LOCUS       NM_022507               2661 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus protein kinase C, zeta (Prkcz), mRNA.
ACCESSION   NM_022507
VERSION     NM_022507.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2661)
  AUTHORS   Marcondes,L.A., de C Myskiw,J., Nachtigall,E.G., Narvaes,R.F.,
            Izquierdo,I. and Furini,C.R.G.
  TITLE     PKMzeta Maintains Remote Contextual Fear Memory by Inhibiting
            GluA2-Dependent AMPA Receptor Endocytosis in the Prelimbic Cortex
  JOURNAL   Neuroscience 497, 97-106 (2022)
   PUBMED   34968669
  REMARK    GeneRIF: PKMzeta Maintains Remote Contextual Fear Memory by
            Inhibiting GluA2-Dependent AMPA Receptor Endocytosis in the
            Prelimbic Cortex.
REFERENCE   2  (bases 1 to 2661)
  AUTHORS   Naseem,M., Tabassum,H. and Parvez,S.
  TITLE     PKM-zeta Expression Is Important in Consolidation of Memory in
            Prelimbic Cortex Formed by the Process of Behavioral Tagging
  JOURNAL   Neuroscience 410, 305-315 (2019)
   PUBMED   31026567
  REMARK    GeneRIF: Protein Kinase M zeta is activated in prelimbic cortex
            during consolidation of memory.
REFERENCE   3  (bases 1 to 2661)
  AUTHORS   Rossato,J.I., Gonzalez,M.C., Radiske,A., Apolinario,G.,
            Conde-Ocazionez,S., Bevilaqua,L.R. and Cammarota,M.
  TITLE     PKMzeta Inhibition Disrupts Reconsolidation and Erases Object
            Recognition Memory
  JOURNAL   J Neurosci 39 (10), 1828-1841 (2019)
   PUBMED   30622166
  REMARK    GeneRIF: PKMzeta inhibition disrupts reconsolidation and erases
            object recognition memory. Results also indicate that hippocampal
            PKMzeta acts downstream of BDNF and controls AMPAR synaptic
            insertion to elicit reconsolidation and suggest that blocking
            PKMzeta activity during this process deletes active object
            recognition memory.
REFERENCE   4  (bases 1 to 2661)
  AUTHORS   Kays,J., Zhang,Y.H., Khorodova,A., Strichartz,G. and Nicol,G.D.
  TITLE     Peripheral Synthesis of an Atypical Protein Kinase C Mediates the
            Enhancement of Excitability and the Development of Mechanical
            Hyperalgesia Produced by Nerve Growth Factor
  JOURNAL   Neuroscience 371, 420-432 (2018)
   PUBMED   29288797
  REMARK    GeneRIF: The current studies demonstrate that enhanced action
            potential firing produced by NGF was blocked by inhibitors of
            translation, but not transcription. In vitro studies showed that
            NGF elevated the protein levels of PKMzeta, which was also
            prevented by inhibitors of translation. Intraplantar injection of
            NGF produced a rapid and maintained increase in mechanical
            sensitivity whose onset was delayed by translation inhibit...
REFERENCE   5  (bases 1 to 2661)
  AUTHORS   Yu,N.K., Uhm,H., Shim,J., Choi,J.H., Bae,S., Sacktor,T.C., Hohng,S.
            and Kaang,B.K.
  TITLE     Increased PKMzeta activity impedes lateral movement of
            GluA2-containing AMPA receptors
  JOURNAL   Mol Brain 10 (1), 56 (2017)
   PUBMED   29202853
  REMARK    GeneRIF: the overexpression of PKMzeta in hippocampal neurons
            immobilized GluA2-containing AMPA receptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2661)
  AUTHORS   Andrea,J.E. and Walsh,M.P.
  TITLE     Identification of a brain-specific protein kinase C zeta pseudogene
            (psi PKC zeta) transcript
  JOURNAL   Biochem J 310 (Pt 3) (Pt 3), 835-843 (1995)
   PUBMED   7575416
REFERENCE   7  (bases 1 to 2661)
  AUTHORS   Alam,R., Hachiya,N., Sakaguchi,M., Kawabata,S., Iwanaga,S.,
            Kitajima,M., Mihara,K. and Omura,T.
