LOCUS       NM_001108327           12767 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein kinase, DNA-activated, catalytic subunit
            (Prkdc), mRNA.
ACCESSION   NM_001108327 XM_001068336 XM_003751100 XM_003752534 XM_341020
VERSION     NM_001108327.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12767)
  AUTHORS   Cardinale,A., Saladini,S., Lupacchini,L., Ruspantini,I., De
            Dominicis,C., Papale,M., Silvagno,F., Garaci,E., Mollinari,C. and
            Merlo,D.
  TITLE     DNA repair protein DNA-PK protects PC12 cells from oxidative
            stress-induced apoptosis involving AKT phosphorylation
  JOURNAL   Mol Biol Rep 49 (2), 1089-1101 (2022)
   PUBMED   34797489
  REMARK    GeneRIF: DNA repair protein DNA-PK protects PC12 cells from
            oxidative stress-induced apoptosis involving AKT phosphorylation.
REFERENCE   2  (bases 1 to 12767)
  AUTHORS   Shao,Z., Flynn,R.A., Crowe,J.L., Zhu,Y., Liang,J., Jiang,W.,
            Aryan,F., Aoude,P., Bertozzi,C.R., Estes,V.M., Lee,B.J., Bhagat,G.,
            Zha,S. and Calo,E.
  TITLE     DNA-PKcs has KU-dependent function in rRNA processing and
            haematopoiesis
  JOURNAL   Nature 579 (7798), 291-296 (2020)
   PUBMED   32103174
REFERENCE   3  (bases 1 to 12767)
  AUTHORS   Beldick,S.R., Hong,J., Altamentova,S., Khazaei,M., Hundal,A.,
            Zavvarian,M.M., Rumajogee,P., Chio,J. and Fehlings,M.G.
  TITLE     Severe-combined immunodeficient rats can be used to generate a
            model of perinatal hypoxic-ischemic brain injury to facilitate
            studies of engrafted human neural stem cells
  JOURNAL   PLoS One 13 (11), e0208105 (2018)
   PUBMED   30485360
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12767)
  AUTHORS   Morchikh,M., Cribier,A., Raffel,R., Amraoui,S., Cau,J., Severac,D.,
            Dubois,E., Schwartz,O., Bennasser,Y. and Benkirane,M.
  TITLE     HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex
            that Regulates DNA-Mediated Innate Immune Response
  JOURNAL   Mol Cell 67 (3), 387-399 (2017)
   PUBMED   28712728
REFERENCE   5  (bases 1 to 12767)
  AUTHORS   Chen,H., Han,L., Tsai,H., Wang,Z., Wu,Y., Duo,Y., Cao,W., Chen,L.,
            Tan,Z., Xu,N., Huang,X., Zhuang,J. and Huang,L.
  TITLE     PICT-1 is a key nucleolar sensor in DNA damage response signaling
            that regulates apoptosis through the RPL11-MDM2-p53 pathway
  JOURNAL   Oncotarget 7 (50), 83241-83257 (2016)
   PUBMED   27829214
REFERENCE   6  (bases 1 to 12767)
  AUTHORS   Taccioli,G.E., Amatucci,A.G., Beamish,H.J., Gell,D., Xiang,X.H.,
            Torres Arzayus,M.I., Priestley,A., Jackson,S.P., Marshak
            Rothstein,A., Jeggo,P.A. and Herrera,V.L.
  TITLE     Targeted disruption of the catalytic subunit of the DNA-PK gene in
            mice confers severe combined immunodeficiency and radiosensitivity
  JOURNAL   Immunity 9 (3), 355-366 (1998)
   PUBMED   9768755
REFERENCE   7  (bases 1 to 12767)
  AUTHORS   Araki,R., Fujimori,A., Hamatani,K., Mita,K., Saito,T., Mori,M.,
            Fukumura,R., Morimyo,M., Muto,M., Itoh,M., Tatsumi,K. and Abe,M.
  TITLE     Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase
            catalytic subunit of severe combined immune deficiency mice
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2438-2443 (1997)
   PUBMED   9122213
REFERENCE   8  (bases 1 to 12767)
  AUTHORS   Li,T., Ramirez,K. and Palacios,R.
  TITLE     Distinct patterns of Fas cell surface expression during development
            of T- or B-lymphocyte lineages in normal, scid, and mutant mice
            lacking or overexpressing p53, bcl-2, or rag-2 genes
  JOURNAL   Cell Growth Differ 7 (1), 107-114 (1996)
   PUBMED   8788039
REFERENCE   9  (bases 1 to 12767)
  AUTHORS   Hartley,K.O., Gell,D., Smith,G.C., Zhang,H., Divecha,N.,
            Connelly,M.A., Admon,A., Lees-Miller,S.P., Anderson,C.W. and
            Jackson,S.P.
  TITLE     DNA-dependent protein kinase catalytic subunit: a relative of
            phosphatidylinositol 3-kinase and the ataxia telangiectasia gene
            product
  JOURNAL   Cell 82 (5), 849-856 (1995)
   PUBMED   7671312
REFERENCE   10 (bases 1 to 12767)
  AUTHORS   Strasser,A., Harris,A.W., Corcoran,L.M. and Cory,S.
  TITLE     Bcl-2 expression promotes B- but not T-lymphoid development in scid
            mice
  JOURNAL   Nature 368 (6470), 457-460 (1994)
   PUBMED   8133891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1 and BF400782.1.
