LOCUS       NM_032059               4501 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus protein kinase C, iota (Prkci), mRNA.
ACCESSION   NM_032059 XM_001064601 XM_342223
VERSION     NM_032059.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4501)
  AUTHORS   Leduc,C. and Etienne-Manneville,S.
  TITLE     Regulation of microtubule-associated motors drives intermediate
            filament network polarization
  JOURNAL   J Cell Biol 216 (6), 1689-1703 (2017)
   PUBMED   28432079
  REMARK    GeneRIF: Polarity signaling via CDC42/atypical protein kinase C can
            affect the dynamic turnover of the intermediate filament network to
            promote the polarization of the network itself.
REFERENCE   2  (bases 1 to 4501)
  AUTHORS   Dorfman,M.D., Krull,J.E., Scarlett,J.M., Guyenet,S.J., Sajan,M.P.,
            Damian,V., Nguyen,H.T., Leitges,M., Morton,G.J., Farese,R.V.,
            Schwartz,M.W. and Thaler,J.P.
  TITLE     Deletion of Protein Kinase C lambda in POMC Neurons Predisposes to
            Diet-Induced Obesity
  JOURNAL   Diabetes 66 (4), 920-934 (2017)
   PUBMED   28073831
  REMARK    GeneRIF: Acute inhibition of CNS aPKC activity increases food
            intake and glucose intolerance. Chronic inactivation of CNS aPKC
            activity increases body weight and food intake during high fat diet
            feeding.
REFERENCE   3  (bases 1 to 4501)
  AUTHORS   Wang,S., Sheng,T., Ren,S., Tian,T. and Lu,W.
  TITLE     Distinct Roles of PKCiota/lambda and PKMzeta in the Initiation and
            Maintenance of Hippocampal Long-Term Potentiation and Memory
  JOURNAL   Cell Rep 16 (7), 1954-1961 (2016)
   PUBMED   27498875
  REMARK    GeneRIF: PKMzeta, but not PKCiota, knock-down disrupted previously
            established long-time memory. PKCiota and PKMz have distinct
            functions in long-term potentiation and memory, with PKMzeta
            playing a specific role in memory maintenance.
REFERENCE   4  (bases 1 to 4501)
  AUTHORS   Ren,S.Q., Yan,J.Z., Zhang,X.Y., Bu,Y.F., Pan,W.W., Yao,W., Tian,T.
            and Lu,W.
  TITLE     PKClambda is critical in AMPA receptor phosphorylation and synaptic
            incorporation during LTP
  JOURNAL   EMBO J 32 (10), 1365-1380 (2013)
   PUBMED   23511975
  REMARK    GeneRIF: PKClambda is critical in AMPA receptor phosphorylation and
            synaptic incorporation during long-term potentiation.
REFERENCE   5  (bases 1 to 4501)
  AUTHORS   Kong,L.J., Feng,W., Wright,M., Chen,Y., Dallas-yang,Q., Zhou,Y.P.
            and Berger,J.P.
  TITLE     FGF21 suppresses hepatic glucose production through the activation
            of atypical protein kinase Ciota/lambda
  JOURNAL   Eur J Pharmacol 702 (1-3), 302-308 (2013)
   PUBMED   23305840
  REMARK    GeneRIF: FGF21 inhibits hepatic glucose production by the
            PI3K-dependent activation of protein kinase c iota.
REFERENCE   6  (bases 1 to 4501)
  AUTHORS   Wooten,M.W., Seibenhener,M.L., Zhou,G., Vandenplas,M.L. and
            Tan,T.H.
  TITLE     Overexpression of atypical PKC in PC12 cells enhances
            NGF-responsiveness and survival through an NF-kappaB dependent
            pathway
  JOURNAL   Cell Death Differ 6 (8), 753-764 (1999)
   PUBMED   10467349
REFERENCE   7  (bases 1 to 4501)
  AUTHORS   Albert,C.J. and Ford,D.A.
  TITLE     Protein kinase C translocation and PKC-dependent protein
            phosphorylation during myocardial ischemia
  JOURNAL   Am J Physiol 276 (2), H642-H650 (1999)
   PUBMED   9950866
REFERENCE   8  (bases 1 to 4501)
  AUTHORS   Kotani,K., Ogawa,W., Matsumoto,M., Kitamura,T., Sakaue,H., Hino,Y.,
            Miyake,K., Sano,W., Akimoto,K., Ohno,S. and Kasuga,M.
