LOCUS       NM_013181               1434 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus protein kinase cAMP-dependent type I regulatory
            subunit alpha (Prkar1a), mRNA.
ACCESSION   NM_013181 XM_579380
VERSION     NM_013181.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1434)
  AUTHORS   Kim,J., Kwon,J.T., Jeong,J., Kim,J., Hong,S.H., Kim,J., Park,Z.Y.,
            Chung,K.H., Eddy,E.M. and Cho,C.
  TITLE     SPATC1L maintains the integrity of the sperm head-tail junction
  JOURNAL   EMBO Rep 19 (9) (2018)
   PUBMED   30026308
REFERENCE   2  (bases 1 to 1434)
  AUTHORS   Gilbert,M.L., Yang,L., Su,T. and McKnight,G.S.
  TITLE     Expression of a dominant negative PKA mutation in the kidney
            elicits a diabetes insipidus phenotype
  JOURNAL   Am J Physiol Renal Physiol 308 (6), F627-F638 (2015)
   PUBMED   25587115
  REMARK    GeneRIF: role for PKA signaling in both short- and long-term
            regulation of AQP2, characterizing a novel mouse model of diabetes
            insipidus
REFERENCE   3  (bases 1 to 1434)
  AUTHORS   Burgers,P.P., van der Heyden,M.A., Kok,B., Heck,A.J. and
            Scholten,A.
  TITLE     A systematic evaluation of protein kinase A-A-kinase anchoring
            protein interaction motifs
  JOURNAL   Biochemistry 54 (1), 11-21 (2015)
   PUBMED   25097019
REFERENCE   4  (bases 1 to 1434)
  AUTHORS   Nishimura,T., Fujii,W., Sugiura,K. and Naito,K.
  TITLE     Cytoplasmic anchoring of cAMP-dependent protein kinase (PKA) by
            A-kinase anchor proteins (AKAPs) is required for meiotic arrest of
            porcine full-grown and growing oocytes
  JOURNAL   Biol Reprod 90 (3), 58 (2014)
   PUBMED   24501172
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1434)
  AUTHORS   Biesemann,C., Gronborg,M., Luquet,E., Wichert,S.P., Bernard,V.,
            Bungers,S.R., Cooper,B., Varoqueaux,F., Li,L., Byrne,J.A.,
            Urlaub,H., Jahn,O., Brose,N. and Herzog,E.
  TITLE     Proteomic screening of glutamatergic mouse brain synaptosomes
            isolated by fluorescence activated sorting
  JOURNAL   EMBO J 33 (2), 157-170 (2014)
   PUBMED   24413018
REFERENCE   6  (bases 1 to 1434)
  AUTHORS   Lazar,S., Galiani,D. and Dekel,N.
  TITLE     cAMP-Dependent PKA negatively regulates polyadenylation of c-mos
            mRNA in rat oocytes
  JOURNAL   Mol Endocrinol 16 (2), 331-341 (2002)
   PUBMED   11818504
  REMARK    GeneRIF: cAMP-Dependent PKA negatively regulates polyadenylation of
            c-mos mRNA in rat oocytes
REFERENCE   7  (bases 1 to 1434)
  AUTHORS   Kirschner,L.S., Carney,J.A., Pack,S.D., Taymans,S.E., Giatzakis,C.,
            Cho,Y.S., Cho-Chung,Y.S. and Stratakis,C.A.
  TITLE     Mutations of the gene encoding the protein kinase A type I-alpha
            regulatory subunit in patients with the Carney complex
  JOURNAL   Nat Genet 26 (1), 89-92 (2000)
   PUBMED   10973256
REFERENCE   8  (bases 1 to 1434)
  AUTHORS   Imaizumi-Scherrer,T., Faust,D.M., Benichou,J.C., Hellio,R. and
            Weiss,M.C.
  TITLE     Accumulation in fetal muscle and localization to the neuromuscular
            junction of cAMP-dependent protein kinase A regulatory and
            catalytic subunits RI alpha and C alpha
  JOURNAL   J Cell Biol 134 (5), 1241-1254 (1996)
   PUBMED   8794865
REFERENCE   9  (bases 1 to 1434)
  AUTHORS   Greene,R.M., Lloyd,M.R., Uberti,M., Nugent,P. and Pisano,M.M.
  TITLE     Patterns of cyclic AMP-dependent protein kinase gene expression
            during ontogeny of the murine palate
  JOURNAL   J Cell Physiol 163 (3), 431-440 (1995)
   PUBMED   7775586
REFERENCE   10 (bases 1 to 1434)
  AUTHORS   Kuno,T., Ono,Y., Hirai,M., Hashimoto,S., Shuntoh,H. and Tanaka,C.