            
            On or before Aug 28, 2019 this sequence version replaced
            XM_003751100.4, XM_003752534.4, NM_001108327.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. This transcript is based on
            transcript alignments from orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000011.1  98761932-98762108   c
            178-254             JAXUCZ010000011.1  98756723-98756799   c
            255-347             JAXUCZ010000011.1  98756539-98756631   c
            348-422             JAXUCZ010000011.1  98755383-98755457   c
            423-531             JAXUCZ010000011.1  98754609-98754717   c
            532-644             JAXUCZ010000011.1  98753937-98754049   c
            645-744             JAXUCZ010000011.1  98753742-98753841   c
            745-800             JAXUCZ010000011.1  98752063-98752118   c
            801-831             JAXUCZ010000011.1  98751951-98751981   c
            832-989             JAXUCZ010000011.1  98750482-98750639   c
            990-1136            JAXUCZ010000011.1  98736799-98736945   c
            1137-1301           JAXUCZ010000011.1  98735589-98735753   c
            1302-1470           JAXUCZ010000011.1  98732951-98733119   c
            1471-1520           JAXUCZ010000011.1  98731443-98731492   c
            1521-1646           JAXUCZ010000011.1  98730369-98730494   c
            1647-1799           JAXUCZ010000011.1  98728101-98728253   c
            1800-1912           JAXUCZ010000011.1  98726323-98726435   c
            1913-2072           JAXUCZ010000011.1  98725778-98725937   c
            2073-2159           JAXUCZ010000011.1  98725033-98725119   c
            2160-2279           JAXUCZ010000011.1  98723557-98723676   c
            2280-2439           JAXUCZ010000011.1  98722813-98722972   c
            2440-2546           JAXUCZ010000011.1  98715076-98715182   c
            2547-2637           JAXUCZ010000011.1  98710916-98711006   c
            2638-2798           JAXUCZ010000011.1  98709132-98709292   c
            2799-2948           JAXUCZ010000011.1  98708204-98708353   c
            2949-3056           JAXUCZ010000011.1  98698358-98698465   c
            3057-3283           JAXUCZ010000011.1  98695951-98696177   c
            3284-3378           JAXUCZ010000011.1  98691843-98691937   c
            3379-3478           JAXUCZ010000011.1  98690069-98690168   c
            3479-3612           JAXUCZ010000011.1  98687277-98687410   c
            3613-3867           JAXUCZ010000011.1  98685594-98685848   c
            3868-4088           JAXUCZ010000011.1  98674416-98674636   c
            4089-4297           JAXUCZ010000011.1  98668125-98668333   c
            4298-4430           JAXUCZ010000011.1  98667572-98667704   c
            4431-4589           JAXUCZ010000011.1  98667005-98667163   c
            4590-4790           JAXUCZ010000011.1  98666094-98666294   c
            4791-4976           JAXUCZ010000011.1  98664492-98664677   c
            4977-5081           JAXUCZ010000011.1  98663847-98663951   c
            5082-5249           JAXUCZ010000011.1  98662356-98662523   c
            5250-5377           JAXUCZ010000011.1  98656465-98656592   c
            5378-5582           JAXUCZ010000011.1  98655261-98655465   c
            5583-5758           JAXUCZ010000011.1  98654097-98654272   c
            5759-5927           JAXUCZ010000011.1  98652127-98652295   c
            5928-5993           JAXUCZ010000011.1  98651622-98651687   c
            5994-6066           JAXUCZ010000011.1  98650573-98650645   c
            6067-6215           JAXUCZ010000011.1  98648174-98648322   c
            6216-6353           JAXUCZ010000011.1  98647274-98647411   c
            6354-6473           JAXUCZ010000011.1  98646962-98647081   c
            6474-6614           JAXUCZ010000011.1  98645584-98645724   c
            6615-6766           JAXUCZ010000011.1  98643913-98644064   c
            6767-6898           JAXUCZ010000011.1  98642719-98642850   c
            6899-7010           JAXUCZ010000011.1  98640632-98640743   c
            7011-7135           JAXUCZ010000011.1  98635116-98635240   c
            7136-7285           JAXUCZ010000011.1  98634867-98635016   c
            7286-7459           JAXUCZ010000011.1  98630553-98630726   c
            7460-7558           JAXUCZ010000011.1  98629968-98630066   c
            7559-7766           JAXUCZ010000011.1  98628505-98628712   c
            7767-7956           JAXUCZ010000011.1  98625275-98625464   c
            7957-8172           JAXUCZ010000011.1  98623969-98624184   c
            8173-8285           JAXUCZ010000011.1  98621966-98622078   c
            8286-8417           JAXUCZ010000011.1  98621512-98621643   c
            8418-8597           JAXUCZ010000011.1  98612261-98612440   c
            8598-8803           JAXUCZ010000011.1  98608695-98608900   c
            8804-8942           JAXUCZ010000011.1  98605311-98605449   c
            8943-9131           JAXUCZ010000011.1  98603999-98604187   c
            9132-9356           JAXUCZ010000011.1  98601358-98601582   c
