LOCUS       NM_017171               2696 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus protein kinase C, epsilon (Prkce), mRNA.
ACCESSION   NM_017171 XM_343012
VERSION     NM_017171.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2696)
  AUTHORS   Kan,Y.Y., Chang,Y.S., Liao,W.C., Chao,T.N. and Hsieh,Y.L.
  TITLE     Roles of Neuronal Protein Kinase Cepsilon on Endoplasmic Reticulum
            Stress and Autophagic Formation in Diabetic Neuropathy
  JOURNAL   Mol Neurobiol 61 (5), 2481-2495 (2024)
   PUBMED   37906389
  REMARK    GeneRIF: Roles of Neuronal Protein Kinase Cepsilon on Endoplasmic
            Reticulum Stress and Autophagic Formation in Diabetic Neuropathy.
REFERENCE   2  (bases 1 to 2696)
  AUTHORS   Serrano-Lopez,E.M., Lopez-Martinez,D., Gomez-Fernandez,J.C.,
            Egea-Jimenez,A.L. and Corbalan-Garcia,S.
  TITLE     PKCepsilon controls the fusion of secretory vesicles in mast cells
            in a phosphatidic acid-dependent mode
  JOURNAL   Int J Biol Macromol 185, 377-389 (2021)
   PUBMED   34147527
  REMARK    GeneRIF: PKCepsilon controls the fusion of secretory vesicles in
            mast cells in a phosphatidic acid-dependent mode.
REFERENCE   3  (bases 1 to 2696)
  AUTHORS   Zemel,B.M., Zhi,L., Brown,E.V., Tymanskyj,S.R., Liang,Q. and
            Covarrubias,M.
  TITLE     PKCepsilon associates with the Kv3.4 channel to promote its
            expression in a kinase activity-dependent manner
  JOURNAL   FASEB J 35 (1), e21241 (2021)
   PUBMED   33368632
  REMARK    GeneRIF: PKCepsilon associates with the Kv3.4 channel to promote
            its expression in a kinase activity-dependent manner.
REFERENCE   4  (bases 1 to 2696)
  AUTHORS   Heckman,C.A., Biswas,T., Dimick,D.M. and Cayer,M.L.
  TITLE     Activated Protein Kinase C (PKC) Is Persistently Trafficked with
            Epidermal Growth Factor (EGF) Receptor
  JOURNAL   Biomolecules 10 (9), 1288 (2020)
   PUBMED   32906765
  REMARK    GeneRIF: Activated Protein Kinase C (PKC) Is Persistently
            Trafficked with Epidermal Growth Factor (EGF) Receptor.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2696)
  AUTHORS   Xu,J., Khoury,N., Jackson,C.W., Escobar,I., Stegelmann,S.D.,
            Dave,K.R. and Perez-Pinzon,M.A.
  TITLE     Ischemic Neuroprotectant PKCepsilon Restores Mitochondrial
            Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle
            after Ischemic Injury
  JOURNAL   Transl Stroke Res 11 (3), 418-432 (2020)
   PUBMED   31473978
  REMARK    GeneRIF: Ischemic Neuroprotectant PKCepsilon Restores Mitochondrial
            Glutamate Oxaloacetate Transaminase in the Neuronal NADH Shuttle
            after Ischemic Injury.
REFERENCE   6  (bases 1 to 2696)
  AUTHORS   Kuroda,S., Tokunaga,C., Kiyohara,Y., Higuchi,O., Konishi,H.,
            Mizuno,K., Gill,G.N. and Kikkawa,U.
  TITLE     Protein-protein interaction of zinc finger LIM domains with protein
            kinase C
  JOURNAL   J Biol Chem 271 (49), 31029-31032 (1996)
   PUBMED   8940095
REFERENCE   7  (bases 1 to 2696)
  AUTHORS   Saito,N., Itouji,A., Totani,Y., Osawa,I., Koide,H., Fujisawa,N.,
            Ogita,K. and Tanaka,C.
  TITLE     Cellular and intracellular localization of epsilon-subspecies of
            protein kinase C in the rat brain; presynaptic localization of the
            epsilon-subspecies
  JOURNAL   Brain Res 607 (1-2), 241-248 (1993)
   PUBMED   8481800
REFERENCE   8  (bases 1 to 2696)
  AUTHORS   Ono,Y., Fujii,T., Ogita,K., Kikkawa,U., Igarashi,K. and
            Nishizuka,Y.
