LOCUS       NM_022176               1159 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus prolactin family 6, subfamily A, member 1
            (Prl6a1), mRNA.
ACCESSION   NM_022176 XM_001069642 XM_341525
VERSION     NM_022176.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1159)
  AUTHORS   Premzl,M.
  TITLE     Curated eutherian third party data gene data sets
  JOURNAL   Data Brief 6, 208-213 (2015)
   PUBMED   26862561
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1159)
  AUTHORS   Premzl,M.
  TITLE     Third party data gene data set of eutherian growth hormone genes
  JOURNAL   Genom Data 6, 166-169 (2015)
   PUBMED   26697363
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1159)
  AUTHORS   Soares,M.J., Alam,S.M., Duckworth,M.L., Horseman,N.D., Konno,T.,
            Linzer,D.I., Maltais,L.J., Nilsen-Hamilton,M., Shiota,K.,
            Smith,J.R. and Wallis,M.
  TITLE     A standardized nomenclature for the mouse and rat prolactin
            superfamilies
  JOURNAL   Mamm Genome 18 (3), 154-156 (2007)
   PUBMED   17476555
REFERENCE   4  (bases 1 to 1159)
  AUTHORS   Alam,S.M., Ain,R., Konno,T., Ho-Chen,J.K. and Soares,M.J.
  TITLE     The rat prolactin gene family locus: species-specific gene family
            expansion
  JOURNAL   Mamm Genome 17 (8), 858-877 (2006)
   PUBMED   16897344
REFERENCE   5  (bases 1 to 1159)
  AUTHORS   Li,Y. and Zhang,Y.P.
  TITLE     Molecular evolution of prolactin gene family in rodents
  JOURNAL   Yi Chuan Xue Bao 33 (7), 590-597 (2006)
   PUBMED   16875316
REFERENCE   6  (bases 1 to 1159)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   7  (bases 1 to 1159)
  AUTHORS   Duckworth,M.L., Peden,L.M. and Friesen,H.G.
  TITLE     A third prolactin-like protein expressed by the developing rat
            placenta: complementary deoxyribonucleic acid sequence and partial
            structure of the gene
  JOURNAL   Mol Endocrinol 2 (10), 912-920 (1988)
   PUBMED   3185566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC158563.1.
            
            On Jun 13, 2010 this sequence version replaced NM_022176.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158563.1, FQ220349.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMN16093048
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1159              BC158563.1         1-1159
FEATURES             Location/Qualifiers
     source          1..1159
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1159
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
                     /note="prolactin family 6, subfamily A, member 1"
                     /db_xref="GeneID:24657"
                     /db_xref="RGD:3405"
     exon            1..336
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..1001
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
                     /note="prolactin-like protein B; growth hormone d13;
                     prolactin-6A1; PLP-B; PRL-like protein B; placental
                     prolactin-like protein B"
                     /codon_start=1
                     /product="prolactin-6A1 precursor"
                     /protein_id="NP_071512.2"
                     /db_xref="GeneID:24657"
                     /db_xref="RGD:3405"
                     /translation="MVKSWLRMSKKMEAGTLLMLLMSNILLWENVASVPRHASGAGRG
                     EMSLHGLLDHAIILAHNVTELIAEMNSVFLEDVLYKPGRWFPERDLTACHRSPFTIAV
                     SKEGTQQRLGVFLVKEMIGMLETWTFSLYHIANEMSHMEEPPDEIISRAKNIEEKIKE
                     LMDVLKGILNKIQPGSPENERFPMWNELAYLRSPDEERRHFAFTNLFQCLLQDSRKFD
                     SKVRLLKCRLIYNRDC"
     exon            337..515
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            516..629
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            630..809
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1152
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1116..1121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
     polyA_site      1152
                     /gene="Prl6a1"
                     /gene_synonym="Ghd13; Plpb; Prlpb"
ORIGIN      
        1 gttagagaca gtgtcttaga gaatcagagc aatgaagatc agcatatcaa aatgtaagtg
       61 gtgagtgatt ttaaaagact agaaagaagg gcactctagc ggcttgtcct ccaggttcag
      121 gttctcttca ctgtttctgg ccagcagttg tggttctgtt tgaagaccca tagcctcagc
      181 tgcatgaagg aatccaactc caaagatatc ccatgtcaga agaagattaa gacaatgtgt
      241 ctctgaatcg agaagcactg agaagattat gtccatgaat tagcgaggga agataaatgg
      301 tgaagagctg gttgagaatg tcaaagaaaa tggaagcagg gacactcctg atgctgttga
      361 tgtcaaacat ccttctgtgg gagaatgtgg cctctgtgcc caggcatgcc agtggggctg
      421 ggcgtggtga gatgtctcta catggcctgc ttgatcatgc catcattcta gctcataatg
      481 tcactgagct cattgcagaa atgaacagtg tatttctgga ggatgtgcta tataaaccag
      541 gcaggtggtt ccctgaaaga gaccttactg cctgccaccg atcaccattt actattgcag
      601 tgtctaaaga aggaacccaa cagaggctgg gtgtattcct ggtgaaagag atgattggta
      661 tgttggaaac ttggacattc tctctatatc atatagcaaa tgaaatgagt catatggagg
      721 aaccccctga tgagattata tcaagagcca aaaacattga agaaaaaatc aaagaactta
      781 tggatgttct taaaggtata ctcaacaaga ttcaacctgg atccccagaa aatgagagat
      841 tccctatgtg gaatgaactg gcatacttgc ggtcacctga tgaagaacgt cgccattttg
      901 cttttacaaa cttattccag tgcttgctcc aggattcacg gaaatttgac tcaaaagtca
      961 gactactgaa gtgtagactt atctataata gagattgcta atctcacaac catccaattt
     1021 actttagaat gattgtgttt aatctttcta gttttaacca attttaaatt tttaactttg
     1081 gatgaatgtt tttatgtgaa gaatccttca ttagaaataa aatggactct ttaaacatat
     1141 taatgtctaa aaaaaaaaa
//
