LOCUS       NM_012629               1016 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Rattus norvegicus prolactin (Prl), mRNA.
ACCESSION   NM_012629
VERSION     NM_012629.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1016)
  AUTHORS   Lin,W.W., Ou,G.Y., Dai,H.F. and Zhao,W.J.
  TITLE     Neuregulin 4 (Nrg4) cooperates with melatonin to regulate the PRL
            expression via ErbB4/Erk signaling pathway as a potential prolactin
            (PRL) regulator
  JOURNAL   J Cell Biochem 125 (5), e30551 (2024)
   PUBMED   38465779
  REMARK    GeneRIF: Neuregulin 4 (Nrg4) cooperates with melatonin to regulate
            the PRL expression via ErbB4/Erk signaling pathway as a potential
            prolactin (PRL) regulator.
REFERENCE   2  (bases 1 to 1016)
  AUTHORS   Laoharatchatathanin,T., Rieanrakwong,D., Hatsugai,Y., Terashima,R.,
            Yonezawa,T., Kurusu,S. and Kawaminami,M.
  TITLE     Mast Cell Dynamics in the Ovary Are Governed by GnRH and Prolactin
  JOURNAL   Endocrinology 164 (11) (2023)
   PUBMED   37797313
  REMARK    GeneRIF: Mast Cell Dynamics in the Ovary Are Governed by GnRH and
            Prolactin.
REFERENCE   3  (bases 1 to 1016)
  AUTHORS   Raut,S., Khambata,K., Goffin,V. and Balasinor,N.
  TITLE     Prolactin Regulates Testicular Gene Expression and Cell Cycle
            Processes Predominantly via JAK2/STAT5 Pathway in the Male Rat
  JOURNAL   Endocrinology 164 (7) (2023)
   PUBMED   37232379
  REMARK    GeneRIF: Prolactin Regulates Testicular Gene Expression and Cell
            Cycle Processes Predominantly via JAK2/STAT5 Pathway in the Male
            Rat.
REFERENCE   4  (bases 1 to 1016)
  AUTHORS   Al-Karagholi,M.A., Kalatharan,V., Ghanizada,H., Dussor,G. and
            Ashina,M.
  TITLE     Prolactin in headache and migraine: A systematic review of
            preclinical studies
  JOURNAL   Headache 63 (5), 577-584 (2023)
   PUBMED   36752584
  REMARK    GeneRIF: Prolactin in headache and migraine: A systematic review of
            preclinical studies.
            Review article
REFERENCE   5  (bases 1 to 1016)
  AUTHORS   Costa-Brito,A.R., Quintela,T., Goncalves,I., Duarte,A.C.,
            Costa,A.R., Arosa,F.A., Cavaco,J.E., Lemos,M.C. and Santos,C.R.A.
  TITLE     The Choroid Plexus Is an Alternative Source of Prolactin to the Rat
            Brain
  JOURNAL   Mol Neurobiol 58 (4), 1846-1858 (2021)
   PUBMED   33409838
  REMARK    GeneRIF: The Choroid Plexus Is an Alternative Source of Prolactin
            to the Rat Brain.
REFERENCE   6  (bases 1 to 1016)
  AUTHORS   Wilson,D.M. 3rd, Emanuele,N.V., Jurgens,J.K. and Kelley,M.R.
  TITLE     Prolactin message in brain and pituitary of adult male rats is
            identical: PCR cloning and sequencing of hypothalamic prolactin
            cDNA from intact and hypophysectomized adult male rats
  JOURNAL   Endocrinology 131 (5), 2488-2490 (1992)
   PUBMED   1339346
REFERENCE   7  (bases 1 to 1016)
  AUTHORS   Shull,J.D.
  TITLE     Transcription of sequences upstream of the rat prolactin gene
            suggests the existence of a second promoter
  JOURNAL   Mol Cell Endocrinol 82 (1), R17-R23 (1991)
   PUBMED   1722177
REFERENCE   8  (bases 1 to 1016)
  AUTHORS   Gubbins,E.J., Maurer,R.A., Hartley,J.L. and Donelson,J.E.
  TITLE     Construction and analysis of recombinant DNAs containing a
            structural gene for rat prolactin
  JOURNAL   Nucleic Acids Res 6 (3), 915-930 (1979)
   PUBMED   375200
REFERENCE   9  (bases 1 to 1016)
  AUTHORS   McKean,D.J. and Maurer,R.A.
