onda,H., Sumino,Y. and Fujino,M.
  TITLE     Tissue distribution of prolactin-releasing peptide (PrRP) and its
            receptor
  JOURNAL   Regul Pept 83 (1), 1-10 (1999)
   PUBMED   10498338
REFERENCE   10 (bases 1 to 485)
  AUTHORS   Hinuma,S., Habata,Y., Fujii,R., Kawamata,Y., Hosoya,M.,
            Fukusumi,S., Kitada,C., Masuo,Y., Asano,T., Matsumoto,H.,
            Sekiguchi,M., Kurokawa,T., Nishimura,O., Onda,H. and Fujino,M.
  TITLE     A prolactin-releasing peptide in the brain
  JOURNAL   Nature 393 (6682), 272-276 (1998)
   PUBMED   9607765
  REMARK    Erratum:[Nature 1998 Jul 16;394(6690):302]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Oct 12, 2022 this sequence version replaced NM_022222.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB015418.1 [ECO:0000331]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                JAXUCZ010000009.1  98994163-98994209
            48-200              JAXUCZ010000009.1  98995427-98995579
            201-485             JAXUCZ010000009.1  98996231-98996515
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..485
                     /gene="Prlh"
                     /gene_synonym="Prh; prrp"
                     /note="prolactin releasing hormone"
                     /db_xref="GeneID:63850"
                     /db_xref="RGD:628634"
     exon            1..47
                     /gene="Prlh"
                     /gene_synonym="Prh; prrp"
                     /inference="alignment:Splign:2.1.0"
     exon            48..200
                     /gene="Prlh"
                     /gene_synonym="Prh; prrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..355
                     /gene="Prlh"
                     /gene_synonym="Prh; prrp"
                     /note="prolactin-releasing peptide;
                     preproprolactin-releasing peptide"
                     /codon_start=1
                     /product="prolactin-releasing peptide precursor"
                     /protein_id="NP_071558.1"
                     /db_xref="GeneID:63850"
                     /db_xref="RGD:628634"
                     /translation="MALKTWLLCLLLLSLVLPGASSRAHQHSMETRTPDINPAWYTGR
                     GIRPVGRFGRRRATPRDVTGLGQLSCLPLDGRTKFSQRG"
     exon            201..485
                     /gene="Prlh"
                     /gene_synonym="Prh; prrp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctcacgcc caggcagcct tatcaccact caagggacag agggtgagct gcaccatccc
       61 ctgtgggatc cgaactcccg ggcatcatcc aggaagacgg agcatggccc tgaagacgtg
      121 gcttctgtgc ttgctgctgc taagcttggt cctcccaggg gcttccagcc gagcccacca
      181 gcactccatg gagacaagaa cccctgatat caatcctgcc tggtacacgg gccgcgggat
      241 caggcctgtg ggccgcttcg gcaggagaag ggcaaccccg agggatgtca ctggacttgg
      301 ccaactcagc tgcctcccac tggatggacg caccaagttc tctcagcgtg gataacaccc
      361 cagctcgaga agacagtgct gctgagccca agcccacact ccctgtcccc tgcagaccct
      421 cctctaccct ccctctcctc tgctttctct ctaatctaat aaaagtgttg gctttgttta
      481 ctcta
//
