LOCUS       NM_001105731            2294 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein kinase cGMP-dependent 1 (Prkg1), mRNA.
ACCESSION   NM_001105731 XM_001080425 XM_001080430 XM_219805
VERSION     NM_001105731.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Fedorova,O.V., Shilova,V.Y., Zernetkina,V., Juhasz,O., Wei,W.,
            Lakatta,E.G. and Bagrov,A.Y.
  TITLE     Silencing of PKG1 Gene Mimics Effect of Aging and Sensitizes Rat
            Vascular Smooth Muscle Cells to Cardiotonic Steroids: Impact on
            Fibrosis and Salt Sensitivity
  JOURNAL   J Am Heart Assoc 12 (12), e028768 (2023)
   PUBMED   37301747
  REMARK    GeneRIF: Silencing of PKG1 Gene Mimics Effect of Aging and
            Sensitizes Rat Vascular Smooth Muscle Cells to Cardiotonic
            Steroids: Impact on Fibrosis and Salt Sensitivity.
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Torregroza,C., Glashoerster,C.O., Feige,K., Stroethoff,M.,
            Raupach,A., Heinen,A., Hollmann,M.W. and Huhn,R.
  TITLE     Mediation of the Cardioprotective Effects of Mannitol Discovered,
            with Refutation of Common Protein Kinases
  JOURNAL   Int J Mol Sci 22 (22), 12471 (2021)
   PUBMED   34830353
  REMARK    GeneRIF: Mediation of the Cardioprotective Effects of Mannitol
            Discovered, with Refutation of Common Protein Kinases.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Yu,L.M., Di,W.C., Dong,X., Li,Z., Zhang,Y., Xue,X.D., Xu,Y.L.,
            Zhang,J., Xiao,X., Han,J.S., Liu,Y., Yang,Y. and Wang,H.S.
  TITLE     Melatonin protects diabetic heart against ischemia-reperfusion
            injury, role of membrane receptor-dependent cGMP-PKG activation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1864 (2), 563-578 (2018)
   PUBMED   29196237
  REMARK    GeneRIF: melatonin ameliorated diabetic myocardial
            ischemia-reperfusion injury through cGMP-PKGIalpha, by modulating
            Nrf-2-HO-1 and MAPK signaling, thus reducing myocardial apoptosis
            and oxidative stress and preserving cardiac function
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Piwkowska,A., Rogacka,D., Audzeyenka,I., Kasztan,M., Angielski,S.
            and Jankowski,M.
  TITLE     Intracellular calcium signaling regulates glomerular filtration
            barrier permeability: the role of the PKGIalpha-dependent pathway
  JOURNAL   FEBS Lett 590 (12), 1739-1748 (2016)
   PUBMED   27230807
  REMARK    GeneRIF: These data suggest the involvement of calcium and
            PKGIalpha signaling in insulin-enhanced filtration barrier
            permeability in podocytes.
REFERENCE   5  (bases 1 to 2294)
  AUTHORS   Kim,J.J., Lorenz,R., Arold,S.T., Reger,A.S., Sankaran,B.,
            Casteel,D.E., Herberg,F.W. and Kim,C.
  TITLE     Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated
            Dimeric Interface that Facilitates cGMP-Induced Activation
  JOURNAL   Structure 24 (5), 710-720 (2016)
   PUBMED   27066748
REFERENCE   6  (bases 1 to 2294)
  AUTHORS   Jorgensen,T.D., Dissing,S. and Gromada,J.
  TITLE     Cyclic GMP potentiates phenylephrine but not cyclic
            ADP-ribose-evoked calcium release from rat lacrimal acinar cells
  JOURNAL   FEBS Lett 391 (1-2), 117-120 (1996)
   PUBMED   8706897
REFERENCE   7  (bases 1 to 2294)
  AUTHORS   Gambaryan,S., Hausler,C., Markert,T., Pohler,D., Jarchau,T.,
            Walter,U., Haase,W., Kurtz,A. and Lohmann,S.M.
  TITLE     Expression of type II cGMP-dependent protein kinase in rat kidney
            is regulated by dehydration and correlated with renin gene
            expression
  JOURNAL   J Clin Invest 98 (3), 662-670 (1996)
   PUBMED   8698857
REFERENCE   8  (bases 1 to 2294)
  AUTHORS   Pohler,D., Butt,E., Meissner,J., Muller,S., Lohse,M., Walter,U.,
            Lohmann,S.M. and Jarchau,T.