  TITLE     Complete amino acid sequence of the precursor region of rat
            prolactin
  JOURNAL   Biochemistry 17 (24), 5215-5219 (1978)
   PUBMED   728396
REFERENCE   10 (bases 1 to 1016)
  AUTHORS   Shome,B. and Parlow,A.F.
  TITLE     Human pituitary prolactin (hPRL): the entire linear amino acid
            sequence
  JOURNAL   J Clin Endocrinol Metab 45 (5), 1112-1115 (1977)
   PUBMED   925136
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF022935.1.
            
            [WARNING] On Aug 19, 2024 this sequence was replaced by
            NM_012629.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF022935.1, BC168729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663594, SAMN13663595
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WF"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1016
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1; PRLB; PRLSD1; Prol;
                     RATPRLSD1; RNPROL"
                     /note="prolactin"
                     /db_xref="GeneID:24683"
                     /db_xref="RGD:3403"
     exon            1..211
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1; PRLB; PRLSD1; Prol;
                     RATPRLSD1; RNPROL"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..864
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1; PRLB; PRLSD1; Prol;
                     RATPRLSD1; RNPROL"
                     /note="prolactin family 1, subfamily a, member 1; growth
                     hormone a1"
                     /codon_start=1
                     /product="prolactin precursor"
                     /protein_id="NP_036761.1"
                     /db_xref="GeneID:24683"
                     /db_xref="RGD:3403"
                     /translation="MNSQVSARKAGTLLLLMMSNLLFCQNVQTLPVCSGGDCQTPLPE
                     LFDRVVMLSHYIHTLYTDMFIEFDKQYVQDREFIAKAINDCPTSSLATPEDKEQAQKV
                     PPEVLLNLILSLVHSWNDPLFQLITGLGGIHEAPDAIISRAKEIEEQNKRLLEGIEKI
                     ISQAYPEAKGNEIYLVWSQLPSLQGVDEESKDLAFYNNIRCLRRDSHKVDNYLKFLRC
                     QIVHKNNC"
     exon            212..384
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1; PRLB; PRLSD1; Prol;
                     RATPRLSD1; RNPROL"
                     /inference="alignment:Splign:2.1.0"
     exon            385..492
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1; PRLB; PRLSD1; Prol;
                     RATPRLSD1; RNPROL"
                     /inference="alignment:Splign:2.1.0"
     exon            493..672
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1; PRLB; PRLSD1; Prol;
                     RATPRLSD1; RNPROL"
                     /inference="alignment:Splign:2.1.0"
     exon            673..1002
                     /gene="Prl"
                     /gene_synonym="Gha1; Prl1a1; PRLB; PRLSD1; Prol;
                     RATPRLSD1; RNPROL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgatgtttaa aattattggg gctatcttaa tgacggaaat agatgattgg gaggggaaga
       61 ggatgcctga ttatatatat attcatgaag gtgtcgaagg tttataaagt caatgtctgc
      121 agatgagaaa gcagtggttc tcttaggact tcttggggaa gtgtggtccc agtggtcatc
      181 accatgaaca gccaagtgtc agcccggaaa gcagggacac tcctcctgct gatgatgtca
      241 aaccttctgt tctgccaaaa tgtgcagacc ctgccagtct gttctggtgg cgactgccag
      301 acacctctcc cggagctgtt tgaccgtgtg gtcatgcttt ctcactacat ccataccctg
      361 tatacagata tgtttattga atttgataaa cagtatgtcc aagatcgtga gtttattgcc
      421 aaggccatca atgactgccc cacttcttcc ctagctactc ctgaagacaa ggaacaagcc
      481 cagaaagtcc ctccggaagt tcttttgaac ctgatcctca gtttggtgca ctcctggaat
      541 gaccctctgt ttcaactaat aactggacta ggtggaatcc atgaagctcc tgatgctatc
      601 atatcaagag ccaaagagat tgaggaacaa aacaagcggc ttcttgaagg gattgaaaag
      661 ataattagcc aggcctatcc tgaagccaaa ggaaatgaga tctacttggt ttggtcacaa
      721 ctcccatccc tgcaaggagt tgatgaagaa tccaaagact tggcttttta taacaacatt
      781 cggtgcctgc gcagggattc ccacaaggtt gacaattatc tcaagttcct gaggtgccaa
      841 attgtccata aaaacaactg ctaagcctac attcattcca tgtacatctg agatgttctt
      901 aaaagtctat ttcttcaaag gttctatttg cattacaact ttcagcacat gcttaagtat
      961 aattggtctc ttcttaaata ataaaaacaa acttttaaaa aaaaaaaaaa aaaaaa
//
