LOCUS       NM_013012               3230 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus protein kinase cGMP-dependent 2 (Prkg2), mRNA.
ACCESSION   NM_013012
VERSION     NM_013012.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Kamemura,N., Murakami,S., Komatsu,H., Sawanoi,M., Miyamoto,K.,
            Ishidoh,K., Kishimoto,K., Tsuji,A. and Yuasa,K.
  TITLE     Type II cGMP-dependent protein kinase negatively regulates
            fibroblast growth factor signaling by phosphorylating Raf-1 at
            serine 43 in rat chondrosarcoma cells
  JOURNAL   Biochem Biophys Res Commun 483 (1), 82-87 (2017)
   PUBMED   28057484
  REMARK    GeneRIF: Wild-type PKGII phosphorylated Raf-1 at Ser-43 in a
            cGMP-dependent manner, but a PKGII D412A/R415A mutant, which has a
            low affinity for cGMP, did not.
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Collado-Alsina,A., Ramirez-Franco,J., Sanchez-Prieto,J. and
            Torres,M.
  TITLE     The regulation of synaptic vesicle recycling by cGMP-dependent
            protein kinase type II in cerebellar granule cells under strong and
            sustained stimulation
  JOURNAL   J Neurosci 34 (26), 8788-8799 (2014)
   PUBMED   24966379
  REMARK    GeneRIF: We conclude that cGKII controls the homeostatic balance of
            vesicle exocytosis and endocytosis in synaptic boutons of rat
            cerebellar granule cells.
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Incontro,S., Ciruela,F., Ziff,E., Hofmann,F., Sanchez-Prieto,J. and
            Torres,M.
  TITLE     The type II cGMP dependent protein kinase regulates GluA1 levels at
            the plasma membrane of developing cerebellar granule cells
  JOURNAL   Biochim Biophys Acta 1833 (8), 1820-1831 (2013)
   PUBMED   23545413
  REMARK    GeneRIF: Which in turn activates cGKII and induces the
            phosphorylation of GluA1.
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Peregud,D.I., Yakovlev,A.A., Stepanichev,M.Y., Onufriev,M.V.,
            Panchenko,L.F. and Gulyaeva,N.V.
  TITLE     Content of mRNA for NMDA glutamate receptor subunits in the frontal
            cortex and striatum of rats after morphine withdrawal is related to
            the degree of abstinence
  JOURNAL   Bull Exp Biol Med 153 (6), 835-838 (2012)
   PUBMED   23113297
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Huang,J. and Siragy,H.M.
  TITLE     Sodium depletion enhances renal expression of (pro)renin receptor
            via cyclic GMP-protein kinase G signaling pathway
  JOURNAL   Hypertension 59 (2), 317-323 (2012)
   PUBMED   22203739
  REMARK    GeneRIF: Sodium depletion enhances renal expression of (pro)renin
            receptor via cyclic GMP-protein kinase G signaling pathway.
REFERENCE   6  (bases 1 to 3230)
  AUTHORS   Gambaryan,S., Palmetshofer,A., Glazova,M., Smolenski,A.,
            Kristjansson,G.I., Zimmer,M. and Lohmann,S.M.
  TITLE     Inhibition of cGMP-dependent protein kinase II by its own splice
            isoform
  JOURNAL   Biochem Biophys Res Commun 293 (5), 1438-1444 (2002)
   PUBMED   12054676
  REMARK    GeneRIF: Inhibition of cGMP-dependent protein kinase II by its own
            splice isoform
REFERENCE   7  (bases 1 to 3230)
  AUTHORS   Vaandrager,A.B., Edixhoven,M., Bot,A.G., Kroos,M.A., Jarchau,T.,
            Lohmann,S., Genieser,H.G. and de Jonge,H.R.
