LOCUS       NM_001033963            4058 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein kinase cAMP-dependent X-linked catalytic
            subunit (Prkx), mRNA.
ACCESSION   NM_001033963 XM_347142 XM_576968
VERSION     NM_001033963.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4058)
  AUTHORS   Li,X., Iomini,C., Hyink,D. and Wilson,P.D.
  TITLE     PRKX critically regulates endothelial cell proliferation,
            migration, and vascular-like structure formation
  JOURNAL   Dev Biol 356 (2), 475-485 (2011)
   PUBMED   21684272
  REMARK    Erratum:[Dev Biol. 2013 Sep 15;381(2):502]
REFERENCE   2  (bases 1 to 4058)
  AUTHORS   Li,X., Burrow,C.R., Polgar,K., Hyink,D.P., Gusella,G.L. and
            Wilson,P.D.
  TITLE     Protein kinase X (PRKX) can rescue the effects of polycystic kidney
            disease-1 gene (PKD1) deficiency
  JOURNAL   Biochim Biophys Acta 1782 (1), 1-9 (2008)
   PUBMED   17980165
REFERENCE   3  (bases 1 to 4058)
  AUTHORS   Glesne,D. and Huberman,E.
  TITLE     Smad6 is a protein kinase X phosphorylation substrate and is
            required for HL-60 cell differentiation
  JOURNAL   Oncogene 25 (29), 4086-4098 (2006)
   PUBMED   16491121
REFERENCE   4  (bases 1 to 4058)
  AUTHORS   Zimmermann,B., Chiorini,J.A., Ma,Y., Kotin,R.M. and Herberg,F.W.
  TITLE     PrKX is a novel catalytic subunit of the cAMP-dependent protein
            kinase regulated by the regulatory subunit type I
  JOURNAL   J Biol Chem 274 (9), 5370-5378 (1999)
   PUBMED   10026146
REFERENCE   5  (bases 1 to 4058)
  AUTHORS   Semizarov,D., Glesne,D., Laouar,A., Schiebel,K. and Huberman,E.
  TITLE     A lineage-specific protein kinase crucial for myeloid maturation
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15412-15417 (1998)
   PUBMED   9860982
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001033963.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091203.1, SRR22582416.1296236.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               JAXUCZ010000021.1  45744647-45745066   c
            421-589             JAXUCZ010000021.1  45736208-45736376   c
            590-853             JAXUCZ010000021.1  45729807-45730070   c
            854-973             JAXUCZ010000021.1  45724080-45724199   c
            974-1069            JAXUCZ010000021.1  45722424-45722519   c
            1070-1127           JAXUCZ010000021.1  45705934-45705991   c
            1128-1205           JAXUCZ010000021.1  45705131-45705208   c
            1206-1354           JAXUCZ010000021.1  45704661-45704809   c
            1355-4058           JAXUCZ010000021.1  45701747-45704450   c
FEATURES             Location/Qualifiers
     source          1..4058
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq21"
     gene            1..4058
                     /gene="Prkx"
                     /note="protein kinase cAMP-dependent X-linked catalytic
                     subunit"
                     /db_xref="GeneID:501563"
                     /db_xref="RGD:1564076"
     exon            1..420
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..1331
                     /gene="Prkx"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase PRKX; protein
