LOCUS       NM_012713               3010 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus protein kinase C, beta (Prkcb), transcript
            variant 1, mRNA.
ACCESSION   NM_012713 XM_001079542
VERSION     NM_012713.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3010)
  AUTHORS   Zheng,J., Wang,J., Qin,X., Li,K., Gao,Q., Yang,M., Liu,H., Li,S.,
            Chang,X. and Sun,Y.
  TITLE     LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary Fibrosis via
            Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun Pathway
  JOURNAL   Toxicol Sci 190 (1), 64-78 (2022)
   PUBMED   36066426
  REMARK    GeneRIF: LncRNA HOTAIRM1 Involved in Nano NiO-Induced Pulmonary
            Fibrosis via Regulating PRKCB DNA Methylation-Mediated JNK/c-Jun
            Pathway.
REFERENCE   2  (bases 1 to 3010)
  AUTHORS   Chen,T., Wang,Y., Wang,Y.H. and Hang,C.H.
  TITLE     The Mfn1-betaIIPKC Interaction Regulates Mitochondrial Dysfunction
            via Sirt3 Following Experimental Subarachnoid Hemorrhage
  JOURNAL   Transl Stroke Res 13 (5), 845-857 (2022)
   PUBMED   35192161
  REMARK    GeneRIF: The Mfn1-betaIIPKC Interaction Regulates Mitochondrial
            Dysfunction via Sirt3 Following Experimental Subarachnoid
            Hemorrhage.
            Erratum:[Transl Stroke Res. 2024 Aug;15(4):861-862. doi:
            10.1007/s12975-024-01253-w.. PMID: 38750251]
REFERENCE   3  (bases 1 to 3010)
  AUTHORS   Zhou,H., Yang,Z., Mu,L. and Shi,Y.
  TITLE     Integrated Analysis of Multiple Microarray Studies to Identify Core
            Gene-Expression Signatures Involved in Tubulointerstitial Injury in
            Diabetic Nephropathy
  JOURNAL   Biomed Res Int 2022, 9554658 (2022)
   PUBMED   35592524
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3010)
  AUTHORS   Chen,X., Qi,L., Su,H., He,Y., Li,N., Gao,Q., Li,H., Xu,T., Lu,L.,
            Xu,Z. and Tang,J.
  TITLE     Prenatal hypoxia attenuated contraction of offspring coronary
            artery associated with decreased PKCbeta Ser660 phosphorylation and
            intracellular calcium
  JOURNAL   Life Sci 261, 118364 (2020)
   PUBMED   32866516
  REMARK    GeneRIF: Prenatal hypoxia attenuated contraction of offspring
            coronary artery associated with decreased PKCbeta Ser(660)
            phosphorylation and intracellular calcium.
REFERENCE   5  (bases 1 to 3010)
  AUTHORS   Snow,J.B., Norton,C.E., Sands,M.A., Weise-Cross,L., Yan,S.,
            Herbert,L.M., Sheak,J.R., Gonzalez Bosc,L.V., Walker,B.R.,
            Kanagy,N.L., Jernigan,N.L. and Resta,T.C.
  TITLE     Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity
            through PKCbeta/Mitochondrial Oxidant Signaling
  JOURNAL   Am J Respir Cell Mol Biol 62 (6), 732-746 (2020)
   PUBMED   32048876
  REMARK    GeneRIF: Intermittent Hypoxia Augments Pulmonary Vasoconstrictor
            Reactivity through PKCbeta/Mitochondrial Oxidant Signaling.
REFERENCE   6  (bases 1 to 3010)
  AUTHORS   Gass,M.
  TITLE     [Continuing education--cross-professional offer not sufficient]
  JOURNAL   Sygeplejersken 92 (47), 20-21 (1992)
   PUBMED   1299012
REFERENCE   7  (bases 1 to 3010)
  AUTHORS   Housey,G.M., Johnson,M.D., Hsiao,W.L., O'Brian,C.A., Murphy,J.P.,
            Kirschmeier,P. and Weinstein,I.B.
  TITLE     Overproduction of protein kinase C causes disordered growth control
            in rat fibroblasts
  JOURNAL   Cell 52 (3), 343-354 (1988)
   PUBMED   3345563
REFERENCE   8  (bases 1 to 3010)
  AUTHORS   Ono,Y., Kikkawa,U., Ogita,K., Fujii,T., Kurokawa,T., Asaoka,Y.,
            Sekiguchi,K., Ase,K., Igarashi,K. and Nishizuka,Y.