  TITLE     Endogenous type II cGMP-dependent protein kinase exists as a dimer
            in membranes and can Be functionally distinguished from the type I
            isoforms
  JOURNAL   J Biol Chem 272 (18), 11816-11823 (1997)
   PUBMED   9115239
REFERENCE   8  (bases 1 to 3230)
  AUTHORS   Gambaryan,S., Hausler,C., Markert,T., Pohler,D., Jarchau,T.,
            Walter,U., Haase,W., Kurtz,A. and Lohmann,S.M.
  TITLE     Expression of type II cGMP-dependent protein kinase in rat kidney
            is regulated by dehydration and correlated with renin gene
            expression
  JOURNAL   J Clin Invest 98 (3), 662-670 (1996)
   PUBMED   8698857
REFERENCE   9  (bases 1 to 3230)
  AUTHORS   Pohler,D., Butt,E., Meissner,J., Muller,S., Lohse,M., Walter,U.,
            Lohmann,S.M. and Jarchau,T.
  TITLE     Expression, purification, and characterization of the
            cGMP-dependent protein kinases I beta and II using the baculovirus
            system
  JOURNAL   FEBS Lett 374 (3), 419-425 (1995)
   PUBMED   7589584
REFERENCE   10 (bases 1 to 3230)
  AUTHORS   Jarchau,T., Hausler,C., Markert,T., Pohler,D., Vanderkerckhove,J.,
            De Jonge,H.R., Lohmann,S.M. and Walter,U.
  TITLE     Cloning, expression, and in situ localization of rat intestinal
            cGMP-dependent protein kinase II
  JOURNAL   Proc Natl Acad Sci U S A 91 (20), 9426-9430 (1994)
   PUBMED   7937783
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 20, 2020 this sequence version replaced NM_013012.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.50927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               JAXUCZ010000014.1  10864020-10864274
            256-729             JAXUCZ010000014.1  10876027-10876500
            730-896             JAXUCZ010000014.1  10901103-10901269
            897-1010            JAXUCZ010000014.1  10903787-10903900
            1011-1116           JAXUCZ010000014.1  10905467-10905572
            1117-1180           JAXUCZ010000014.1  10915736-10915799
            1181-1258           JAXUCZ010000014.1  10922769-10922846
            1259-1353           JAXUCZ010000014.1  10923992-10924086
            1354-1422           JAXUCZ010000014.1  10927178-10927246
            1423-1521           JAXUCZ010000014.1  10929657-10929755
            1522-1675           JAXUCZ010000014.1  10930835-10930988
            1676-1812           JAXUCZ010000014.1  10932739-10932875
            1813-1902           JAXUCZ010000014.1  10935514-10935603
            1903-2044           JAXUCZ010000014.1  10936700-10936841
            2045-2208           JAXUCZ010000014.1  10954876-10955039
            2209-2331           JAXUCZ010000014.1  10958829-10958951
            2332-2394           JAXUCZ010000014.1  10960242-10960304
            2395-2461           JAXUCZ010000014.1  10968482-10968548
            2462-3230           JAXUCZ010000014.1  10970288-10971056
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3230
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /note="protein kinase cGMP-dependent 2"
                     /db_xref="GeneID:25523"
                     /db_xref="RGD:3401"
     exon            1..255
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            256..729
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..2557
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /EC_number="2.7.11.12"
                     /function="phosphotransferase"
