LOCUS       NM_012628               3152 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein kinase C, gamma (Prkcg), mRNA.
ACCESSION   NM_012628
VERSION     NM_012628.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3152)
  AUTHORS   Guo,R., Xue,J., Shao,P., Cai,C. and Wang,Y.
  TITLE     NETO2-GluK2 interaction contributes to postoperative pain
            hypersensitivity through inducing PKCgamma activation and synaptic
            incorporation of AMPA receptor GluR1 subunits in rat dorsal horn
  JOURNAL   Neurosci Lett 813, 137430 (2023)
   PUBMED   37544581
  REMARK    GeneRIF: NETO2-GluK2 interaction contributes to postoperative pain
            hypersensitivity through inducing PKCgamma activation and synaptic
            incorporation of AMPA receptor GluR1 subunits in rat dorsal horn.
REFERENCE   2  (bases 1 to 3152)
  AUTHORS   Joshua Cohen,D., ElBaradie,K., Boyan,B.D. and Schwartz,Z.
  TITLE     Sex-specific effects of 17beta-estradiol and dihydrotestosterone
            (DHT) on growth plate chondrocytes are dependent on both ERalpha
            and ERbeta and require palmitoylation to translocate the receptors
            to the plasma membrane
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1866 (12), 159028 (2021)
   PUBMED   34416391
  REMARK    GeneRIF: Sex-specific effects of 17beta-estradiol and
            dihydrotestosterone (DHT) on growth plate chondrocytes are
            dependent on both ERalpha and ERbeta and require palmitoylation to
            translocate the receptors to the plasma membrane.
REFERENCE   3  (bases 1 to 3152)
  AUTHORS   Islam,J., Kc,E., Oh,B.H., Moon,H.C. and Park,Y.S.
  TITLE     Pain modulation effect on motor cortex after optogenetic
            stimulation in shPKCgamma knockdown dorsal root ganglion-compressed
            Sprague-Dawley rat model
  JOURNAL   Mol Pain 16, 1744806920943685 (2020)
   PUBMED   32865105
  REMARK    GeneRIF: Pain modulation effect on motor cortex after optogenetic
            stimulation in shPKCgamma knockdown dorsal root ganglion-compressed
            Sprague-Dawley rat model.
REFERENCE   4  (bases 1 to 3152)
  AUTHORS   Su,Q., Zhang,H., Dang,S., Yao,D., Shao,S., Zhu,Z. and Li,H.
  TITLE     Hippocampal Protein Kinase C Gamma Signaling Mediates the
            Impairment of Spatial Learning and Memory in Prenatally Stressed
            Offspring Rats
  JOURNAL   Neuroscience 414, 186-199 (2019)
   PUBMED   31283971
  REMARK    GeneRIF: Prenatal stress possibly decreases hippocampal PKCgamma
            activity, resulting in a reduction of p-GAP-43 and p-Ng, which
            underlies insufficient CaMKII activation, thereby impairing spatial
            learning and memory.
REFERENCE   5  (bases 1 to 3152)
  AUTHORS   Alba-Delgado,C., Mountadem,S., Mermet-Joret,N., Monconduit,L.,
            Dallel,R., Artola,A. and Antri,M.
  TITLE     5-HT2A Receptor-Induced Morphological Reorganization of
            PKCgamma-Expressing Interneurons Gates Inflammatory Mechanical
            Allodynia in Rat
  JOURNAL   J Neurosci 38 (49), 10489-10504 (2018)
   PUBMED   30355630
  REMARK    GeneRIF: A 5-HT2A receptor to protein kinase C gamma pathway leads
            to the behavioral allodynia and morphological changes in protein
            kinase C gamma interneurons.
REFERENCE   6  (bases 1 to 3152)
  AUTHORS   Chen,C., Kano,M., Abeliovich,A., Chen,L., Bao,S., Kim,J.J.,
            Hashimoto,K., Thompson,R.F. and Tonegawa,S.
  TITLE     Impaired motor coordination correlates with persistent multiple
            climbing fiber innervation in PKC gamma mutant mice
  JOURNAL   Cell 83 (7), 1233-1242 (1995)
   PUBMED   8548809
REFERENCE   7  (bases 1 to 3152)
  AUTHORS   Chen,K.H., Widen,S.G., Wilson,S.H. and Huang,K.P.
  TITLE     Characterization of the 5'-flanking region of the rat protein
            kinase C gamma gene
  JOURNAL   J Biol Chem 265 (32), 19961-19965 (1990)
   PUBMED   2246272
REFERENCE   8  (bases 1 to 3152)
  AUTHORS   Kose,A., Ito,A., Saito,N. and Tanaka,C.
