LOCUS       NM_020093               1564 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus parkin RBR E3 ubiquitin protein ligase (Prkn),
            mRNA.
ACCESSION   NM_020093
VERSION     NM_020093.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1564)
  AUTHORS   Qiu,Y., Xu,J., Chen,Y., Wu,Y., Lin,Y.N., Liu,W., Wang,Z., Wu,Y.,
            Qian,X. and Li,Y.C.
  TITLE     Parkin plays a crucial role in acute viral myocarditis by
            regulating mitophagy activity
  JOURNAL   Theranostics 14 (13), 5303-5315 (2024)
   PUBMED   39267792
  REMARK    GeneRIF: Parkin plays a crucial role in acute viral myocarditis by
            regulating mitophagy activity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1564)
  AUTHORS   Zhao,L., Chen,Y., Li,H., Ding,X. and Li,J.
  TITLE     Deciphering the neuroprotective mechanisms of RACK1 in cerebral
            ischemia-reperfusion injury: Pioneering insights into mitochondrial
            autophagy and the PINK1/Parkin axis
  JOURNAL   CNS Neurosci Ther 30 (8), e14836 (2024)
   PUBMED   39097918
  REMARK    GeneRIF: Deciphering the neuroprotective mechanisms of RACK1 in
            cerebral ischemia-reperfusion injury: Pioneering insights into
            mitochondrial autophagy and the PINK1/Parkin axis.
REFERENCE   3  (bases 1 to 1564)
  AUTHORS   Zhang,L.W., Feng,H.Q., Fu,S.B. and Sun,D.J.
  TITLE     Low Selenium and Low Protein Exacerbate Myocardial Damage in Keshan
            Disease by Affecting the PINK1/Parkin-mediated Mitochondrial
            Autophagy Pathway
  JOURNAL   Curr Med Sci 44 (1), 93-101 (2024)
   PUBMED   38393524
  REMARK    GeneRIF: Low Selenium and Low Protein Exacerbate Myocardial Damage
            in Keshan Disease by Affecting the PINK1/Parkin-mediated
            Mitochondrial Autophagy Pathway.
REFERENCE   4  (bases 1 to 1564)
  AUTHORS   Wang,J., Sun,Z., Jiang,L., Xuan,L., Ma,Y., Wang,J., Gu,Y. and
            Zhang,Y.
  TITLE     Activation of Pink1/Parkin-mediated mitochondrial autophagy
            alleviates exertional heat stroke-induced acute lung injury in rats
  JOURNAL   Clin Hemorheol Microcirc 88 (1), 13-31 (2024)
   PUBMED   38788061
  REMARK    GeneRIF: Activation of Pink1/Parkin-mediated mitochondrial
            autophagy alleviates exertional heat stroke-induced acute lung
            injury in rats.
REFERENCE   5  (bases 1 to 1564)
  AUTHORS   Verdi,H., Baysan Cebi,H.P., Yilmaz Yalcin,Y., Ozkan,T., Akcil
            Ok,M., Sunguroglu,A. and Atac,F.B.
  TITLE     The Role of Parkin in Rat Pancreatic Beta Cells Fate
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (8), 57-67 (2023)
   PUBMED   37715413
  REMARK    GeneRIF: The Role of Parkin in Rat Pancreatic Beta Cells Fate.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1564)
  AUTHORS   Zhang,Y., Gao,J., Chung,K.K., Huang,H., Dawson,V.L. and Dawson,T.M.
  TITLE     Parkin functions as an E2-dependent ubiquitin- protein ligase and
            promotes the degradation of the synaptic vesicle-associated
            protein, CDCrel-1
  JOURNAL   Proc Natl Acad Sci U S A 97 (24), 13354-13359 (2000)
   PUBMED   11078524
REFERENCE   7  (bases 1 to 1564)
  AUTHORS   Imai,Y., Soda,M. and Takahashi,R.
  TITLE     Parkin suppresses unfolded protein stress-induced cell death
            through its E3 ubiquitin-protein ligase activity
  JOURNAL   J Biol Chem 275 (46), 35661-35664 (2000)
   PUBMED   10973942
REFERENCE   8  (bases 1 to 1564)
  AUTHORS   Gu,W.J., Abbas,N., Lagunes,M.Z., Parent,A., Pradier,L., Bohme,G.A.,
            Agid,Y., Hirsch,E.C., Raisman-Vozari,R. and Brice,A.
  TITLE     Cloning of rat parkin cDNA and distribution of parkin in rat brain
  JOURNAL   J Neurochem 74 (4), 1773-1776 (2000)
   PUBMED   10737637
REFERENCE   9  (bases 1 to 1564)
  AUTHORS   D'Agata,V., Zhao,W. and Cavallaro,S.
  TITLE     Cloning and distribution of the rat parkin mRNA
  JOURNAL   Brain Res Mol Brain Res 75 (2), 345-349 (2000)
   PUBMED   10686358
REFERENCE   10 (bases 1 to 1564)
  AUTHORS   Kitada,T., Asakawa,S., Hattori,N., Matsumine,H., Yamamura,Y.,
            Minoshima,S., Yokochi,M., Mizuno,Y. and Shimizu,N.