  TITLE     The structure, expression, and properties of additional members of
            the protein kinase C family
  JOURNAL   J Biol Chem 263 (14), 6927-6932 (1988)
   PUBMED   2834397
REFERENCE   9  (bases 1 to 2696)
  AUTHORS   Ono,Y., Fujii,T., Ogita,K., Kikkawa,U., Igarashi,K. and
            Nishizuka,Y.
  TITLE     Identification of three additional members of rat protein kinase C
            family: delta-, epsilon- and zeta-subspecies
  JOURNAL   FEBS Lett 226 (1), 125-128 (1987)
   PUBMED   3691811
REFERENCE   10 (bases 1 to 2696)
  AUTHORS   Housey,G.M., O'Brian,C.A., Johnson,M.D., Kirschmeier,P. and
            Weinstein,I.B.
  TITLE     Isolation of cDNA clones encoding protein kinase C: evidence for a
            protein kinase C-related gene family
  JOURNAL   Proc Natl Acad Sci U S A 84 (4), 1065-1069 (1987)
   PUBMED   3469647
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_017171.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY642593.1, SRR26643297.21471.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               JAXUCZ010000006.1  14203747-14204288   c
            543-606             JAXUCZ010000006.1  14016363-14016426   c
            607-766             JAXUCZ010000006.1  13901370-13901529   c
            767-801             JAXUCZ010000006.1  13899660-13899694   c
            802-887             JAXUCZ010000006.1  13898364-13898449   c
            888-1017            JAXUCZ010000006.1  13893021-13893150   c
            1018-1160           JAXUCZ010000006.1  13881486-13881628   c
            1161-1257           JAXUCZ010000006.1  13878948-13879044   c
            1258-1457           JAXUCZ010000006.1  13876306-13876505   c
            1458-1631           JAXUCZ010000006.1  13873570-13873743   c
            1632-1786           JAXUCZ010000006.1  13811218-13811372   c
            1787-1925           JAXUCZ010000006.1  13752932-13753070   c
            1926-2114           JAXUCZ010000006.1  13747519-13747707   c
            2115-2261           JAXUCZ010000006.1  13743372-13743518   c
            2262-2696           JAXUCZ010000006.1  13718050-13718484   c
FEATURES             Location/Qualifiers
     source          1..2696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q12"
     gene            1..2696
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /note="protein kinase C, epsilon"
                     /db_xref="GeneID:29340"
                     /db_xref="RGD:61925"
     exon            1..542
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2408
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /EC_number="2.7.11.13"
                     /note="nPKC-epsilon"
                     /codon_start=1
                     /product="protein kinase C epsilon type"
                     /protein_id="NP_058867.2"
                     /db_xref="GeneID:29340"
                     /db_xref="RGD:61925"
                     /translation="MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIAL
                     NVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF
                     EELLQNGSRHFEDWIDLEPEGKVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAV
                     RRRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIIT
                     KCAGLKKQETPDEVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVC
                     KMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLAAGAESPQPAS
                     GNSPSEDDRSKSAPTSPCDQELKELENNIRKALSFDNRGEEHRASSSTDGQLASPGEN
                     GEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDV
                     DCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPR
                     SRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT
                     FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDV
                     LYPVWLSKEAVSILKAFMTKNPHKRLGCVAAQNGEDAIKQHPFFKEIDWVLLEQKKIK
                     PPFKPRIKTKRDVNNFDQDFTREEPILTLVDEAIVKQINQEEFKGFSYFGEDLMP"
     exon            543..606
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            607..766
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            767..801