            9357-9465           JAXUCZ010000011.1  98600959-98601067   c
            9466-9577           JAXUCZ010000011.1  98597934-98598045   c
            9578-9764           JAXUCZ010000011.1  98593178-98593364   c
            9765-9939           JAXUCZ010000011.1  98584099-98584273   c
            9940-10133          JAXUCZ010000011.1  98582074-98582267   c
            10134-10338         JAXUCZ010000011.1  98580530-98580734   c
            10339-10484         JAXUCZ010000011.1  98579842-98579987   c
            10485-10696         JAXUCZ010000011.1  98572054-98572265   c
            10697-10784         JAXUCZ010000011.1  98567987-98568074   c
            10785-10928         JAXUCZ010000011.1  98567759-98567902   c
            10929-11124         JAXUCZ010000011.1  98555994-98556189   c
            11125-11192         JAXUCZ010000011.1  98553969-98554036   c
            11193-11413         JAXUCZ010000011.1  98552552-98552772   c
            11414-11506         JAXUCZ010000011.1  98552221-98552313   c
            11507-11596         JAXUCZ010000011.1  98551371-98551460   c
            11597-11668         JAXUCZ010000011.1  98550832-98550903   c
            11669-11870         JAXUCZ010000011.1  98550562-98550763   c
            11871-12059         JAXUCZ010000011.1  98548556-98548744   c
            12060-12199         JAXUCZ010000011.1  98547508-98547647   c
            12200-12751         JAXUCZ010000011.1  98544953-98545504   c
            12752-12767         BF400782.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..12767
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..12767
                     /gene="Prkdc"
                     /note="protein kinase, DNA-activated, catalytic subunit"
                     /db_xref="GeneID:360748"
                     /db_xref="RGD:1308982"
     exon            1..177
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..12404
                     /gene="Prkdc"
                     /EC_number="2.7.11.1"
                     /note="protein kinase, DNA activated, catalytic
                     polypeptide"
                     /codon_start=1
                     /product="DNA-dependent protein kinase catalytic subunit"
                     /protein_id="NP_001101797.2"
                     /db_xref="GeneID:360748"
                     /db_xref="RGD:1308982"
                     /translation="MADPGAGLRCWLLQLQEFVSAADRYNAAGASYQLIRGLGQECVL
                     STCSAVQALQISLVFSKEFGLLVFIRKSLSIDEFRDCREEALKFLCVFLEKIDQKVLH
                     YSFDIKNTCISVYTKDRTAKCKIPALDLLIKLLKILRSSRVMDEFKIGELFNKFYGEL
                     VSKSKLPDTVLEKVYELLGVLGEVHPSEMVNHSENLFRAFLGELKTQMTSTVREPKFP
                     VLAGCLKGLSSLLCNFTKSMEEDPQTSKEIFGFTLKAIRPQIEMKRYAVPLAGLRLLT
                     LHASQFTTCLLDNYITLFEVLSKWCNHTNVELKKAAHSALESFLKQISFTVAEDAELH
                     KSKLKYFMEQFYGIIRNADSNNKDLAIAIRGYGLFAGPCKVINAKDVDFMYVELIQRC
                     KQMFLTQTDATEDHVYQMPSFLQSIASVLLYLDTVPEVYTPVLEHLMVVQIDSFPQYS
                     PKMQLVCCKALVKVFLSLTEKGPVHWNCISAVVHQGLIRICSKPVVLQKDVESRSENR
                     WASEEVRMGRWKVPTYKDYVDLFQNLLGCDQMADFILGDETFLFVNSSLKSLNHLLYD
                     EFIRSVLKIVEKLDLTLEKQTTGEQEDERTADVWVIPTSDPAANLHPIKPNDFSAFIN
                     LVEFCREILPKKQVSFFEPWVYSFAYELILQSTRLPLISGFYKLLSIAVKNARKIKYF
                     EGVSPKCLKHSPENTEKHSCFALFAKFGKEVSVKMKQYKDELLASCLTFVLSLPPDII
                     KLDVRAYVPALQMAFKLGLSHLPLAEIGLHALKEWSVHIDKSIMQPYYKDIVPCLDGY
                     LNTSTLSDETKSHWEVSALSRAARKGFNRDVVKLLKRTRNVTSDEALSLEEIRIRVVQ
                     ILGSLGGQINKNLITATSGERMKKYVAWDREKRLSFAVPFREMKPVIYLDVFLPRVTE
                     LALSASDRQTKVAACELLHSMVMFMLGRATQMPEGQGLPPMYQLYKHMFPVLLKLACD
                     VDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTLRDFCGQCV
                     QEFLKWSIKQTTPQQQEKSPVNSKSLFKRLYSLALHPNAFKRLGAALAFNHIYKEFRE
                     EGSLVEQFVFEALVTYMESLALAHADEKSLGTIQQCCDAIDHLRRIIEKKYISLNKAK
                     KRRLPRGFPPLTSLCLLDLVKWLFAHCGRPQTECRHKSIELFYKFVPLLPGNKSPSLW
                     LRDLIKAEGISFLINTFEGGASSSGQPSGILAQPTLLHLQGPVSLRGMLQWLDHLLAA
                     LECYNTFIEEKTVQVQEVLGTEVQSSLLKSVAFFLESIATCDARTVEQRFGTGLTGPP
                     SVQEEEKYNYSKCTVLVRIMEFTTTLLVTFPEDCKLLEKDLCNTKLMKVLVKMLCEPL
                     SIGFNIGDVQVMNHLPSICVNLLKALRKSPYRDKLETHLKEKVTAQSVEELCAINLCS
                     SAACQERTKLLSLLSACKQLHKAGFSHIISASQSTALNHSIGMRLLSLVYNGIAPAQE
                     KQYLQSLDPSCKSLASGLLELAFAFGGLCEHLVSLLLNSSMLSTQYLGSSQRNISFSH
                     GEYFYSLFPEVINTELLKSLDVTVSRLLESSSDNPKMVSTILNGMLDMSFRDRAVQKH
                     QGLKLATAILQNWRKCDSWWAPDSAPESKTTVLSLLAKMLQIDSTLSFDTNHSSFSEI
                     FTTYANLLADTKLGLHLKGQAVILLPFFTRVTEDRLGDLKHILEKFIVLNFPMKSDEF
                     PPDSLKYNNYVDCMKKFLDALELSQSPMLLQLMTDILCREQQHIMEELFQTTFKRIAR
                     RSPCVTQLNLLESVYTMFRKGGLLSDVTQAFVDRSLLTLLWHCDLDTLKEFFSRIVVE
                     AIDVLKSRFTKLNDTFDTQITKKMCYYKMLAVMYSRLLKDDVHSKESKINQAFQGSCV
                     AEGNELTKTLLKLCHDAFTENMAGESQLLEKRRLYHCAAYNCAISLISRVFNELKFYQ