  TITLE     Mutations in the parkin gene cause autosomal recessive juvenile
            parkinsonism
  JOURNAL   Nature 392 (6676), 605-608 (1998)
   PUBMED   9560156
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB039878.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039878.1, AF210434.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1564
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1564
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /note="parkin RBR E3 ubiquitin protein ligase"
                     /db_xref="GeneID:56816"
                     /db_xref="RGD:61797"
     exon            1..77
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1468
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /EC_number="2.3.2.31"
                     /note="Parkinson disease (autosomal recessive, juvenile)
                     2, parkin; parkin variant SV5DEL; parkinson protein 2, E3
                     ubiquitin protein ligase; parkin RBR E3 ubiquitin protein
                     ligase 2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase parkin"
                     /protein_id="NP_064478.1"
                     /db_xref="GeneID:56816"
                     /db_xref="RGD:61797"
                     /translation="MIVFVRFNSSYGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVI
                     FAGKELQNHLTVQNCDLEQQSIVHIVQRPQRKSHETNASGGDKPQSTPEGSIWEPRSL
                     TRVDLSSHILPADSVGLAVILDTDSKSDSEAARGPAAKPTYHSFFVYCKGPCHKVQPG
                     KLRVQCGTCRQATLTLAQGPSCWDDVLIPNRMSGECQSPDCPGTRAEFFFKCGAHPTS
                     DKDTSVALNLITNNSRSIPCIACTDVRNPVLVFQCNHRHVICLDCFHLYCVTRLNDRQ
                     FVHDAQLGYSLPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPR
                     PGCGAGLLPEQGQRKVTCEGGNGLGCGFVFCRDCKEAYHEGECDSMFEASGATSQAYR
                     VDQRAAEQARWEEASKETIKKTTKPCPRCNVPIEKNGGCMHMKCPQPQCKLEWCWNCG
                     CEWNRACMGDHWFDV"
     exon            78..241
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            242..482
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..604
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..688
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..804
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            805..941
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1003
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1153
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1237
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1355
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1564
                     /gene="Prkn"
                     /gene_synonym="Park; Park2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaggctcag gcgggtgcca gtgcccgcgt aggtcctgct cgccccgcag ccaccaccct
       61 cccggtgacc atgatagtgt ttgtcaggtt caactccagc tatggcttcc cagtggaggt
      121 cgattctgac accagcatct tccagctcaa ggaagtggtt gctaagcgac agggggttcc
      181 agctgaccag ctgcgagtga tttttgctgg gaaggagctg cagaatcacc tgacagtaca
      241 gaactgtgac ctggaacaac agagtatcgt tcacatagta cagagaccac agaggaaaag
      301 tcacgaaaca aatgcctctg gaggggacaa accccagagc accccggagg gctccatatg
      361 ggagcccaga agcttgactc gagtggacct cagcagccat atcctgccag cggactccgt
      421 ggggctggca gtcattctgg acacagacag caagagtgac tcagaagcag ccagaggtcc
      481 agcagctaaa cccacctacc acagcttttt tgtctactgc aaaggcccct gccacaaggt
      541 ccagcctggg aaactccgag ttcagtgcgg cacctgcaga caagcaaccc tcaccttggc
      601 ccagggccca tcttgctggg atgatgtctt aattccaaac cggatgagtg gagagtgcca
      661 atctccagac tgccctggga caagagctga atttttcttt aaatgtggag cacacccaac
      721 ctcagacaag gacacatcag tagctttgaa cctgatcacc aacaacagcc gcagcatccc
      781 ctgcatcgcg tgcacggatg tcaggaaccc tgtcttggtc ttccaatgta accaccgcca
      841 cgtgatctgt ttggactgct tccacttgta ctgtgtcaca aggctcaacg atcggcagtt
      901 tgtccacgac gctcaacttg gctactccct gccgtgtgtg gctggctgtc ccaactccct
      961 gattaaagag ctccatcact tcaggatcct tggagaagag cagtacaaca ggtaccagca
     1021 gtatggtgcc gaggagtgcg tgctgcagat gggaggtgtg ctgtgccccc gtcctggctg
     1081 cggagctggg ctgctgcctg aacagggcca gaggaaagtc acctgcgaag ggggcaacgg
     1141 cctgggctgt gggttcgttt tctgccggga ctgcaaggaa gcataccatg aaggggagtg
     1201 cgactcgatg ttcgaagcct cgggggcgac ttctcaggca taccgggtgg atcaaagagc
     1261 tgctgagcaa gcacggtggg aggaggcctc caaggaaacc atcaagaaaa ccaccaagcc
     1321 ttgtcctcgc tgcaatgtgc ccattgaaaa gaatggagga tgtatgcaca tgaagtgtcc
     1381 tcagccccag tgcaagctgg agtggtgctg gaactgtggc tgtgagtgga accgagcctg
     1441 catgggtgat cactggtttg acgtgtagag agggatgtca cttggcaatg gccgcacgac
     1501 ctcatgggaa acacctcaga ctcctacctt tgttagccat ttcttcttct ctgtgcatat
     1561 aagc
//