  TITLE     Electron microscopic localization of gamma- and beta II-subspecies
            of protein kinase C in rat hippocampus
  JOURNAL   Brain Res 518 (1-2), 209-217 (1990)
   PUBMED   2202488
REFERENCE   9  (bases 1 to 3152)
  AUTHORS   Ono,Y., Fujii,T., Igarashi,K., Kikkawa,U., Ogita,K. and
            Nishizuka,Y.
  TITLE     Nucleotide sequences of cDNAs for alpha and gamma subspecies of rat
            brain protein kinase C
  JOURNAL   Nucleic Acids Res 16 (11), 5199-5200 (1988)
   PUBMED   3387228
REFERENCE   10 (bases 1 to 3152)
  AUTHORS   Knopf,J.L., Lee,M.H., Sultzman,L.A., Kriz,R.W., Loomis,C.R.,
            Hewick,R.M. and Bell,R.M.
  TITLE     Cloning and expression of multiple protein kinase C cDNAs
  JOURNAL   Cell 46 (4), 491-502 (1986)
   PUBMED   3755379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 8, 2021 this sequence version replaced NM_012628.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089226.1, M13707.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-422               JAXUCZ010000001.1  74774393-74774814   c
            423-454             JAXUCZ010000001.1  74774008-74774039   c
            455-537             JAXUCZ010000001.1  74772885-74772967   c
            538-649             JAXUCZ010000001.1  74767692-74767803   c
            650-781             JAXUCZ010000001.1  74767401-74767532   c
            782-938             JAXUCZ010000001.1  74766150-74766306   c
            939-1073            JAXUCZ010000001.1  74764859-74764993   c
            1074-1161           JAXUCZ010000001.1  74764472-74764559   c
            1162-1191           JAXUCZ010000001.1  74764149-74764178   c
            1192-1344           JAXUCZ010000001.1  74759965-74760117   c
            1345-1533           JAXUCZ010000001.1  74759013-74759201   c
            1534-1625           JAXUCZ010000001.1  74755734-74755825   c
            1626-1688           JAXUCZ010000001.1  74755587-74755649   c
            1689-1827           JAXUCZ010000001.1  74754230-74754368   c
            1828-1908           JAXUCZ010000001.1  74750860-74750940   c
            1909-2016           JAXUCZ010000001.1  74750268-74750375   c
            2017-2157           JAXUCZ010000001.1  74749446-74749586   c
            2158-3152           JAXUCZ010000001.1  74748272-74749266   c
FEATURES             Location/Qualifiers
     source          1..3152
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..3152
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /note="protein kinase C, gamma"
                     /db_xref="GeneID:24681"
                     /db_xref="RGD:3397"
     exon            1..422
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..2346
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /EC_number="2.7.11.13"
                     /note="protein kinase C type I (gamma type); PKC-gamma"
                     /codon_start=1
                     /product="protein kinase C gamma type"
                     /protein_id="NP_036760.1"
                     /db_xref="GeneID:24681"
                     /db_xref="RGD:3397"
                     /translation="MAGLGPGGGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFK
                     QPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHK
                     FRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGR
                     LQLEIRAPTSDEIHITVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTKTVKAT
                     LNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYK
                     LLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDS
                     KRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDD
                     VDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLG
                     KFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFP
                     GSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQA
                     IMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLER
                     LEIAPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVH
                     PDARSPTSPVPVPVM"
     exon            423..454
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            455..537
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            538..649
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            650..781
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            782..938
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1073
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1161
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1191