                     GFLFSEKPEKNLFIFENLIDLKRCYTFPIEVEVPMERKKKYVEIRKEARDAANGASGN
                     PRYMSSLSYLTESSLSEEMSQFDFSTGVQSYSYSSQDRKPTTGHFQRREHQDSMAQDD
                     IIELEMDELNQHECMAPMTSLIKHMQRNVIAPKGQEGSISKDLPPWMKFLHDKLENAS
                     VSLNIRLFLAKLVINTEEVFRPYAKHWLGPLLQLAVCENIGEGIHYMIVEIVATILSW
                     TGLATPTGVPKYEVLANRLLYFLMKYVFHPKRAVFRHNLEIIKTLVECWKECLSIPYR
                     LIFEKFSNKDPNSKDNSVGIQLLGIVVANNLPPYDLKGDITSAMYFEALVNNMSFVKY
                     KEVYAAAAEVLGLILQHVTERKHVIAESVYELVVKQLKQHQNTMEDKFIVCLNKIVKG
                     FPPLADRFLNALFFLLPKFHGVMKTLCLEVVLCRAEAITGLYLQLKSKDFLQVMRHRD
                     DERQKVCLDIIYKMVAKLKPTELRELLNPVVEFVSHPSPTCREQMYNILMWIHDNYRD
                     PESQMDEDSQEIFKLAKDVLIQGLIDENLGLQLIIRNFWSHETRLPSNTLDRLLALNS
                     LYSPKIEVHFLSLATNFLLEMTRMSPDYLNPIFEHPLSECEFQEYTIDPDWRFRSTVL
                     TPMFIETQAFPSTLNTQTQEGSPSDRRQKPGQVRATQQQYDFTPTQTSVERSSFDWLT
                     GSSIDLMADHTVFSSESLSSSLLFSHKKSEKSQRVSWKSVGPDFGTKKLGLPGDEVDN
                     QVKSGTHSQTEILRLRRRFLKDQEKLSLLYAKRGLMEQKLEKDIKSELKMKQDAQVVL
                     YRSYRHGDLPDIQIQHSSLITPLQAVAQKDPIIAKQLFSSLFSGILKEMHKFRTTSEK
                     NIIIQNLLQDFNRFLNTTFLFFPPFVSCIQEISCQHVDLLTLDPAAVRVGCLASLQQP
                     GGIRLLEEALLHLLPKEPPTKRIRGKTCLPPDVLRWMELAKLYRSIGEYDVLHGIFSS
                     ELGTKQDTQNALLAEARSDYFQAANLYKEALNKLEWLDGEPTEAEKEFWEMASLDCYN
                     NLSQWKELEYRSTVNIGSENSLDLSKMWSKPFYQETYLPYVIRSKLKLLLQGEDNQSL
                     LTFVDEAMHKELQQMVLELQYSQELSLLYILQDDIDRATYYIKNAIQIFMQNYSSIDV
                     LLYRSRLAKLQSVQTLAEIEEFLNFIRKHGDLSSLGPLRRLLKTWTSRYPDTVTDPMH
                     IWDDIITNRCFFLSKIEERLTVSPGDHSMSVDEDEDSFAREGSEPKEDAHHILQSCRF
                     TMKMKMIESSWKQNNFSLSMKLLKEMHKESKIRESWRMQWIHSFCQLNHCRSHTQSPQ
                     EQVLTMLKTITLLDESDISNYLNKNIQAFCDQNILLGTSCRIMADALSREPACLSGLE
                     KSKTESIFALSGSNTENTERVISGLYQRAFHHLSMAVQSAEEETQLSCWGHEAAAERA
                     HAYMTLVGFCDQQLRKVEESASTASQKISTELEGYPALVVEKMLRALKLNSSEARLKF
                     PRLLQIIEQYPEETVNIIIKEISSIPCWQFIGWIGHMVALLDKEEAIAVQHTVEEIAD
                     NYPQAIIYPFIISSESYSFQNTSSGHNNKAFVERIKSKLDQGGVIQGFINALDQLSNP
                     DMLFKDWVNDTKDELGKNPVNKKNIEKLYERMYAALGDFRAPGLGPFRRKFIQTFGKE
                     FVKSFGNGGSKLLTMKLDEFRNITDSLFVRMRKDSKLPGNLKEYSPWMSEFTVKSELE
                     IPGQYDGKSKPLPEYHVRISGFDERVKVMVSLRKPKRIVIRGHDEKEYPFLVKGGEDL
                     RQDQRIEQLFEVMNAILSQDAACSQRNMQLRTYRVVPMTSRLGLIEWIENTMTLKDLL
                     LSNMSQEEKVAYDSDSKAPIYDYRDWLIKVSGRSDVKGYTLMYSRANRTETVTAFRRR
                     ENKVPADLLKRAFVKMSTSPEAFLALRSHFASSHALLCISHWLLGIGDRHLNNFMVAM
                     ETGSVIGIDFGHAFGSATQFLPIPELMPFRLTRQFISLMLPMKETGLVCTVMVHALRA
                     FRSCAGLLTDTMEVFVKEPSFDWKGFEQTMLRKGGSWIQEINVTEKNWYPQHKIRYAK
                     RKLAGANPAVITCDELRLGHEASPAFRSYVAVARGNKDYNIRAQEPESRLSEETQVKC
                     LVDQATDPNILGRTWEGWEPWM"
     exon            178..254
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            255..347
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            348..422
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            423..531
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            532..644
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            645..744
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            745..800
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            801..831
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            832..989
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1136
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1301
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1470
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1520
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1646
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1799
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1912
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2072
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2159
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2279
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2439
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2546
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2637
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2798
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2799..2948
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3056
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3283
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3378
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            3379..3478
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            3479..3612
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            3613..3867
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            3868..4088
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            4089..4297