                     /note="CGK 2; type II cGMP-dependent protein kinase; cGK2;
                     cGMP-dependent protein kinase II; protein kinase, cGMP-
                     dependent, type 2; cGMP dependent protein kinase type II;
                     protein kinase, cGMP-dependent, type II"
                     /codon_start=1
                     /product="cGMP-dependent protein kinase 2"
                     /protein_id="NP_037144.1"
                     /db_xref="GeneID:25523"
                     /db_xref="RGD:3401"
                     /translation="MGNGSVKPKHSKHPDGQSGNLSNEALRSKVAELEREVKRKDAEL
                     QEREYHLKELREQLAKQTVAIAELTEELQSKCIQLNKLQDVIHVQGGSPLQASPDKVP
                     LDVHRKTSGLVSLHSRRGAKAGVSAEPTSRTYDLNKPPEFSFEKARVRKDSSEKKLIT
                     DALNKNQFLKRLDPQQIKDMVECMYGRNYQQGSYIVKQGEPGNHIFVLAEGRLEVFQG
                     EKLLSSIPMWTTFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEE
                     YRNFLRSVSLLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVT
                     QSTEGHDQPQLIKTLQKGEYFGEKALISDDVRSANIIAEENDVACLVIDRETFNQTVG
                     TFDELQKYLEGYVATLNRDDEKRHAKRSMSSWKLSKALSLEMIQLKEKVARFSSTSPF
                     QNLEIIATLGVGGFGRVELVKVKNENIAFAMKCIRKKHIVDTKQQEHVYSEKRILEEL
                     CSPFIVKLYRTFKDNKYVYMLLEACLGGELWSILRDRGSFDEPTSKFCVACVTEAFDY
                     LHRLGIIYRDLKPENLILDADGYLKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILN
                     KGHDFSVDFWSLGILVYELLTGNPPFSGIDQMMTYNLILKGIEKMDFPRKITRRPEDL
                     IRRLCRQNPTERLGNLKNGINDIKKHRWLNGFNWEGLKARSLPSPLRRELSGPIDHSY
                     FDKYPPEKGVPPDEMSGWDKDF"
     exon            730..896
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1010
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1116
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1180
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1258
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1353
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1422
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1521
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1675
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1812
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1902
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2044
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2208
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2331
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2394
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2461
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
     exon            2462..3230
                     /gene="Prkg2"
                     /gene_synonym="cGKII; GDPKII"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagagcag cgaggcggca gcacccacgt cgccgcagct cccgcccgca gcgcgcccgc
       61 cgcgtccccg gctcccacgc agcgcgagcg gcggcgccag cagcccggac cccgcacggt
      121 gcgcacggcg cgtcggggct gagctgagct gagcccggct ggggccgcag aggagcggcg
      181 tggcggagga cgccgagacg ctgcggccgc gcggagggga cgagctgcgc acttggaaag
      241 ttacccggcg gcctggttcc tgagcaacat gggaaatggt tcagtgaaac ccaagcattc
      301 gaagcaccca gacggccagt cagggaacct cagcaatgaa gccctgcgga gcaaagtggc
      361 agagctggag cgcgaggtga agaggaagga tgcagaactt caggagcgcg agtaccacct
      421 gaaggagctt cgggagcagc tggctaagca gaccgtggcc attgcggagc tcaccgagga
      481 gctgcagagc aagtgcatcc agctgaacaa gctgcaggat gttatccacg tgcagggagg
