LOCUS       NM_001106806            2011 bp    mRNA    linear   ROD 09-JAN-2024
DEFINITION  Rattus norvegicus PRKCSH beta subunit of glucosidase II (Prkcsh),
            mRNA.
ACCESSION   NM_001106806 XM_001075568 XM_001077601 XM_238534
VERSION     NM_001106806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2011)
  AUTHORS   Caputo AT, Alonzi DS, Marti L, Reca IB, Kiappes JL, Struwe WB,
            Cross A, Basu S, Lowe ED, Darlot B, Santino A, Roversi P and
            Zitzmann N.
  TITLE     Structures of mammalian ER alpha-glucosidase II capture the binding
            modes of broad-spectrum iminosugar antivirals
  JOURNAL   Proc Natl Acad Sci U S A 113 (32), E4630-E4638 (2016)
   PUBMED   27462106
REFERENCE   2  (bases 1 to 2011)
  AUTHORS   Shin GC, Ahn SH, Choi HS, Kim J, Park ES, Kim DH and Kim KH.
  TITLE     Hepatocystin contributes to interferon-mediated antiviral response
            to hepatitis B virus by regulating hepatocyte nuclear factor 4alpha
  JOURNAL   Biochim Biophys Acta 1842 (9), 1648-1657 (2014)
   PUBMED   24769044
REFERENCE   3  (bases 1 to 2011)
  AUTHORS   Yaguchi H, Okumura F, Takahashi H, Kano T, Kameda H, Uchigashima M,
            Tanaka S, Watanabe M, Sasaki H and Hatakeyama S.
  TITLE     TRIM67 protein negatively regulates Ras activity through
            degradation of 80K-H and induces neuritogenesis
  JOURNAL   J Biol Chem 287 (15), 12050-12059 (2012)
   PUBMED   22337885
REFERENCE   4  (bases 1 to 2011)
  AUTHORS   Fedeles SV, Tian X, Gallagher AR, Mitobe M, Nishio S, Lee SH, Cai
            Y, Geng L, Crews CM and Somlo S.
  TITLE     A genetic interaction network of five genes for human polycystic
            kidney and liver diseases defines polycystin-1 as the central
            determinant of cyst formation
  JOURNAL   Nat Genet 43 (7), 639-647 (2011)
   PUBMED   21685914
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2011)
  AUTHORS   Gao H, Wang Y, Wegierski T, Skouloudaki K, Putz M, Fu X, Engel C,
            Boehlke C, Peng H, Kuehn EW, Kim E, Kramer-Zucker A and Walz G.
  TITLE     PRKCSH/80K-H, the protein mutated in polycystic liver disease,
            protects polycystin-2/TRPP2 against HERP-mediated degradation
  JOURNAL   Hum Mol Genet 19 (1), 16-24 (2010)
   PUBMED   19801576
REFERENCE   6  (bases 1 to 2011)
  AUTHORS   Drenth JP, Tahvanainen E, te Morsche RH, Tahvanainen P, Kaariainen
            H, Hockerstedt K, van de Kamp JM, Breuning MH and Jansen JB.
  TITLE     Abnormal hepatocystin caused by truncating PRKCSH mutations leads
            to autosomal dominant polycystic liver disease
  JOURNAL   Hepatology 39 (4), 924-931 (2004)
   PUBMED   15057895
REFERENCE   7  (bases 1 to 2011)
  AUTHORS   Li A, Davila S, Furu L, Qian Q, Tian X, Kamath PS, King BF, Torres
            VE and Somlo S.
  TITLE     Mutations in PRKCSH cause isolated autosomal dominant polycystic
            liver disease
  JOURNAL   Am J Hum Genet 72 (3), 691-703 (2003)
   PUBMED   12529853
REFERENCE   8  (bases 1 to 2011)
  AUTHORS   Pelletier MF, Marcil A, Sevigny G, Jakob CA, Tessier DC, Chevet E,
            Menard R, Bergeron JJ and Thomas DY.
  TITLE     The heterodimeric structure of glucosidase II is required for its
            activity, solubility, and localization in vivo
  JOURNAL   Glycobiology 10 (8), 815-827 (2000)
   PUBMED   10929008
REFERENCE   9  (bases 1 to 2011)
  AUTHORS   Arendt CW and Ostergaard HL.
  TITLE     Identification of the CD45-associated 116-kDa and 80-kDa proteins
            as the alpha- and beta-subunits of alpha-glucosidase II
  JOURNAL   J Biol Chem 272 (20), 13117-13125 (1997)
   PUBMED   9148925
REFERENCE   10 (bases 1 to 2011)
  AUTHORS   Hollnagel A, Schroder D and Gross G.
  TITLE     Domain-specific gene activation by parathyroid hormone in
            osteoblastic ROS17/2.8 cells
  JOURNAL   J Biol Chem 271 (36), 21870-21877 (1996)
   PUBMED   8702988
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC161987.1.