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            4298..4430
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            4431..4589
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            4590..4790
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            4791..4976
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            4977..5081
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            5082..5249
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            5250..5377
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            5378..5582
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            5583..5758
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            5759..5927
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            5928..5993
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            5994..6066
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            6067..6215
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            6216..6353
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            6354..6473
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            6474..6614
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            6615..6766
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            6767..6898
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            6899..7010
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            7011..7135
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            7136..7285
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            7286..7459
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            7460..7558
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            7559..7766
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            7767..7956
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            7957..8172
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            8173..8285
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            8286..8417
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            8418..8597
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            8598..8803
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            8804..8942
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            8943..9131
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            9132..9356
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            9357..9465
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            9466..9577
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            9578..9764
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            9765..9939
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            9940..10133
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            10134..10338
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            10339..10484
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            10485..10696
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            10697..10784
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            10785..10928
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            10929..11124
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            11125..11192
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            11193..11413
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            11414..11506
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            11507..11596
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            11597..11668
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            11669..11870
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            11871..12059
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            12060..12199
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
     exon            12200..12752
                     /gene="Prkdc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcgctaag cggttccggc actatggcgg acccgggggc cggcttgcgg tgctggctac
       61 tacagctgca ggagttcgtg tccgcagcag accgctacaa tgctgccggg gccagttacc
      121 agctgatccg tggcctgggg caagagtgcg tgctgagcac ttgctctgca gtgcaggcat
      181 tgcagatctc cttagttttt tccaaagagt ttggtttgct tgtatttatc cggaagtcac
      241 ttagcattga tgaatttcgt gattgtagag aagaagccct aaaattttta tgtgttttct
      301 tagaaaaaat tgaccagaag gttctgcatt actcttttga tattaagaat acttgtatca
      361 gtgtttatac aaaagataga actgctaaat gtaaaattcc agccttagat cttctgatta
      421 agttacttaa gatactaaga agttccagag tcatggatga atttaagatc ggagaattat
      481 ttaacaaatt ctatggagaa cttgtatcaa aatcaaaact acctgataca gttttagaaa
      541 aagtctatga gctcctggga gtgttaggtg aggttcatcc tagtgaaatg gtaaatcatt
      601 cagaaaacct gttccgggca tttctgggag agcttaagac ccagatgaca tctacagtca
      661 gagaacctaa atttcctgtc ctagctggct gtctaaaggg actgtcctca cttctgtgca