  TITLE     Requirement of atypical protein kinase clambda for insulin
            stimulation of glucose uptake but not for Akt activation in 3T3-L1
            adipocytes
  JOURNAL   Mol Cell Biol 18 (12), 6971-6982 (1998)
   PUBMED   9819385
REFERENCE   9  (bases 1 to 4501)
  AUTHORS   Izumi,Y., Hirose,T., Tamai,Y., Hirai,S., Nagashima,Y., Fujimoto,T.,
            Tabuse,Y., Kemphues,K.J. and Ohno,S.
  TITLE     An atypical PKC directly associates and colocalizes at the
            epithelial tight junction with ASIP, a mammalian homologue of
            Caenorhabditis elegans polarity protein PAR-3
  JOURNAL   J Cell Biol 143 (1), 95-106 (1998)
   PUBMED   9763423
REFERENCE   10 (bases 1 to 4501)
  AUTHORS   Selbie,L.A., Schmitz-Peiffer,C., Sheng,Y. and Biden,T.J.
  TITLE     Molecular cloning and characterization of PKC iota, an atypical
            isoform of protein kinase C derived from insulin-secreting cells
  JOURNAL   J Biol Chem 268 (32), 24296-24302 (1993)
   PUBMED   8226978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On or before Sep 6, 2008 this sequence version replaced
            XM_001064601.1, XM_342223.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU517502.1, SRR26643286.6988.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               JAXUCZ010000002.1  114310543-114310784 c
            243-364             JAXUCZ010000002.1  114284763-114284884 c
            365-454             JAXUCZ010000002.1  114276828-114276917 c
            455-505             JAXUCZ010000002.1  114275659-114275709 c
            506-591             JAXUCZ010000002.1  114272550-114272635 c
            592-732             JAXUCZ010000002.1  114270888-114271028 c
            733-787             JAXUCZ010000002.1  114268706-114268760 c
            788-846             JAXUCZ010000002.1  114267100-114267158 c
            847-1023            JAXUCZ010000002.1  114264757-114264933 c
            1024-1121           JAXUCZ010000002.1  114264153-114264250 c
            1122-1208           JAXUCZ010000002.1  114263578-114263664 c
            1209-1344           JAXUCZ010000002.1  114263202-114263337 c
            1345-1432           JAXUCZ010000002.1  114261218-114261305 c
            1433-1558           JAXUCZ010000002.1  114259759-114259884 c
            1559-1638           JAXUCZ010000002.1  114258689-114258768 c
            1639-1728           JAXUCZ010000002.1  114257066-114257155 c
            1729-1844           JAXUCZ010000002.1  114256616-114256731 c
            1845-4501           JAXUCZ010000002.1  114250398-114253054 c
FEATURES             Location/Qualifiers
     source          1..4501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..4501
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /note="protein kinase C, iota"
                     /db_xref="GeneID:84006"
                     /db_xref="RGD:620961"
     exon            1..242
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1932
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /EC_number="2.7.11.13"
                     /note="protein kinase C, lambda; nPKC-iota;
                     aPKC-lambda/iota; atypical protein kinase C-lambda/iota"
                     /codon_start=1
                     /product="protein kinase C iota type"
                     /protein_id="NP_114448.1"
                     /db_xref="GeneID:84006"
                     /db_xref="RGD:620961"
                     /translation="MPTQRDSSTMSHTVACGGGGDHSHQVRVKAYYRGDIMITHFEPS
                     ISFEGLCSEVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELL
                     IHVFPCVPERPGMPCPGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDR
                     IWGLGRQGYKCINCKLLVHKKCHKLVTIECGRHSLPPEPMMPMDQSSMHPDHTQTVIP