                     kinase, X-linked"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase catalytic subunit
                     PRKX"
                     /protein_id="NP_001029135.1"
                     /db_xref="GeneID:501563"
                     /db_xref="RGD:1564076"
                     /translation="MEPPACAEAAVKDPAARDHDPVDAKISAPAADPLPRTSSQKEGH
                     SLQDWDTIATVGTGTFGRVNLVKEKTGRRYCALKIMSIPDVIRLKQEQHVQNEKAVLK
                     EINHPFLIKLLWTDHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVAAIFYATEIVCAI
                     EYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQS
                     KGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPRQLDFTSKDLIK
                     KLLVVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSSDGDISNFE
                     TYPEGELDKTPSVSDEDLETFKNF"
     exon            421..589
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
     exon            590..853
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
     exon            854..973
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1069
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1127
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1205
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1354
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..4058
                     /gene="Prkx"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagcacaag ctggtccccg cccagccggc ttccgccggg aatgaagagc gttgcggttg
       61 gctccggtcc cgcggacccc acgcgcgtcc gtggagctct cgggcggctt ccgagagccc
      121 ctcccatcgt tctgagcccc gctgagttcg cttccattgt cctctcggcc gcgggctccg
      181 gaacgcgcga gtgagccctc tgctgatgcc caggctgccg ttgtgccgct gtcacaccgt
      241 gcgttccccg ccccatggag ccacccgctt gtgccgaggc ggccgtaaaa gatcctgcag
      301 ccagagacca tgaccccgtg gacgcaaaga tctcagcgcc cgccgcggat cccctaccca
      361 ggacgtcgtc acagaaagag gggcactcgt tacaagattg ggacaccata gccaccgtgg
      421 gcactggaac ctttggccga gtaaacctgg tgaaggagaa gacaggcagg cgatactgtg
      481 ccttgaagat tatgagcatc ccagatgtca tccgcctgaa gcaggaacaa catgtgcaga
      541 atgagaaagc agtcctgaag gaaataaacc accccttcct cattaaactg ctttggacag
      601 accatgacaa ccgcttcctg tacatgctga tggagtttgt gcctggtggt gagctgttca
      661 cctacctgcg taatcgtggc cgcttttcct cagttgctgc aatcttctat gccacagaga
      721 ttgtgtgtgc catagaatac ctgcactcca aggaaatcgt atacagggac ctgaagcctg
      781 aaaacatcct tctggacagg gaaggacata tcaaactcac tgacttcggc ttcgccaaga
      841 aactggtgga taggacatgg actctctgtg ggacaccgga ataccttgcc ccagaagtta
      901 tccagagcaa aggtcatgga agagctgtgg actggtgggc attgggcatc cttatattcg
      961 agatgctgtc tgggtttccc ccatttttcg atgacaaccc atttgggatt taccagaaaa
     1021 tccttgcatg caaaatagat ttccccagac aattggattt cacctctaag gacctcatca
     1081 agaagcttct ggtggtagac aggacccggc gcctgggcaa catgaagaat ggggcagaag
     1141 acatcaagcg gcaccggtgg ttccgaggtg tggagtggga gtccgtgcca cagaggaaac
     1201 ttaagccacc cattgtgccc aagttatcca gtgatggtga catctccaac tttgagactt
     1261 atccagaggg tgagttggac aagactcctt ctgtatctga tgaagatctg gaaacattca
     1321 aaaatttctg aggatgagaa ctcatgtctg caagaagtgt gtgaagacat ccacaccaca
     1381 ctgatgacca gaaccgtttt gttgttgtat ccgtttcttg ctgtgaaact agaaggtttg
     1441 gtgtgtgtgt gtgggtgtgt atatgcaagt tcctgcaatg ttaacacaat ccatcaccct
