LOCUS       NM_001276715            3810 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein kinase D1 (Prkd1), transcript variant 1,
            mRNA.
ACCESSION   NM_001276715 XM_001078506 XM_234108
VERSION     NM_001276715.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3810)
  AUTHORS   Sugawara,Y., Mizuno,Y., Oku,S., Sawada,Y. and Goto,T.
  TITLE     Role of protein kinase D1 in vasoconstriction and haemodynamics in
            rats
  JOURNAL   Microvasc Res 152, 104627 (2024)
   PUBMED   37963515
  REMARK    GeneRIF: Role of protein kinase D1 in vasoconstriction and
            haemodynamics in rats.
REFERENCE   2  (bases 1 to 3810)
  AUTHORS   Chen,J., Chen,H., Muhammad,I., Han,T., Zhang,D., Li,B., Zhou,X. and
            Zhou,F.
  TITLE     Protein kinase D1 promotes the survival of random-pattern skin
            flaps in rats
  JOURNAL   Biochem Biophys Res Commun 641, 67-76 (2023)
   PUBMED   36525926
  REMARK    GeneRIF: Protein kinase D1 promotes the survival of random-pattern
            skin flaps in rats.
REFERENCE   3  (bases 1 to 3810)
  AUTHORS   Bossuyt,J., Borst,J.M., Verberckmoes,M., Bailey,L.R.J., Bers,D.M.
            and Hegyi,B.
  TITLE     Protein Kinase D1 Regulates Cardiac Hypertrophy, Potassium Channel
            Remodeling, and Arrhythmias in Heart Failure
  JOURNAL   J Am Heart Assoc 11 (19), e027573 (2022)
   PUBMED   36172952
REFERENCE   4  (bases 1 to 3810)
  AUTHORS   Massadeh,S., Albeladi,M., Albesher,N., Alhabshan,F., Kampe,K.D.,
            Chaikhouni,F., Kabbani,M.S., Beetz,C. and Alaamery,M.
  TITLE     Novel Autosomal Recessive Splice-Altering Variant in PRKD1 Is
            Associated with Congenital Heart Disease
  JOURNAL   Genes (Basel) 12 (5), 612 (2021)
   PUBMED   33919081
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3810)
  AUTHORS   Zhao,D., Gao,Y., Wang,W., Pei,H., Xu,C. and Zhao,Z.
  TITLE     PKD deletion promotes autophagy and inhibits hypertrophy in
            cardiomyocyte
  JOURNAL   Exp Cell Res 386 (2), 111742 (2020)
   PUBMED   31759056
  REMARK    GeneRIF: The results suggest that PKD participates in the
            development of cardiac hypertrophy by regulating autophagy via
            AKT/mTOR/S6K pathway.
REFERENCE   6  (bases 1 to 3810)
  AUTHORS   Bradford,M.D. and Soltoff,S.P.
  TITLE     P2X7 receptors activate protein kinase D and p42/p44
            mitogen-activated protein kinase (MAPK) downstream of protein
            kinase C
  JOURNAL   Biochem J 366 (Pt 3), 745-755 (2002)
   PUBMED   12057008
  REMARK    GeneRIF: P2X7 receptor activation of PKCM in rat parotid acinar
            cells
REFERENCE   7  (bases 1 to 3810)
  AUTHORS   Hermanto,U., Zong,C.S., Li,W. and Wang,L.H.
  TITLE     RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting
            protein, modulates IGF-I-dependent integrin signaling and promotes
            cell spreading and contact with extracellular matrix
  JOURNAL   Mol Cell Biol 22 (7), 2345-2365 (2002)
   PUBMED   11884618
REFERENCE   8  (bases 1 to 3810)
  AUTHORS   Liljedahl,M., Maeda,Y., Colanzi,A., Ayala,I., Van Lint,J. and
            Malhotra,V.