  TITLE     Expression and properties of two types of protein kinase C:
            alternative splicing from a single gene
  JOURNAL   Science 236 (4805), 1116-1120 (1987)
   PUBMED   3576226
REFERENCE   9  (bases 1 to 3010)
  AUTHORS   Housey,G.M., O'Brian,C.A., Johnson,M.D., Kirschmeier,P. and
            Weinstein,I.B.
  TITLE     Isolation of cDNA clones encoding protein kinase C: evidence for a
            protein kinase C-related gene family
  JOURNAL   Proc Natl Acad Sci U S A 84 (4), 1065-1069 (1987)
   PUBMED   3469647
REFERENCE   10 (bases 1 to 3010)
  AUTHORS   Ono,Y., Kurokawa,T., Fujii,T., Kawahara,K., Igarashi,K.,
            Kikkawa,U., Ogita,K. and Nishizuka,Y.
  TITLE     Two types of complementary DNAs of rat brain protein kinase C.
            Heterogeneity determined by alternative splicing
  JOURNAL   FEBS Lett 206 (2), 347-352 (1986)
   PUBMED   2428667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 6, 2017 this sequence version replaced NM_012713.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               JAXUCZ010000001.1  186263906-186264208
            304-308             JAXUCZ010000001.1  186306095-186306099
            309-329             JAXUCZ010000001.1  186344675-186344695
            330-335             JAXUCZ010000001.1  186358453-186358458
            336-418             JAXUCZ010000001.1  186400515-186400597
            419-530             JAXUCZ010000001.1  186429345-186429456
            531-659             JAXUCZ010000001.1  186430189-186430317
            660-816             JAXUCZ010000001.1  186486550-186486706
            817-951             JAXUCZ010000001.1  186487814-186487948
            952-1048            JAXUCZ010000001.1  186498259-186498355
            1049-1195           JAXUCZ010000001.1  186506699-186506845
            1196-1369           JAXUCZ010000001.1  186528842-186529015
            1370-1461           JAXUCZ010000001.1  186544534-186544625
            1462-1524           JAXUCZ010000001.1  186546483-186546545
            1525-1663           JAXUCZ010000001.1  186550930-186551068
            1664-1744           JAXUCZ010000001.1  186554145-186554225
            1745-1852           JAXUCZ010000001.1  186554510-186554617
            1853-1993           JAXUCZ010000001.1  186560272-186560412
            1994-3010           JAXUCZ010000001.1  186587934-186588950
FEATURES             Location/Qualifiers
     source          1..3010
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q36"
     gene            1..3010
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /note="protein kinase C, beta"
                     /db_xref="GeneID:25023"
                     /db_xref="RGD:3396"
     exon            1..303
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..2152
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /EC_number="2.7.11.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase C beta I; protein kinase C beta II;
                     PKC-beta; protein kinase C, beta 1"
                     /codon_start=1
                     /product="protein kinase C beta type isoform 1"
                     /protein_id="NP_036845.3"
                     /db_xref="GeneID:25023"
                     /db_xref="RGD:3396"
                     /translation="MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFF
                     KQPTFCSHCTDFIWGLGLQGFQSQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKH
                     KFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRG
                     RIYIQAHIDREVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCS
                     LNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKAGVDGWFK
                     LLSQEEGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNR
                     DRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKR
                     VLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEI
                     AIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYI
                     APEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSK
                     EAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR
                     NAENFDRFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFLKPEVKS"
     exon            304..308
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..329
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..335
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..418
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..530
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..659