  TITLE     cDNA cloning and characterization of mitochondrial import
            stimulation factor (MSF) purified from rat liver cytosol
  JOURNAL   J Biochem 116 (2), 416-425 (1994)
   PUBMED   7822263
REFERENCE   8  (bases 1 to 2661)
  AUTHORS   Ono,Y., Fujii,T., Ogita,K., Kikkawa,U., Igarashi,K. and
            Nishizuka,Y.
  TITLE     Protein kinase C zeta subspecies from rat brain: its structure,
            expression, and properties
  JOURNAL   Proc Natl Acad Sci U S A 86 (9), 3099-3103 (1989)
   PUBMED   2470089
REFERENCE   9  (bases 1 to 2661)
  AUTHORS   Ono,Y., Fujii,T., Ogita,K., Kikkawa,U., Igarashi,K. and
            Nishizuka,Y.
  TITLE     The structure, expression, and properties of additional members of
            the protein kinase C family
  JOURNAL   J Biol Chem 263 (14), 6927-6932 (1988)
   PUBMED   2834397
REFERENCE   10 (bases 1 to 2661)
  AUTHORS   Ono,Y., Fujii,T., Ogita,K., Kikkawa,U., Igarashi,K. and
            Nishizuka,Y.
  TITLE     Identification of three additional members of rat protein kinase C
            family: delta-, epsilon- and zeta-subspecies
  JOURNAL   FEBS Lett 226 (1), 125-128 (1987)
   PUBMED   3691811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from J04532.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_022507.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J04532.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2661
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2661
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /note="protein kinase C, zeta"
                     /db_xref="GeneID:25522"
                     /db_xref="RGD:3399"
     exon            1..218
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1926
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /EC_number="2.7.11.13"
                     /note="nPKC-zeta"
                     /codon_start=1
                     /product="protein kinase C zeta type"
                     /protein_id="NP_071952.1"
                     /db_xref="GeneID:25522"
                     /db_xref="RGD:3399"
                     /translation="MPSRTDPKMDRSGGRVRLKAHYGGDILITSVDPTTTFQDLCEEV
                     RDMCGLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLACQGRDEVLIIHVFPSIPEQ
                     PGMPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYR
                     CINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDDKNDGVDLPSEETDGIAYISSS
                     RKHDNIKDDSEDLKPVIDGVDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQ
                     IYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVN
                     GGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKL
                     TDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSP
                     FDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTG
                     FSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDV
                     IKRIDQSEFEGFEYINPLLLSAEESV"
     exon            219..340
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            341..430
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            431..481
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            482..567
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..699
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            700..781
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..834
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1023
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1121
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1208
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1344
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1432
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1552
