LOCUS       NM_031085               3398 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus protein kinase C, eta (Prkch), mRNA.
ACCESSION   NM_031085
VERSION     NM_031085.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3398)
  AUTHORS   Wang,H., Li,Y., Jiang,S., Liu,N., Zhou,Q., Li,Q., Chen,Z., Lin,Y.,
            Chen,C. and Deng,Y.
  TITLE     LncRNA xist regulates sepsis associated neuroinflammation in the
            periventricular white matter of CLP rats by miR-122-5p/PKCeta Axis
  JOURNAL   Front Immunol 14, 1225482 (2023)
   PUBMED   38115999
  REMARK    GeneRIF: LncRNA xist regulates sepsis associated neuroinflammation
            in the periventricular white matter of CLP rats by
            miR-122-5p/PKCeta Axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3398)
  AUTHORS   Li,X., Xu,L., Hou,X., Geng,J., Tian,J., Liu,X. and Bai,X.
  TITLE     Advanced Oxidation Protein Products Aggravate Tubulointerstitial
            Fibrosis Through Protein Kinase C-Dependent Mitochondrial Injury in
            Early Diabetic Nephropathy
  JOURNAL   Antioxid Redox Signal 30 (9), 1162-1185 (2019)
   PUBMED   29482336
  REMARK    GeneRIF: Study provides mechanistic evidence that inhibition of
            PKCeta isoform alleviated mitochondrial injuries and function,
            attenuated apoptosis, and renal fibrosis in high glucose
            (HG)-cultured advanced oxidation protein products (AOPPs)-induced
            HK-2 cells. Thus, AOPPs-induced mitochondrial dysfunction and
            oxidative stress cause tubulointerstitial fibrosis in diabetic
            nephropathy via activation of the PKCeta isoform.
REFERENCE   3  (bases 1 to 3398)
  AUTHORS   Liang,Y., Cucchetti,M., Roncagalli,R., Yokosuka,T., Malzac,A.,
            Bertosio,E., Imbert,J., Nijman,I.J., Suchanek,M., Saito,T.,
            Wulfing,C., Malissen,B. and Malissen,M.
  TITLE     The lymphoid lineage-specific actin-uncapping protein Rltpr is
            essential for costimulation via CD28 and the development of
            regulatory T cells
  JOURNAL   Nat Immunol 14 (8), 858-866 (2013)
   PUBMED   23793062
REFERENCE   4  (bases 1 to 3398)
  AUTHORS   Lau,E., Kluger,H., Varsano,T., Lee,K., Scheffler,I., Rimm,D.L.,
            Ideker,T. and Ronai,Z.A.
  TITLE     PKCepsilon promotes oncogenic functions of ATF2 in the nucleus
            while blocking its apoptotic function at mitochondria
  JOURNAL   Cell 148 (3), 543-555 (2012)
   PUBMED   22304920
REFERENCE   5  (bases 1 to 3398)
  AUTHORS   Raveh-Amit,H., Hai,N., Rotem-Dai,N., Shahaf,G., Gopas,J. and
            Livneh,E.
  TITLE     Protein kinase Ceta activates NF-kappaB in response to
            camptothecin-induced DNA damage
  JOURNAL   Biochem Biophys Res Commun 412 (2), 313-317 (2011)
   PUBMED   21820409
REFERENCE   6  (bases 1 to 3398)
  AUTHORS   Hussaini,I.M., Karns,L.R., Vinton,G., Carpenter,J.E., Redpath,G.T.,
            Sando,J.J. and VandenBerg,S.R.
  TITLE     Phorbol 12-myristate 13-acetate induces protein kinase
            ceta-specific proliferative response in astrocytic tumor cells
  JOURNAL   J Biol Chem 275 (29), 22348-22354 (2000)
   PUBMED   10806212
REFERENCE   7  (bases 1 to 3398)
  AUTHORS   Albert,C.J. and Ford,D.A.
  TITLE     Protein kinase C translocation and PKC-dependent protein
            phosphorylation during myocardial ischemia
  JOURNAL   Am J Physiol 276 (2), H642-H650 (1999)
   PUBMED   9950866
REFERENCE   8  (bases 1 to 3398)
  AUTHORS   Mahadev,K. and Vemuri,M.C.
  TITLE     Selective changes in protein kinase C isoforms and phosphorylation
            of endogenous substrate proteins in rat cerebral cortex during pre-
            and postnatal ethanol exposure
  JOURNAL   Arch Biochem Biophys 356 (2), 249-257 (1998)
   PUBMED   9705215
REFERENCE   9  (bases 1 to 3398)
  AUTHORS   Chen,C.C., Wang,J.K., Chen,W.C. and Lin,S.B.
