LOCUS       NM_001013895            3144 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein kinase D2 (Prkd2), mRNA.
ACCESSION   NM_001013895 XM_214834
VERSION     NM_001013895.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3144)
  AUTHORS   Cobbaut,M., Derua,R., Doppler,H., Lou,H.J., Vandoninck,S.,
            Storz,P., Turk,B.E., Seufferlein,T., Waelkens,E., Janssens,V. and
            Van Lint,J.
  TITLE     Differential regulation of PKD isoforms in oxidative stress
            conditions through phosphorylation of a conserved Tyr in the P+1
            loop
  JOURNAL   Sci Rep 7 (1), 887 (2017)
   PUBMED   28428613
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3144)
  AUTHORS   Wang,J., Sinnett-Smith,J., Stevens,J.V., Young,S.H. and
            Rozengurt,E.
  TITLE     Biphasic Regulation of Yes-associated Protein (YAP) Cellular
            Localization, Phosphorylation, and Activity by G Protein-coupled
            Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR
            PROTEIN KINASE D (PKD)
  JOURNAL   J Biol Chem 291 (34), 17988-18005 (2016)
   PUBMED   27369082
  REMARK    GeneRIF: siRNA-mediated knockdown of PKD1, PKD2, and PKD3 markedly
            attenuated YAP nuclear-cytoplasmic shuttling, phosphorylation at
            Ser(127), and induction of Ctgf and Areg expression in response to
            GPCR activation.
REFERENCE   3  (bases 1 to 3144)
  AUTHORS   Pusapati,G.V., Eiseler,T., Rykx,A., Vandoninck,S., Derua,R.,
            Waelkens,E., Van Lint,J., von Wichert,G. and Seufferlein,T.
  TITLE     Protein kinase D regulates RhoA activity via rhotekin
            phosphorylation
  JOURNAL   J Biol Chem 287 (12), 9473-9483 (2012)
   PUBMED   22228765
REFERENCE   4  (bases 1 to 3144)
  AUTHORS   Matthews,S.A., Navarro,M.N., Sinclair,L.V., Emslie,E.,
            Feijoo-Carnero,C. and Cantrell,D.A.
  TITLE     Unique functions for protein kinase D1 and protein kinase D2 in
            mammalian cells
  JOURNAL   Biochem J 432 (1), 153-163 (2010)
   PUBMED   20819079
REFERENCE   5  (bases 1 to 3144)
  AUTHORS   Evans,I.M., Bagherzadeh,A., Charles,M., Raynham,T., Ireson,C.,
            Boakes,A., Kelland,L. and Zachary,I.C.
  TITLE     Characterization of the biological effects of a novel protein
            kinase D inhibitor in endothelial cells
  JOURNAL   Biochem J 429 (3), 565-572 (2010)
   PUBMED   20497126
REFERENCE   6  (bases 1 to 3144)
  AUTHORS   Sinnett-Smith,J., Zhukova,E., Rey,O. and Rozengurt,E.
  TITLE     Protein kinase D2 potentiates MEK/ERK/RSK signaling, c-Fos
            accumulation and DNA synthesis induced by bombesin in Swiss 3T3
            cells
  JOURNAL   J Cell Physiol 211 (3), 781-790 (2007)
   PUBMED   17226786
REFERENCE   7  (bases 1 to 3144)
  AUTHORS   Chiu,T.T., Leung,W.Y., Moyer,M.P., Strieter,R.M. and Rozengurt,E.
  TITLE     Protein kinase D2 mediates lysophosphatidic acid-induced
            interleukin 8 production in nontransformed human colonic epithelial
            cells through NF-kappaB
  JOURNAL   Am J Physiol Cell Physiol 292 (2), C767-C777 (2007)
   PUBMED   16928771
REFERENCE   8  (bases 1 to 3144)
  AUTHORS   Irie,A., Harada,K., Tsukamoto,H., Kim,J.R., Araki,N. and
            Nishimura,Y.
  TITLE     Protein kinase D2 contributes to either IL-2 promoter regulation or
            induction of cell death upon TCR stimulation depending on its
            activity in Jurkat cells
  JOURNAL   Int Immunol 18 (12), 1737-1747 (2006)
   PUBMED   17077180
REFERENCE   9  (bases 1 to 3144)
  AUTHORS   Hoffert,J.D., Pisitkun,T., Wang,G., Shen,R.F. and Knepper,M.A.