            
            On Apr 6, 2008 this sequence version replaced NM_001106806.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161987.1, SRR8487230.9684.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2011
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2011
                     /gene="Prkcsh"
                     /note="PRKCSH beta subunit of glucosidase II"
                     /db_xref="GeneID:300445"
                     /db_xref="RGD:1309628"
     exon            1..23
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            24..159
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1661
                     /gene="Prkcsh"
                     /EC_number="2.7.11.1"
                     /note="glucosidase 2 subunit beta; protein kinase C
                     substrate 80K-H"
                     /codon_start=1
                     /product="glucosidase 2 subunit beta precursor"
                     /protein_id="NP_001100276.1"
                     /db_xref="GeneID:300445"
                     /db_xref="RGD:1309628"
                     /translation="MLLLLLLLPLCWAVEVKRPRGVSLSNHHFYDESKPFTCLDGTAT
                     IPFDQVNDDYCDCKDGSDEPGTAACPNGSFHCTNTGYKPLYILSSRVNDGVCDCCDGT
                     DEYNSGTVCENTCREKGRKEKESLQQLAEVTREGFRLKKILIEEWKTAREEKQSKLLE
                     LQAGKKSLEDQVETLRTAKEEAERPEKEAKDQHRKLWEEQQAAAKARREQELAASAFQ
                     ELDDNMDGLVSLAELQTHPELDTDGDGGLSEEEAQALLSGDTQTDTTSFYDRVWAAIR
                     DKYRSEVPPTDIPVPEVTEPKEEKLPVLPPMEEEEEEEEPEEEEEEEEEEVPGEQPKE
                     VPPPQQPLRPPSPAEDEKMPPYDEETQAIIDAAQEARNKFEEVERSLKEMEESIRSLE
                     QEISFDFGPSGEFAYLYSQCYELTTNEYVYRLCPFKLVSQKPKHGGSPTSLGTWGSWA
                     GPDDDKFSAMKYEQGTGCWQGPNRSTTVRLLCGKETVVTSTTEPSRCEYLMELMTPAA
                     CPEPPPEVPTDGDHDEL"
     exon            160..276
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            277..372
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            373..430
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            431..548
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            549..678
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            679..763
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            764..842
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            843..929
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1082
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1179
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1249
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1339
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1414
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1514
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1665
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1977
                     /gene="Prkcsh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgaccttt gcttctgcct cgttgaaagg acatcgcgta tcttcctgcc gcagaacaca
       61 cttccggtct cggcccggac gggatgttgc tgctgctgct gctgctaccc ctctgttggg
      121 cagtagaagt taagagaccc cggggcgttt ccctcagcaa ccatcacttc tatgacgaat
      181 ctaaaccttt cacgtgtttg gatggcacag ccactatccc cttcgatcag gtgaacgatg
      241 attactgcga ctgtaaggat ggttctgatg agcctggcac agctgcgtgt cccaatggca
      301 gctttcactg caccaacact gggtataagc ctttgtacat cctctctagc cgggtcaatg
      361 atggggtgtg tgactgctgt gatgggacgg acgagtacaa cagtggcacc gtctgtgaga
      421 acacctgcag agagaagggt cgcaaggaaa aagagtccct gcagcagctg gccgaggtca
      481 cccgagaagg gttccgtctc aagaagatac tcattgagga gtggaagaca gctcgggaag
      541 aaaagcagag taagcttctt gagcttcagg ctggaaagaa gtctctggaa gaccaggtag
      601 aaacgctgcg gacagcgaaa gaggaagcag agaggccaga gaaggaggcc aaggaccagc
      661 accggaagct gtgggaagag cagcaggctg ctgccaaggc ccggcgggaa caggagctgg
      721 cagccagtgc cttccaggaa ctggacgaca acatggatgg gctggtctca ctggctgagt
      781 tacagactca cccagagctg gacacagatg gagatggagg actgtcggag gaggaggccc
      841 aggctcttct cagtggagac acacagactg acactacctc cttctatgac cgtgtctggg
      901 ctgccatcag ggacaagtac cgctctgagg tcccacccac ggacatacct gttcctgagg
      961 tcaccgaacc caaagaagaa aagctgccag tgttgccccc catggaagag gaggaggaag
     1021 aggaggagcc agaggaggaa gaggaggagg aggaggagga ggtgccgggg gagcagccca
     1081 aggaggtccc gcccccacag cagcccctac ggcctcccag tcctgctgag gatgagaaga
     1141 tgccacccta tgatgaggag acacaggcta tcatcgatgc cgcacaagag gcccggaaca
     1201 agtttgagga ggtcgaacgg tccttgaaag agatggagga gtccatcagg agtttggaac
     1261 aagagatctc ctttgatttc ggtccctctg gagagtttgc atacctctac agccaatgct
     1321 acgagctcac caccaatgag tatgtctacc ggctttgccc cttcaaactt gtctcccaga
     1381 aacccaaaca tgggggctcc ccgaccagtc tgggtacatg gggctcctgg gctggcccag
     1441 atgacgacaa gttcagcgca atgaagtacg agcagggcac aggctgctgg cagggcccca
     1501 accgctccac cacagtacgc ctcctgtgtg gcaaggagac tgtggtgacc agtaccacag
     1561 agcccagtcg ctgcgagtac ctcatggagc tgatgacacc agcagcctgc ccagagccgc
     1621 ctccagaagt acccactgat ggagaccatg atgaactgta gccggaacct caaggcctac
     1681 agatagtcta ccgatcccat agtctgcgga ccaatgcctg cccaccctgg ggtctctggc
     1741 cattctccag gcagcaggaa cccgaggggc tctaagcccc acttctggcc caggctagcc
     1801 aagccatgtt cctgaggccc cagcggcctc cagagatgga taatgagctc acctaccttg
     1861 gattcctgag aggagttaat ccctgcaccc cacctcaccc ctgtctccct agctggtggg
     1921 agatggatgt atgacttgac ctgtgacctc agaacaataa atgtgacttg tccacacaaa
     1981 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