  TITLE     Protein kinase C eta mediates lipopolysaccharide-induced
            nitric-oxide synthase expression in primary astrocytes
  JOURNAL   J Biol Chem 273 (31), 19424-19430 (1998)
   PUBMED   9677361
REFERENCE   10 (bases 1 to 3398)
  AUTHORS   Dekker,L.V., Parker,P.J. and McIntyre,P.
  TITLE     Biochemical properties of rat protein kinase C-eta expressed in COS
            cells
  JOURNAL   FEBS Lett 312 (2-3), 195-199 (1992)
   PUBMED   1426252
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081782.1.
            
            On Sep 16, 2004 this sequence version replaced NM_031085.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081782.1, X68400.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132293
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3398
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3398
                     /gene="Prkch"
                     /note="protein kinase C, eta"
                     /db_xref="GeneID:81749"
                     /db_xref="RGD:621888"
     exon            1..550
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2239
                     /gene="Prkch"
                     /EC_number="2.7.11.13"
                     /note="PKC-L; nPKC-eta"
                     /codon_start=1
                     /product="protein kinase C eta type"
                     /protein_id="NP_112347.1"
                     /db_xref="GeneID:81749"
                     /db_xref="RGD:621888"
                     /translation="MSSGTMKFNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPY
                     LTVSVDQVRVGQTSTKQKTNKPTYNEEFCTNVSDGGHLELAVFHETPLGYDHFVANCT
                     LQFQELLRTAGTSDTFEGWVDLEPEGKVFVVITLTGSFTEATLQRDRIFKHFTRKRQR
                     AMRRRVHQVNGHKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLI
                     VTACTCQNNINKVDAKIAEQRFGINIPHKFNVHNYKVPTFCDHCGSLLWGIMRQGLQC
                     KICKMNVHIRCQANVAPNCGVNAVELAKTLAGMGLQPGNISPTSKLISRSTLRRQGKE
                     GSKEGNGIGVNSSSRFGIDNFEFIRVLGKGSFGKVMLARIKETGELYAVKVLKKDVIL
                     QDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR
                     FDEARARFYAAEIISALMFLHEKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNG
                     VTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
                     LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHEILRHPFFKEIDWVQLNH
                     RQLEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPELQ
                     P"
     exon            551..614
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            615..765
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            766..800
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            801..889
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            890..1019
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1147
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1291
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1465
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1620
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1759
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1948
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2092
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..3377
                     /gene="Prkch"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaaggagg ggaggggaag gtccctcgga ggaggcggaa tggccggtcg cagggggctt
       61 gggtgctgct tctcccggga gctgcctcca cgagcgtggc tgcggagagg actgccttga
      121 gcccgggctc tccgttcccc ggtgccagcc agcccggccc cctcggggct ccggcagcag
      181 cgccagcatg tcgtccggca cgatgaagtt caatggctat ctgagggtcc gcatcggaga
      241 ggcagtgggg ctgcagccca cccgctggtc cctgcggcac tcgctcttca aaaagggcca
      301 ccagctgctg gacccctacc tgacggtgag cgtagaccag gtacgcgtgg gccagaccag