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            802..887
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1017
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1160
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1257
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1457
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1631
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1786
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1925
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2114
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2261
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2696
                     /gene="Prkce"
                     /gene_synonym="Pkce"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgttagg aatccggcga ggaaatacat gcactcgctg agaatcgccg gcgccaggac
       61 gcagcgccac aaggtgtagc gagtgagtgg ggtggggcaa gaggggaccc aggagtcccc
      121 ccaggctccc agcgcgcctg ctcctgctct tcaatcctgc cctcggggcg gacggagtga
      181 cccccgcccc gaccatggta gtgttcaatg gccttcttaa gatcaaaatc tgcgaggccg
      241 tgagcttgaa gcccacagcc tggtcgctgc gccatgcggt gggaccccgg ccccagacgt
      301 tccttctgga cccctacatt gcccttaacg tggacgactc gcgcatcggc caaacagcca
      361 ccaagcagaa gaccaacagt ccggcctggc acgatgagtt cgtcactgat gtgtgcaatg
      421 ggcgcaagat cgagctggct gtctttcacg atgctcctat cggctacgac gacttcgtgg
      481 ccaactgcac catccagttc gaggagctgc tgcagaatgg gagccgtcac ttcgaggact
      541 ggattgatct ggagccagaa ggaaaagtct acgtgatcat cgatctctcg ggatcatcgg
      601 gcgaagcccc taaagacaat gaagaacgag tgtttaggga gcggatgcgg ccaaggaagc
      661 gccaaggggc tgtcaggcgc agggtccacc aggtcaatgg ccacaagttc atggccacct
      721 acttgcggca gcccacctac tgctcccact gtagggattt catctggggt gtcataggaa
      781 aacagggata tcaatgtcaa gtttgtacct gcgtcgtcca caaacgatgc catgagctca
      841 ttattacgaa gtgcgctggg ctaaagaaac aggaaacccc tgacgaggtg ggctcccaac
      901 gcttcagcgt caacatgccc cacaagttcg ggatccacaa ctacaaggtc cccacgttct
      961 gtgaccactg tggctccctg ctctggggcc tcttgcggca gggcctgcag tgtaaagtct
     1021 gcaaaatgaa tgttcaccgt cgatgcgaga ccaacgtggc tcccaattgt ggggtggacg
     1081 ccagaggaat tgccaaggtg ctggccgatc ttggcgttac tccagacaaa atcaccaaca
     1141 gtggccagag aaggaaaaag ctcgctgctg gtgctgagtc cccacagccg gcttctggaa
     1201 actccccatc agaagacgac cgatccaagt cagcgcccac ctccccttgt gaccaggaac
     1261 taaaagaact tgaaaacaac atccggaagg ccttgtcatt tgacaaccga ggagaggagc
     1321 accgagcctc gtcgtctact gatggccagc tggcaagccc tggcgagaac ggtgaagtcc
     1381 ggcaaggcca ggccaagcgc ttgggcctgg atgagttcaa cttcatcaag gtgttaggca
     1441 aaggcagctt tggcaaggtc atgctggccg agctcaaggg taaggatgaa gtctatgctg
     1501 tgaaggtctt aaagaaggac gtcatcctgc aggatgacga cgtggactgc acgatgacag
     1561 agaagaggat tttggctctg gcgcggaaac acccttatct aacccaactc tattgctgct
     1621 tccagaccaa ggaccgcctc ttcttcgtca tggaatatgt aaacggtgga gacctcatgt
     1681 tccagattca gcggtcccga aaattcgatg agcctcgttc ccggttctat gctgccgagg
     1741 tcacatctgc tctcatgttt ctccaccaac atggagtgat ctacagggat ttgaaactgg
     1801 acaacatcct tctagatgca gaaggtcact gcaagctggc tgactttggg atgtgcaagg
     1861 aagggattct gaatggcgtg acaactacca ccttctgtgg gactcctgac tacatagctc
     1921 cagagatcct gcaggagttg gagtacggcc cctcagtgga ctggtgggcc ctgggcgtgc
     1981 tgatgtacga gatgatggcc gggcagcccc cctttgaagc tgacaacgag gacgacttgt
     2041 ttgaatccat ccttcacgat gacgttctct accctgtctg gcttagcaag gaggctgtca
     2101 gcatcctgaa agctttcatg accaagaacc cgcacaagcg cctgggctgc gtggcagcac
     2161 agaacgggga agatgccatc aagcaacatc cattcttcaa ggagattgac tgggtactgc
     2221 tggagcagaa gaaaatcaag ccccccttca agccgagaat taaaaccaag agagatgtca
     2281 ataactttga ccaagacttt acccgggaag agccaatact tacacttgtg gatgaagcaa
     2341 tcgtgaagca gatcaaccag gaagaattca aaggcttctc ctactttggt gaagacctga
     2401 tgccctgaga aactgcttca catggagtta gctcactgca aggagggtgt tgagacaatc
     2461 ccgtgttgca gaggctcaga atgtctcgaa ctattcgtcc tccccagagc cccagtccca
     2521 catctgctct cttatttatt gcatcccctc atcccaggcc ctgtccttcc ccaccctccc
     2581 agtgaccaga aggccctctt tggtccagac tcaccaagat cacagatttg aactgcgtct
     2641 gctctgtgtg cagtgctagg tctggagtag ccgtccaccc acaaccctga agcagc
//