      721 acttcaccaa gtccatggaa gaagatcccc agacttcaaa ggaaatattt ggttttacat
      781 taaaagcaat tcgtcctcag attgagatga agcgatacgc tgtgccctta gctggcctac
      841 gactacttac cctacatgca tctcaattta ctacctgcct tctggacaac tatattactt
      901 tatttgaagt actgtcaaag tggtgtaacc atacaaatgt ggaattaaaa aaagctgcac
      961 attcagccct ggagtccttc ctgaaacaga tttcatttac tgtggcagaa gatgcagagt
     1021 tgcataagag taagctgaag tacttcatgg aacagttcta tggaatcatc agaaatgcag
     1081 attcaaacaa caaggactta gccattgcta ttcgtggata tggactattt gcgggacctt
     1141 gcaaggttat aaatgcaaaa gatgttgact tcatgtacgt ggagctcatt cagcgctgta
     1201 agcagatgtt cctcactcag acagatgcta ctgaggatca tgtttaccag atgccaagtt
     1261 tccttcagtc tattgcaagt gtgttgcttt accttgacac agttccagag gtatatactc
     1321 cagtactgga acatctcatg gtggtacaga tagacagctt ccctcagtat agtcccaaaa
     1381 tgcagttggt gtgttgtaaa gcactagtaa aagttttcct atccttaaca gagaagggac
     1441 cagttcactg gaattgcatt agtgctgtgg tgcatcaagg tttaattcga atatgttcta
     1501 aaccagtggt tcttcaaaag gatgttgagt caaggtctga aaaccgttgg gcctcggagg
     1561 aagtcagaat gggcaggtgg aaagtaccca catacaaaga ctacgtggat ctttttcaga
     1621 atcttttagg ctgtgaccag atggcggatt ttatcttagg agatgaaaca tttctttttg
     1681 taaattcctc ccttaaaagt ctgaatcatt tactctatga tgaatttata agatcagttt
     1741 tgaagattgt ggaaaagttg gatcttacac tggaaaaaca gactactgga gagcaggagg
     1801 acgaacgcac tgctgatgtc tgggtgatcc caacttcaga tccagccgct aacttgcacc
     1861 ctataaaacc aaatgatttt tcagcattca ttaacctggt ggagttttgc agggagattc
     1921 ttcctaagaa acaagtaagc ttttttgagc catgggtgta ctcatttgca tatgagttaa
     1981 ttttacagtc tacacgctta ccactcatca gtggtttcta caaattgctt tctattgcag
     2041 tgaaaaatgc caggaaaata aaatattttg agggagttag cccaaagtgt ctgaaacatt
     2101 ctcctgaaaa tacagaaaag cattcttgct ttgctttatt tgcaaaattt ggcaaagagg
     2161 tgtcagttaa aatgaagcag tacaaggatg aacttttggc ttcttgttta acatttgttc
     2221 tgtccttgcc acctgacatc attaaacttg atgttcgagc ctatgttcct gcattgcaga
     2281 tggctttcaa gctgggcctg agccatctgc cattggcaga aataggtctg catgccctta
     2341 aagaatggtc agttcacatt gacaagtcta taatgcagcc ttactacaaa gacatcgtcc
     2401 cctgccttga tggatacctg aatacgtcaa ccttatcaga tgaaaccaag agccactggg
     2461 aagtgtcagc actttctcgg gctgctcgga agggatttaa tagagatgta gtgaagcttc
     2521 tgaaaaggac aagaaatgtt acatctgacg aagcactgtc cttagaagaa ataagaatta
     2581 gagtagtaca aatacttgga tctctgggag gacaaataaa caaaaatctt ataacagcta
     2641 catcaggaga aaggatgaag aagtatgtgg cgtgggacag ggagaaaaga ctcagctttg
     2701 cagtaccctt cagagagatg aagcctgtca tctatctgga tgtctttctg cctcgggtca
     2761 ctgaattggc tctttctgct agtgatcgac aaactaaagt agcagcttgt gaactgttac
     2821 acagcatggt tatgttcatg ttgggaagag ccactcagat gcctgaaggt caggggttgc
     2881 ctcccatgta ccagctttat aagcacatgt ttcctgtgct gcttaaactt gcatgtgatg
     2941 tggatcaagt gacaaggcaa ctctatgaac cacttgttat gcagctcatc cactggttta
     3001 ctaacaataa gaaattcgaa agtcaagata ctgtcgcctt attagaagcc atactggatg
     3061 gcattgtgga tcctgttgac agtactttaa gagatttttg tggacagtgt gttcaagaat
     3121 tcctcaaatg gtccattaag caaacaacac ctcagcagca agagaagagc ccagtaaaca
     3181 gcaagtcact tttcaagcgg ctctacagcc ttgcactaca tcctaatgcg ttcaagaggc
     3241 taggcgcagc acttgctttt aatcacatct acaaggaatt cagggaagaa ggatccctgg
     3301 tagaacagtt tgtttttgaa gccttagtga catatatgga aagtctggcc ttggcacatg
     3361 cagatgagaa atccttaggt acaattcagc agtgctgtga tgccattgat cacctaagac
     3421 gcatcattga aaagaagtac atttctttaa acaaagcaaa aaagcggcgt ttgccacggg
     3481 gatttccacc tttgacatca ttatgtttat tggatctggt caagtggctt ttcgctcact
     3541 gtggaagacc ccagacagaa tgtcgacaca agtccataga actcttttat aaatttgttc
     3601 ctttattacc aggcaacaaa tccccttctt tatggttgag agatcttata aaagcggaag
     3661 gtatttcttt tctcataaac acatttgaag gaggggcaag cagcagcggt cagccatcag
     3721 gcattcttgc tcagccaacc ctcctccact tgcaagggcc agtcagcctg cgaggaatgc
     3781 tccagtggct ggaccacctc cttgcagcac tggagtgcta caacacattt atcgaggaga
     3841 agactgtaca agtgcaagag gtcctgggta ctgaagtaca gtcttcactt ttgaagtctg
     3901 tggccttctt tttggaaagc atagcaacat gtgatgctag aacagtagaa caacgctttg
     3961 gcactgggct gaccggccct cccagtgtcc aagaggaaga aaaatacaat tacagcaaat
     4021 gcacagtctt ggtccggatt atggaattta ccacaaccct gctcgtcacc tttccagaag
     4081 attgcaagct cctggagaag gacttgtgta acacaaagct tatgaaggtc ttagtgaaaa
     4141 tgctctgtga gcccctgagc ataggtttca atattggcga cgtccaggtt atgaaccatc
     4201 ttcccagcat ttgtgtgaac ctgctgaaag cattgaggaa gtccccatac agagacaagc
     4261 tggagactca cctgaaggag aaagtgacag cacagagtgt tgaagagctc tgtgctatta
     4321 acttgtgtag ctctgcagct tgccaagaaa ggaccaagtt gctgtctctc ttatcagctt
     4381 gtaaacagct tcacaaagct ggtttctctc atattatatc tgcatctcag tctacagcat
     4441 taaaccattc cattggcatg agactgctgt ccttggttta taatggcatt gcgcctgcac
     4501 aggaaaagca gtacctgcag tctttggatc ccagctgtaa gagcctggcc agtggactcc
     4561 tggaattagc ctttgctttt ggaggactgt gtgagcatct tgtgagtttg ctcctgaatt
     4621 catcaatgtt gtctacacaa tatctgggca gttcacagag aaacattagc ttctcccatg
     4681 gggagtattt ctacagtttg tttccagaag taatcaacac tgaactgttg aaaagtcttg
