LOCUS       NM_001024780            1589 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus protein activator of interferon induced protein
            kinase EIF2AK2 (Prkra), mRNA.
ACCESSION   NM_001024780 XM_230047
VERSION     NM_001024780.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1589)
  AUTHORS   Dong,Y., Jiang,X., Chen,F., Wang,D. and Zhang,Z.
  TITLE     Inhibiting the aberrant PACT-p53 axis activation ameliorates spinal
            cord ischaemia-reperfusion injury in rats
  JOURNAL   Int Immunopharmacol 108, 108745 (2022)
   PUBMED   35421805
  REMARK    GeneRIF: Inhibiting the aberrant PACT-p53 axis activation
            ameliorates spinal cord ischaemia-reperfusion injury in rats.
REFERENCE   2  (bases 1 to 1589)
  AUTHORS   Haneji,T.
  TITLE     Roles of PKR in differentiation and apoptosis of bone-related cells
  JOURNAL   Anat Sci Int 92 (3), 313-319 (2017)
   PUBMED   27987116
  REMARK    GeneRIF: PKR regulates bone metabolism in vitro and in vivo.
            Review article
REFERENCE   3  (bases 1 to 1589)
  AUTHORS   Palmer,K., Fairfield,H., Borgeia,S., Curtain,M., Hassan,M.G.,
            Dionne,L., Yong Karst,S., Coombs,H., Bronson,R.T., Reinholdt,L.G.,
            Bergstrom,D.E., Donahue,L.R., Cox,T.C. and Murray,S.A.
  TITLE     Discovery and characterization of spontaneous mouse models of
            craniofacial dysmorphology
  JOURNAL   Dev Biol 415 (2), 216-227 (2016)
   PUBMED   26234751
REFERENCE   4  (bases 1 to 1589)
  AUTHORS   Lee,H.Y., Zhou,K., Smith,A.M., Noland,C.L. and Doudna,J.A.
  TITLE     Differential roles of human Dicer-binding proteins TRBP and PACT in
            small RNA processing
  JOURNAL   Nucleic Acids Res 41 (13), 6568-6576 (2013)
   PUBMED   23661684
REFERENCE   5  (bases 1 to 1589)
  AUTHORS   Zhang,Y.N., Cao,P.P., Zhang,X.H., Lu,X. and Liu,Z.
  TITLE     Expression of microRNA machinery proteins in different types of
            chronic rhinosinusitis
  JOURNAL   Laryngoscope 122 (12), 2621-2627 (2012)
   PUBMED   22961479
REFERENCE   6  (bases 1 to 1589)
  AUTHORS   Lee,Y., Hur,I., Park,S.Y., Kim,Y.K., Suh,M.R. and Kim,V.N.
  TITLE     The role of PACT in the RNA silencing pathway
  JOURNAL   EMBO J 25 (3), 522-532 (2006)
   PUBMED   16424907
REFERENCE   7  (bases 1 to 1589)
  AUTHORS   Moser,K. and White,F.M.
  TITLE     Phosphoproteomic analysis of rat liver by high capacity IMAC and
            LC-MS/MS
  JOURNAL   J Proteome Res 5 (1), 98-104 (2006)
   PUBMED   16396499
REFERENCE   8  (bases 1 to 1589)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 1589)
  AUTHORS   Gupta,V. and Patel,R.C.
  TITLE     Proapoptotic protein PACT is expressed at high levels in colonic
            epithelial cells in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 283 (3), G801-G808 (2002)
   PUBMED   12181197
REFERENCE   10 (bases 1 to 1589)
  AUTHORS   Ito,T., Yang,M. and May,W.S.
  TITLE     RAX, a cellular activator for double-stranded RNA-dependent protein
            kinase during stress signaling
  JOURNAL   J Biol Chem 274 (22), 15427-15432 (1999)
   PUBMED   10336432
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097446.1.