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..816
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..951
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1048
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1195
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1369
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1461
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1524
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1663
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1744
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1852
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1853..1993
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..3010
                     /gene="Prkcb"
                     /gene_synonym="Pkcb; Prkcb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccctgc ggtccccggg cggcagcagc ggccgcctag tcccgcgcct ctccgggctt
       61 acagccccgc ggtcccgccg ccccggggcc gccacctctc ggggctcccc ccagtccccg
      121 cgcgcgcaag atggctgacc cggctgcggg gccgccgccg agcgagggcg aggagagcac
      181 ggtgcgcttc gcccgcaaag gcgccctccg gcagaagaac gtgcacgagg tgaagaacca
      241 caaattcacc gcccgcttct tcaagcagcc caccttctgc agccactgca ccgacttcat
      301 ttggggctta ggtttgcagg gattccagag tcaggtctgc tgctttgttg tacacaagcg
      361 ctgccatgaa ttcgtcacgt tctcctgccc tggtgcagac aagggcccgg cctctgatga
      421 cccacggagc aaacacaagt ttaagatcca cacctactcc agccctacct tctgtgacca
      481 ctgtggatca ctgctgtatg ggctcatcca ccaggggatg aaatgcgaca cctgtatgat
      541 gaatgtccac aagcgctgcg tgatgaacgt ccccagcctc tgtggcaccg accacacaga
      601 acgccgtggc cgcatctaca tccaggccca catcgacagg gaggtcctca tcgttgttgt
      661 aagagatgct aaaaatctgg tacctatgga ccccaacggc ttgtcagatc cctacgtaaa
      721 actgaaactg atccctgatc ccaaaagtga gagcaagcag aagaccaaga ctatcaaatg
      781 ctccctcaac ccggagtgga acgaaacctt cagatttcag ctgaaggaat cagacaaaga
      841 cagaagactg tccgtagaga tctgggattg ggacctgacc agcaggaatg acttcatggg
      901 atctctgtcg tttgggattt cagaactaca gaaagccgga gtggatggct ggttcaagtt
      961 actaagccag gaagaaggcg agtactttaa tgtgccggtg ccgccggaag gaagcgaggg
     1021 caatgaagag ctgcggcaga agtttgagag agccaagatt ggccaaggta ccaaggctcc
     1081 agaagaaaag acagcgaaca ctatatccaa atttgacaac aatggcaaca gggaccggat
     1141 gaaactgacc gattttaact tcctgatggt gctggggaaa ggcagctttg gcaaggtcat
     1201 gctctcagag cggaagggta cagatgaact ctatgccgtg aagatcctga agaaagatgt
     1261 ggtgatccaa gatgacgatg tggagtgcac aatggtggag aagagggtgc tggccctgcc
     1321 tgggaagccc ccattcctga ctcagctcca ttcctgcttc cagaccatgg accgcctcta
     1381 ctttgtgatg gagtatgtga acgggggcga cctcatgtac cacatccaac aagttggccg
     1441 tttcaaggag ccccatgctg tattttacgc tgcagagatt gccatcggtc ttttcttctt
     1501 gcagagcaag ggcatcattt accgtgacct gaaacttgac aacgtgatgc tggattccga
     1561 ggggcacatc aaaatcgctg actttggcat gtgtaaagag aatatctggg atggggtgac
     1621 aaccaagaca ttctgtggca ctccagacta cattgcccca gagatcattg cttatcagcc
     1681 ctacgggaag tctgtggact ggtgggcgtt tggagtcctg ctgtatgaaa tgttggctgg
     1741 ccaggcacct tttgaagggg aggatgagga tgaactcttc cagtcaatca tggagcacaa
     1801 cgtggcgtat cccaagtcca tgtctaagga agctgtggca atctgcaaag ggctaatgac
     1861 caaacaccca ggcaagcgcc tgggttgtgg gcctgaaggg gaacgagaca ttaaggagca
     1921 tgcatttttc cggtatatcg actgggagaa actcgaacgc aaggagattc agccacctta
     1981 taaaccaaaa gcttgtgggc gaaacgctga aaacttcgac cggtttttca cccgccatcc
     2041 accagtccta acacctcctg accaggaagt catcaggaat attgaccaat cagaattcga
     2101 aggattttcc tttgttaact ctgaattttt aaaacccgaa gtcaagagct aagtagatct
     2161 gtagacctcc gtccttcatt tctgtcattc aagctcaaca gctatcatgg tgacattttt
     2221 tttcttttcc attgccaagt tacatccgtg ttttcttttc tgatgaggct agagtggcca
     2281 tgtttcagaa cccaaatgtc ctcaagtagt ttggagcatc tcgaggagat ggaattatgc
     2341 aggtggcatg tagaaagtgc tgcataatcg agacacgctc agagccctac tatgtgcatc
     2401 cctagcatgt cggctcacag gcccccaggg gagagaaaat gcttgctttt ctccctggtc
     2461 ctctgcactg ccatttttac cctgaccccc agtctacatc cttcctacaa aatggataga
     2521 cgagccaaat gctagcaaca ttcttccacc ttcccggctg ggagcttggc ttgaatccaa
     2581 gtatatggct gctttgccct agagggaatc cctccacgct gcctgttctg gaggcagtgg
     2641 agctttgaaa agaacatgct aaaaataaaa atttattttt atttttttaa ctcaatgtta
     2701 agaagattat ctaagtcctg gggaaaaaag gaatgcgctt ttagacaagt ttccatctaa
     2761 aagcacttcc agggtcgaag gcaaccagct tgtgtgctgt caccttgctg tagtttctaa
     2821 tactgtgtgt ctgatagtgg taccctcatc ccccaaacta ctccagaatg acatttggca
     2881 ctgttcttag aaccacatgg tcactctagc aaggtcctaa aggaccctga ttctacatta
     2941 catttcaaat gttacttgct ttttttttta atttctgtca tcattgaaat gcaaaaagaa
     3001 aaaaaagaaa
//