                     YNPSSHESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKT
                     DRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEY
                     VNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHI
                     KLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGR
                     SPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCH
                     PQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPD
                     DDDIVRKIDQSEFEGFEYINPLLMSAEECV"
     exon            243..364
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            365..454
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            455..505
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            506..591
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            592..732
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            733..787
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            788..846
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1023
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1121
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1208
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1344
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1432
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1558
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1638
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1728
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1844
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..4501
                     /gene="Prkci"
                     /gene_synonym="Pkcl"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcgctctggc gggttaggcg tgttggtccg ggaggcgggc ggccacggct tcccgacagg
       61 ctcgggaggc cgagaccctc gcggcgcccg gcgctgcccg gatcccctca gcctccagcg
      121 gagaggcggg ggagtgagga gatgccgacc cagagggaca gcagcaccat gtctcacacg
      181 gtcgcgtgcg gcggcggcgg ggaccattcc caccaggtcc gggtgaaagc ctactaccgc
      241 ggggatatta tgataacaca cttcgagcct tccatctcct ttgaaggact ttgcagtgag
      301 gttcgagata tgtgttcttt tgacaatgag cagccattca ccatgaaatg gatagatgag
      361 gaaggagacc cgtgcacagt gtcttctcag ttggagttgg aagaggcttt caggctgtat
      421 gagttgaaca aggattctga actcctgatc cacgtgttcc cgtgtgtacc agagcgtcct
      481 ggaatgcctt gcccagggga agacaagtcc atttaccgca gaggggcgcg caggtggaga
      541 aagctgtatt gtgcaaatgg ccacactttt caagccaaac gctttaacag gcgtgcccac
      601 tgtgccatct gcacagacag gatctgggga cttggacgac aaggatataa atgcatcaac
      661 tgcaaactgc tggttcataa gaagtgccac aagcttgtca caattgagtg tgggcggcat
      721 tctttgccac cggaacccat gatgccaatg gaccagtcat ccatgcaccc agaccacaca
      781 cagacagtaa ttccatataa tccttcaagt catgagagtt tggaccaagt tggtgaagaa
      841 aaggaggcaa tgaacaccag ggagagtggg aaggcgtcat caagcttagg tctccaggat
      901 ttcgatttgc ttcgagttat agggagagga agttacgcca aagtactgct ggttcgatta
      961 aaaaagacag atcgcattta tgcaatgaag gttgtgaaga aagagctcgt caatgacgat
     1021 gaggatattg attgggtaca gacagaaaag catgtgtttg agcaggcgtc caatcaccct
     1081 ttccttgttg gtctgcattc ctgcttccag acagaaagca ggctgttttt tgtcatagaa
     1141 tatgtgaatg gaggggatct catgtttcat atgcagcggc aaagaaaact tcctgaagaa
     1201 catgccaggt tttactcagc agaaatcagt ctagcactaa attatcttca tgagcgaggg
     1261 ataatttata gagatttgaa gttggacaat gtactgctgg actctgaagg acacatcaaa
     1321 ctcactgact acggcatgtg taaggaagga ttacggcccg gagatacaac cagcaccttc
     1381 tgtgggactc ccaattacat tgctcctgag atcttaagag gagaagacta tggcttcagc
     1441 gttgactggt gggctcttgg agtactcatg tttgagatga tggcgggaag gtctccattt
     1501 gatatcgttg ggagctctga caatcctgac caaaacacag aggattatct gttccaagtc
