LOCUS       NM_133307               2942 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus protein kinase C, delta (Prkcd), mRNA.
ACCESSION   NM_133307
VERSION     NM_133307.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2942)
  AUTHORS   Ohm,A.M., Affandi,T., Reisz,J.A., Caino,M.C., D'Alessandro,A. and
            Reyland,M.E.
  TITLE     Metabolic reprogramming contributes to radioprotection by protein
            kinase Cdelta
  JOURNAL   J Biol Chem 299 (10), 105186 (2023)
   PUBMED   37611829
  REMARK    GeneRIF: Metabolic reprogramming contributes to radioprotection by
            protein kinase Cdelta.
REFERENCE   2  (bases 1 to 2942)
  AUTHORS   Zhu,J., Zhang,G., Song,Z., Xiang,X., Shu,S., Liu,Z., Yang,D.,
            Wei,Q. and Dong,Z.
  TITLE     Protein Kinase C-delta Mediates Kidney Tubular Injury in Cold
            Storage-Associated Kidney Transplantation
  JOURNAL   J Am Soc Nephrol 31 (5), 1050-1065 (2020)
   PUBMED   32291286
  REMARK    GeneRIF: Protein Kinase C-delta Mediates Kidney Tubular Injury in
            Cold Storage-Associated Kidney Transplantation.
REFERENCE   3  (bases 1 to 2942)
  AUTHORS   Liverani,E., Tursi,S.A., Cornwell,W.D., Mondrinos,M.J., Sun,S.,
            Buttaro,B.A., Wolfson,M.R., Rogers,T.J., Tukel,C. and
            Kilpatrick,L.E.
  TITLE     Protein kinase C-delta inhibition is organ-protective, enhances
            pathogen clearance, and improves survival in sepsis
  JOURNAL   FASEB J 34 (2), 2497-2510 (2020)
   PUBMED   31908004
  REMARK    GeneRIF: Protein kinase C-delta inhibition is organ-protective,
            enhances pathogen clearance, and improves survival in sepsis.
REFERENCE   4  (bases 1 to 2942)
  AUTHORS   Liu,C., Li,H., Zheng,H., Zhai,M., Lu,F., Dong,S., Fang,T. and
            Zhang,W.
  TITLE     CaSR activates PKCdelta to induce cardiomyocyte apoptosis via ER
            stress-associated apoptotic pathways during ischemia/reperfusion
  JOURNAL   Int J Mol Med 44 (3), 1117-1126 (2019)
   PUBMED   31257458
  REMARK    GeneRIF: These results confirmed that CaSR activated PKCdelta to
            induce cardiomyocyte apoptosis through ER stressassociated
            apoptotic pathways during I/R in vivo.
REFERENCE   5  (bases 1 to 2942)
  AUTHORS   Hou,M., Gu,H.C., Wang,H.H., Liu,X.M., Zhou,C.L., Yang,Q.,
            Jiang,Z.R., Lin,J., Wu,Y.M., Wu,Y.T., Sheng,J.Z. and Huang,H.F.
  TITLE     Prenatal exposure to testosterone induces cardiac hypertrophy in
            adult female rats through enhanced Pkcdelta expression in cardiac
            myocytes
  JOURNAL   J Mol Cell Cardiol 128, 1-10 (2019)
   PUBMED   30641088
  REMARK    GeneRIF: Chromatin immunoprecipitation revealed that AR could bind
            to Pkcd promoter. Our results indicate that prenatal exposure to
            testosterone may induce cardiac hypertrophy in adult female rats
            through enhanced Pkcd expression in cardiac myocytes.
REFERENCE   6  (bases 1 to 2942)
  AUTHORS   Konishi,H., Matsuzaki,H., Tanaka,M., Ono,Y., Tokunaga,C., Kuroda,S.
            and Kikkawa,U.
  TITLE     Activation of RAC-protein kinase by heat shock and hyperosmolarity
            stress through a pathway independent of phosphatidylinositol
            3-kinase
  JOURNAL   Proc Natl Acad Sci U S A 93 (15), 7639-7643 (1996)
   PUBMED   8755528
REFERENCE   7  (bases 1 to 2942)
  AUTHORS   Merchenthaler,I., Liposits,Z., Reid,J.J. and Wetsel,W.C.
  TITLE     Light and electron microscopic immunocytochemical localization of
            PKC delta immunoreactivity in the rat central nervous system
  JOURNAL   J Comp Neurol 336 (3), 378-399 (1993)
   PUBMED   8263228
REFERENCE   8  (bases 1 to 2942)
  AUTHORS   Olivier,A.R. and Parker,P.J.
  TITLE     Expression and characterization of protein kinase C-delta
  JOURNAL   Eur J Biochem 200 (3), 805-810 (1991)
   PUBMED   1915352
REFERENCE   9  (bases 1 to 2942)
  AUTHORS   Ono,Y., Fujii,T., Ogita,K., Kikkawa,U., Igarashi,K. and
            Nishizuka,Y.