     4741 atgttactgt atcaaggctt ctggagtcat cttcagataa tcccaaaatg gtgagtacta
     4801 ttttaaatgg tatgttagat atgagcttca gggatcgagc tgttcagaaa caccaaggac
     4861 tgaagcttgc gactgcaatt ctgcaaaact ggaggaagtg tgattcatgg tgggccccag
     4921 attctgctcc agagagcaaa acgactgtgc tgtccttact ggcaaaaatg ttgcagattg
     4981 attcaacttt atcttttgat acaaatcaca gctcattttc tgaaatcttc acaacgtatg
     5041 ctaatctact tgcagataca aagttgggtc tacacttaaa gggccaagcc gtcatccttc
     5101 ttccattctt caccagagtg acagaagaca ggctaggaga cctaaagcac attctggaaa
     5161 agttcattgt tcttaatttc cccatgaagt ctgacgaatt tcctcctgat tccctgaagt
     5221 acaataatta tgtggactgc atgaaaaagt tcctagatgc tttggaatta tctcagagtc
     5281 ctatgttgct tcagttgatg acagacattc tttgtaggga acagcaacat attatggaag
     5341 aattgttcca aaccaccttc aaaaggatcg ctaggcggag tccatgtgtc acacaattaa
     5401 atcttttgga aagtgtatac acaatgttcc ggaagggtgg cctcctttca gatgtcactc
     5461 aggcattcgt ggatcgctct ctcctcacct tgttgtggca ctgtgacttg gacacactga
     5521 aagagttctt tagcagaatt gtggtggagg ccattgatgt gttgaagtcc agatttacaa
     5581 agctaaatga cacttttgac actcaaatca ccaagaagat gtgctattac aagatgctag
     5641 ctgtgatgta ttctcgtctt ttaaaagatg atgttcactc taaagaatct aaaattaatc
     5701 aagctttcca aggctcctgt gttgcagaag gaaatgaact tacaaagaca cttcttaagt
     5761 tgtgccacga tgcatttaca gagaacatgg caggggaaag ccagttactg gaaaagagaa
     5821 gactttatca ttgtgctgca tacaactgtg ccatttctct gataagccga gtcttcaatg
     5881 agttgaaatt ttaccaaggg tttttgttta gtgaaaaacc agaaaagaat ttgtttattt
     5941 ttgaaaattt gatagacctg aaacgttgct atacatttcc tatagaagtt gaggttccta
     6001 tggaaagaaa gaaaaagtac gttgaaatta ggaaagaggc cagggatgca gcaaatgggg
     6061 cttcaggcaa tcctcgttat atgtcttcat tgtcatattt aacagagagt agcctaagtg
     6121 aagaaatgag tcaatttgat ttctcaactg gagttcagag ctattcatac agttctcaag
     6181 atcgtaaacc tacgacgggc cattttcaga gaagggagca tcaagattcc atggctcagg
     6241 atgacatcat agagttagag atggatgagc tcaatcaaca tgaatgtatg gcacccatga
     6301 catccctgat taaacacatg cagagaaatg tgattgcacc caagggacaa gagggttcaa
     6361 tatcaaaaga tcttccacct tggatgaaat ttctccatga caaactagaa aatgcgtcag
     6421 tatctttaaa tatccgtctc ttcttagcca agcttgttat taatacagaa gaggtctttc
     6481 gcccttatgc aaagcactgg ctgggccccc tgctacagct agctgtttgt gagaacattg
     6541 gagaaggaat tcactacatg atagtagaaa tagtagctac cattctctct tggacaggct
     6601 tggctacacc tacaggagtc cctaaatatg aagtcttagc aaatcgattg ctttattttc
     6661 taatgaaata tgtcttccat cccaaaagag ctgtgtttag acacaacctt gaaatcatta
     6721 aaacccttgt tgaatgctgg aaggagtgtc tgtccatccc ttacaggtta atatttgaaa
     6781 aattttccaa taaggacccc aattctaaag acaattctgt aggaattcaa ttattgggca
     6841 ttgtagtagc taataacttg cctccctatg acctaaaggg tgacatcacg agtgccatgt
     6901 attttgaagc tttagtcaat aacatgtcct ttgtgaagta taaagaagta tatgcagctg
     6961 cagcagaagt tctaggactc attcttcaac atgttactga gagaaaacac gtgatagcag
     7021 agtcggtata tgaactggtt gtaaaacaac taaagcaaca tcaaaatact atggaagaca
     7081 aatttatcgt atgcttaaac aaaatagtga agggcttccc tcctcttgct gacaggttct
     7141 tgaatgcttt gttctttctg ctgccaaaat ttcatggagt aatgaagacg ctttgtctgg
     7201 aagtggtact ttgtcgagca gaggcgatca caggcctata cttacagtta aagagtaagg
     7261 actttcttca agtcatgaga catagagatg atgaaagaca aaaggtgtgt ttggatataa
     7321 tttataagat ggtggcaaaa ttaaaaccaa cggaactccg agaacttctg aatcctgttg
     7381 tggaatttgt ttcccatcct tctccaacat gtagagaaca aatgtataat attcttatgt
     7441 ggattcatga caattacaga gatccagaga gtcaaatgga tgaagactcc caggaaatat
     7501 ttaaactcgc aaaagatgtg ctgattcaag gactgattga tgagaacctt ggactccaac
     7561 taattattcg gaatttctgg agccatgaaa cgagattgcc atccaataca ttggaccgat
     7621 tgttggcatt aaattcttta tattctccca agatagaagt ccacttttta agtttagcaa
     7681 caaattttct gcttgaaatg accaggatga gcccagatta tctaaacccc atttttgagc
     7741 atcctctttc agaatgtgaa tttcaggaat atactataga tcctgactgg cgttttcgta
     7801 gtactgttct taccccgatg tttattgaga cccaggcctt tccaagtact ctcaataccc
     7861 aaacccaaga agggtccccg tcagaccgaa ggcagaagcc tggacaagtg cgggccaccc
     7921 aacagcagta tgatttcact ccaacacaaa cttcagttga aaggagctca tttgattggc
     7981 taactggaag cagcattgac ctaatggcag atcatacagt cttctcttca gagtccttgt
     8041 cttcttcctt gctgttttcc cacaagaaga gtgaaaagtc acaaagagta tcctggaagt
     8101 cagtaggacc tgacttcggg acaaaaaagc tgggcctgcc tggtgatgag gtggataacc
     8161 aagtaaaaag tggcactcac agccagacag aaattctgag attacgcaga cgatttttaa
     8221 aggaccaaga aaaactgagt ttgctgtatg ccaaaagggg tctcatggag caaaaactag
     8281 aaaaggatat caagagtgag ttaaaaatga agcaggatgc ccaggttgtt ctttacagaa
     8341 gttatcgtca tggcgacctt cctgatatcc agatccagca cagcagtctg atcaccccct
     8401 tgcaggctgt ggcccagaaa gacccaataa ttgcaaaaca actcttcagc agcttgtttt
     8461 ctgggatttt gaaagaaatg cataaattta ggaccacatc tgaaaagaac atcatcatcc
     8521 aaaatttgct tcaagacttc aaccgcttcc tcaatacaac tttcttgttc tttccaccct
     8581 ttgtctcttg catccaggaa ataagttgcc aacacgtaga cttgctgaca cttgacccag
     8641 ccgcagttcg agtgggatgc ctggccagtc tgcaacagcc tggaggtatt cgtcttctgg
     8701 aagaggccct acttcacctg ctgcccaagg aaccacccac caaacgaatc cggggcaaga