     1501 tgggacccag cctcatttca acaactggaa acctgcccag tgaaaatttc gcaaaaactg
     1561 ttaaattgta ggttttctcc ttcttcatga gtcttgtgtt cgtgttgtga atttggtttg
     1621 ttcgtttgtt tttctactga acttttaaag tttgaatttg acccatttga ttatagctgt
     1681 cagtgtgtat gtgcacaaaa actgtgcaaa ctggaaattt tggcactttg atgtgcctgt
     1741 gacatgttca acttttaaag atttctgaaa attctgttgc cttgcaggca aaaaaaaggt
     1801 gagatatatg catttttaaa atgcctttct atgcattttg caatcatatt tgtacattgt
     1861 ttattgagtt gttatttgtt tatttagttc ttttctgatc actttaaact tggaagtcag
     1921 gaagccacat gccctgcaga cccttattca gttatagcac aaatgtgtgg ctttcctcaa
     1981 atcttccagt ttagatgttt tcagtaaaat atcccttcct aaagttaagc cagaactctg
     2041 catacagcat tagccgcctg gcaacctggt tgcaaaaatt gcctttttta tgataatata
     2101 aatgtatcca catccccaaa agggaacttt taaggatcca ccccttaagc ccctccttcc
     2161 tctgttgtaa atgacatttt cttctcacca tctcaacttt gttctcacag ccatgtctgt
     2221 ccatgaaaac tcaggttcca ggccgggatc ttctatgaaa gtttgtacaa agctgtattt
     2281 ttagcaagct ttctcagtgc tttccaatat gcaaactaac tgggttagta cctcaaacaa
     2341 acaaacacat acaggagata gaatgcagaa ttataatcaa gtcctgtcag tagatgtttg
     2401 ttatgaagta ggaaatagcg taaaattagc atagataact ttgccttaat tctaaaccca
     2461 catggggaga tcaaacatgc acacatgcac tctctttgtg ctcctaaagc actttgcaat
     2521 ctgactccaa tcctaaaaat caaattaaaa tcccttaatt gagccgtaaa ttataacatg
     2581 tggtgtcact gcagtgacat cagacagcac atagtaatca taatttttta ttttaatctt
     2641 tttaattatg tgtgtacatg tgactctggt acacacagcc tgcaagtgca ccagagacca
     2701 tacagctgaa cttacaggca gttgtgtgcc gccctgtgga tactgggaac ccaacctgga
     2761 tcctctccag ttcacacagt taacatgcaa aaaataaatt aggaaggggt ggtgggacaa
     2821 aagcagccac ggaaaaagat gagggaaata ggtcctgttc ttcactctca gtccagggag
     2881 tgagagtgtg cacccagcac agttcttatg aagcaatggg atagttaata aatttaaatt
     2941 cctcgggtgg ttgcttgatt ccaaccaagt gtaaaagata aaaataatca ctagccaata
     3001 ataatttaaa aacaactttc catgctcttc aactaagact gacattttaa tgtttagtac
     3061 agataaagta ctgagtgctg tggaatggtg cttgtctcgc ctactagctg ttacacgttg
     3121 cactgtaaaa tgtgacttga tggctaaata ctgttcacag gaccctcagg ctgtgcaaat
     3181 atcctgacat tggaccaaaa cataccaatc accactgtgt tgctaggtga accctagtga
     3241 aaatttagca ttgtgtgggt cttgatgttg aggtgaaaat cacagaaagg gtctctaact
     3301 cctgactgta gaattgaaat atgttgattt cctgggattt tttgtttgtt tttgttgtta
     3361 ctgtttttga tgaagcttca gaggaagcat ttgatgaaca tctgacacct atcattctta
     3421 tttgtcagac acactgtaaa ccacctgaaa attataatac aaaatcaagg tttatgtgtg
     3481 ggggatcccc ccattaggtt gtgtgtgtcc ccatcagttt agggggagga tctgctcccc
     3541 aaccattata tgttcccata aaatctgcct tgtgaatctt acaaccttgc atccagcctc
     3601 atactgtcat tcaggaggtg ggggcgttgc tccagttggt tatgtaatag acattattac
     3661 ctgtgtgact tagaggaagt gaccaggtgc ctccccagcg ctcctggtct tcacagatca
     3721 gactcaaatc ctcttgtcaa cctccatcct tctcagagtg tgggactcac cacttgacct
     3781 gctataacac aggtgccaca tgcactgcgg aggggcaccc cctgctgccg agcacctgtc
     3841 agcttgcctg aaattatcat gcaaaatgaa aaagcctgtt tttctctcac tttctaatcc
     3901 cgatgcataa ttacaaaaaa aaatcactgt gatttgtgta tatatctatc tatatctctc
     3961 tatatatttg acccaggaaa actttttctg ctgtctaatt tataaaatct attattgagt
     4021 ccaggtttgt ttaataaaag tttgtatgtt ttaagaaa
//