  TITLE     The structure, expression, and properties of additional members of
            the protein kinase C family
  JOURNAL   J Biol Chem 263 (14), 6927-6932 (1988)
   PUBMED   2834397
REFERENCE   10 (bases 1 to 2942)
  AUTHORS   Ono,Y., Fujii,T., Ogita,K., Kikkawa,U., Igarashi,K. and
            Nishizuka,Y.
  TITLE     Identification of three additional members of rat protein kinase C
            family: delta-, epsilon- and zeta-subspecies
  JOURNAL   FEBS Lett 226 (1), 125-128 (1987)
   PUBMED   3691811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Apr 22, 2021 this sequence version replaced NM_133307.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643287.32141.1,
                                           SRR26643291.37645.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-229               JAXUCZ010000016.1  5805611-5805839     c
            230-375             JAXUCZ010000016.1  5796553-5796698     c
            376-498             JAXUCZ010000016.1  5789491-5789613     c
            499-698             JAXUCZ010000016.1  5788419-5788618     c
            699-759             JAXUCZ010000016.1  5787071-5787131     c
            760-922             JAXUCZ010000016.1  5786747-5786909     c
            923-954             JAXUCZ010000016.1  5786619-5786650     c
            955-1040            JAXUCZ010000016.1  5785477-5785562     c
            1041-1170           JAXUCZ010000016.1  5785109-5785238     c
            1171-1271           JAXUCZ010000016.1  5784310-5784410     c
            1272-1362           JAXUCZ010000016.1  5783033-5783123     c
            1363-1463           JAXUCZ010000016.1  5782637-5782737     c
            1464-1637           JAXUCZ010000016.1  5782358-5782531     c
            1638-1729           JAXUCZ010000016.1  5782059-5782150     c
            1730-1792           JAXUCZ010000016.1  5781595-5781657     c
            1793-1931           JAXUCZ010000016.1  5780168-5780306     c
            1932-2120           JAXUCZ010000016.1  5779878-5780066     c
            2121-2249           JAXUCZ010000016.1  5779285-5779413     c
            2250-2942           JAXUCZ010000016.1  5775681-5776373     c
FEATURES             Location/Qualifiers
     source          1..2942
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p16"
     gene            1..2942
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /note="protein kinase C, delta"
                     /db_xref="GeneID:170538"
                     /db_xref="RGD:67383"
     exon            1..229
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            230..375
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            376..498
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..2405
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /EC_number="2.7.11.13"
                     /note="nPKC-delta"
                     /codon_start=1
                     /product="protein kinase C delta type"
                     /protein_id="NP_579841.2"
                     /db_xref="GeneID:170538"
                     /db_xref="RGD:67383"
                     /translation="MAPFLRISFNSYELGSLQAEDDASQPFCAVKMKEALTTDRGKTL
                     VQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEDPMSEVTVGVSVLAERCKKNNGKA
                     EFWLDLQPQAKVLMCVQYFLEDGDCKQSMRSEEEAMFPTMNRRGAIKQAKIHYIKNHE
                     FIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDT
                     IFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKV
                     ANLCGINQKLLAEALNQVTQKASRKPETPETVGIYQGFEKKTAVSGNDIPDNNGTYGK
                     IWEGSNRCRLENFTFQKVLGKGSFGKVLLAELKGKERYFAIKYLKKDVVLIDDDVECT
                     MVEKRVLALAWENPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATF
                     YAAEIICGLQFLHGKGIIYRDLKLDNVMLDKDGHIKIADFGMCKENIFGENRASTFCG
                     TPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYP
                     RWITKESKDIMEKLFERDPAKRLGVTGNIRLHPFFKTINWNLLEKRKVEPPFKPKVKS
                     PSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQTAFKGFSFVNPKYEQFLE"
     exon            499..698
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            699..759
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            760..922
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            923..954
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1040
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1170