     8761 cttgcttgcc tcccgatgtt ctccggtgga tggaacttgc taaactctat cgatcaattg
     8821 gggaatatga tgtcctccat ggcattttta gcagcgagtt aggaacaaag caggacactc
     8881 agaacgcact gttagcagaa gccagaagtg attattttca agctgctaac ttgtataagg
     8941 aggctttaaa taaattggag tggttagatg gtgaacccac agaagctgag aaggagttct
     9001 gggagatggc atcccttgac tgttacaaca acctctctca atggaaagaa cttgagtaca
     9061 ggtctacagt caatataggc agtgagaact ctcttgatct aagtaaaatg tggagcaaac
     9121 cattttacca ggagacgtat cttccttatg tgatccgcag caaactgaag ctcttgcttc
     9181 aaggagaaga caaccagtct ctgctaacat ttgtggatga agccatgcac aaagagctgc
     9241 agcagatggt cctagaactt cagtatagtc aagagctgag tcttctttac atcttacagg
     9301 atgatattga cagagccaca tactacatta aaaatgccat tcagattttc atgcaaaatt
     9361 attctagtat tgatgtcctc ttgtatagaa gtagactcgc caaattacag tctgtacaga
     9421 ctttagcaga aattgaggag ttcctcaatt ttatacgtaa acatggtgat ttatcatctc
     9481 tgggtcccct aaggaggctt ctgaaaacct ggaccagcag atacccagat actgtgacag
     9541 acccaatgca catctgggat gacatcatca caaatcgctg cttttttctc agtaaaatag
     9601 aggagagact gactgtttct ccaggagatc acagtatgag tgtggatgag gatgaagatt
     9661 cctttgccag ggaagggtcc gagccaaagg aagatgctca tcacatcctt cagagctgca
     9721 gattcaccat gaagatgaag atgatagaaa gctcctggaa gcagaataat ttctcacttt
     9781 ccatgaaact cctgaaagaa atgcataaag aatcaaaaat aagagagtct tggcgaatgc
     9841 agtggataca cagtttctgc cagctgaacc actgccggag ccacactcag agccctcagg
     9901 aacaagtcct caccatgctc aagaccatca cactgttgga tgaaagtgat atttcaaact
     9961 acttaaataa aaacattcag gccttttgtg accagaacat cctcttgggc acaagttgca
    10021 ggatcatggc tgatgctctc agcagggagc cagcctgcct gtctggcctg gagaaaagta
    10081 agacggaatc catctttgca ctttccggat ctaatacgga gaacacagag agggtaatct
    10141 caggtctgta ccagagagca ttccatcacc tctccatggc tgtgcagtca gctgaagagg
    10201 agacccaact ttcctgttgg ggccatgagg ctgcagctga gagggcccat gcttatatga
    10261 cactggtagg tttctgtgac caacaactcc gaaaggtaga agagagtgca tccactgcct
    10321 cacagaagat aagtacagaa ctggaaggat atccagcact tgtggtggag aaaatgttga
    10381 gagcgttaaa gttgaactct tctgaagcca ggctgaaatt tcctagatta cttcagatta
    10441 tagaacaata tccagaagag accgtaaaca taataataaa agagatttca tccattcctt
    10501 gctggcagtt cattggctgg atcggccaca tggttgcctt actggacaaa gaggaagcta
    10561 ttgcggtgca gcataccgtg gaagaaattg ctgataacta tccacaggcc attatctacc
    10621 cttttataat aagcagtgaa agctactcct ttcaaaatac ttcttctggc cataataata
    10681 aagcatttgt tgagaggata aaaagtaaac ttgatcaagg aggagtgatt caaggtttta
    10741 ttaatgcctt agaccagctc tccaatcctg atatgctctt taaggactgg gttaatgata
    10801 caaaagatga actaggaaag aatcctgtga ataagaaaaa tattgaaaaa ttgtatgaaa
    10861 ggatgtatgc tgccttgggt gactttcggg ctccaggcct ggggcccttt cggaggaagt
    10921 tcatacagac ctttgggaaa gaatttgtca aaagctttgg gaatggtggt tctaagctgc
    10981 ttacaatgaa gctcgatgag tttcgcaata tcactgactc actatttgta aggatgagaa
    11041 aagactcaaa gctacctggg aacctgaaag agtattcccc ctggatgagt gagttcacag
    11101 tgaagagtga actggagatt cctggacaat atgatgggaa gagcaaacca ttgcctgagt
    11161 atcatgtgcg gatctctgga tttgacgagc gggtaaaagt aatggtctcc ttgaggaaac
    11221 caaagcgcat tgttattcga ggccatgatg aaaaggaata cccattcctg gtaaaaggtg
    11281 gtgaggacct ccgacaagac cagcgcattg agcagctctt tgaggtcatg aatgccatcc
    11341 tctctcagga tgctgcctgc agtcagagaa acatgcagtt aaggacttac cgtgttgtgc
    11401 ccatgacctc tagattagga ttaattgaat ggattgaaaa tactatgacc ttgaaggacc
    11461 ttcttttgag taatatgtca caagaggaga aagtggctta tgacagtgat tccaaagcac
    11521 caatttatga ctacagagac tggctgataa aagtgtcagg gagaagtgat gttaaaggct
    11581 acacactaat gtacagcaga gctaaccgta cagaaacagt tacggctttt agaagaaggg
    11641 aaaataaagt acctgctgat ctcttaaagc gggcctttgt gaagatgagc accagccctg
    11701 aggccttcct ggcacttcgt tcccactttg ccagttctca cgcactgctg tgcatcagcc
    11761 actggctcct tggtattgga gacagacacc tgaacaattt catggtggcc atggaaacag
    11821 gcagtgtgat tggaattgac tttggacatg cttttggatc agctactcag tttcttccaa
    11881 tccctgagtt gatgcctttt cgtctaaccc gccaatttat cagtctcatg ttgccaatga
    11941 aagaaacggg tcttgtgtgc acagtcatgg tgcatgcact gagggctttc cgctcgtgtg
    12001 caggtctgct cactgatacc atggaagttt ttgtgaagga accctccttt gattggaagg
    12061 gttttgagca gacgatgcta agaaaaggag gatcatggat tcaagaaata aatgtaactg
    12121 aaaagaattg gtatccacaa cacaaaatac gctatgctaa gagaaagtta gcaggggcca
    12181 acccagcagt tataacttgt gatgaactac gtctaggcca tgaagcttca ccagccttca
    12241 gaagttatgt agctgtagct cgaggcaaca aagactacaa cattcgtgca caagagccag
    12301 agagtagact ttcagaagag actcaagtga agtgcttggt ggatcaggcg acagacccca
    12361 acatccttgg caggacttgg gaaggatggg agccttggat gtaaagccta tgagtgtcac
    12421 caaccataaa gcattctgtc tccgagagtc tcctagacct tcaccgatgg caggatatta
    12481 ctgacagact gaatcaatct actttagagt gctggtgaga tggctcaggg ataaaggcac
    12541 tcattaccaa ccctaatgtc ctaactaact tcaatccctg agacccatat tggaggcaat
    12601 gaaccaactc ttggaagttg tcctttgacc tccacacatg tgccatgtgt tatattcacc
    12661 cacacatacc cacacataaa tacatatgca tacatgtaaa tacaaaaaat atgacaaata
    12721 ttaaatattt ctttcttgtt tcaaagaacc aaaaaaaaaa aaaaaaa
//