      541 aagcccactg caggcctctc ccgacaaagt gcctctggat gttcaccgca agacctcagg
      601 cttggtctcc ctccacagca ggaggggggc gaaggctgga gtgtctgcag agcccacaag
      661 ccggacctat gacctcaaca agccccctga gttctccttt gagaaagcga gggtcaggaa
      721 ggattccagt gagaaaaaac ttatcacaga cgccctgaat aagaaccagt ttctgaagag
      781 actggatccg cagcagatca aagacatggt ggaatgcatg tacgggagaa actatcaaca
      841 gggcagttac atcgttaagc aaggggaacc tggaaaccac atctttgtgc tggccgaggg
      901 tagactggag gtgttccaag gagagaaatt gctgtcgtcc atcccaatgt ggaccacgtt
      961 tggggagctg gctattttgt ataattgtac gcggactgcc tctgtgaaag ctattaccaa
     1021 tgttaaaact tgggctctcg atagagaggt tttccagaac attatgagga gaacggcgca
     1081 agccagggat gaggaataca gaaacttcct cagaagtgtc tccttgttga agaatttacc
     1141 tgaagacaaa ctaaccaaga ttattgactg cttggaagtg gaatactatg acaaaggaga
     1201 ttatatcatc agagaaggag aggaagggag cacctttttc atcttggcaa aaggaaaggt
     1261 gaaagtcaca cagagcacag agggccatga tcagccacag ttgatcaaaa cactgcagaa
     1321 aggagagtac tttggagaaa aggctctgat cagtgatgat gtcagatcgg ccaatataat
     1381 cgcggaagaa aatgatgtcg catgcctcgt gatcgaccga gaaacattca accaaactgt
     1441 cgggacattt gatgaactcc aaaaatacct tgaggggtat gtggccaccc tgaaccgtga
     1501 cgatgaaaag agacacgcaa agcgctccat gtctagctgg aagttgtcca aagccctttc
     1561 tctggagatg attcagctga aagagaaggt ggccagattc tcctcaacct ccccattcca
     1621 gaaccttgag attatcgcaa cactgggcgt tggtgggttc ggaagagtgg agcttgttaa
     1681 agttaaaaat gagaacatcg cttttgccat gaagtgtata aggaagaagc acattgttga
     1741 cactaaacag caggaacatg tctactccga gaagaggatc ctggaggagc tgtgttctcc
     1801 cttcatcgtg aaattgtatc gtactttcaa ggacaataaa tacgtataca tgcttctgga
     1861 ggcctgctta ggtggggagc tctggagtat attaagggac agaggcagct tcgatgaacc
     1921 cacctccaaa ttctgtgtgg cctgcgtgac agaagcattc gattatctac accgactagg
     1981 cattatctac agagacctga agccagagaa cttaattctg gatgccgatg gctaccttaa
     2041 gttggttgac tttggattcg ctaagaagat tggctctggg cagaaaacgt ggacattctg
     2101 tgggactcca gagtatgtgg cccccgaggt cattcttaac aaaggacatg acttcagtgt
     2161 ggatttctgg tccctgggga ttctggtcta tgagcttcta acgggcaacc ctcccttttc
     2221 tgggatagac caaatgatga cctacaattt gattctcaaa gggatcgaga aaatggattt
     2281 tcctagaaag ataacaaggc gacccgagga tttgatccgg aggctttgca ggcaaaaccc
     2341 aacagaaagg ctggggaacc tgaagaatgg gatcaacgac attaagaaac acaggtggtt
     2401 aaacggtttc aattgggagg ggttgaaagc acggagcctt ccctcacctt tacgaagaga
     2461 gctcagtggc cccatagatc acagctactt tgacaagtat cctcctgaaa agggggttcc
     2521 tccggatgaa atgtcaggct gggataagga cttctgacag gagagaaacc gacgccaccg
     2581 tggaagagga ccgtgaggat cggtgacacg atgctgatta tccctctctt caaagcattg
     2641 ttagatctcc cggaagacaa tggcagaaaa gaaaaccctg atagacaggg aaggagagtg
     2701 gccggatgtg gttctgaatg agaatgtgtc ctttagatgc tgtgaattat tcctgtattc
     2761 cattctgttc ttgtctaaag atgtcaaagg ttgttccttt ccatttccat ggtccgatcc
     2821 attttcgttg gcatagcaca gttttctctc aaatcggttt ctccctccaa atcaaactct
     2881 cctgcctaga atcctaataa tattaatatg gcttttgttc tcgagcacct aagttatcca
     2941 gatagaagga agactacaga acaacgttag aagaatcact ccagggctca gcagacacca
     3001 gggacttcct cctccgattg tggtttccag acatcttggg aagtcaatag aagaccatga
     3061 attttatttt ctttcaactt acagatacac taatatattt ttcgatgtta ttgaagcaaa
     3121 aggaaacatt tggatattaa tgagtagtgc cagttactaa agaaggccag tcaatcaaat
     3181 cagataatca tatcagtttt aataaaaaaa tagaaaaaat aaagcaaaaa
//
