LOCUS       NM_001276721            3370 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus protein kinase C, theta (Prkcq), mRNA.
ACCESSION   NM_001276721 XM_001064127 XM_341553
VERSION     NM_001276721.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Wang,Y., Gao,N., Feng,Y., Cai,M., Li,Y., Xu,X., Zhang,H. and Yao,D.
  TITLE     Protein kinase C theta (Prkcq) affects nerve degeneration and
            regeneration through the c-fos and c-jun pathways in injured rat
            sciatic nerves
  JOURNAL   Exp Neurol 346, 113843 (2021)
   PUBMED   34418453
  REMARK    GeneRIF: Protein kinase C theta (Prkcq) affects nerve degeneration
            and regeneration through the c-fos and c-jun pathways in injured
            rat sciatic nerves.
REFERENCE   2  (bases 1 to 3370)
  AUTHORS   Devinney,M.J., Fields,D.P., Huxtable,A.G., Peterson,T.J., Dale,E.A.
            and Mitchell,G.S.
  TITLE     Phrenic long-term facilitation requires PKCtheta; activity within
            phrenic motor neurons
  JOURNAL   J Neurosci 35 (21), 8107-8117 (2015)
   PUBMED   26019328
  REMARK    GeneRIF: Protein kinase C theta plays a critical role in spinal
            acute intermittent hypoxia-induced respiratory motor plasticity.
REFERENCE   3  (bases 1 to 3370)
  AUTHORS   Griffith,G.L., Russell,R.A., Kasus-Jacobi,A., Thavathiru,E.,
            Gonzalez,M.L., Logan,S. and Pereira,H.A.
  TITLE     CAP37 activation of PKC promotes human corneal epithelial cell
            chemotaxis
  JOURNAL   Invest Ophthalmol Vis Sci 54 (10), 6712-6723 (2013)
   PUBMED   24008408
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3370)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   5  (bases 1 to 3370)
  AUTHORS   Park-York,M., Boghossian,S., Oh,H. and York,D.A.
  TITLE     PKCtheta; expression in the amygdala regulates insulin signaling,
            food intake and body weight
  JOURNAL   Obesity (Silver Spring) 21 (4), 755-764 (2013)
   PUBMED   23712979
  REMARK    GeneRIF: PKC theta expression is increased and the enzyme is
            activated in the central nucleus of the amygdala of rats fed a high
            fat diet.
REFERENCE   6  (bases 1 to 3370)
  AUTHORS   Schmitz-Peiffer,C., Browne,C.L., Oakes,N.D., Watkinson,A.,
            Chisholm,D.J., Kraegen,E.W. and Biden,T.J.
  TITLE     Alterations in the expression and cellular localization of protein
            kinase C isozymes epsilon and theta are associated with insulin
            resistance in skeletal muscle of the high-fat-fed rat
  JOURNAL   Diabetes 46 (2), 169-178 (1997)
   PUBMED   9000691
REFERENCE   7  (bases 1 to 3370)
  AUTHORS   Avignon,A., Yamada,K., Zhou,X., Spencer,B., Cardona,O.,
            Saba-Siddique,S., Galloway,L., Standaert,M.L. and Farese,R.V.
  TITLE     Chronic activation of protein kinase C in soleus muscles and other
            tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK),
            obese/aged, and obese/Zucker rats. A mechanism for inhibiting
            glycogen synthesis
  JOURNAL   Diabetes 45 (10), 1396-1404 (1996)
   PUBMED   8826977
REFERENCE   8  (bases 1 to 3370)
  AUTHORS   Avignon,A., Standaert,M.L., Yamada,K., Mischak,H., Spencer,B. and
            Farese,R.V.
  TITLE     Insulin increases mRNA levels of protein kinase C-alpha and -beta
            in rat adipocytes and protein kinase C-alpha, -beta and -theta in
            rat skeletal muscle
  JOURNAL   Biochem J 308 (Pt 1) (Pt 1), 181-187 (1995)
   PUBMED   7755564
REFERENCE   9  (bases 1 to 3370)
  AUTHORS   Hilgenberg,L. and Miles,K.
  TITLE     Developmental regulation of a protein kinase C isoform localized in
            the neuromuscular junction
  JOURNAL   J Cell Sci 108 (Pt 1), 51-61 (1995)
   PUBMED   7738116
REFERENCE   10 (bases 1 to 3370)
  AUTHORS   Powell,C.T., Fair,W.R. and Heston,W.D.