  TITLE     Molecular cloning and cDNA structure of the regulatory subunit of
            type I cAMP-dependent protein kinase from rat brain
  JOURNAL   Biochem Biophys Res Commun 146 (2), 878-883 (1987)
   PUBMED   3619906
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 26, 2020 this sequence version replaced NM_013181.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M17086.1, SRR22399484.1275394.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000010.1  95120537-95120625
            90-272              JAXUCZ010000010.1  95123812-95123994
            273-443             JAXUCZ010000010.1  95129397-95129567
            444-535             JAXUCZ010000010.1  95130302-95130393
            536-597             JAXUCZ010000010.1  95130563-95130624
            598-644             JAXUCZ010000010.1  95131564-95131610
            645-803             JAXUCZ010000010.1  95132272-95132430
            804-864             JAXUCZ010000010.1  95134126-95134186
            865-986             JAXUCZ010000010.1  95135161-95135282
            987-1068            JAXUCZ010000010.1  95136017-95136098
            1069-1434           JAXUCZ010000010.1  95136800-95137165
FEATURES             Location/Qualifiers
     source          1..1434
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..1434
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /note="protein kinase cAMP-dependent type I regulatory
                     subunit alpha"
                     /db_xref="GeneID:25725"
                     /db_xref="RGD:3391"
     exon            1..89
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            90..272
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1241
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /EC_number="2.7.11.1"
                     /note="protein kinase cAMP-dependent type 1 regulatory
                     subunit alpha; protein kinase, cAMP-dependent, regulatory,
                     type I, alpha; protein kinase, cAMP-dependent, regulatory
                     subunit type I alpha"
                     /codon_start=1
                     /product="cAMP-dependent protein kinase type I-alpha
                     regulatory subunit"
                     /protein_id="NP_037313.1"
                     /db_xref="GeneID:25725"
                     /db_xref="RGD:3391"
                     /translation="MASGSMAASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPE
                     RPMAFLREYFERLEKEEARQIQSLQKSGIRTDSREDEISPPPPNPVVKGRRRRGAISA
                     EVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIA
                     GETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAK
                     TNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQF
                     EDGQKIVVQGEPGDEFFIILEGTAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRP
                     RAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV"
     exon            273..443
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            444..535
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            536..597
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            598..644
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            645..803
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            804..864
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            865..986
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1068
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1434
                     /gene="Prkar1a"
                     /gene_synonym="RIIA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgttgagg gaggcagacg cgaggaggaa cggaggagag gcggagatca ccgaacagca
       61 gaacaatcta gaggatccct cgacacctga gaaccatggc gtctggcagt atggcagcca
      121 gtgaggaaga gcggagtctc cgggaatgcg agctctatgt gcagaagcac aacatccagg
      181 ccctgctgaa ggactccatc gtgcagctgt gcactgctcg gcccgagagg cccatggcat
      241 tccttcggga atactttgag aggctggaga aggaggaggc aagacagatt cagagcctac
      301 agaaatccgg cattcgtaca gactcgaggg aggatgagat ctctcctcca cccccaaatc
      361 cggtggtgaa gggccgtcgg cgccgcggtg ctatcagcgc tgaggtttac actgaggaag
      421 atgctgcgtc ctacgttaga aaggttatac caaaagatta taagacaatg gctgctttag
      481 ccaaggccat cgaaaagaac gtgttatttt cacaccttga tgacaatgag agaagtgaca
      541 tttttgatgc aatgtttcca gtctccttta ttgctggaga gacagttatt cagcaagggg
      601 atgaagggga taacttctat gtgattgatc aaggagaaat ggatgtgtat gtcaataatg
      661 aatgggcaac cagtgttggg gaaggaggga gctttggaga gctggctttg atttacggaa
      721 cacccagagc agccactgtc aaagcaaaga caaacgtgaa actgtggggc attgaccgag
      781 acagctaccg gagaatcctc atgggaagca ctctgcgaaa gaggaagatg tatgaagaat
      841 ttcttagtaa agtgtctatt ttagagtctc tggacaagtg ggagcgtctc acagtagctg
      901 atgcactgga gcctgtccag tttgaagatg gacagaagat tgtggtgcaa ggagaaccgg
      961 gggatgagtt cttcattatt ttagagggca cggccgctgt gctgcagcgt cggtcagaaa
     1021 acgaagagtt tgttgaagtg ggacgcctgg ggccttctga ctattttggt gaaattgccc
     1081 tgctgatgaa tcgtcctcgg gctgccactg tggttgcgcg tggccctttg aagtgcgtta
     1141 agttggaccg acctcggttt gaacgcgtcc ttggcccatg ctcagatatc ctcaagcgaa
     1201 acatccagca gtacaacagc tttgtgtcac tgtccgtctg agatccgcct cctgtgcctc
     1261 tcctccccag tctatgcttc actcacgcag actgctttct cctccctctc tgcagcgcca
     1321 agtggccact ggcttcacag cttcttgtct ctgtatacta aaggttgctt tattgcacca
     1381 ttttccattg gagcgttact gaatgctcac tcacaaataa atagagttgt atgg
//