  TITLE     Quantitative phosphoproteomics of vasopressin-sensitive renal
            cells: regulation of aquaporin-2 phosphorylation at two sites
  JOURNAL   Proc Natl Acad Sci U S A 103 (18), 7159-7164 (2006)
   PUBMED   16641100
REFERENCE   10 (bases 1 to 3144)
  AUTHORS   Mihailovic,T., Marx,M., Auer,A., Van Lint,J., Schmid,M., Weber,C.
            and Seufferlein,T.
  TITLE     Protein kinase D2 mediates activation of nuclear factor kappaB by
            Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells
  JOURNAL   Cancer Res 64 (24), 8939-8944 (2004)
   PUBMED   15604256
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC083592.1.
            
            On Apr 20, 2005 this sequence version replaced XM_214834.3.
            
            Sequence Note: This sequence has been modified as follows: removed
            36 bp suspected to be vector contamination from the 3' end.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083592.1, FQ218070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132263
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3144              BC083592.1         1-3144
FEATURES             Location/Qualifiers
     source          1..3144
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3144
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /note="protein kinase D2"
                     /db_xref="GeneID:292658"
                     /db_xref="RGD:1308054"
     exon            1..14
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            15..396
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..2784
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /EC_number="2.7.11.13"
                     /note="nPKC-D2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase D2"
                     /protein_id="NP_001013917.1"
                     /db_xref="GeneID:292658"
                     /db_xref="RGD:1308054"
                     /translation="MAAAPSHPAGLPCSPGPGSPPPPGGSDLQSLPPLLPQIPAPGSG
                     VSFHIQIGLTREFVLLPAASELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPTS
                     ANLLQLVRSAADIQEGDLVEVVLSASATFEDFQIRPHALTVHSYRAPAFCDHCGEMLF
                     GLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGSSESLPCT
                     AEELSRSTTDLLPRRPPSSSSSSSSSSFYTGRPIELDKMLMSKVKVPHTFLIHSYTRP
                     TVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGDVPMEEAADYS
                     EADKSSLSDELEDSGVIPGSHAENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHT
                     TRKSSTTLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILAV
                     EPAQNFSLVPPGTNPHCFEIITANVTYFVGETPGGAPGGPSGQGTEAARGWETAIRQA
                     LMPVILQDAPSAPGHTPHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQFGVV
                     YGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKV
                     FVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVL
                     LASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGV
                     IMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYS
                     VDKSLSHPWLQEYQTWLDLRELEGKMGERYITHESDDARWDQFVSERHGTPAEGDLGG
                     ACLPQDHEMQGLAERISIL"
     exon            397..535
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            536..667
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            668..822
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            823..1048
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1126
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1280
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1398
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1476
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1735
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1788
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1861
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..1968
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2130
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2229
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2497
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2583