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1271
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1362
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1463
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1637
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1729
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1792
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1931
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2120
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2249
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2942
                     /gene="Prkcd"
                     /gene_synonym="Pkcd"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttccgtgt gccgcggcgc cagaacagga ggcggcggcc gcggggatcc cgcgagcggc
       61 ccctgaacat ctacccttct tgccgggacc cgggaggtcc ccactggcct ccgggcccgt
      121 cctgatcaga ctcgtgtcga cctccccgtc cacgcgcatc cgggagagcc gcgccacgag
      181 acggacccgg gcccgccggg acccctggtg tctggccctg cgtcgagagg ctggtgactg
      241 ccacccataa gctccagctt cagcctcggc ttactcccct caggggcttg caggctaagg
      301 cctgccctcg gacgcggctg accagcctct ccctctcttc cacactttgg acttctcttt
      361 ggacctccta aaaaggctcc atcatggcac cgttcctgcg catctccttc aattcctatg
      421 agctgggctc cctgcaggcg gaggacgacg caagccagcc tttctgtgcc gtgaagatga
      481 aggaggcact caccacagac cgagggaaga ctctggtaca gaagaagccc accatgtacc
      541 ctgagtggaa gtcaacattc gacgcccaca tctatgaagg ccgtgtcatc cagatcgtgc
      601 tgatgcgggc agctgaagac cccatgtcgg aggtgaccgt gggcgtgtca gtgctggctg
      661 agcgctgcaa gaagaacaac ggcaaggctg agttctggct ggacctgcag cctcaggcca
      721 aggtgctgat gtgtgtgcag tatttcctgg aggatgggga ttgcaaacag tccatgcgta
      781 gtgaggagga ggccatgttc ccaactatga accgccgtgg agccattaaa caggccaaga
      841 ttcactacat caagaaccac gagttcatcg ccaccttctt tgggcagccc accttctgtt
      901 ctgtgtgcaa agagtttgtc tggggcctca acaagcaagg ctacaaatgc aggcaatgca
      961 acgctgccat ccataagaaa tgcatcgaca agattatcgg ccgctgcact ggcactgcta
     1021 ccaatagccg ggacaccatc ttccagaaag aacgcttcaa catcgacatg cctcaccgat
     1081 tcaaggtcta taactacatg agccccacct tctgtgacca ctgtggcagt ttgctctggg
     1141 gattggtgaa acagggatta aagtgtgaag actgcggcat gaatgtgcac cacaaatgcc
     1201 gggagaaggt ggccaacctg tgtggtatca accaaaagct cttggctgag gccttgaacc
     1261 aagtgaccca gaaagcttcc cggaagccag agacaccaga gactgtcgga atataccagg
     1321 gattcgagaa gaagacagct gtctctggga atgacatccc agacaacaac gggacctatg
     1381 gcaagatctg ggaggggagc aaccggtgcc gccttgagaa cttcaccttc cagaaagtac
     1441 ttggcaaagg cagctttggc aaggtactgc ttgcagaact gaagggcaag gaaaggtact
     1501 ttgcaatcaa gtacctgaag aaggacgtgg tgttgatcga cgatgacgtg gagtgcacca
     1561 tggtggagaa gcgggtgctg gcgctcgcct gggagaatcc cttcctcacc catctcatct
     1621 gtaccttcca gaccaaggac cacctcttct ttgtgatgga gttcctcaat gggggtgatc
     1681 tgatgttcca cattcaggac aaaggccgct tcgaactcta ccgggctacg ttttatgcag
     1741 ctgagatcat ctgcggactg cagtttctac atggcaaagg catcatttac agggacctca
     1801 agctagacaa tgtaatgctg gacaaggatg gccacatcaa gattgctgac ttcgggatgt
     1861 gcaaagagaa tatatttggg gagaaccggg ccagcacatt ctgcggcact cctgactaca
     1921 tcgcccctga gatcctgcag ggcctgaagt actcattttc cgtggactgg tggtcttttg
     1981 gggtcctcct ctatgagatg ctcattggcc agtccccctt ccatggtgat gatgaggacg
     2041 agctctttga gtccatccgg gtggacacac cacactaccc gcgctggatc accaaggagt
     2101 ccaaggacat catggagaag ctcttcgaga gggaccctgc caagaggctg ggagtaacag
     2161 gaaacatcag gcttcacccc tttttcaaga ctatcaactg gaacctgctg gagaagcgga
     2221 aggtggagcc gccctttaag cccaaagtga aatccccttc agactacagc aactttgacc
     2281 cagagttcct gaatgagaaa ccccaacttt ccttcagtga caagaacctc atcgactcta
     2341 tggaccagac agccttcaag ggcttctcct ttgtgaaccc caaatatgag caattcctgg
     2401 aatagtgagc tcccagacct gcttttaatg ccccggcaga gtaggcccat ctgccctggt
     2461 ttgcatccgc actgcccatg aagaagagtg ggtgactggt gattcctgct gctgccccct
     2521 cttcctcgga gagtctggct cctgttggct gggctcacag tacttcctct gtgaactgtt
     2581 tgtgaatttg ccttcctttt gccatcggag ggaaactgta aatcctgtgt gtcattactt
     2641 gaatgtagtt attgaaatat atattatata tatgcacata tatataatag gctgtatata
     2701 ttgctcagta tagaaagcat gtaggagact ggtgatgtgt tgaccttttt ttaaaaaaaa
     2761 ccatatgtat acgtgtgtat gtatacatct acacacgtat acatatatgt atgtatgtat
     2821 gtatgtatgt atgtatgtat gtatgtatgt atatatgacc aaaagaaaaa gagagcacaa
     2881 gctacctgaa ccacaggatt gtttatgtgt gtataaataa acactgaatg gtaccaacct
     2941 ga
//