  TITLE     Differential expression of protein kinase C isozyme messenger RNAs
            in dunning R-3327 rat prostatic tumors
  JOURNAL   Cell Growth Differ 5 (2), 143-149 (1994)
   PUBMED   8180127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On or before Mar 1, 2013 this sequence version replaced
            XM_341553.5, XM_001064127.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.39773.1,
                                           SRR26643292.58290.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000017.1  72288334-72288508   c
            176-302             JAXUCZ010000017.1  72233750-72233876   c
            303-502             JAXUCZ010000017.1  72228279-72228478   c
            503-563             JAXUCZ010000017.1  72224571-72224631   c
            564-726             JAXUCZ010000017.1  72216849-72217011   c
            727-758             JAXUCZ010000017.1  72215361-72215392   c
            759-844             JAXUCZ010000017.1  72215178-72215263   c
            845-974             JAXUCZ010000017.1  72213880-72214009   c
            975-1084            JAXUCZ010000017.1  72209265-72209374   c
            1085-1202           JAXUCZ010000017.1  72208436-72208553   c
            1203-1363           JAXUCZ010000017.1  72206260-72206420   c
            1364-1537           JAXUCZ010000017.1  72203070-72203243   c
            1538-1629           JAXUCZ010000017.1  72183951-72184042   c
            1630-1692           JAXUCZ010000017.1  72181213-72181275   c
            1693-1831           JAXUCZ010000017.1  72175984-72176122   c
            1832-2020           JAXUCZ010000017.1  72167155-72167343   c
            2021-2149           JAXUCZ010000017.1  72157919-72158047   c
            2150-3370           JAXUCZ010000017.1  72156215-72157435   c
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     gene            1..3370
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /note="protein kinase C, theta"
                     /db_xref="GeneID:85420"
                     /db_xref="RGD:620968"
     exon            1..175
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            176..302
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2308
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /EC_number="2.7.11.13"
                     /note="nPKC-theta"
                     /codon_start=1
                     /product="protein kinase C theta type"
                     /protein_id="NP_001263650.1"
                     /db_xref="GeneID:85420"
                     /db_xref="RGD:620968"
                     /translation="MSPFLRIGLSNFDCGTCQACQGEAVNPYCAVLVKEYVESENGQM
                     YIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGR
                     TEIWLELKPQGRMLMNARYFLEMSDTKDMSEFENEGFFALHHRRGAIKQAKVHHVKCH
                     EFTATFFPQPTFCSVCHEFVWGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRE
                     TMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK
                     VANLCGINQKLMAEALAMIESTQQARTLRDSEHIFREGPIEISFPRSIKSETRPPCVP
                     TPGKKEPQGICWESPLDGADKTAQPPEPEVNLQRASLQLKLKIDDFILHKMLGKGSFG
                     KVFLAEFKRTKQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQT
                     KENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLD
                     NILLDRDGHIKIADFGMCKENMLGDAKTNTFCGTPDYIAPEILLGQKYNHSVDWWSFG
                     VLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEREAKDLLVKLFVREPEKRLGV
                     RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPYDCSNFDKEFLSEKPRLSFADRAL
                     INSMDQNMFSNFSFINPGMETLICS"
     exon            303..502
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            503..563
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            564..726
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            727..758
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            759..844
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            845..974
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1084
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1202
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1363
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1537
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1629
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1692
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1831
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2020
