LOCUS       NM_017036                850 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus prolactin family 4, subfamily A, member 1
            (Prl4a1), mRNA.
ACCESSION   NM_017036
VERSION     NM_017036.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 850)
  AUTHORS   Premzl,M.
  TITLE     Curated eutherian third party data gene data sets
  JOURNAL   Data Brief 6, 208-213 (2015)
   PUBMED   26862561
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 850)
  AUTHORS   Premzl,M.
  TITLE     Third party data gene data set of eutherian growth hormone genes
  JOURNAL   Genom Data 6, 166-169 (2015)
   PUBMED   26697363
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 850)
  AUTHORS   Ain,R., Canham,L.N. and Soares,M.J.
  TITLE     Gestation stage-dependent intrauterine trophoblast cell invasion in
            the rat and mouse: novel endocrine phenotype and regulation
  JOURNAL   Dev Biol 260 (1), 176-190 (2003)
   PUBMED   12885563
  REMARK    GeneRIF: Both interstitial and endovascular rat trophoblast cells
            synthesize plpa.
REFERENCE   4  (bases 1 to 850)
  AUTHORS   Ain,R., Tash,J.S. and Soares,M.J.
  TITLE     Prolactin-like protein-A is a functional modulator of natural
            killer cells at the maternal-fetal interface
  JOURNAL   Mol Cell Endocrinol 204 (1-2), 65-74 (2003)
   PUBMED   12850282
  REMARK    GeneRIF: PLP-A interactions with NK cells are not mediated by
            receptors of known modulators of NK cell function. PLP-A causes
            intracellular calcium mobilization to increase and suppresses
            production of IFNgamma in uterine NK cells.
REFERENCE   5  (bases 1 to 850)
  AUTHORS   Duckworth,M.L., Peden,L.M. and Friesen,H.G.
  TITLE     Isolation of a novel prolactin-like cDNA clone from developing rat
            placenta
  JOURNAL   J Biol Chem 261 (23), 10879-10884 (1986)
   PUBMED   3755436
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC097332.1 and AA996704.1.
            
            On Oct 19, 2007 this sequence version replaced NM_017036.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097332.1, FQ228460.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-830               BC097332.1         1-830
            831-850             AA996704.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..850
                     /gene="Prl4a1"
                     /gene_synonym="Ghd3; Plpa; Prlpa"
                     /note="prolactin family 4, subfamily A, member 1"
                     /db_xref="GeneID:24656"
                     /db_xref="RGD:3404"
     exon            1..60
                     /gene="Prl4a1"
                     /gene_synonym="Ghd3; Plpa; Prlpa"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..710
                     /gene="Prl4a1"
                     /gene_synonym="Ghd3; Plpa; Prlpa"
                     /note="prolactin-like protein A; prolactin-4A1; PLP-A;
                     PRL-like protein A; placental prolactin-like protein A;
                     growth hormone d3"
                     /codon_start=1
                     /product="prolactin-4A1 precursor"
                     /protein_id="NP_058732.2"
                     /db_xref="GeneID:24656"
                     /db_xref="RGD:3404"
                     /translation="MHLSLSHQWSSWTVLLLLVSNLLLWENTASAMRAKLLNVHNYTS
                     YGDTWNQAIKISQDMNQYISDLSTHVKIFYAQGRGFERRTTRCHTSSLSSPENKEQAQ
                     QFQLEVLLGLSHSLLQAWLNPLHHLWAEMCDRLGSTPPTLYKALMLKESNIKLLDAIK
                     NIAKKGNFEINEKANYTAWSELGFLQSPNRDTRYFAFYNLFHCLKKDSNNVEMYLKLL
                     KCRLIRSKC"
     exon            61..236
                     /gene="Prl4a1"
                     /gene_synonym="Ghd3; Plpa; Prlpa"
                     /inference="alignment:Splign:2.1.0"
     exon            237..341
                     /gene="Prl4a1"
                     /gene_synonym="Ghd3; Plpa; Prlpa"
                     /inference="alignment:Splign:2.1.0"
     exon            342..521
                     /gene="Prl4a1"
                     /gene_synonym="Ghd3; Plpa; Prlpa"
                     /inference="alignment:Splign:2.1.0"
     exon            522..833
                     /gene="Prl4a1"
                     /gene_synonym="Ghd3; Plpa; Prlpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaagctgca gtgcgacatc tcagagatgc atctgtcttt gtctcaccaa tggtcctcct
       61 ggacagtcct cttgctgctg gtgtccaacc tgcttctgtg ggagaacaca gcctctgcta
      121 tgagagctaa actgttgaat gtccacaact acacatccta tggagacact tggaatcagg
      181 caattaagat atcccaggac atgaatcagt acatttcaga tctgtccact cacgttaaaa
      241 tattttatgc ccaaggccga gggtttgaac gccggaccac cagatgccac acttcttccc
      301 tctctagtcc agaaaacaag gagcaagccc aacagttcca actggaagta ctactggggt
      361 tgtcacacag cctattgcaa gcctggctca accctctgca ccatctgtgg gctgaaatgt
      421 gtgacaggct aggatccact cctcctaccc tctacaaggc cttgatgctt aaggaatcaa
      481 acataaagct cctggatgcc ataaagaata ttgccaaaaa gggtaatttt gaaatcaacg
      541 aaaaggcgaa ctacactgcc tggtctgaat tgggattctt gcaatcgccc aatagagaca
      601 ctagatactt tgccttttat aacctgtttc actgcctcaa gaaggactca aataacgtgg
      661 aaatgtatct gaagcttctg aagtgccgac tgatccgaag caagtgctaa gaacgcataa
      721 catccttaat atccttctgc cccagtgatg gttcttaaat tgcacttgta caaagtacct
      781 gagtctaatg gctctgttct ttaaaaacaa aaaataaaaa actgaacaaa gttaaaaaaa
      841 aaaaaaaaaa
//