  TITLE     Protein kinase D regulates the fission of cell surface destined
            transport carriers from the trans-Golgi network
  JOURNAL   Cell 104 (3), 409-420 (2001)
   PUBMED   11239398
REFERENCE   9  (bases 1 to 3810)
  AUTHORS   Storz,P., Hausser,A., Link,G., Dedio,J., Ghebrehiwet,B.,
            Pfizenmaier,K. and Johannes,F.J.
  TITLE     Protein kinase C [micro] is regulated by the multifunctional
            chaperon protein p32
  JOURNAL   J Biol Chem 275 (32), 24601-24607 (2000)
   PUBMED   10831594
REFERENCE   10 (bases 1 to 3810)
  AUTHORS   Pauken,C.M. and Capco,D.G.
  TITLE     The expression and stage-specific localization of protein kinase C
            isotypes during mouse preimplantation development
  JOURNAL   Dev Biol 223 (2), 411-421 (2000)
   PUBMED   10882525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 16, 2022 this sequence version replaced NM_001276715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.35463.1,
                                           SRR26643429.23751.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               JAXUCZ010000006.1  73773868-73774406   c
            540-678             JAXUCZ010000006.1  73605932-73606070   c
            679-810             JAXUCZ010000006.1  73547402-73547533   c
            811-971             JAXUCZ010000006.1  73544736-73544896   c
            972-995             JAXUCZ010000006.1  73532585-73532608   c
            996-1206            JAXUCZ010000006.1  73515271-73515481   c
            1207-1284           JAXUCZ010000006.1  73515049-73515126   c
            1285-1489           JAXUCZ010000006.1  73513276-73513480   c
            1490-1613           JAXUCZ010000006.1  73511741-73511864   c
            1614-1691           JAXUCZ010000006.1  73510321-73510398   c
            1692-1971           JAXUCZ010000006.1  73508543-73508822   c
            1972-2024           JAXUCZ010000006.1  73507432-73507484   c
            2025-2097           JAXUCZ010000006.1  73505420-73505492   c
            2098-2204           JAXUCZ010000006.1  73503887-73503993   c
            2205-2366           JAXUCZ010000006.1  73487310-73487471   c
            2367-2465           JAXUCZ010000006.1  73486634-73486732   c
            2466-2733           JAXUCZ010000006.1  73485491-73485758   c
            2734-2819           JAXUCZ010000006.1  73462498-73462583   c
            2820-3810           JAXUCZ010000006.1  73460640-73461630   c
FEATURES             Location/Qualifiers
     source          1..3810
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q22"
     gene            1..3810
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /note="protein kinase D1"
                     /db_xref="GeneID:85421"
                     /db_xref="RGD:620964"
     exon            1..539
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     CDS             282..3038
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /EC_number="2.7.11.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine/threonine-protein kinase D1; protein kinase C mu
                     type"
                     /codon_start=1
                     /product="serine/threonine-protein kinase D1 isoform 1"
                     /protein_id="NP_001263644.1"
                     /db_xref="GeneID:85421"
                     /db_xref="RGD:620964"
                     /translation="MSAPPLLRPPSPLLPAAAAVAAAAAALVPGSGPAPFPAPGAAPA
                     GGISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGLYDKILLF
                     RHDPASENILQLVKIASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDH
                     CGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGLGTVRTASA
                     EFSTSAPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSYVGRPIQLDKLLMSKVKVP
                     HTFVIHSYTRPTVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTING
                     ELLSPGAESDVVMEEGSDDNDSERNSGLMDDMDEAMVQDTEMALAEGQSDGAEMQDPD
                     ADQEDSNRTISPSTSNNIPLMRVVQSVKHTKRRSSTVMKEGWMVHYTSKDTLRKRHYW
                     RLDSKSITLFQNDTGSRYYKEIPLSEILCLEPAKPSALIPTGANPHCFEITTANVVYY
                     VGENVVNPSSPPPNNSVPPSGIGTDVARMWEVAIQHALMPVIPKGSSVGSGTNSHKDI
                     SVSISVSNSQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLR
                     FPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKG
                     RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARII
                     GEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQ
                     IQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRE
                     LECRIGERYITHESDDSRWEQYAGEQGLQYPAHLINLSASHGDSPEAEEREMKALSER
                     VSIL"
     exon            540..678
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            679..810
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            811..971
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            972..995
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1206
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1284
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1489
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1613
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1691
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1971
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2024
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2097
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2204
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2366
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2367..2465
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2733
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..2819
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
     exon            2820..3810
                     /gene="Prkd1"
                     /gene_synonym="nPKC-D1; nPKC-mu; Pkcm; Prkcm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgccgacc cgccgcggtc cccggagcgg agcgcgcggc ggcggcagta gctgggcgcc
       61 tcccacgcgc tgccgcgtgc ccgcccgctc gcccgccagt ctgcccgtcc accggccccg
      121 actccgctcg gccatcttcg ccgctcccgc cctcgccagc ccgggccgcg cgccctgtcc
      181 ccgcgcgcgg actttcccgg aaagtttggt ggttgttttc ggccgccgca ggcagcggcg
      241 ccgcgcccca cctccgccaa actttggggc tcactcgcgc catgagcgcc cctccgctac
      301 tacggccgcc tagcccgctg ctgcccgccg cggccgctgt ggccgccgcc gctgctgcgc
      361 tggtcccggg ctccgggccc gcgcccttcc cagcgcctgg ggccgccccg gcggggggca
      421 tctcgttcca tctgcagatc ggcctgagcc gcgagccggt gctgctcctt caggactcct
      481 ctggcgacta cagcctggcg catgtccggg agatggcttg ctccatcgtg gaccagaagt
      541 tccctgaatg tggcttctat ggactctatg acaagatcct gcttttccgt cacgatcctg
      601 cctctgaaaa catccttcag ctggtaaaaa tcgcaagtga cattcaggag ggcgatctta
      661 ttgaagtggt cctgtcagct tcagccacct tcgaagactt ccagatccgg cctcacgctc
      721 tcttcgttca ttcatacaga gcccctgctt tctgtgatca ctgtggagaa atgctgtggg
      781 gactggtgcg ccaaggcctt aaatgtgaag gatgtggcct gaattaccat aagagatgtg
      841 catttaaaat ccccaacaat tgcagtggag tgagaaggag aaggctctca aatgtttccc
      901 tcactggact gggtactgtc cgcacagcgt ctgcggagtt ctccaccagt gcccccgatg