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1344
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1533
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1625
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1688
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1827
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1908
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2016
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2157
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..3152
                     /gene="Prkcg"
                     /gene_synonym="PKC; PKCI; Prkc; Prkcc; RATPKCI"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggagctcc cgccgccgcc cgtgcctgcg gctcctagat gccccagtct tctactgctc
       61 tgaccccacc cgctttctcc cggctcggta cagctggtgc cggggggtgc tgctttctgc
      121 cctgcgctgc gcaccgttag gtgccctgcc cctgtccttc cgatctcaga gtctgcggag
      181 tgcccctatc gccgtccacc tgtttcctca gaaaaaaggc cagctcgtga tccctgctgc
      241 gttcctgggg ccatggcggg tctgggtcct ggcgggggcg actcagaagg gggaccccga
      301 cccctgtttt gcagaaaggg ggcgctgagg cagaaggtgg tccacgaggt gaagagccac
      361 aagttcaccg ctcgtttctt caagcagcca accttctgca gtcactgtac cgacttcatc
      421 tggggcattg gaaagcaggg cctgcaatgt caagtctgca gctttgtggt tcaccgccga
      481 tgccacgaat ttgtgacctt cgagtgtcca ggcgctggaa agggccccca gacggacgac
      541 cctcgcaaca agcacaagtt ccgtctgcac agctacagca gtcccacctt ctgcgaccac
      601 tgtggttccc tcctctacgg gctggtgcac cagggcatga aatgttcctg ttgcgaaatg
      661 aatgtgcacc gacgctgtgt gcgcagcgtg ccctcccttt gcggcgtgga ccatacagag
      721 cgccgtggac gtctgcaact ggaaatccgg gctcccacat cagatgagat ccatattact
      781 gtgggtgagg cccggaacct cattcctatg gaccccaatg gcctgtctga tccctatgtg
      841 aaactgaagc tcatcccgga ccctcggaac ctgacaaaac agaagacaaa gaccgtgaaa
      901 gccacactga atcccgtgtg gaacgagacc ttcgtgttca acctgaagcc gggggatgtg
      961 gagcgccggc tcagtgtgga ggtgtgggat tgggatagga catcccgaaa tgacttcatg
     1021 ggtgccatgt cctttggtgt ctcagagcta ctcaaggctc ctgtggatgg atggtacaag
     1081 ttactgaacc aggaggaggg cgagtattac aatgtaccgg tggccgatgc tgacaactgc
     1141 agcctcctcc agaagtttga ggcctgtaat taccccttgg aattgtatga gagagtgcgg
     1201 atgggcccct cttcctctcc cattccttct ccatccccca gtcccacgga ctccaagaga
     1261 tgcttcttcg gtgccagccc aggacgcctg catatctctg acttcagctt cctcatggtt
     1321 ctagggaaag gcagttttgg gaaggtgatg ctggcagagc gcagaggatc cgatgaactc
     1381 tatgccatca agatactgaa aaaagacgtc attgtccagg atgatgatgt agactgcacc
     1441 cttgtggaga agcgtgtgct ggcattggga ggccgaggtc ctggaggccg gccacacttt
     1501 ctcacacaac ttcattccac ctttcagact ccggaccgcc tgtattttgt gatggagtac
     1561 gtcactgggg gcgatttaat gtaccacatt cagcaactgg gcaagtttaa ggagccccac
     1621 gcagcattct atgccgcgga aatcgccata ggcctcttct tccttcacaa ccagggcatc
     1681 atctacaggg acctcaagtt ggataatgtg atgctggatg ctgaaggaca catcaagatc
     1741 acagacttcg gcatgtgtaa agagaatgtc ttccctgggt ccacaacccg caccttctgt
     1801 gggaccccag actacatagc acctgagatc attgcctatc agccctatgg gaagtctgtc
     1861 gactggtggt cctttggagt cctgctgtat gagatgttgg caggacagcc accctttgat
     1921 ggggaagatg aggaggagct gtttcaagcc atcatggaac aaactgtcac ctatcccaag
     1981 tcactttccc gggaagctgt ggccatctgc aaggggttcc tgaccaagca cccaggaaag
     2041 cgcctgggct cagggccaga tggggaaccc accatccggg ctcatggctt tttccgttgg
     2101 atcgattggg agaggttgga gagactggaa attgcgcctc cttttagacc acgtccgtgt
     2161 ggccgcagcg gcgaaaactt tgacaagttc ttcacgcggg cagcgccagc cttgaccccg
     2221 ccagaccgct tggtcctagc cagcatcgac caagctgatt tccagggctt tacttatgtg
     2281 aacccggact tcgtgcaccc agatgcccgc agccccacaa gccctgtgcc tgtgcccgtc
     2341 atgtaatctc atctgctgcc gctaggtgtt cccagtgctc cctccgccaa gttggctgta
     2401 actcccatcc acccccatcc ccgcctctag tccgaatttt aggtctctta aaccacccaa
     2461 ccttctggcc tctttcacgc gccccaatgg gttctagacg ctgttcccca gcattgctgg
     2521 cattttaaac ttcaaacagt ctctagagcc tttctgtgtt ctagattcgt tgtgctgagc
     2581 cctggttttt ccccaccccc aacatctgga tgctgttcca actcttccca gaaaccccac
     2641 tccgtgtggg gttctagact ctatcttggt agttttatgc cttctctctc cctagaccac
     2701 gttgggagaa atagtctcat gagattgcct gctccagact aagattccag atcagctctc
     2761 tgcatccttc aaggcccctc ctacctccac ttcagttgta gaattaagtg ggaggctggg
     2821 ctccgtgttc caggccacct cccttccatg ttctggggat tcctggcatg cacggaggat
     2881 tctctccccg acttttctca gtcagctttt gttctagatt tgttccagaa cccttcactg
     2941 ctcacctgcc ccgtgcatgg ctccagcctt ggtcggaatc acacacacac acacacacac
     3001 acacacacac acacacacac acacacacac accccttgtc ctccgcagtg cctgccactt
     3061 tctgggactt tctcatcccc cacgcccttc ctttatcctc tcccacccag acacagctgc
     3121 tggagaataa atttgggatg ctgatgctaa aa
//