     1561 attttggaga agcagattcg cataccgcgc tccctgtctg tgaaagcagc aagtgtgctg
     1621 aagagtttcc tcaacaagga cccaaaggaa cgattgggtt gtcaccctca aactggattt
     1681 gctgacatcc aaggacaccc attcttccgt aatgtggatt gggacatgat ggagcagaag
     1741 caagtggttc cgccctttaa accaaacatt tctggagaat ttggtttgga taactttgac
     1801 tcccagttta ccaacgaacc agtccagctc actccagatg atgatgacat cgtgaggaag
     1861 attgatcagt ctgaatttga aggtttcgag tatatcaacc ctctcttgat gtctgcagaa
     1921 gagtgtgtct gattctgctt actgccattt agtgcatgga tcaaccgtta gcccggtcac
     1981 agttagcatt ttatgttgtc cctacagaaa tctctctcaa tatcctgtta gcgactatag
     2041 gaatcatata gctaagcaga gctaaaaaaa cagaaactag tttcctgaca gtcatgtcaa
     2101 actccagtta tgcttgctct ccagaggctc ctaatgagaa aggacagtgt ctttgtgtaa
     2161 aggaaacagc ctagcttgtc aaagaaagcc tctgctgcgt tgtgacactc agtgggatga
     2221 catcatcagt ctcccacagt tgtcactttg ggttaaggca tggaaggctt aattgtagag
     2281 tggagggcca tgctaaatat atctgctagt gttactggtt tctgagttcc ctcagtttga
     2341 atcctcctat aaatcttctc attactttgg gtaatttaaa gaagcagtta tcaaattgat
     2401 acacaattga cttgttttat taagaattgg gttctaagtt attatctgtg tttcaaaaac
     2461 taacacagtg atttattttg tgtttttaat ttttcttttt cttttttttt acaataaggg
     2521 gttagcttct gagcttgcct cttccgtgaa tactagcata atgatacctg acgtgcagag
     2581 acccaggctg catgggaata ggcagctgct caggtaaagg agaaaggagg agtgtaccgt
     2641 agctgcagaa agaacaatgg tagtattctg tctcttctgg agaatgagtc ctgtagctgg
     2701 tggttaagat ttgatgtaaa taatgaggag gctctcgctt cttaccctac ttagaaaagc
     2761 attccatgtc ttcaggggag gcggagtgaa tatattttta ttatttagta tatgggaaaa
     2821 taatttatct gctaagtaga atgtcttaac tacttgtgat tccttcccca gagtacatta
     2881 tctgtacttt gagagctttt cgtggagtct gcagtgaagc tcaagaccag tactggtgac
     2941 ttgatagctg tgtgacacat ccagtacaga ccagtactgg tgacttgata gctgtgtaac
     3001 acatcccagt tcgggctctt cctgagtttt tgtgtctagg taacaagtgt gatacagtac
     3061 agtccattca gggcagagtc ttcagttctc cacaatattt ttattaacag tagtatttag
     3121 caatctttta tttaaagaag caccatttta agcaccattc tgctgtttat tttaaatatt
     3181 tttatataaa ggactttaaa atggtcacct aaacaagcta ccattgtcaa atcagtagac
     3241 ttagtttcat gaatgctgta cggtgttgag cttataaggc ttcaaacacg tagtcattga
     3301 agacatctct gaggatgcca catttcatta caagtgtaag ttgtgtcaag ttgggtcgtg
     3361 cattttctta aataatgaaa gactgggagc cgtgaaaacc tccactgagg aaagccaacc
     3421 agggaccatc agtcggtcga ggcagctcag cacctgatga cctgatgcct ggaacccaca
     3481 agctgagagg aaggacagac cagctcccac aggctggcac ccgtggcacg cacgaggccc
     3541 tccctgcagg acataactgt gagggagcag acaagggagt gcagtgaatg cacacctaga
     3601 ggcagatgtt tgtgcacact tcatgtttaa gaagcgcggg tttccctgag atctagaaca
     3661 ttcttaaatc aaaaggcagt gttcacgtcc taagcttgtg gggagttctg agatatctat
     3721 gacctaagtg gggcttctcc cttggggcac ttcagactga gccttgttaa agtgcagtgc
     3781 cgagcctgcc tgggagtctt ctgggacttg atatttcatc gtgagaagca ttttcgtcaa
     3841 ggtattcttt atcttgtggc catatttctt actggagtgt gagtctgtgt tttttgtgat
     3901 aaaacatttt aagaagggga aatcagtaaa ttatcatgca tttatcaaca aatttagatg
     3961 aataaattca agttatatgt cttccctgcc ctcatcccca acaaaactta tccgtttctg
     4021 ccaataccgt acaaatgatg aacatttttc tatgatgagg ttctcaccat aattaaggtg
     4081 gtctttgttt ttaaatcttt ctgttgttgt tgataactaa taagacaacg tactatgtat
     4141 gctttataca gaattattac aatgatttta gttccgttct tgttttctgt ccttccgagc
     4201 catgccaaat ctgtatgtta tggaaatgtt ctcagaatcc tgccagggga atgcagtgtg
     4261 gacgggcagt gattggcact tggtgtcata gaaattactt accttgcata agctcgtggt
     4321 tggatcggtt atcacgtgta gctggatgga tatctagtcc tgtgttcttg ttgtcggtac
     4381 tcaccttaga aacttgtttt gatttttgtc atgtagaaca ctgccttgtt cactataatg
     4441 taactgtatt tgtataattt ttttacatta agatcttaaa ataaaatgtt taatacctat
     4501 g
//