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..3144
                     /gene="Prkd2"
                     /gene_synonym="RGD1308054"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgccccgcc ttcggatccc gccatcctcg agtctctcaa cctgacagat ttctctctca
       61 aatgcctggg ttcttaccac caccgcgcga gagctctcgg atctaggtcc caggttcctc
      121 ggtgagctct gggcggcagg tcggggtctg gccccaatgg ccgccgcccc ctcccatccc
      181 gccggactcc cctgctctcc ggggcccggg tctcctccgc cccccggtgg ctcggatctc
      241 cagtctctgc cacctctgct gcctcagatc cctgctccgg gatcgggggt ctccttccac
      301 atccagatcg gattaacacg agagtttgtg ctgttgccgg cagcttcgga gttggctcat
      361 gtgaagcaac tagcctgttc tatcgtggac cagaagttcc cagagtgtgg cttctacggc
      421 ctgtacgaca agatcctgct cttcaaacat gacccaacat cagccaacct cctgcagctg
      481 gtgcgatcag ctgcagatat ccaggagggc gacttggtgg aggtggttct gtcggcctca
      541 gccaccttcg aggatttcca gatccgtccg catgctctca ctgtgcactc gtaccgcgca
      601 ccagctttct gtgaccactg tggggagatg ctgtttggcc ttgtgcgcca gggcctcaag
      661 tgcgatggct gcgggctgaa ttaccacaaa cgctgcgcct tcagcatccc gaacaactgc
      721 agtggcgctc ggaagcgcag actgtcatcc acgtctctgg ccagtggcca ttctgtgcgt
      781 ctcggcagct ccgagtccct accctgcacc gccgaagagc tgagccgtag caccaccgac
      841 ctccttcctc gccgaccacc ctcgtcgtcg tcctcctcct cttcctcttc cttctacaca
      901 ggccgaccca ttgagctgga caagatgctg atgtccaagg tcaaggtgcc acacaccttc
      961 cttatacata gctacacacg gcccaccgtt tgccaggctt gcaagaaact gctcaagggt
     1021 ctcttccgcc agggcctgca gtgcaaagac tgcaagttta actgtcacaa acgctgtgct
     1081 acccgagtcc ctaatgactg cctgggggag gcgctcatca atggagatgt gcccatggaa
     1141 gaagctgctg attacagtga ggctgataag agctccctct cagatgagtt ggaggactct
     1201 ggtgtcatcc caggctccca tgcagagaat gctctccatg ccagtgagga agaggaaggc
     1261 gagggaggca aggcccagag ctcgctgggc tacatccccc tgatgcgtgt ggtacagtct
     1321 gtgcgacaca cgacccggaa atccagcacc accctgcggg agggctgggt ggtccattac
     1381 agcaacaagg acacactgag gaagcggcac tactggcgcc tagactgcaa atgcattacc
     1441 ctcttccaga acaacacgac caacagatac tacaaggaga tcccgctgtc tgaaatcctc
     1501 gcagtggagc cggctcagaa cttcagcctc gtacctccgg gcaccaaccc acactgcttt
     1561 gagatcatca ccgccaatgt cacctacttt gtgggcgaga cacctggcgg ggccccggga
     1621 gggccgagcg ggcagggaac agaggctgcc cggggttggg agacagccat ccgccaggca
     1681 ctgatgcctg ttatcctcca agatgcaccc agtgccccag gccacacacc acacagacaa
     1741 gcttctctga gcatctctgt gtccaacagt cagatccaag agaacgtgga catcgccact
     1801 gtctaccaga tcttccccga tgaggtgctg ggctctggac agtttggagt ggtctatgga
     1861 ggaaaacaca ggaagactgg cagagatgtt gcagtaaagg tcattgacaa actacgcttc
     1921 cccaccaagc aggagagcca gctcaggaat gaagtggcca tcctccagag cctgcggcac
     1981 cccgggattg tgaacctcga gtgcatgttt gagacccctg agaaggtatt cgtggtgatg
     2041 gagaaactgc atggggacat gttggagatg atcctctcca gtgagaaggg ccggcttcct
     2101 gagcgcctca ccaagttcct tatcacgcag attctggtgg cactgagaca cctacacttc
     2161 aagaacatcg tccactgtga cttgaaacca gagaatgtgt tactggcatc agccgatccg
     2221 tttcctcagg tgaagctatg tgacttcggc ttcgctcgca tcatcggtga gaagtccttc
     2281 cggcgctcag tggtgggcac gcccgcctac ctggcacctg aggtactgct caaccagggt
     2341 tacaaccgct cgctggacat gtggtccgtg ggtgtgatca tgtatgtgag cctcagtggc
     2401 acgtttccct tcaatgagga cgaggacatc aatgaccaga tacagaatgc agcctttatg
     2461 tacccggcca gcccctggag ccacatctca tctggagcca tcgacctcat caacaacctg
     2521 ttgcaggtga agatgcgcaa gcgctacagc gtggacaagt ctctcagcca cccatggtta
     2581 caggagtacc agacgtggct tgacctccga gagctagagg gaaagatggg cgagcgatat
     2641 atcacccatg agagcgacga cgcacgctgg gatcagtttg tatcagagcg ccatgggacg
     2701 cctgcagaag gggacctggg tggcgcctgt ctgccacagg accatgagat gcaggggctg
     2761 gctgagcgga tcagcatcct ctgaggccag tgttccccgc tgggctgctt gctttctttg
     2821 gagtcctgca catcatccta aaagtgaact gttctagagg aagcagcttt ctgcacagac
     2881 tgaatgaggc attatgcagg agggccaggg ctctctctct ttcccgtcac tgaaatagac
     2941 tgttcccagg gcaatgattt tagtctctga tgccccaatc ttggagtgat aaggctggag
     3001 agttggttct gtgggtaaag gcgcttgcca ccaagcctaa caagttgagt ttgattcctg
     3061 ggatgaacct ctttggagaa ttgactgccg tttgccccct gaccaccaca tgtgcacaca
     3121 caaacacaga caataaatgt attt
//