  TITLE     Expression, purification, and characterization of the
            cGMP-dependent protein kinases I beta and II using the baculovirus
            system
  JOURNAL   FEBS Lett 374 (3), 419-425 (1995)
   PUBMED   7589584
REFERENCE   9  (bases 1 to 2294)
  AUTHORS   Clementi,E., Vecchio,I., Sciorati,C. and Nistico,G.
  TITLE     Nitric oxide modulation of agonist-evoked intracellular Ca2+
            release in neurosecretory PC-12 cells: inhibition of phospholipase
            C activity via cyclic GMP-dependent protein kinase I
  JOURNAL   Mol Pharmacol 47 (3), 517-524 (1995)
   PUBMED   7535379
REFERENCE   10 (bases 1 to 2294)
  AUTHORS   Sandberg,M., Natarajan,V., Ronander,I., Kalderon,D., Walter,U.,
            Lohmann,S.M. and Jahnsen,T.
  TITLE     Molecular cloning and predicted full-length amino acid sequence of
            the type I beta isozyme of cGMP-dependent protein kinase from human
            placenta. Tissue distribution and developmental changes in rat
  JOURNAL   FEBS Lett 255 (2), 321-329 (1989)
   PUBMED   2792381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 7, 2022 this sequence version replaced NM_001105731.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU251189.1, SRR26643298.7728.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               JAXUCZ010000001.1  239051919-239052184 c
            267-433             JAXUCZ010000001.1  238886618-238886784 c
            434-547             JAXUCZ010000001.1  238589038-238589151 c
            548-653             JAXUCZ010000001.1  238254188-238254293 c
            654-717             JAXUCZ010000001.1  238157296-238157359 c
            718-795             JAXUCZ010000001.1  238018637-238018714 c
            796-890             JAXUCZ010000001.1  238013372-238013466 c
            891-956             JAXUCZ010000001.1  237959298-237959363 c
            957-1031            JAXUCZ010000001.1  237932423-237932497 c
            1032-1128           JAXUCZ010000001.1  237868527-237868623 c
            1129-1268           JAXUCZ010000001.1  237848351-237848490 c
            1269-1358           JAXUCZ010000001.1  237846829-237846918 c
            1359-1500           JAXUCZ010000001.1  237840038-237840179 c
            1501-1664           JAXUCZ010000001.1  237838620-237838783 c
            1665-1787           JAXUCZ010000001.1  237834893-237835015 c
            1788-1850           JAXUCZ010000001.1  237834745-237834807 c
            1851-1917           JAXUCZ010000001.1  237826057-237826123 c
            1918-2294           JAXUCZ010000001.1  237823053-237823429 c
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..2294
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /note="protein kinase cGMP-dependent 1"
                     /db_xref="GeneID:54286"
                     /db_xref="RGD:1587390"
     CDS             1..2016
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /note="protein kinase, cGMP-dependent, type I; cGMP
                     dependent protein kinase type 1; protein kinase,
                     cGMP-dependent, type 1; cAMP-dependent protein kinase
                     catalytic subunit PRKX-like"
                     /codon_start=1
                     /product="cGMP-dependent protein kinase 1"
                     /protein_id="NP_001099201.3"
                     /db_xref="GeneID:54286"
                     /db_xref="RGD:1587390"
                     /translation="MSELEEDFAKILMLKEERIKELEKRLSEKEEEIQELKRKLHKCQ
                     SVLPVPSTHIGPRTTRAQGISAEPQTYRSFHDLRQAFRKFTKSERSKDLIKEAILDND
                     FMKNLELSQIQEIVDCMYPVEYGKDSCIIKEGDVGSLVYVMEDGKVEVTKEGVKLCTM
                     GPGKVFGELAILYNCTRTATVKTLVNVKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKS
                     VPTFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGKVNVTREDSPSE
                     DPVFLRTLGKGDWFGEKALQGEDVRTANVIAAEAVTCLVIDRDSFKHLIGGLDDVSNK
                     AYEDAEAKAKYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKIL
                     KKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTIL
                     RDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKK
                     IGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKT
                     YNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNW
                     EGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEPPPDDNSGWDIDF"
     exon            1..266
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            267..433
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            434..547
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            548..653
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            654..717
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            718..795
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            796..890
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            891..956
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1031
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1128
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1268
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1358
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1500
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1664
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1787
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..1850
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1917
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..2294
                     /gene="Prkg1"
                     /gene_synonym="cGk1; Pkgi"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagcgaac tggaggaaga ctttgcgaag attctcatgc tcaaggagga gaggatcaaa
       61 gagctggaga agcggctgtc agagaaagag gaagaaatcc aggagctgaa gaggaaactc
      121 cacaaatgcc agtcggtgct gcccgtgccc tccacccaca ttggcccgcg gaccacccgg
      181 gcgcagggca tctccgcgga gccgcagacc tacaggtcct tccacgacct gcgccaggcg
      241 ttccggaagt tcactaaatc cgagaggtcg aaggatctca taaaggaggc tatccttgac
      301 aatgacttca tgaagaactt ggagctgtca cagatccagg agattgtgga ttgtatgtac
      361 cccgtggaat atgggaagga cagctgcatc atcaaggaag gcgatgtggg gtcactggtg
      421 tatgtcatgg aagatgggaa ggtcgaagtc acaaaagaag gtgtgaagtt gtgcaccatg
      481 ggtcccggga aagtgttcgg ggagctggct attctttaca actgtacccg gacagcgacc
      541 gtcaagactc ttgtaaatgt gaaactctgg gccattgatc gacaatgttt tcaaacaata
      601 atgatgagaa caggactcat caagcacacc gagtacatgg agtttttaaa aagtgttcca
      661 acattccaga gccttcctga tgaaatcctc agcaagctgg ctgatgtcct cgaagagact
      721 cactatgaaa atggagaata tatcataagg cagggtgcaa gaggagacac cttcttcatc
      781 atcagcaaag ggaaggtaaa cgttacccga gaagactcac caagtgaaga cccagtcttt
      841 cttagaactt tagggaaggg agattggttt ggagagaaag ccttgcaggg ggaggatgta
      901 agaacagcga acgtcattgc tgcagaggct gtcacctgcc tcgtgattga cagagactct
      961 ttcaagcatt taattggagg actggatgat gtctctaaca aagcatatga ggatgcagaa
     1021 gcgaaagcaa aatatgaagc cgaagctgcc ttcttcgcca acctgaagct gtctgacttc
     1081 aacatcattg acacccttgg agtgggaggt ttcggacgag tggagctggt ccagttgaag
     1141 agtgaagaat ctaaaacatt tgcgatgaag atcctcaaga aacgacacat tgtggacacg
     1201 agacagcagg agcacatccg ctcagagaag cagatcatgc agggggctca ttccgatttc
     1261 atcgtgaggc tataccggac atttaaagac agcaaatact tgtatatgtt gatggaagct
     1321 tgcctaggtg gagaactctg gactattctc agggataggg gttcatttga agactcgaca
     1381 accagatttt acacagcatg tgtggtagaa gcgtttgcct atctgcattc caaaggaatc
     1441 atttacaggg acctcaagcc agaaaatctc atcctagatc accgaggtta tgccaaactg
     1501 gttgactttg gctttgcaaa gaaaatagga tttggaaaga aaacatggac tttttgtggg
     1561 accccagaat acgtggcccc agagatcatc ctgaacaaag gccatgacat ttctgctgac
     1621 tactggtcac tagggattct gatgtatgag cttctgactg gcagcccacc tttctcaggc
     1681 ccagatccta tgaaaaccta caacatcata ctgcggggga ttgacatgat agaatttcca
     1741 aagaagattg caaaaaatgc tgctaattta attaaaaaac tatgcaggga caacccatca
     1801 gaaaggttag gaaatttgaa aaacggagtc aaagacattc aaaaacacaa gtggtttgag
     1861 ggctttaact gggaaggctt aagaaaaggc accttgactc ctcccataat tccgagcgtt
     1921 gcgtcgccca cggacacaag caattttgac agtttccctg aggacagcga cgagccaccg
     1981 cctgatgaca actcaggctg ggacatagac ttctaatgca tttctcttac ctgcttctgc
     2041 cttgctgaag acagcttttt tctctgagac acagctgcca gcaaacctga gggaaagaga
     2101 gaagatgagt gctcggggtc accatgatgc ctttgatcga tgctgctcca gtcagtaact
     2161 acagtggcat taggacttaa tgcttagact acgacagtgc tctttacctg ttttatgttt
     2221 gaacctaaaa tagcagttga catggtggtc ctgaagcaaa gcctttcacc agtaaagcga
     2281 tgttttctat tgtt
//