      961 agcctctact gtctcctgtg agccctggct ttgagcaaaa gtctccatct gagtcattta
     1021 tcggtcgtga gaagaggtca aattctcagt catatgttgg acggccgatt cagctcgaca
     1081 agctcctgat gtctaaggtg aaggtgccac acacctttgt catccactcc tacacacggc
     1141 ccacggtctg ccagttctgt aagaagctcc tcaagggcct cttccggcag ggtttgcagt
     1201 gcaaagattg ccgattcaac tgtcacaaac gctgtgcacc aaaagtacca aacaactgct
     1261 tgggcgaagt gaccatcaat ggagaattgc ttagccctgg ggcagagtct gatgttgtca
     1321 tggaagaagg gagcgatgac aatgacagcg aacggaacag tggactcatg gatgacatgg
     1381 acgaggccat ggtccaggac actgagatgg ctttggcgga gggtcagagt gacggtgcag
     1441 agatgcagga tccagacgca gaccaggagg actccaacag aaccatcagc ccttctacga
     1501 gcaacaacat accgcttatg agggtagtgc agtctgtcaa gcacacaaag aggagaagca
     1561 gcacagtgat gaaggaaggg tggatggtcc actacaccag caaggacaca ctgaggaaaa
     1621 ggcattactg gagactggac agcaaaagca tcacactctt ccaaaacgac acaggcagcc
     1681 ggtactacaa ggaaattcct ttatcagaaa ttttatgtct ggaaccagca aaaccttcag
     1741 cattaattcc cactggagct aaccctcatt gttttgaaat cactacagca aacgtagtgt
     1801 attatgtggg agaaaacgtg gtcaaccctt caagcccccc accaaacaac agcgtccccc
     1861 cgagcggcat cggtaccgat gtggcgagga tgtgggaggt cgccatccag cacgctctca
     1921 tgcctgtcat ccccaagggc tcctctgtgg gttccggaac caactcacac aaagatattt
     1981 cggtgagcat ttccgtttcg aatagccaga ttcaggaaaa tgtggatatc agcacagtct
     2041 atcagatttt cccggatgag gttctgggtt ctggacagtt cggaattgtt tatggaggta
     2101 aacatcgtaa aacaggaaga gatgtagcta ttaagattat tgacaaatta agatttccaa
     2161 caaaacaaga aagtcagctt cgtaatgagg ttgcaatttt acagaacctt catcaccctg
     2221 gtgttgtaaa tttggagtgt atgtttgaga cgcctgaaag agtgtttgtt gttatggaaa
     2281 aactccatgg agacatgctg gagatgatcc tgtcaagtga aaagggcagg ttgccagaac
     2341 acataacgaa gtttttaatt actcagatac tagtggcttt gcgacatctt cattttaaaa
     2401 acatcgttca ctgtgacctc aagccagaaa atgtgttgct ggcatcagca gaccctttcc
     2461 ctcaggtgaa actttgtgat tttggttttg cccggatcat tggcgagaag tctttccgga
     2521 gatcagtggt gggtacccca gcctacctgg cacctgaggt tctgaggaac aagggctata
     2581 accgctcgct agacatgtgg tctgttgggg tcatcatcta tgtgagcctg agtggcacct
     2641 tcccttttaa tgaagatgaa gatatccacg atcagatcca gaacgcagcc ttcatgtatc
     2701 cacccaatcc ctggaaggag atttctcatg aagccattga tcttatcaat aacttgctac
     2761 aagtgaaaat gagaaaacgc tacagtgtgg acaagacctt gagtcacccc tggctacagg
     2821 actaccagac ctggttagat ttacgcgagc tggaatgcag aattggagaa cgctatatta
     2881 cccatgaaag cgatgactcg aggtgggaac agtatgcagg cgagcaggga ctgcagtatc
     2941 ccgcgcacct gatcaatctg agtgctagcc atggcgacag tcctgaggct gaagagagag
     3001 agatgaaagc cctcagtgag cgtgtcagca tcctctgatt ccctcccctc taatctgtca
     3061 aaacactgtg gaattaataa atacatacgg tcaggtttaa catttgcctt gcagaactgc
     3121 cattattttc tgtcagatga gaacaaagct gttaaactgt tagcactgtt gatgtatctg
     3181 agttgccaag acaaatcaac agaagcattt gtattttgtg tgaccaactg tgttgtatta
     3241 acaaaagttc ccggaaacac taaacttgtt attgtgaatg atttatgtta tatttaatac
     3301 attaaacctg tctccactgt gcctttgcaa atcagtgttt ttcctaccag agcctcattt
     3361 tggtgagagc cagctccaat ccatgacacc attgtgtttg gtgtgcccct attgatagtg
     3421 gtgttgtaag caaactcttg aagagtagat aatctgccgg tgttctgtga acaactcaaa
     3481 atgcacagtg ggtggggtgg ggggggagaa tgaaagatga ggagaaggcg tataagtgct
     3541 aagattgact tgcatgaaaa cagttctact gtgtggtgtc agatcctctg cctgtctggt
     3601 gtgcctcagt gtatttaact ctagtgagtg cacctcatta tgtggagcca ctgcactaag
     3661 cctaaatgcc ttagactgta aactgcttta cataccagat gcatttcctc ctttcttaca
     3721 atagcaactg tatcaaggaa aaccagcaac ccaccaaatg ttggcctttt gtgtattttt
     3781 gaataataag aaataaatac tcttttcaaa
//