            
            On Jun 10, 2005 this sequence version replaced XM_230047.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097446.1, SRR8487230.27871.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1589
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1589
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /note="protein activator of interferon induced protein
                     kinase EIF2AK2"
                     /db_xref="GeneID:311130"
                     /db_xref="RGD:1306707"
     exon            1..192
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..1069
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /note="protein activator of the interferon-induced protein
                     kinase; protein kinase, interferon-inducible
                     double-stranded RNA-dependent activator; PKR associated
                     protein X"
                     /codon_start=1
                     /product="interferon-inducible double-stranded
                     RNA-dependent protein kinase activator A"
                     /protein_id="NP_001019951.1"
                     /db_xref="GeneID:311130"
                     /db_xref="RGD:1306707"
                     /translation="MSHSRHRAEAPPLQREDSGTFSLGKMITAKPGKTPIQVLHEYGT
                     KTKNIPVYECERSDVQVHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKAN
                     ASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYT
                     TICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSL
                     RNSPGEKINLLKRSLLSLPNTDYIQLLSEIAKEQGFSITYLDIEELSANGQYQCLAEL
                     STSPITVCHGSGISCGNAQSDAAHNALQYLKIIAERK"
     exon            193..362
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            363..444
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            445..523
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            524..641
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            642..736
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            737..911
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1554
                     /gene="Prkra"
                     /gene_synonym="RAX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcagcgatc cgaggggcgt ccaagcggta gcgcgggcac gctcctctcg ggaactggcc
       61 gacgtggaga gggaggaccc agattctcac tgctccggat tgctgtggcc agccgtccct
      121 tctcgccatg tcccacagca ggcatcgtgc cgaggccccg ccgctgcagc gcgaggacag
      181 cgggaccttc agtttgggca agatgataac agctaagcct gggaaaacac cgattcaggt
      241 attgcacgag tacggcacga agaccaagaa cattccagtt tatgaatgtg aaagatccga
      301 tgtgcaagta cacgtgccca ctttcacctt cagagtaacc gttggtgaca taacttgcac
      361 aggtgaaggg acgagtaaga agctggcgaa gcacagagct gcagaggctg ccataaacat
      421 tttgaaagcc aatgcaagta tttgctttgc agttcctgac cccttaatgc ctgatccatc
      481 caaacagcca aagaaccagc tgaatccaat tggctcatta caggaattag caattcacca
      541 tggctggcgg cttcctgaat ataccctttc ccaggaagga ggacccgctc ataagagaga
      601 atataccacg atttgcaggc tagagtcatt catggaaact ggaaaggggg catcaaaaaa
      661 acaagcaaag agaaacgctg ctgagaaatt cctcgccaaa tttagtaata tttctccaga
      721 gaaccacatt tctctaacga atgtggtcgg acattccctg ggatgcactt ggcactcctt
      781 gaggaattcc cctggtgaaa agatcaacct tctgaaaagg agcctcctca gtctgcccaa
      841 cacagactac atccagctgc tcagtgagat agccaaagag caaggcttca gtataacata
      901 cttggatata gaggagctga gtgccaacgg gcagtatcag tgtctcgcag agctgtccac
      961 cagtcccatc accgtgtgtc atggctcagg catctcctgt ggcaatgccc agagtgacgc
     1021 cgctcacaat gccctgcagt atctaaagat aatagcagaa agaaagtagg ctcggagcaa
     1081 gtgagtcttt ccaaagcgca aagaagtttc cctcgcacct cttcccagta aaacatttac
     1141 cgtaatgtac gtctgcgtgt cctttccaaa tcctcttcgg attccctcaa cttcccagat
     1201 ttaatcgtct cctggtagtt gttattaagc tctttttaat ggcttcaact ttgtattggt
     1261 atattgtgtt tataaacttt gtaccacaag gctgagtgtg gcatccattt tacagggtca
     1321 gacacatagg ttgaacctgc atgtttgact gtaacagtga agggataaga gcactgctaa
     1381 caacagtctt actggtgctt aaactgttct gtgcaaagct ttgtgaagtg gattctgaag
     1441 agccctttta gactagagcg ttgaggcttg tgatgaatgt cattgctaaa tttcagggaa
     1501 catggtcggt ttgctatgta tttgaaacca tggaataaaa agctgttctt ataaaaaaaa
     1561 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