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2149
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..3370
                     /gene="Prkcq"
                     /gene_synonym="Pkcq"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggaaggcc gagagcgctc gtggaacgca actaggcgcg cgtccctgag ccggcgtggc
       61 gagcgccctc tggccggtgt cgccgcccgg agtaccctcg ggtcgccagg cccgcgccag
      121 tccccgccat cggagcagca gcggcactgc gctgggactg cggccacgac accagggaac
      181 aaccatgtca ccgtttcttc gaattggttt atccaacttt gactgtggga cctgtcaagc
      241 ttgtcaggga gaggcggtga acccctactg tgccgtgctt gtcaaagagt atgtggaatc
      301 agaaaacggg cagatgtaca tccagaaaaa gccgaccatg tacccgcctt gggacagcac
      361 ctttgatgcc cacattaaca agggaagggt gatgcagatc atcgtgaaag gcaaaaatgt
      421 agacctcata tcagaaacca ccgtggagct ctactccctg gcagagagat gccgcaagaa
      481 caatgggcgg acagaaatat ggttagagct gaaacctcaa ggccgaatgc taatgaatgc
      541 aagatacttt ctggaaatga gtgacacaaa ggacatgagt gaatttgaga acgaaggatt
      601 ctttgcactg catcaccgcc gaggcgccat caaacaagcc aaagtccacc acgtcaagtg
      661 tcacgagttc acagccacct ttttccctca acccacgttc tgctctgtct gccatgaatt
      721 tgtctggggg ctgaacaagc agggctacca gtgccgacaa tgtaatgcag cgattcacaa
      781 gaagtgcatc gataaagtga tagccaagtg cacaggatcg gcgatcaata gtcgagagac
      841 catgttccac aaggagagat tcaagatcga catgccacac agattcaaag tctacaacta
      901 caagagtcca accttctgtg agcactgtgg taccctgcta tgggggctgg cgaggcaagg
      961 tctcaagtgt gatgcatgtg gcatgaacgt ccaccaccga tgccagacaa aggttgccaa
     1021 cctctgtggt ataaaccaga agctaatggc tgaagcgcta gcaatgattg aaagcactca
     1081 acaggctcgc accttaagag attcagaaca catcttccga gaaggaccaa ttgaaatcag
     1141 tttcccgcgc tccatcaaaa gtgaaaccag gccaccatgc gtaccaacac ctgggaaaaa
     1201 agaaccccag ggaatttgct gggagtcccc tttggatggg gcagataaaa cggcccagcc
     1261 tcctgaacct gaagtgaact tgcaaagggc ttctctgcaa ctgaaactga agatcgatga
     1321 cttcatcctg cacaagatgc tggggaaagg aagttttggc aaggtcttcc tggcagagtt
     1381 caagagaacc aaacagtttt tcgcaataaa agccttaaag aaagatgtgg tgttgatgga
     1441 cgatgacgtc gagtgcacga tggtggagaa gagagttctg tccttggcct gggagcatcc
     1501 gtttcttaca cacatgttct gcacattcca gaccaaggaa aatctctttt tcgtgatgga
     1561 gtatctcaat ggaggagact taatgtacca catccaaagt tgccacaaat ttgatctttc
     1621 cagagccacg ttttatgctg ctgagatcat ccttggtcta cagttccttc attccaaagg
     1681 aattgtctac agggacctga agctagataa tatcctgtta gacagagatg gccatatcaa
     1741 aatagcagac tttgggatgt gcaaagagaa tatgctggga gatgcgaaga caaatacttt
     1801 ctgtgggacg cctgactaca tcgctccgga gatcttgctg ggtcagaaat acaaccattc
     1861 cgttgactgg tggtcctttg gggttcttct ttacgagatg ctgattggcc agtcgccttt
     1921 ccacgggcag gacgaagagg agcttttcca ctccatccgc atggacaatc ccttttaccc
     1981 aaggtggcta gaaagggagg ccaaggatct tctagtgaag ctttttgtga gagagcctga
     2041 aaagaggctg ggagtgagag gagacatccg ccagcatcct ttgtttcgag agatcaactg
     2101 ggaagagctt gagagaaaag agattgaccc acccttcaga ccaaaagtga aatcaccata
     2161 tgactgtagc aatttcgaca aggaattcct aagtgagaaa ccccggctat cgttcgctga
     2221 cagagcactc atcaacagca tggaccagaa catgttcagc aacttctcct tcattaaccc
     2281 ggggatggag actctcattt gctcctgaac ctcatccctc ttccccagac tggaagaaat
     2341 tcgccttctc tctgggaact ggttcaagta acacttctgg gggtctcttt ttcacgttgg
     2401 agaagagaag aaacactcaa cctcgaaagc agggaggacc gctgagctcc tcgagggaca
     2461 cgcagcacaa accatgtctc cttcactaat ggcatcatcc tgttatatct cctggaatct
     2521 ctctcaccgc agccctagaa gttagaccat tgttaactct agtcatttac ttgaaagatg
     2581 gttcccgatc ctgcgaacga ttcgaaatgt aattctgctc ttgtcgttga caagagctgc
     2641 tggttggtga cgaaccaagg tgcaagtgga acagatttct caagaccggg agggcagatt
     2701 gcctgtcatg gaagtcgatt ccactcaacc acagagaagg acccactaac ccgcatcgtc
     2761 ctgcgcatgt ctgtggaaat gtcgatggca gaagggaggg aaagggatgt gatgggatgt
     2821 tctccaataa acttagcgtg aaacttgaga tttacaaacc cgttcgttct ggccagccct
     2881 gaaattcaca aggcagcgga aagtaagggg tgaggtgcag agcctttgtc accaacagga
     2941 agggtaagga tgtttcggat gtggtgcatc tcattcccac agaagtaaag tccaaccaac
     3001 gaaggcaggg cagtttactg ctgccaatca aaccttctct tccctcttgt tctggctgat
     3061 ttctctgtca gcgtcggcat tcgtcatcgt cctcccgttg cacaagaaat gaagtacatg
     3121 actcttgtga gagaaagaaa accaatccca tatcatgttg ctcctggtga ttcggtgaca
     3181 aataagtccc tctttaggca tcctgcaaga caaacgaccc acgcatgcta tttccactag
     3241 tcagccctgt tgagttggag tactaattag acacttagag tctcgcgtgc tgtttgtata
     3301 ttttgatggg atgttgtgat gatgacgtac gtggacgtgt aaaacggaat aaaagaagaa
     3361 aagaaagatg
//