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1632
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1722
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1838
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2661
                     /gene="Prkcz"
                     /gene_synonym="14-3-3-zetaisoform; Pkcz; r14-3-3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaggcgggt gccgtcggtc ccgcgctgcg cgctcccttc cgcgttccgc cgtctgcccc
       61 gcctggcaac ccggccctgc tcgggggccg ctagccatgg ccggagtgcc ctggacacag
      121 cgctgacggc ggctggcgga gtgcgccatg cccagcagga ccgaccccaa gatggaccgg
      181 agcggcggcc gcgtccgtct gaaggcgcac tacggcgggg acatcctgat taccagcgtg
      241 gaccccacga caactttcca ggacctctgt gaggaagtgc gagacatgtg tggcctgcac
      301 cagcagcacc cactcaccct caagtgggtg gacagtgaag gtgacccttg tactgtgtcc
      361 tcacagatgg agctggagga ggccttccgc ctggcctgtc agggcaggga cgaagtgctc
      421 atcatccacg ttttcccaag catcccagaa caaccgggca tgccttgtcc tggagaagac
      481 aagtccatct accgccgtgg agccagaaga tggaggaagc tataccgagc caacggccac
      541 ctcttccaag ccaagcgctt taacaggaga gcgtactgtg gccagtgcag cgaaaggata
      601 tggggcctcg cgaggcaggg gtacaggtgc atcaactgca agctgcttgt ccataaacgc
      661 tgccacgtcc tcgtcccgct gacctgcagg aggcatatgg attctgtcat gccttcccaa
      721 gagcctccag tagatgacaa gaacgatggt gtagaccttc cttcagaaga aactgatgga
      781 attgcttata tttcttcatc tcggaaacat gacaatatca aagatgattc tgaggacctt
      841 aagcctgtca tcgatggggt ggatgggatc aaaatctctc aggggctggg gctgcaagac
      901 tttgacctca tcagagtcat cgggcgtgga agctatgcca aggtcctcct ggtgcggttg
      961 aagaaaaacg accagattta cgccatgaag gtggtgaaga aggagctcgt ccacgacgat
     1021 gaggatatcg actgggtgca gacagagaag cacgtgttcg agcaggcatc cagcaacccc
     1081 ttcctggttg gcttacactc ctgcttccag acaacgagcc ggttgttcct ggtcatcgag
     1141 tatgtcaacg ggggggacct catgttccac atgcagaggc agaggaagct tccagaggaa
     1201 cacgccaggt tctatgctgc tgagatctgt atcgctctca acttcctaca tgagagaggg
     1261 atcatctacc gggacctaaa actggacaac gtcctcctcg atgccgatgg acacattaag
     1321 ctgacggact acggcatgtg caaggaaggc ctaggccccg gcgacacaac aagcactttt
     1381 tgtggaaccc cgaactatat cgcccccgaa atcctgcgag gagaagagta cgggttcagc
     1441 gtggactggt gggcgctggg tgtccttatg tttgagatga tggctgggcg ctcccccttt
     1501 gacatcatca cagacaaccc tgacatgaat actgaagact accttttcca agttatcctg
     1561 gaaaagccaa ttcggattcc ccgtttcctg tctgtcaagg cctcacacgt cttgaaagga
     1621 tttttaaata aggatcccaa agagaggctt ggctgccggc cgcagactgg gttttccgac
     1681 atcaagtccc atgccttctt ccgaagcata gactgggacc tgcttgaaaa gaagcagacc
     1741 ctgcctccct tccagcccca gatcacagat gactatggcc tggacaactt cgacacgcag
     1801 ttcaccagcg agcccgtaca gctgacccca gatgatgagg acgtcataaa gaggatcgac
     1861 cagtccgagt tcgaaggctt cgagtacatc aacccgcttc tgctgtctgc tgaggagtcc
     1921 gtgtgaggcc atgagcatct ctgttgtgga cacgtctgtg aatgaccctg tcactttacc
     1981 cttaactaca gcatatgcat gccaggccag acaccgaggc tccaagcagc cagagaggga
     2041 tgctggccac caagaccgca gagggggcac ccaacaggca cttctagaca gagcaatctc
     2101 ttgtgtccag gccccagagg ctggctttgt gctggaagga accacttcct gtgcccatgg
     2161 cggccctacc agagggtgag acagccacgc cgtcttgaaa ggcgcacatc ttccacagag
     2221 acagaactcg atgcactgat ccgctccagg aaaagttagc gtgtaatgcc ctgaggaata
     2281 aagtgtactg atgatgtcga agcttcctct gatgcctttt ttctgtggca cccgcctgat
     2341 gtccccaatg cagcccccca cacgaggagg agctgcgctt tccaagcagg cagaacgtag
     2401 gcaggggacg ggcacccaag tgcctgcagg gatgttgtgc tgcaacaaga attgttacag
     2461 attcggaacg ttttctaaat cccggtaagt tctgttgtta atatttaaca agtattttca
     2521 tacctagggc agctaaccgt ggtaggctga agccgaaggg acaccccggc caggttggtg
     2581 gcgctgttcc caccagccca gcccgttcgg actctgaagg gggggaaatt ggatcacgga
     2641 gattctaaaa cattgctcac c
//