      361 cacaaagcag aagactaaca aacccaccta caacgaggag ttctgcacca atgtctccga
      421 cggcggccac ctggagctag ccgtcttcca cgagacgccc ctgggctatg accactttgt
      481 ggccaactgc acgctgcagt tccaggagct gttgcgcacg gccggcacat cggacacctt
      541 cgagggctgg gtggatctgg agcctgaggg gaaagtgttc gtggtaataa ccctaacagg
      601 gagcttcact gaagccactc tccagagaga ccgcatcttc aagcatttta ccaggaagcg
      661 ccaacgggct atgcgaagga gagtccatca agtcaacgga cacaagttca tggccacata
      721 cctgaggcag cccacctact gctctcactg ccgggagttc atctggggag tatttgggaa
      781 acagggttat caatgccaag tgtgcacctg cgtcgtccat aaacgctgcc atcacctaat
      841 tgttacagcc tgcacttgcc aaaacaatat taacaaagtg gatgccaaga tcgcagagca
      901 acggtttggc atcaacatcc cacacaagtt caacgttcac aactacaagg tgcccacgtt
      961 ctgcgaccac tgtggctccc tgctctgggg gataatgcga caaggacttc agtgtaaaat
     1021 atgtaagatg aacgtacata ttcggtgtca ggcgaacgtg gccccaaact gcggggtgaa
     1081 cgccgtggag cttgccaaga ccctggcagg gatgggtctc caacccggaa atatttctcc
     1141 aacctcgaaa ctcatttcca ggtctacgct gagacggcag gggaaggagg gctccaaaga
     1201 aggaaatggg atcggtgtta attcttccag cagattcggc atcgacaact ttgagttcat
     1261 ccgggtgttg gggaagggga gcttcgggaa ggtgatgctc gccagaataa aggagacagg
     1321 agagctgtac gctgtgaagg tgctgaagaa ggacgtcatc ctgcaggatg acgatgtgga
     1381 atgcaccatg actgagaaga ggatcctctc cttggcccgc aaccacccct tcctcaccca
     1441 gctcttctgc tgctttcaga ctcctgaccg tctgttcttt gtcatggagt ttgtgaacgg
     1501 aggtgacctg atgttccaca tccaaaagtc caggcgtttc gatgaagccc gagctcgttt
     1561 ctacgctgca gagatcattt ctgcactcat gttcctccac gagaaaggca tcatctacag
     1621 agacttgaaa ctggacaacg tactactgga ccacgaaggc cactgtaaac tggccgactt
     1681 cggaatgtgc aaggagggca tttgtaacgg ggtcaccaca gccaccttct gcggcacgcc
     1741 tgactacatt gccccagaga tccttcagga gatgttgtat ggacctgcag tagactggtg
     1801 ggccatgggc gtgttgcttt atgagatgct gtgcggacat gcgcccttcg aggctgagaa
     1861 tgaagatgac ctttttgagg ccatactgaa tgatgaagtt gtctacccta cctggctcca
     1921 tgaagatgcc acagggatcc tcaaatcttt catgaccaag aaccccacca tgcgcttggg
     1981 cagcctgact cagggaggcg agcatgagat cttgagacat cctttcttta aggaaatcga
     2041 ctgggtccag ttgaaccatc gccagctaga accgcctttc cgacccagaa tcaaatcccg
     2101 agaagacgtc agcaattttg acccagactt cataaaagaa gagcctgttt taactccgat
     2161 cgatgaggga catcttccta tgattaacca ggatgagttt agaaactttt cctatgtgtc
     2221 accagaattg caaccgtagc cttatgggaa gcaacaaaga gaaaggggga tctttccaga
     2281 gatttcttgt gtgggaagtc cccagctcct gccttttaac accaccttca ccttcacgga
     2341 gcaaatgttc acaactctgc gaagggcgga gcctcaagag agccactctg tcaagtcccg
     2401 gggagccatg gtacacttcg gtagttgata ctgaggtaag atgttacaga gacgtgcacc
     2461 gcccaccccg gagtctccat ggctttcagg cttggagtaa aggacagaag ccaaaagaag
     2521 agatgctggg taacacagga ggtcctaggg atcctcagcc aaacaggctt cttgttttta
     2581 acttcaagag acaaatctag actttccgtg gagcacccca cactgttctt cacgccaata
     2641 gtgcagtctg cgaaagatca aatgctgatg aagaagttaa aagtctctct agggaaacgg
     2701 acggcattct aagcagactg attcgcttcg aagaaaccgc agttgggcgt ccttcaagct
     2761 cccaacctaa acccagtgtt gagaacagag gttggacacc acgacgacct ctgttgtctt
     2821 gacaacagct caagtgtctt gagtctcttc cttccagtaa ctagatattt attgagtgtc
     2881 aaataaaaag gtgccatact cttcagtagt gtacacggta gagtcacctt catgatgcct
     2941 ttactcgttc tggggtccac ctaatggtgt tcgcactctg cgaaaggcct ctccacattg
     3001 catataggtc tgtcttcttt gtctcctgtt catagaaggg ccaccaccac agtagtgcgg
     3061 tcagcaggcg ggcttccgct gcatgccacc tgctgactgg ccggtggaat ctaatctcca
     3121 catccttcat cccacgtcga ctcattggcg aagaagtccg tgccactccc atcctcgaac
     3181 acgtgtgtgg caggtccatc ggccgcctac ttgagttatg tttcagagac aaagaaggtt
     3241 gtttgatact cacattaata agaagctctg ggtcttgtaa acaaggccga cgacagaggt
     3301 gtaccttttc atgtgtaacc atatatacag ttgaaaaaat tttatctggc tggaaataaa
     3361 ggcatttttt agcaaaaaaa aaaaaaaaaa aaaaaaaa
//
